Review
Developmental Biology
Heather B. Patisaul
Summary: This review discusses how endocrine-disrupting compounds adversely impact human reproductive health, including pregnancy outcomes, semen quality, age at puberty, and exert permanent changes to the structure and function of the hypothalamic-pituitary-gonadal axis.
Article
Multidisciplinary Sciences
Rosa Manca, Monia Delia, Marianna Abate, Silvia Zappavigna, Sergio Papa, Chester Glomski, Alessandra Pica
Summary: Apoptosis, programmed cell death, plays a central role in haematopoiesis. This study investigates the expression and subcellular distribution of Bcl-2, Bcl-X-L, and Bax proteins in nucleated erythrocytes and the effect of X-ray irradiation on these cells. The results demonstrate the role of these proteins in the maturation of erythrocytes.
SCIENTIFIC REPORTS
(2022)
Review
Endocrinology & Metabolism
Emilio J. Velez, Suraj Unniappan
Summary: Growth hormone (GH) is a key endocrine regulator of somatic growth, involved in regulating various vital processes and affecting cellular processes. Recent discoveries of new regulators provide insights into GH and have important applications in fields such as livestock industry and aquaculture.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
M. H. Vickers
Summary: Changes in early life nutrition can have significant effects on the risk of obesity and metabolic disorders in later life, which can be passed on to future generations. This process, known as developmental programming, plays a role in the origins of health and disease. Early nutritional compromise can lead to adverse health outcomes in offspring, with the potential for exacerbation by a poor postnatal nutrition environment. The mechanisms underlying programming are not yet fully understood, but altered neuroendocrine circuits that regulate satiety and energy balance have been identified as a common feature in preclinical models.
Article
Pharmacology & Pharmacy
Michael E. Baker
Summary: This article discusses the evolution of steroid receptors in ray-finned fish and terrestrial vertebrates, as well as the different responses to various steroids in these species. The progesterone receptor and mineralocorticoid receptor in fish and terrestrial vertebrates have evolved to respond differently to different steroids. These differences should be considered when studying the disruption of steroid hormones by chemicals in these species.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Eun-Seon Yoo, Jieun Yu, Jong-Woo Sohn
Summary: Hormones secreted by endocrine organs predominantly control body homeostasis. Recent advances in mouse genetics have revealed important metabolic functions of hypothalamic neurohormone-expressing cells. These cells not only impact hormones but also act as neurotransmitters in a neuronal circuit to regulate appetite and metabolism, providing potential insights for treating obesity and metabolic disorders.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Behavioral Sciences
Nigel K. Anderson, Sarah E. Goodwin, Eric. R. Schuppe, AllexAndrya Dawn, Doris Preininger, Lisa A. Mangiamele, Matthew J. Fuxjager
Summary: Sex steroids play a crucial role in regulating the reproductive phenotype of vertebrates, activating sexual behaviors and guiding the development of neural and muscular systems. However, little is known about how organizational effects of sex steroids evolve in nature to support the adaptation and diversification of reproductive behavior.
HORMONES AND BEHAVIOR
(2022)
Review
Endocrinology & Metabolism
Yasuko Tobari, Yana Aleksandrova, Yoko Fukahori, Kazuyoshi Tsutsui, Simone L. Meddle
Summary: Social environment influences hormone levels and social behavior in animals, with GnIH being identified as a negative regulator of the HPG axis. It responds to social cues and regulates both reproductive physiology and behavior, highlighting the intricate connection between social information and neural processes.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Engineering, Environmental
Jian Li, Ying Xu, Na Li, Rui Zuo, Yuanzheng Zhai, Haiyang Chen
Summary: Through integrated in vitro, in vivo, and in silico assays, the study investigated the thyroid hormone-disrupting effects and mechanisms of 8 typical organophosphate esters (OPEs). It was found that these chemicals competitively bound to the membrane thyroid hormone receptor (mTR) and some OPEs also interacted with the nuclear thyroid hormone receptor (nTR). Molecular docking simulation supported these findings. In addition, in vivo analyses using zebrafish embryo development demonstrated the thyroid hormone-disrupting effects of OPEs and their possible association with mTR.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Studies
IpKin Anthony Wong, Juanjuan Ou, Andrew Wilson
Summary: This research examines the evolution of corporate crisis communication in response to the pandemic, using corpus linguistics to analyze press releases from Fortune 500 hotel corporations. The study found that the lodging industry was not fully prepared for the crisis until March, with management focusing on past achievements even in February. The overall tone shifted from demonstrating success and performance to a more crisis-response approach.
TOURISM MANAGEMENT
(2021)
Article
Endocrinology & Metabolism
Edward O. List, Darlene E. Berryman, Julie Slyby, Silvana Duran-Ortiz, Kevin Funk, Elise S. Bisset, Susan E. Howlett, John J. Kopchick
Summary: By disrupting the growth hormone receptor in adipocytes, insulin sensitivity can be improved in the elderly and lifespan can be increased in mice. In male mice, adipocyte-specific disruption of the growth hormone receptor can increase lifespan, while also increasing fat mass, reducing circulating levels of insulin, adiponectin, resistin, and improving frailty scores. Comparison of lifespan data between GHRKO mice and adipocyte-specific GHRKO and muscle-specific GHRKO mice suggests that adipocyte-specific disruption contributes approximately 23% to the lifespan extension observed in male GHRKO mice.
Article
Food Science & Technology
Meifang Wu, Naying Zheng, Xiaoxiao Zhan, Jianzhang He, Min Xiao, Zhenghong Zuo, Chengyong He
Summary: This study demonstrates that Icariin may cause developmental toxicity by disrupting thyroid development and hormone synthesis, highlighting the importance of risk assessments in clinical practice.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Endocrinology & Metabolism
Laura Canesi, Angelica Miglioli, Teresa Balbi, Elena Fabbri
Summary: Contaminants of Emerging Concerns (CECs) refer to chemicals that are not commonly monitored in aquatic ecosystems but have the potential to cause adverse effects on biota. This review focuses on the effects of CECs on the serotonergic system of bivalve molluscs, which is a sensitive target for neuroendocrine disruption in these animals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Agriculture, Dairy & Animal Science
A. H. Duittoz, D. A. Kenny
Summary: This article reviews the scientific literature on puberty, focusing on ruminants, and draws inference from recent findings in transgenic mouse models and human pathology. Early genetic determinants of puberty have been discovered, and the development of neuroendocrine networks and GnRH neurons play a crucial role. Nutritional factors, season, and social environment are also important regulators of puberty onset.
Article
Biology
Sebastian Hueckesfeld, Philipp Schlegel, Anton Miroschnikow, Andreas Schoofs, Ingo Zinke, Andre N. Haubrich, Casey M. Schneider-Mizell, James W. Truman, Richard D. Fetter, Albert Cardona, Michael J. Pankratz
Summary: In this study, using electron microscopy reconstruction, researchers revealed the sensory pathways and synaptic inputs provided by interneurons to neurosecretory cells in the central nervous system of Drosophila larvae. The findings identified a novel carbon dioxide-responsive network targeting specific neurosecretory cells expressing neuropeptides such as Crz and Dh44. The analysis uncovered a neuronal network architecture for combinatorial action based on sensory and interneuronal pathways converging onto distinct combinations of neuroendocrine outputs.
Article
Environmental Sciences
Maria Vu, Laia Navarro-Martin, Juan Manuel Gutierrez-Villagomez, Vance L. Trudeau
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2015)
Article
Marine & Freshwater Biology
Lei Xing, Juan Manuel Gutierrez-Villagomez, Dillon F. Da Fonte, Maddie J. Venables, Vance L. Trudeau
AQUATIC TOXICOLOGY
(2016)
Article
Chemistry, Analytical
Juan Manuel Gutierrez-Villagomez, Juan Vazquez-Martinez, Enrique Ramirez-Chavez, Jorge Molina-Torres, Vance L. Trudeau
Article
Plant Sciences
Juan Vazquez-Martinez, Juan Manuel Gutierrez-Villagomez, Citlali Fonseca-Garcia, Enrique Ramirez-Chavez, M. A. Lourdes Mondragon-Sanchez, Laila Partida-Martinez, Jeffrey R. Johansen, Jorge Molina-Torres
Article
Engineering, Environmental
Juan M. Gutierrez-Villagomez, Kerry M. Peru, Connor Edington, John V. Headley, Bruce D. Pauli, Vance L. Trudeau
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2019)
Article
Marine & Freshwater Biology
J. C. Bilodeau, J. M. Gutierrez Villagomez, L. E. Kimpe, P. J. Thomas, B. D. Pauli, V. L. Trudeau, J. M. Blais
AQUATIC TOXICOLOGY
(2019)
Article
Toxicology
Sarah D. Young, Melody J. Gavel, Juan M. Gutierrez-Villagomez, Mark R. Forbes, Stacey A. Robinson
JOURNAL OF APPLIED TOXICOLOGY
(2020)
Article
Engineering, Environmental
Juan Manuel Gutierrez-Villagomez, Juan Vazquez-Martinez, Enrique Ramirez-Chavez, Jorge Molina-Torres, Vance L. Trudeau
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Chemistry, Physical
Juan Manuel Gutierrez-Villagomez, Tonatiu Campos-Garcia, Jorge Molina-Torres, Mercedes G. Lopez, Juan Vazquez-Martinez
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2020)
Review
Environmental Sciences
Madelaine A. Empey, Molly Lefebvre-Raine, Juan Manuel Gutierrez-Villagomez, Valerie S. Langlois, Vance L. Trudeau
Summary: Insecticides play a crucial role in agriculture and environmental protection, but they may have toxic effects on nontarget organisms. Existing research on the effects of Bti on amphibians has produced varying results, leading to controversies in the field.
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2021)
Article
Environmental Sciences
Marc Lebordais, Juan Manuel Gutierrez-Villagomez, Julien Gigault, Magalie Baudrimont, Valerie S. Langlois
Summary: This study investigated the synergistic effects of nanoplastic combined with arsenic on genetic expression in oysters, showing significant impacts on specific gene expression levels at certain concentrations. Results provide insights into the comparative molecular effects of nanoplastics and arsenic in farmed oysters as well as different species sensitivity.
Article
Engineering, Environmental
Juan Manuel Gutierrez-Villagomez, Geraldine Patey, Tuan Anh To, Molly Lefebvre-Raine, Linda Ramona Lara-Jacobo, Jerome Comte, Bert Klein, Valerie S. Langlois
Summary: The research revealed that while Bti biopesticides had limited impact on certain parameters of Lithobates sylvaticus and Anaxyrus americanus tadpoles, they might affect the time to metamorphosis and the intestinal microbiota composition.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Juan Vazquez-Martinez, Genesis V. Buitemea-Cantua, Juan Manuel Gutierrez-Villagomez, Julia P. Garcia-Gonzalez, Enrique Ramirez-Chavez, Jorge Molina-Torres
Article
Environmental Sciences
Juan Manuel Gutierrez-Villagomez, Christopher J. Martyniuk, Lei Xing, Valerie S. Langlois, Bruce D. Pauli, Jules M. Blais, Vance L. Trudeau
FRONTIERS IN MARINE SCIENCE
(2019)