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Trace elements in early phase type 2 diabetes mellitus-A population-based study. The HUNT study in Norway

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2017)

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JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
卷 40, 期 -, 页码 46-53

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ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.jtemb.2016.12.008

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Type 2 diabetes; Case-control study; HUNT3; Trace elements; HR-ICP-MS; Whole blood

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Biochemistry & Molecular Biology Endocrinology & Metabolism

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  1. European Union Seventh Framework Programme [261433]

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Differences in trace elements levels between individuals with type 2 diabetes and controls have been reported in several studies in various body fluids and tissues, but results have been inconsistent. In order to examine trace element levels in the early phase of type 2 diabetes, we investigated the association between whole blood levels of 26 trace elements and the prevalence of previously undiagnosed, screening-detected type 2 diabetes. The study was conducted as a case-control study nested within the third survey of the population-based Nord-Trondelag Health Study (HUNT3 Survey). Among participants without previously known diabetes, 128 cases of type 2 diabetes were diagnosed in people with a high diabetes risk score (FINDRISC >= 15), and frequency-matched for age and sex with 755 controls. Blood samples were analyzed by high resolution inductively coupled plasma mass spectrometry. Associations between trace element levels and the prevalence of previously undiagnosed type 2 diabetes were evaluated with multivariable conditional logistic regression controlling for age, sex, body mass index, waist-to-hip ratio, education, income, smoking and family history of diabetes. The prevalence of previously undiagnosed type 2 diabetes increased across tertiles/quartiles for cadmium, chromium, iron, nickel, silver and zinc, and decreased with increasing quartiles of bromine (P-trend < 0.05). After corrections for multiple testing, associations for chromium remained significant (Q(trend) < 0.05), while associations for iron and silver were borderline significant. No associations were found for arsenic, boron, calcium, cesium, copper, gallium, gold, indium, lead, magnesium, manganese, mercury, molybdenum, rubidium, selenium, strontium, tantalum, thallium and tin. Our results suggest a possible role of bromine, cadmium, chromium, iron, nickel, silver and zinc in the development of type 2 diabetes. (C) 2016 Elsevier GmbH. All rights reserved.

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Mechanosignaling-related angiocrine factors drive osteoblastic phenotype in response to zirconia

Celio Junior da C. Fernandes, Gerson Santos de Almeida, Patricia Fretes Wood, Anderson M. Gomes, Fabio J. Bezerra, Jose C. S. Vieira, Pedro M. Padilha, Willian F. Zambuzzi

Summary: This study demonstrates the role of mechanosignaling in the promotion of an osteoblastic phenotype in response to zirconia exposure. The release of angiocrine factors modulated by mechanosignaling is crucial in creating a microenvironment that promotes wound healing and osseointegration. These findings highlight the importance of considering endothelial cell mechanosignaling in bone healing and osseointegration in the context of blood vessel effects.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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Article Biochemistry & Molecular Biology

The ameliorative effect of cerium oxide nanoparticles on chlorpyrifos induced hepatotoxicity in a rat model: Biochemical, molecular and immunohistochemical study

Rehab I. Abdel-Karim, Rania K. Hashish, Dahlia I. Badran, Sally S. Mohammed, Noha A. Salem

Summary: The study found that chlorpyrifos has hepatotoxicity, while cerium oxide nanoparticles can alleviate this toxicity. Cerium oxide nanoparticles can protect the liver by reducing the expression of inflammatory and apoptotic proteins and increasing the activity of antioxidant enzymes.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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Article Biochemistry & Molecular Biology

Effects of rare earth element samarium doped zinc oxide nanoparticles on Mytilus galloprovincialis (Lamarck, 1819): Filtration rates and histopathology

Tahani El Ayari, Raja Ben Ahmed, Zaineb Hammemi, Abdessalem Kouki, Emna Chelb, Salwa Nechi, Najoua Trigui El Menif

Summary: This study assessed the effects of samarium doped zinc oxide nanoparticles (Sm doped ZnO NPs) on the edible mussel Mytilus galloprovincialis and found that it led to a decrease in filtration rates and histopathological alterations in the gills, digestive glands, and gonads.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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Article Biochemistry & Molecular Biology

A preliminary predictive model for selenium nutritional status in residents based on three selenium biomarkers

Shanshan Niu, Zhangmin Wang, Xuebin Yin, Xiaodong Liu, Liqiang Qin, Muhammad Raza Farooq, Ofori Prince Danso, Zezhou Zhang, Qin Luo, Chenlu Sun, Jiaping Song

Summary: This study investigated the transport of selenium through the soil-crop-human chain in regions with different selenium levels. It found that the residents' dietary selenium intake was related to the selenium content in soil, with one village within the WHO recommended intake range while the other village was at risk of selenium deficiency. There were significant positive correlations between residents' dietary selenium intake and the three selenium biomarkers.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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Article Biochemistry & Molecular Biology

Selenium and selenoproteins role in Parkinson's disease: Is there a link between selenoproteins and accumulated alpha-synuclein?

Sanaz Salaramoli, Hamid Reza Joshaghani, Ali Shoeibi, Seyed Isaac Hashemy

Summary: The study suggests that serum levels of selenium and selenoprotein P may serve as biomarkers or risk factors for Parkinson's disease. Additionally, there is a correlation between alpha-synuclein levels and disease stage. Further research is needed to understand the role of selenoprotein S in reducing alpha-synuclein aggregation.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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Article Biochemistry & Molecular Biology

Differences in serum selenoprotein P profile between C57BL/6 and BALB/c mice fed high-fat diet

Motozumi Ando, Keiko Suzuki, Riko Kitamoto, Ayako Nakayama, Norio Watanabe, Masami Kawahara

Summary: C57BL/6 mice and BALB/c mice showed different expression profiles of selenoprotein P after a high-fat diet (HFD). C57BL/6 mice in the HFD group had higher body weight, fasting plasma glucose levels, and plasma selenoprotein P levels compared to the ND group. However, BALB/c mice did not show significant differences in fasting plasma selenoprotein P levels between the HFD and ND groups.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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Article Biochemistry & Molecular Biology

Vitamin E protects dopaminergic neurons against manganese-induced neurotoxicity through stimulation of CHRM1 and KCNJ4

Ruihan Song, Huanhuan Chen, Runqing Zhan, Miaomiao Han, Longzhu Zhao, Xiaoli Shen

Summary: This study aims to investigate the protective effects of Vitamin E (Vit E) on manganese (Mn)-induced nigrostriatal system lesions. The results demonstrate that Vit E improves behavioral disorders, attenuates the loss of nigral dopaminergic neurons, and restores mitochondrial function. Additionally, the protective effect of Vit E may be associated with the upregulation of CHRM1 and KCNJ4 mRNA.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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Article Biochemistry & Molecular Biology

Selenium in plant-based beverages: Total content, estimated bioaccessibility and contribution to daily intake

Jose Luan da Paixao Teixeira, Ana Paula Rebellato, Maria Isabel Andrekowisk Fioravanti, Raquel Fernanda Milani, Marcelo Antonio Morgano

Summary: The study aimed to determine the total Se content and bioaccessibility in commercial plant-based beverages, with results showing that only one beverage made from organic cashew nuts could meet the recommended Se intake for different populations. High bioacessibility percentages were observed in the beverages.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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Article Biochemistry & Molecular Biology

Dried blood spot analysis for elements of nutritional concern as demonstrated in studies of Galapagos land iguanas (Conolophus species)

Andreas F. Lehner, Sarah Rebolloso, Paul P. Calle, Karen Ingerman, Gregory A. Lewbart, Juan Pablo Munoz-Perez, Carlos A. Valle, John P. Buchweitz

Summary: The dried blood spot (DBS) technology is useful for storing blood samples from wildlife, and this study developed methods for measuring several important elements in DBS and used them for health assessments of Galapagos land iguanas. The results showed that the DBS samples accurately reflected the concentrations of various elements compared to plasma samples, with some divergences observed between different species.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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Article Biochemistry & Molecular Biology

Iodine status of school-aged children in the changing context of universal salt iodization program during 1997-2018 in Chongqing, China

Shuang Zhou, Chunbei Zhou, Jun Xie, Fei Luo, Ning Yao

Summary: The study illustrates the changes in iodized salt usage, goiter rate, and median urinary iodine concentration in school-aged children in Chongqing over the past 21 years. Adequate iodized salt consumption can eliminate iodine deficiency disorders in children, but excessive iodine intake from salt can lead to high urinary iodine excretion and even goiter. Continuous monitoring and adjustment of iodine fortification levels in household table salt is crucial.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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Article Biochemistry & Molecular Biology

Improvement of the cardiovascular effect of methyldopa by complexation with Zn(II): Synthesis, characterization and mechanism of action

Agustin B. Actis Dato, Valeria R. Martinez, Jorge O. Velez Rueda, Enrique L. Portiansky, Veronica De Giustu, Evelina G. Ferrer, Patricia A. M. Williams

Summary: The zinc coordination complex ZnMD, synthesized in this study, showed promising effects in treating hypertension and cardiac hypertrophy. It was more effective than the antihypertensive drug MD in reducing blood pressure and preventing myocardial hypertrophy. ZnMD also exhibited protective effects on the heart by reducing oxidative damage and regulating the expression of oxidative enzymes. These findings suggest that ZnMD has the potential to be developed as a therapeutic drug for hypertension and cardiac dysfunction.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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Article Biochemistry & Molecular Biology

Green synthesis of Ag and Cu-doped Bismuth oxide nanoparticles: Revealing synergistic antimicrobial and selective cytotoxic potentials for biomedical advancements

Mina Sarani, Maryam Roostaee, Mahboubeh Adeli-Sardou, Davood Kalantar-Neyestanaki, Seyed Amin Ayatollahi Mousavi, Azam Amanizadeh, Mahmood Barani, Alireza Amirbeigi

Summary: This study successfully synthesized nano bismuth oxide using green synthesis methods. The nano particles doped with silver and copper demonstrated excellent antibacterial properties and selective cytotoxicity against cancer cells. These findings have important implications for biomedical and therapeutic applications.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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Article Biochemistry & Molecular Biology

Neurological study on the effect of CeNPs and/or La Cl3 on adult male albino rats

Mona Abdel-Rahman, Heba M. Elmasry, Omar A. Ahmed-Farid, Sherein M. Hegazy, Mohamed M. Rezk

Summary: This study investigates the neuro effects of lanthanides on different brain areas in rats and finds that they can distribute and accumulate in various brain regions. Treatment with cerium nanoparticles or lanthanum causes a significant decrease in norepinephrine, dopamine, serotonin, and GABA, accompanied by a significant increase in 5-hydroxyl indoleacetic acid levels. Moreover, cerium nanoparticles exhibit high activity in scavenging free radicals.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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Article Biochemistry & Molecular Biology

The protective impact of curcumin, vitamin D and E along with manganese oxide and Iron (III) oxide nanoparticles in rats with scrotal hyperthermia: Role of apoptotic genes, miRNA and circRNA

Mahshid Deldar Abad Paskeh, Nahid Babaei, Mehrdad Hashemi, Abbas Doosti, Kiavash Hushmandi, Maliheh Entezari, Saeed Samarghandian

Summary: The combination of curcumin, vitamins D and E with Fe2O3-NPs and MnO2-NPs has shown to improve semen parameters and reduce apoptosis in germ cells in rats with testicular hyperthermia. This study suggests that this combination therapy may have a positive effect on fertility and decreasing the toxic effects of nanoparticles.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2024)

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