Article
Neurosciences
Maxim De Schaepdryver, Pegah Masrori, Philip Van Damme, Koen Poesen
Summary: The aim of this study was to investigate the impact of measuring neurofilament levels in cerebrospinal fluid (CSF) before referral to a neuromuscular reference center (NMRC) on the diagnostic delay in patients with amyotrophic lateral sclerosis (ALS). The results showed that measuring neurofilament levels in CSF before referral shortened the diagnostic delay in specific cases, but this effect disappeared when other covariates were taken into account.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Julia Costa, Marta Gromicho, Ana Pronto-Laborinho, Conceicao Almeida, Ricardo A. Gomes, Ana C. L. Guerreiro, Abel Oliva, Susana Pinto, Mamede de Carvalho
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease causing motor neuron dysfunction, with chitinases like Chitotriosidase and chitinase-3-like proteins showing potential as important biomarkers for disease progression in ALS patients.
Article
Biochemistry & Molecular Biology
Sungtaek Oh, Yura Jang, Chan Hyun Na
Summary: This study used discovery-based approaches and quantitative comparative analyses to identify differential proteins in the cerebrospinal fluid (CSF) of patients with ALS. They found 15 proteins that showed significant differences between ALS and the control group, providing a foundation for biomarker research in ALS.
Article
Neurosciences
Marie Dreger, Robert Steinbach, Nayana Gaur, Klara Metzner, Beatrice Stubendorff, Otto W. Witte, Julian Grosskreutz
Summary: The study investigated the correlation between CSF NfL levels and disease aggressiveness in ALS using the D50 disease progression model. Significant differences in NfL concentrations were found between different disease aggressiveness subgroups, indicating an increase of NfL levels with more aggressive disease progression. The study suggests that CSF NfL could potentially serve as a biomarker for disease aggressiveness in ALS, but further research is needed to address analytical variations.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Hugo Alarcan, Romane Chaumond, Patrick Emond, Isabelle Benz-De Bretagne, Antoine Lefevre, Salah-eddine Bakkouche, Charlotte Veyrat-Durebex, Patrick Vourc'h, Christian Andres, Philippe Corcia, Helene Blasco
Summary: This study aimed to evaluate the kynurenine pathway and amino acids profile in the cerebrospinal fluid of ALS patients, revealing some metabolites involved in group discrimination and identifying common discriminant metabolites for disease evolution criteria. The findings suggest a possible impairment of the kynurenine pathway towards neurotoxicity in ALS patients and highlight the need for further exploration of these pathways during disease evolution.
Review
Clinical Neurology
Cristiano Farace, Giovanni Fiorito, Andrea Pisano, Federica Etzi, Angela Sabalic, Grazia Fenu, Yolande Asara, Giuliana Solinas, Roberto Madeddu
Summary: This study aims to combine the current scientific literature evidence and clarify the differences in lead (Pb) bioaccumulation in human tissues by comparing amyotrophic lateral sclerosis (ALS) patients and healthy controls. The results show higher Pb levels in the blood, plasma/serum, and cerebrospinal fluid of ALS cases compared to controls. However, due to the lack of association studies in solid tissues, a robust meta-analysis could not be conducted. Future prospective studies are needed to determine the causality of lead bioaccumulation in ALS.
NEUROLOGICAL SCIENCES
(2022)
Review
Neurosciences
Federico Verde, Markus Otto, Vincenzo Silani
Summary: ALS and FTD are currently incurable neurodegenerative diseases lacking specific neurochemical biomarkers, but NFL has shown considerable progress as a biomarker in both diseases, distinguishing them from mimic conditions and providing prognostic information.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cell Biology
Tanja Ducic, Jan Christoph Koch
Summary: By analyzing the cerebrospinal fluid (CSF) of ALS patients using FTIR spectroscopy, this study reveals significant changes in the molecular contents, including RNA, glutamate, carbohydrates, and key markers of lipid metabolism. These findings suggest that FTIR characterization of CSF could be a powerful tool for ALS diagnosis and provide insights into the pathophysiology of ALS.
Article
Medicine, General & Internal
Greig Joilin, Elizabeth Gray, Alexander G. Thompson, Kevin Talbot, P. Nigel Leigh, Sarah F. Newbury, Martin R. Turner, Majid Hafezparast
Summary: In this study, we investigated the expression of non-coding RNA transcripts in the cerebrospinal fluid of ALS patients compared to healthy controls. RNA-seq identified dysregulated non-coding RNA transcripts, but these were not validated with RT-qPCR. We conclude that cerebrospinal fluid is not a suitable source of diagnostic biomarkers.
ANNALS OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sebastian Sjoqvist, Kentaro Otake
Summary: The study analyzed cerebrospinal fluid (CSF) from ALS patients and identified several proteins that could potentially serve as biomarkers for the disease. These findings could contribute to the early diagnosis and treatment of ALS, as well as enhance our understanding of its pathology.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Agathe Vrillon, Vincent Deramecourt, Florence Pasquier, Eloi Magnin, David Wallon, Pierre Lozeron, Elodie Bouaziz-Amar, Claire Paquet
Summary: ALS and frontotemporal dementia are closely related, but association of ALS with Alzheimer's disease is rare. This study reported 5 cases of ALS associated with AD, with patients initially presenting with AD symptoms before developing ALS. The study suggests that ALS-AD phenotype could be an underexplored entity.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Immunology
Anne-Lene Kjaeldgaard, Katrine Pilely, Karsten Skovgaard Olsen, Anne Oberg Lauritsen, Stephen Worlich Pedersen, Kirsten Svenstrup, Merete Karlsborg, Helle Thagesen, Morten Blaabjerg, Asta Theodorsdottir, Elisabeth Gundtoft Elmo, Anette Torvin Moller, Niels Anker Pedersen, Niels Kirkegaard, Kirsten Moller, Peter Garred
Summary: This study compared levels of selected complement markers to clinical outcome in ALS patients and found that patients exhibited aberrant expression of certain complement markers, suggesting the involvement of the complement system in the pathophysiology of ALS.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Environmental Sciences
Angeline Andrew, Jie Zhou, Jiang Gui, Antoinette Harrison, Xun Shi, Meifang Li, Bart Guetti, Ramaa Nathan, Maeve Tischbein, Erik Pioro, Elijah Stommel, Walter Bradley
Summary: This study used geospatial estimation to assess the exposure of ALS patients to airborne contaminants and found that airborne lead and polychlorinated biphenyls (PCBs) may be associated with an increased risk of ALS. The main sources of these contaminants include small aircraft, power plants burning biomass, and industrial boilers. The association with a residential history of lead exposure was confirmed in two additional cohorts.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Clinical Neurology
Daniel Baumgartner, Radim Mazanec, Jitka Hanzalova
Summary: This study measured the levels of NfL and p-NfH in cerebrospinal fluid (CSF) and p-NfH in serum to assess their diagnostic performance as markers of MND. The results showed that NfL and p-NfH in CSF were reliable diagnostic markers for MND, while p-NfH in serum had limited diagnostic ability.
JOURNAL OF NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Aida Kamalian, Iman Foroughmand, Lassi Koski, Mahtab Darvish, Amene Saghazadeh, Amirhossein Kamalian, Seyedeh Zahra Emami Razavi, Siamak Abdi, Shahram Rahimi Dehgolan, Akbar Fotouhi, Per M. Roos
Summary: Metal concentrations in body fluids and tissues of ALS patients were analyzed, and elevated levels of lead and selenium were found, suggesting their involvement in the pathophysiology of ALS.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Editorial Material
Immunology
Marco Vinceti, Tommaso Filippini, Susan Fairweather-Tait
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Clinical Neurology
Jessica Mandrioli, Elisabetta Zucchi, Ilaria Martinelli, Laura Van der Most, Giulia Gianferrari, Cristina Moglia, Umberto Manera, Luca Solero, Rosario Vasta, Antonio Canosa, Maurizio Grassano, Maura Brunetti, Letizia Mazzini, Fabiola De Marchi, Cecilia Simonini, Nicola Fini, Rossella Tupler, Marco Vinceti, Adriano Chio, Andrea Calvo
Summary: This population-based cohort study identified clinical features, comorbidities, disease progression, and prognostic factors in ALS patients carrying C9ORF72 expansion. Compared to patients without mutations, C9 + ALS patients had a higher proportion of family history and frontotemporal dementia, as well as faster disease progression, shorter diagnostic delay, and earlier onset. However, when coexisting with thyroid disorders, C9 + ALS patients had a longer survival.
JOURNAL OF NEUROLOGY
(2023)
Review
Nutrition & Dietetics
Tommaso Filippini, Susan Fairweather-Tait, Marco Vinceti
Summary: This systematic review and meta-analysis on the effects of selenium supplementation on immune function in healthy people concludes that the overall impact is inconsistent and heterogeneous. The evidence does not support the need to supplement selenium beyond the recommended dietary intake for beneficial effects on immune function.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Environmental Sciences
Teresa Urbano, Tommaso Filippini, Lauren A. Wise, Sabrina Sucato, Elisa Polledri, Marcella Malavolti, Silvia Fustinoni, Bernhard Michalke, Marco Vinceti
Summary: This study assessed the association between selenium status and urinary 8-oxodG concentrations in a Northern Italian population and found that this association varied by sex, with background exposure to selenium species positively associated with oxidative stress.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Food Science & Technology
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J. McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera-Gomez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Miguel Prieto Maradona, Rosangela Marchelli, Monika Neuhaeuser-Berthold, Morten Poulsen, Josef Rudolf Schlatter, Henk van Loveren, Eirini Kouloura, Helle Katrine Knutsen
Summary: Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) evaluated water lentil protein concentrate and concluded that it is safe for consumption as a food ingredient and food supplement, considering its composition and proposed conditions of use.
Article
Food Science & Technology
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan de Henauw, Karen-Ildico Hirsch-Ernst, Helle Katrine Knutsen, Alexandre Maciuk, Inge Mangelsdorf, Harry J. McArdle, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Susan Fairweather-Tait, Misha Vrolijk, Lucia Fabiani, Ariane Titz, Androniki Naska
Summary: In response to a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens conducted a scientific evaluation on the tolerable upper intake level (UL) for vitamin B6. The evaluation established that excessive intake of vitamin B6 can lead to peripheral neuropathy. Based on a case-control study, case reports, and vigilance data, the Panel identified a reference point of 50 mg/day, and after applying an uncertainty factor, set the UL for vitamin B6 at 12.5 mg/day.
Article
Food Science & Technology
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J. McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera-Gomez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Miguel Prieto Maradona, Rosangela Marchelli, Monika Neuhaeuser-Berthold, Morten Poulsen, Josef Rudolf Schlatter, Alexandros Siskos, Henk van Loveren, Paolo Colombo, Estefania Noriega Fernandez, Helle Katrine Knutsen
Summary: Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) concluded that 6'-sialyllactose (6'-SL) sodium salt is safe as a novel food. The NF is mainly composed of human-identical milk oligosaccharide (HiMO) 6'-SL (sodium salt) and is produced through fermentation by a genetically modified strain of E. coli. The applicant intends to use the NF in various foods for the general population, and since it is similar to a previously assessed 6'-SL sodium salt, no new estimates of intake were carried out.
Review
Cardiac & Cardiovascular Systems
Marco Vitolo, Davide A. Mei, Paolo Cimato, Niccolo Bonini, Jacopo F. Imberti, Paolo Cataldo, Matteo Menozzi, Tommaso Filippini, Marco Vinceti, Giuseppe Boriani
Summary: Strategies for blood conservation and careful preoperative assessment can be applied to JW patients undergoing cardiac surgery. This systematic review and meta-analysis found no substantial differences in terms of short-term mortality, myocardial infarction, and re-exploration for bleeding between JW patients receiving bloodless surgery and controls. The results support the safety and feasibility of bloodless cardiac surgery.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Clinical Neurology
Ilaria Martinelli, Elisabetta Zucchi, Cecilia Simonini, Giulia Gianferrari, Roberta Bedin, Chiara Biral, Andrea Ghezzi, Nicola Fini, Serena Carra, Jessica Mandrioli
Summary: This study investigated the levels of SerpinA1 in the cerebrospinal fluid and serum of ALS patients, and found that SerpinA1 was elevated in fast progressors, suggesting its involvement in the neuroinflammatory mechanisms of fast-progressing ALS. Neurofilaments or CHI3L1 outperformed SerpinA1 in predicting disease progression rate.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Caputo, Ilaria Martinelli, Nicola Fini, Giulia Gianferrari, Cecilia Simonini, Rosanna Trovato, Filippo Maria Santorelli, Alessandra Tessa, Jessica Mandrioli, Elisabetta Zucchi
Summary: Mutations in the TBCD gene lead to neurodevelopment regression, epilepsy, and mental retardation. We report a rare homozygous variant in TBCD, causing distal motorneuronopathy and mild mental retardation, with evidence of corpus callosum hypoplasia on neuroimaging. The molecular interpretation of this unique phenotype expands the literature on tubulinopathies associated with TBCD mutations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tommaso Filippini, Teresa Urbano, Peter Grill, Carlotta Malagoli, Angela Ferrari, Cristina Marchesi, Nicoletta Natalini, Bernhard Michalke, Marco Vinceti
Summary: This study aimed to investigate the relationship between human serum albumin-bound selenium (Se-HSA) and total selenium as well as specific organic and inorganic selenium species. The findings indicated that Se-HSA was positively associated with inorganic selenium species and inversely associated with organic selenium species. Se-HSA incorporated more selenium when circulating levels of inorganic compounds were higher.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Medicine, General & Internal
Rosaria Di Lorenzo, Jessica Balducci, Anna Cutino, Emanuela Latella, Giulia Venturi, Sergio Rovesti, Tommaso Filippini, Paola Ferri
Summary: This observational study investigated the long-term follow-up of patients treated for ADHD in childhood and adolescence. The results showed that a proportion of patients still exhibited symptoms of ADHD in adulthood, indicating that ADHD is not limited to childhood/adolescence but can persist as a chronic condition into adulthood.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Rosaria Di Lorenzo, Matteo Reami, Diego Dragone, Martina Morgante, Giulia Panini, Sergio Rovesti, Tommaso Filippini, Silvia Ferrari, Paola Ferri
Summary: This study evaluated the differences between voluntary and involuntary hospitalizations in an acute psychiatric ward over a 6-year period. The results showed a decrease in voluntary hospitalizations during the pandemic while involuntary hospitalizations remained stable and increased. Involuntary hospitalizations had longer lengths of stay, increased aggressive behavior, and a higher prevalence of schizophrenia and bipolar disorders compared to voluntary hospitalizations.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Article
Environmental Sciences
Manuela Tondelli, Annalisa Chiari, Giulia Vinceti, Chiara Galli, Simone Salemme, Tommaso Filippini, Chiara Carbone, Claudia Minafra, Claudia De Luca, Riccardo Prandi, Simona Tondelli, Giovanna Zamboni
Summary: This study explores the relationship between greenness and neuropsychiatric symptoms in individuals with dementia. The findings suggest that green environments may have an impact on the mental well-being of people with dementia.
ENVIRONMENTAL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Teresa Urbano, Pietro Verzelloni, Marcella Malavolti, Sabrina Sucato, Elisa Polledri, Claudia Agnoli, Sabina Sieri, Nicoletta Natalini, Cristina Marchesi, Silvia Fustinoni, Marco Vinceti, Tommaso Filippini
Summary: This study investigated the association between adherence to healthy dietary patterns and cadmium exposure. The results suggest that increasing adherence to the DASH and MIND diets is associated with decreased cadmium levels only at a moderate level.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sadia Anjum, Hamile Ali, Faiza Naseer, Maisa S. Abduh, Halima Qadir, Salik Kakar, Yasir Waheed, Tahir Ahmad
Summary: This study demonstrates that avocado and papaya fruit juices can reduce the accumulation of cadmium in the liver, kidney, and hippocampal tissues, and upregulate the expression of antioxidant enzymes while reducing lipid peroxidation. Compared to avocado, papaya has a stronger potential for improving memory and learning, as well as reducing lipid peroxidation in various tissues.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Celio Junior da C. Fernandes, Gerson Santos de Almeida, Patricia Fretes Wood, Anderson M. Gomes, Fabio J. Bezerra, Jose C. S. Vieira, Pedro M. Padilha, Willian F. Zambuzzi
Summary: This study demonstrates the role of mechanosignaling in the promotion of an osteoblastic phenotype in response to zirconia exposure. The release of angiocrine factors modulated by mechanosignaling is crucial in creating a microenvironment that promotes wound healing and osseointegration. These findings highlight the importance of considering endothelial cell mechanosignaling in bone healing and osseointegration in the context of blood vessel effects.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Rehab I. Abdel-Karim, Rania K. Hashish, Dahlia I. Badran, Sally S. Mohammed, Noha A. Salem
Summary: The study found that chlorpyrifos has hepatotoxicity, while cerium oxide nanoparticles can alleviate this toxicity. Cerium oxide nanoparticles can protect the liver by reducing the expression of inflammatory and apoptotic proteins and increasing the activity of antioxidant enzymes.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tahani El Ayari, Raja Ben Ahmed, Zaineb Hammemi, Abdessalem Kouki, Emna Chelb, Salwa Nechi, Najoua Trigui El Menif
Summary: This study assessed the effects of samarium doped zinc oxide nanoparticles (Sm doped ZnO NPs) on the edible mussel Mytilus galloprovincialis and found that it led to a decrease in filtration rates and histopathological alterations in the gills, digestive glands, and gonads.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shanshan Niu, Zhangmin Wang, Xuebin Yin, Xiaodong Liu, Liqiang Qin, Muhammad Raza Farooq, Ofori Prince Danso, Zezhou Zhang, Qin Luo, Chenlu Sun, Jiaping Song
Summary: This study investigated the transport of selenium through the soil-crop-human chain in regions with different selenium levels. It found that the residents' dietary selenium intake was related to the selenium content in soil, with one village within the WHO recommended intake range while the other village was at risk of selenium deficiency. There were significant positive correlations between residents' dietary selenium intake and the three selenium biomarkers.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Sanaz Salaramoli, Hamid Reza Joshaghani, Ali Shoeibi, Seyed Isaac Hashemy
Summary: The study suggests that serum levels of selenium and selenoprotein P may serve as biomarkers or risk factors for Parkinson's disease. Additionally, there is a correlation between alpha-synuclein levels and disease stage. Further research is needed to understand the role of selenoprotein S in reducing alpha-synuclein aggregation.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Motozumi Ando, Keiko Suzuki, Riko Kitamoto, Ayako Nakayama, Norio Watanabe, Masami Kawahara
Summary: C57BL/6 mice and BALB/c mice showed different expression profiles of selenoprotein P after a high-fat diet (HFD). C57BL/6 mice in the HFD group had higher body weight, fasting plasma glucose levels, and plasma selenoprotein P levels compared to the ND group. However, BALB/c mice did not show significant differences in fasting plasma selenoprotein P levels between the HFD and ND groups.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ruihan Song, Huanhuan Chen, Runqing Zhan, Miaomiao Han, Longzhu Zhao, Xiaoli Shen
Summary: This study aims to investigate the protective effects of Vitamin E (Vit E) on manganese (Mn)-induced nigrostriatal system lesions. The results demonstrate that Vit E improves behavioral disorders, attenuates the loss of nigral dopaminergic neurons, and restores mitochondrial function. Additionally, the protective effect of Vit E may be associated with the upregulation of CHRM1 and KCNJ4 mRNA.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jose Luan da Paixao Teixeira, Ana Paula Rebellato, Maria Isabel Andrekowisk Fioravanti, Raquel Fernanda Milani, Marcelo Antonio Morgano
Summary: The study aimed to determine the total Se content and bioaccessibility in commercial plant-based beverages, with results showing that only one beverage made from organic cashew nuts could meet the recommended Se intake for different populations. High bioacessibility percentages were observed in the beverages.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Andreas F. Lehner, Sarah Rebolloso, Paul P. Calle, Karen Ingerman, Gregory A. Lewbart, Juan Pablo Munoz-Perez, Carlos A. Valle, John P. Buchweitz
Summary: The dried blood spot (DBS) technology is useful for storing blood samples from wildlife, and this study developed methods for measuring several important elements in DBS and used them for health assessments of Galapagos land iguanas. The results showed that the DBS samples accurately reflected the concentrations of various elements compared to plasma samples, with some divergences observed between different species.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Zhou, Chunbei Zhou, Jun Xie, Fei Luo, Ning Yao
Summary: The study illustrates the changes in iodized salt usage, goiter rate, and median urinary iodine concentration in school-aged children in Chongqing over the past 21 years. Adequate iodized salt consumption can eliminate iodine deficiency disorders in children, but excessive iodine intake from salt can lead to high urinary iodine excretion and even goiter. Continuous monitoring and adjustment of iodine fortification levels in household table salt is crucial.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Agustin B. Actis Dato, Valeria R. Martinez, Jorge O. Velez Rueda, Enrique L. Portiansky, Veronica De Giustu, Evelina G. Ferrer, Patricia A. M. Williams
Summary: The zinc coordination complex ZnMD, synthesized in this study, showed promising effects in treating hypertension and cardiac hypertrophy. It was more effective than the antihypertensive drug MD in reducing blood pressure and preventing myocardial hypertrophy. ZnMD also exhibited protective effects on the heart by reducing oxidative damage and regulating the expression of oxidative enzymes. These findings suggest that ZnMD has the potential to be developed as a therapeutic drug for hypertension and cardiac dysfunction.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mina Sarani, Maryam Roostaee, Mahboubeh Adeli-Sardou, Davood Kalantar-Neyestanaki, Seyed Amin Ayatollahi Mousavi, Azam Amanizadeh, Mahmood Barani, Alireza Amirbeigi
Summary: This study successfully synthesized nano bismuth oxide using green synthesis methods. The nano particles doped with silver and copper demonstrated excellent antibacterial properties and selective cytotoxicity against cancer cells. These findings have important implications for biomedical and therapeutic applications.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mona Abdel-Rahman, Heba M. Elmasry, Omar A. Ahmed-Farid, Sherein M. Hegazy, Mohamed M. Rezk
Summary: This study investigates the neuro effects of lanthanides on different brain areas in rats and finds that they can distribute and accumulate in various brain regions. Treatment with cerium nanoparticles or lanthanum causes a significant decrease in norepinephrine, dopamine, serotonin, and GABA, accompanied by a significant increase in 5-hydroxyl indoleacetic acid levels. Moreover, cerium nanoparticles exhibit high activity in scavenging free radicals.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mahshid Deldar Abad Paskeh, Nahid Babaei, Mehrdad Hashemi, Abbas Doosti, Kiavash Hushmandi, Maliheh Entezari, Saeed Samarghandian
Summary: The combination of curcumin, vitamins D and E with Fe2O3-NPs and MnO2-NPs has shown to improve semen parameters and reduce apoptosis in germ cells in rats with testicular hyperthermia. This study suggests that this combination therapy may have a positive effect on fertility and decreasing the toxic effects of nanoparticles.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)