Article
Biochemistry & Molecular Biology
Bjarke Follin, Cecilie Hoeeg, Lisbeth D. Hojgaard, Morten Juhl, Kaya B. Lund, Kristina B. Dossing, Simon Bentsen, Ingrid Hunter, Carsten H. Nielsen, Rasmus S. Ripa, Jens Kastrup, Annette Ekblond, Andreas Kjaer
Summary: In a rat model of chronic ischemic cardiomyopathy, treatment with ASC initiated an immune response involving monocytes/macrophages and T-cells, inducing a gene expression pattern associated with angiogenesis and monocyte/macrophage differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biology
Xue Yang, Ying Wang, Valentina Rovella, Eleonora Candi, Wei Jia, Francesca Bernassola, Pierluigi Bove, Mauro Piacentini, Manuel Scimeca, Giuseppe Sica, Giuseppe Tisone, Alessandro Mauriello, Lixin Wei, Gerry Melino, Yufang Shi
Summary: Natural ageing of organisms and age-related diseases are mainly caused by stem cell ageing and inflammaging. Mesenchymal stem cells (MSCs) have high immune-regulating capacity and are potential candidates for immune-related disease treatment. However, MSC application is not satisfactory for some patients, especially the elderly, possibly due to changes in MSCs with ageing, including reduced cell population and differentiation ability, decreased migratory and homing capacity, and defective immunosuppression. It is important to explore the relationship between inflammaging and aged MSCs in order to prevent age-related diseases and improve the therapeutic effects of MSCs. This review discusses the changes in naturally ageing MSCs mainly from an inflammation perspective and proposes ideas for rejuvenating aged MSCs in future treatments.
Article
Oncology
Zhenbo Tu, Antoine E. Karnoub
Summary: Mesenchymal stem/stromal cells (MSCs) are a heterogeneous population of fibroblastic progenitor cells that reside in multiple tissues around the body and have the ability to differentiate into various connective tissue cells. They play critical regulatory roles in breast tumor development and progression, participating in multiple aspects of the process.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Cell Biology
Chuanbin Liu, Dong Han, Ping Liang, Yang Li, Feng Cao
Summary: Ischemic heart disease is the leading cause of mortality globally, and stem cell transplantation is considered a promising treatment approach. While preclinical studies have shown promising results, clinical studies still face challenges such as improving cell engraftment and understanding functional mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell & Tissue Engineering
Mahshid Saleh, Seyedeh Zahra Fotook Kiaei, Maria Kavianpour
Summary: Pulmonary fibrosis is a devastating disease with no effective treatment options. Basic research using stem cells, specifically Wharton jelly-derived mesenchymal stem cells, shows promise in finding alternative therapies. However, further clinical trials are needed to determine their safety and efficacy.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Reed Berlet, Stefan Anthony, Beverly Brooks, Zhen-Jie Wang, Nadia Sadanandan, Alex Shear, Blaise Cozene, Bella Gonzales-Portillo, Blake Parsons, Felipe Esparza Salazar, Alma R. Lezama Toledo, German Rivera Monroy, Joaquin Vega Gonzales-Portillo, Cesario Borlongan
Summary: Combining stem cell transplantation with rehabilitation therapy presents a promising approach in treating stroke, with potential for better functional outcomes for patients. This comprehensive review assesses the advantages and disadvantages of using this combined therapy to mitigate the devastating effects of stroke.
Article
Biotechnology & Applied Microbiology
Niji Nandakumar, Malini Mohan, Akhil T. Thilakan, Hridhya K. Sidharthan, Janarthanan Ramu, Deepti Sharma, Shantikumar V. Nair, Binulal N. Sathy
Summary: The development of a bioengineered 3D microfibrous matrix that decreases the release of osteopontin (OPN) from mesenchymal stem cells (MSCs) has shown a significant increase in the expansion of hematopoietic stem cells (HSCs) by over 24-fold. The culture system with the lowest amount of OPN resulted in the highest cell viability and purity of HSCs. This suggests that bioengineered microfibrous 3D matrices seeded with MSCs, primed under suitable culture conditions, can be a promising ex vivo expansion system for HSC culture.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Cardiac & Cardiovascular Systems
Laura L. Hocum Stone, Cory Swingen, Christin Wright, Steven S. Qi, Matt Rassette, Edward O. McFalls, Rosemary F. Kelly
Summary: This study investigated the utility of mesenchymal stem cells applied as an epicardial patch during coronary artery bypass graft to target hibernating myocardium in a large animal model. Results showed that the stem cell patch improved myocardial function by enhancing mitochondrial morphology and function.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Review
Engineering, Biomedical
Nityanand Prakash, Jiseong Kim, Jieun Jeon, Siyeon Kim, Yoshie Arai, Alvin Bacero Bello, Hansoo Park, Soo-Hong Lee
Summary: The use of mesenchymal stem cells (MSCs) in clinical applications has significantly increased in the past decade due to their differentiation potential and immunomodulatory properties. However, the heterogeneity among MSC sources, as well as limitations in adult-sourced MSCs, have posed challenges for their effective use. Recent research has focused on generating MSCs from pluripotent stem cells (PSCs), such as induced pluripotent stem cells (iPSCs), to overcome these limitations.
BIOMATERIALS RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Yi-Hsien Fang, Saprina P. H. Wang, Hsien-Yuan Chang, Pei-Jung Yang, Ping-Yen Liu, Yen-Wen Liu
Summary: Cardiovascular disease is the leading cause of global mortality, and pluripotent stem cells from amniotic fluid show potential for cardiac regeneration therapy with their high immune tolerance. This review highlights the progress of amniotic fluid stem cell therapy in recent years for the treatment of heart diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Marko Banovic, Gregor Poglajen, Bojan Vrtovec, Arsen Ristic
Summary: Clinical trials of stem cell therapy for heart repair have been conducted for almost 20 years, but the clinical benefits have not been consistently confirmed. There are still many unanswered questions and challenges in the field of stem cell therapy for heart failure, including protocol streamlining, patient selection, stem cell type and dose, and cell delivery mode.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Christophe Tribouilloy, Yohann Bohbot, Maciej Kubala, Frank Ruschitzka, Bogdan Popescu, Olaf Wendler, Cecile Laroche, Elektra Bartha, Huseyin Ince, Iveta Simakova, Alec Vahanian, Bernard Iung
Summary: Patients with multiple native valvular heart disease are more common in women, have more severe heart failure and comorbidities, higher left atrial volumes and pulmonary pressures, lower survival rates, and higher rates of heart failure occurrence.
EUROPEAN HEART JOURNAL
(2022)
Review
Cell Biology
Yelei Cen, Guohua Lou, Jinjin Qi, Min Zheng, Yanning Liu
Summary: Mesenchymal stem cells (MSCs) show promise as an alternative treatment for liver disease due to their ability to regenerate, inhibit fibrosis, and regulate the immune system. Impaired mitochondrial function is a common feature in liver diseases, leading to ATP synthesis dysfunction, decreased respiratory chain activity, and altered mitochondrial dynamics. Recent evidence suggests that MSCs can not only replace damaged cells and have paracrine effects, but also regulate mitochondrial dysfunction in liver disease. This review comprehensively discusses the role of mitochondrial dysfunction in liver disease and how MSCs can target it, as well as recent advances in modifying MSCs to enhance their functions in treating liver disease.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Cell & Tissue Engineering
Yi Zhao, Jiawei He, Tao Qiu, Haoyu Zhang, Li Liao, Xiaoxia Su
Summary: With the acceleration of global aging, the prevention and treatment of age-related bone diseases have become critical. The dysfunction of bone marrow mesenchymal stem cells (BMSCs), which lose the capability of self-renewal and functional differentiation during aging, is a key factor in impaired bone tissue regeneration and homeostasis disorders. Epigenetic modifications play a crucial role in the dysfunction of BMSCs during aging, and reversing these modifications provides a potential avenue to combat BMSC aging.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cardiac & Cardiovascular Systems
Gemma Vilahur, Phuong Hue Nguyen, Lina Badimon
Summary: This study discusses the impact of diabetes on stem cell potential, focusing on the effects of diabetes on stem cell phenotype, molecular fingerprint, and extracellular vesicle profile. While cell-based therapy has potential in repairing damaged hearts, inconsistent benefits from treatments with adult-derived stem cells are shown in randomized controlled trials and meta-analyses, and cardiovascular risk factors can impair stem cell potential.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Letter
Immunology
Jose Medina-Pestana, Marina Pontello Cristelli, Laila Almeida Viana, Renato Demarchi Foresto, Lucio R. Requiao-Moura, Helio Tedesco-Silva, Dimas Tadeu Covas
Article
Immunology
Sonia Aparecida Andrade, Joao Victor Batalha-Carvalho, Rui Curi, Fan Hui Wen, Dimas Tadeu Covas, Ana Marisa Chudzinski-Tavassi, Ana Maria Moro
Summary: The COVID-19 pandemic caused by SARS-CoV-2 and its variants has led to a global health crisis. ECIG, an antibody, has shown potential in binding to proteins of VOCs and may have therapeutic effects in reducing viral infectivity and the emergence of new variants in COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Giovana B. de Oliveira, Janine Alessi, Isadora Nunes Erthal, Julia Belato Teixeira, Milena Sbalchiero Morello, Raquel Jaqueline Eder Ribeiro, Guilherme H. Telo, Beatriz D. Schaan, Gabriela H. Telo
Summary: During the COVID-19 pandemic, adolescents with diabetes had significantly worse eating habits compared to those without diabetes.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2022)
Article
Hematology
Victoria Simionatto Zucherato, Pericles Natan Mendes da Costa, Marta Giovanetti, Luciana Maria Fontanari Krause, Daiani Cristina Ciliao Alves, Renata Maria Alencar Moreira, Barbara Maciel Sidou Pimentel, Rodrigo Haddad, Hellen Tayana Bitencourt, Massimo Ciccozzi, Luiz Carlos Junior Alcantara, Simone Kashima, Dimas Tadeu Covas, Svetoslav Nanev Slavov
Summary: The study evaluated the prevalence of MCPyV DNA among Brazilian blood donors and found an overall prevalence of 1.1%, with similar rates in different regions.
TRANSFUSION CLINIQUE ET BIOLOGIQUE
(2023)
Article
Public, Environmental & Occupational Health
Maria Carolina Elias, Svetoslav Nanev Slavov, Alex Ranieri Jeronimo Lima, Antonio Jorge Martins, Claudia Renata dos Santos Barros, Debora Botequio Moretti, Eduardo L. Araujo, Elaine Cristina Marqueze, Gabriela Ribeiro, Gabriela Mauric Frossard Ribeiro, Jardelina Souza Todao Bernardino, Jaqueline Reginato Koser, Luan Gaspar Clemente, Luiz Aurelio Campos Crispin, Luiz Carlos Alcantara Jr, Luiz Lehmann Coutinho, Marta Giovanetti, Quetura Oliveira Silva, Raul Machado Neto, Ricardo Haddad, Simone Kashima, Vincent Louis Viala, Dimas Tadeu Covas, Sandra Coccuzzo Sampaio
Summary: Brazil has been severely affected by the SARS-CoV-2 pandemic and has been a continuous source of virus variants. Due to insufficient infrastructure in some regions of the country, the Butantan Institute established a mobile laboratory (LabMovel) to conduct SARS-CoV-2 testing and monitor the pandemic in key areas.
Article
Obstetrics & Gynecology
Roberta de Padua Borges, Georgia Oliveira Avila, Amanda Cunha Ritter, Janine Alessi, Angela Jacob Reichelt, Maria Lucia da Rocha Oppermann, Gabriela Heiden Telo, Beatriz D. Schaan
Summary: This study evaluated the indirect effects of the COVID-19 pandemic on the care of women with pregnancies complicated by gestational or pre-existing diabetes, and their maternal-fetal outcomes. The study found that despite the impact of the pandemic on the economy, society, and structure, parameters of maternal care were similar, diabetes control improved, and neonatal hypoglycemia and SGA rates were lower among pregnant women with diabetes during the pandemic.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Dimas Tadeu Covas, Ariane de Jesus Lopes de Abreu, Carolina Zampirolli Dias, Rafaela Vansan Ferreira, Ramon Goncalves Pereira, Guilherme Silva Julian
Summary: This study aims to describe the adverse events of COVID-19 vaccines in pregnant and postpartum women in Brazil. The results support the recommendation of vaccination for these groups, but further studies with longer observation time are still needed to provide more comprehensive safety evidence.
Article
Virology
Patricia Akemi Assato, Luan Gaspar Clemente, Marta Giovanetti, Gabriela Ribeiro, Alex Ranieri Jeronimo Lima, Melissa Palmieri, Leonardo Nazario de Moraes, Simone Kashima, Heidge Fukumasu, Mauricio Lacerda Nogueira, Luiz Carlos Alcantara, Aline Lais Nicolodelli, Antonio Jorge Martins, Bruna Petry, Cecilia Artico Banho, Claudia Renata Dos Santos Barros, Cristina Tschorny Moncau-Gadbem, Debora Botequio Moretti, Debora Glenda De La Roque, Elaine Cristina Marqueze, Elisangela Chicaroni Mattos, Fabiana Erica Vilanova Da Silva, Felipe Allan Da Silva Da Costa, Giselle Cacherik, Jardelina De Souza Todao Bernardino, Jessika Cristina Chagas Lesbon, Livia Sacchetto, Loyze Paola Oliveira De Lima, Luiz Artur Vieira Caldeira, Maiara Martininghi, Marilia Mazzi Moraes, Mirele Daiana Poleti, Pedro De Queiroz Cattony Neto, Raquel De Lello Rocha Campos Cassano, Ricardo Augusto Brassaloti, Svetoslav Nanev Slavov, Vincent Louis Viala, Luiz Lehmann Coutinho, Rejane Maria Tommasini Grotto, Raul Machado Neto, Dimas Tadeu Covas, Sandra Coccuzzo Sampaio, Maria Carolina Elias, Jayme A. Souza-Neto
Summary: This study provides a retrospective overview of the COVID-19 epidemic in Sao Paulo City, Brazil, by analyzing near-complete genome sequences. The analysis reveals multiple independent introduction events of different variants and identifies the viral movement within different regions. The results emphasize the importance of increasing genomic monitoring to track the real-time evolution of the virus and detect any potential emergence of new variants of concern.
Editorial Material
Endocrinology & Metabolism
Beatriz D. Schaan
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Article
Virology
Anielly S. da Silva, Gabriel Montenegro de Campos, Marta Giovanetti, Victoria Simonatto Zucherato, Alex Ranieri Jeronimo Lima, Elaine Vieira Santos, Rodrigo Haddad, Massimo Ciccozzi, Luiz Carlos Junior Alcantara, Maria Carolina Elias, Sandra Coccuzzo Sampaio, Dimas Tadeu Covas, Simone Kashima, Svetoslav Nanev Slavov
Summary: In this study, metagenomics was used to identify viral infections among pediatric patients with acute respiratory disease. Two pools of samples were found to contain the little-known Malawi polyomavirus (MWPyV). Further testing revealed that MWPyV-positive samples also tested positive for respiratory syncytial virus. Phylogenetic analysis of MWPyV genome sequences from index samples was conducted, providing insights into its viral origin. This study represents the first molecular and genomic characterization of MWPyV in pediatric patients in South America.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Oncology
Dalila Luciola Zanette, Karoline Brito Caetano Andrade Coelho, Eneas de Carvalho, Mateus Nobrega Aoki, Jeanine Marie Nardin, Larissa Araujo Lalli, Rafael dos Santos Bezerra, Marta Giovanetti, Victoria Simionatto Zucherato, Gabriel Montenegro de Campos, Jardelina de Souza Todao Bernardino, Vincent Louis Viala, Massimo Ciccozzi, Luiz Carlos Junior Alcantara, Sandra Coccuzzo Sampaio, Maria Carolina Elias, Simone Kashima, Dimas Tadeu Covas, Svetoslav Nanev Slavov
Summary: A study examined the composition of plasma virome in patients with prostate cancer, finding that Anelloviruses and Human Pegivirus-1 (HPgV-1) were the most abundant components. Clinically important viruses like hepatitis C virus (HCV), cytomegalovirus, and human adenovirus type C were also identified. In comparison, the virome of blood donors was mainly composed of torque teno virus types (TTV). This study sheds light on the viral abundance and diversity in patients with prostate cancer, suggesting that malignant processes may influence virome composition.
MOLECULAR & CELLULAR ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Augusto Cesar Ferreira De Moraes, Vanessa Cassia Medeiros-Oliveira, Katie Burford, Beatriz D. Schaan, Katia Bloch, Kenia Mara Baiocchi de Carvalho, Felipe Vogt Cureau, Marcus Vinicius Nascimento-Ferreira
Summary: This study aimed to investigate the associations between movement behaviors, abdominal obesity, and inflammatory biomarkers in adolescents, as well as the mediating role of waist circumference. The results showed a negative association between sleep duration and inflammatory biomarkers, and waist circumference partially mediated this association. Therefore, maintaining healthy sleep habits can have positive implications for reducing waist circumference and inflammatory indicators in adolescents.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Article
Hematology
Victoria Simionatto Zucherato, Marta Giovanetti, Lara Okuyama Afonso Costa, Luciana Maria Fontanari Krause, Daiani Cristina Ciliao Alves, Renata Maria Alencar Moreira, Barbara Maciel Sidou Pimentel, Rodrigo Haddad, Hellen Tayana Bitencourt, Massimo Ciccozzi, Luiz Carlos Alcantara Jr, Simone Kashima, Dimas Tadeu Covas, Svetoslav Nanev Slavov
Summary: This study investigated the prevalence of HuGkV-2 DNA among healthy blood donors from different regions in Brazil. The results showed that the highest prevalence was recorded in the Brazilian Amazon at 15.3%. Although this provides preliminary insights into the impact of this emerging viral agent, further studies are needed to understand the prevalence, transmission routes, and possible clinical effects.
TRANSFUSION AND APHERESIS SCIENCE
(2023)
Review
Endocrinology & Metabolism
Aline Chagastelles Pinto de Macedo, Camila Wohlgemuth Schaan, Patricia Martins Bock, Mariana Brutto de Pinto, Cintia Ehlers Botton, Daniel Umpierre, Beatriz D. Schaan
Summary: This systematic review and meta-analysis found that individuals with type 2 diabetes had lower cardiorespiratory fitness compared to individuals without diabetes, as demonstrated by lower maximal oxygen consumption (VO(2)max) and smaller walking distance in the 6-minute walk test. However, the quality of the studies included in the analysis was low.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Article
Immunology
Gil C. De Santis, Luciana Correa Oliveira, Pedro M. M. Garibaldi, Carlos E. L. Almado, Julio Croda, Ghislaine G. A. Arcanjo, Erika A. F. Oliveira, Adriana C. Tonacio, Dante M. Langhi Jr, Jose O. Bordin, Renato N. Gilio, Leonardo C. Palma, Elaine Santos, Simone K. Haddad, Benedito P. A. Prado Jr, Marjorie Cornejo Pontelli, Rogerio Gomes, Carlos H. Miranda, Maria Auxiliadora Martins, Dimas T. Covas, Eurico Arruda, Benedito A. L. Fonseca, Rodrigo T. Calado
Summary: A multicenter randomized trial in Brazil showed that high-dose convalescent plasma transfusion within 10 days of symptom onset did not benefit patients with severe COVID-19.
EMERGING INFECTIOUS DISEASES
(2022)