期刊
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
卷 44, 期 -, 页码 132-136出版社
ELSEVIER GMBH
DOI: 10.1016/j.jtemb.2017.07.004
关键词
Zinc; Type 2 diabetes mellitus; Glycemia; Glycated hemoglobin; Insulin
资金
- CNPq Brazil - National Council for Scientific and Technological Development (Master's program scholarship for Veronica da Silva Bandeira) [133544/2013-3]
This study evaluated the relationship between the zinc-related nutritional status and glycemic and insulinemic markers in individuals with type 2 diabetes mellitus (T2DM). A total of 82 individuals with T2DM aged between 29 and 59 years were evaluated. The concentration of zinc in the plasma, erythrocytes, and urine was determined by the flame atomic absorption spectrometry method. Dietary intake was assessed using a 3-day 24-h recall. In addition, concentrations of serum glucose, glycated hemoglobin percentage, total cholesterol and fractions, triglycerides, and serum insulin were determined. The insulin resistance index (HOMA-IR) and beta-cell function (HOMA-beta) were calculated. The markers of zinc status (plasma: 83.3 +/- 11.9 mu g/dL, erythrocytes: 30.1 +/- 4.6 mu g/g Hb, urine: 899.1 +/- 622.4 mu g Zn/24 h, and dietary: 9.9 +/- 0.8 mg/day) were classified in terries and compared to insulinemic and glycemic markers. The results showed that lower zinc concentrations in plasma and erythrocytes, as well as its high urinary excretion, were associated with higher percentages of glycated hemoglobin, reflecting a worse glycemic control in individuals with T2DM (p < 0.05). Furthermore, there was a significant inverse correlation between plasma zinc levels and glycated hemoglobin percentage (r = 0.325, p = 0.003), and a positive correlation between urinary zinc excretion and glycemia (r = 0.269, p = 0.016), glycated hemoglobin percentage (r = 0.318, p = 0.004) and HOMA-IR (r = 0.289, p = 0.009). According to our study results, conclude that T2DM individuals with reduced zinc status exhibited poor glycemic control.
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