期刊
JOURNAL OF VETERINARY MEDICAL SCIENCE
卷 79, 期 8, 页码 1394-1397出版社
JAPAN SOC VET SCI
DOI: 10.1292/jvms.17-0054
关键词
interferon antagonist; muscle cells; phosphoprotein; rabies virus
资金
- Japan Society for the Promotion of Science [23380179, 24580424, 15K07720]
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Grants-in-Aid for Scientific Research [23380179, 24580424, 15K07720] Funding Source: KAKEN
Attenuated derivative rabies virus Ni-CE replicates in muscle cells less efficiently than does the parental pathogenic strain Nishigahara. To examine the mechanism underlying the less efficient replication of Ni-CE, we compared the activities of Ni-CE and Nishigahara phosphoproteins, viral interferon (IFN) antagonists, to suppress IFN-beta promoter activity in muscle cells and we demonstrated a defect of Ni-CE phosphoprotein in this ability. Treatment with an IFN-beta neutralizing antibody improved the replication efficiency of Ni-CE in muscle cells, indicating that produced IFN inhibits Ni-CE replication. The results indicate the importance of IFN antagonism of rabies virus phosphoprotein for viral replication in muscle cells.
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