Article
Biochemistry & Molecular Biology
Ha Yeong Kim, Ji Min Seok, Soo Yeon Jung, Min Ji Lee, An Nguyen-Thuy Tran, Seon Ju Yeo, Su A. Park, Han Su Kim
Summary: This study investigated the feasibility of using three-dimensional structural microbeads fabricated with tonsil-derived mesenchymal stem cells (TMSCs) and alginate to treat hypoparathyroidism. The results showed that differentiated alginate microbeads with TMSCs had significantly higher protein expression of parathyroid hormone (PTH). In vivo experiments on rats with hypoparathyroidism showed that the group with implanted differentiated alginate microbeads had the highest survival rate and weight change, as well as an increase in serum intact PTH levels. Immunofluorescence analysis also confirmed higher expression of PTH in the retrieved tissues.
Article
Endocrinology & Metabolism
Sofia Ish-Shalom, Yoseph Caraco, Nariman Saba Khazen, Michal Gershinsky, Auryan Szalat, Phillip Schwartz, Ehud Arbit, Hillel Galitzer, Jonathan C. Y. Tang, Gregory Burshtein, Ariel Rothner, Arthur Raskin, Miriam Blum, William D. Fraser
Summary: Oral hPTH(1-34) treatment as an adjunct to standard therapy in adult patients with hypoparathyroidism was found to be safe and effective, allowing for a reduction in exogenous calcium supplementation while maintaining normocalcemia.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Lukas Ochsner Ridder, Torben Harslof, Tanja Sikjaer, Line Underbjerg, Lars Rejnmark
Summary: Hypercalciuria, impaired kidney function, and renal calcifications are common in hypoparathyroidism. Urinary calcium levels are influenced by various physiological factors, but in this study, high urinary calcium levels did not significantly explain renal impairment or kidney calcifications.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Guido Zavatta, Peter J. Tebben, Cynthia H. McCollough, Lifeng Yu, Thomas Vrieze, Bart L. Clarke
Summary: Basal ganglia calcification is more common in chronic hypoparathyroidism patients, especially in nonsurgical patients with lower serum calcium and calcium/phosphate ratio.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Surgery
Yuxuan Qiu, Yuan Fei, Zhichao Xing, Jingqiang Zhu, Yan Luo, Anping Su
Summary: Autotransplantation of parathyroid glands (PGs) is an effective strategy for preserving parathyroid function in the mid and long term. Although transient hypoparathyroidism is positively correlated with the number of autotransplanted PGs, there is no remarkable correlation with permanent hypoparathyroidism.
ASIAN JOURNAL OF SURGERY
(2022)
Review
Endocrinology & Metabolism
Liang Yao, Jing Li, Meixuan Li, Clement Lin, Xu Hui, Divyalakshmi Tamilselvan, Maryam Kandi, Ashwini Sreekanta, Nima Makhdami, Dalal S. Ali, Karel Dandurand, Kehu Yang, John P. Bilezikian, Maria Luisa Brandi, Bart L. Clarke, Michael Mannstadt, Lars Rejnmark, Aliya A. Khan, Gordon Guyatt
Summary: The efficacy and safety of PTH therapy for managing long-term hypoparathyroidism is being evaluated, and this systematic review and meta-analysis found that PTH therapy may improve physical health-related quality of life and reduce the dose of active vitamin D and calcium in patients with chronic hypoparathyroidism, but it may increase the risk of hypercalcemia.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Dengwei Lu, Enjie Tang, Supeng Yin, Junping Zhu, Hongbiao Mo, Ziying Yi, Fan Chai, Yizeng Sun, Yao Li, Tingjie Yin, Zeyu Yang, Fan Zhang
Summary: This retrospective cohort study aimed to investigate influential factors in the occurrence and restoration of postoperative hypoparathyroidism (POH) in thyroid cancer patients who underwent total thyroidectomy with intraoperative parathyroid autotransplantation (TTIPA). The study found that high postoperative fasting blood glucose levels, a large number of transplanted parathyroid glands, open surgery, and Hashimoto's thyroiditis are risk factors for postoperative POH. Female patients and patients without same-side central lymph node dissection (CLND) on the transplant side are more prone to increased PTH levels. Patients without CLND and those who underwent endoscopic surgery on the transplant side have a faster PTH restoration.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Konstantin Kulebyakin, Pyotr Tyurin-Kuzmin, Leila Sozaeva, Nikita Voloshin, Mikhail Nikolaev, Vadim Chechekhin, Maxim Vigovskiy, Veronika Sysoeva, Elizaveta Korchagina, Daria Naida, Maria Vorontsova
Summary: This study investigated the functional responses of multipotent mesenchymal stromal cells (MSCs) to parathyroid hormone (PTH). Through the activation of different calcium responses, PTH was found to regulate the cellular differentiation of MSCs. A smooth increase in intracellular calcium was associated with pro-osteogenic action, while calcium oscillations led to a decrease in osteogenic differentiation intensity. These different calcium responses are dynamically balanced, as the suppression of one type leads to increased activation of another type and a change in the effect of PTH on cell differentiation.
Article
Endocrinology & Metabolism
Georgios Kontogeorgos, Zoi Mamasoula, Emily Krantz, Penelope Trimpou, Kerstin Landin-Wilhelmsen, Christine M. Laine
Summary: The study showed that patients with HypoPT had significantly lower physical and mental health-related quality of life compared to controls, with 23% of patients experiencing low HRQoL and low calcium levels simultaneously. Despite being on more medications and having poorer renal function, HypoPT patients did not have higher mortality rates than controls.
ENDOCRINE CONNECTIONS
(2022)
Article
Surgery
Hadiza S. Kazaure, Alan Zambeli-Ljepovic, Taofik Oyekunle, Sanziana A. Roman, Julie A. Sosa, Michael T. Stang, Randall P. Scheri
Summary: Severe post-thyroidectomy hypocalcemia is a common complication, with an incidence of approximately 5.8%. Patients who experience severe hypocalcemia are at higher risk of nerve injury and unplanned reoperations, indicating the impact of surgical complexity and provider experience on this complication.
Article
Endocrinology & Metabolism
Kristina Vabalayte, Anatoly Romanchishen, Aleksandra Somova
Summary: The study aimed to evaluate the effectiveness of ICG-angiography and intrathyroid injection of Brilliant Green in preventing postoperative hypoparathyroidism. The results showed that these methods are safe and effective in identifying and sparing the parathyroid glands, with a more prominent occurrence of hypocalcemia in the group with visually estimated PTG postoperatively.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Otorhinolaryngology
Shireen Samargandy, John Wadie, Haytham Msallak, Albino Chiodo, William El Masri, Bradley Hubbard, Danny Enepekides, Kevin Higgins, Angela Assal, Rebecca Fine, Raymond Fung, Everton Nicholas, Valrie Beadle, Antoine Eskander
Summary: This study aimed to develop a PTH-based protocol to predict hypocalcemia after thyroidectomy. The results showed that using postoperative PTH cut-offs can effectively predict hypocalcemia and reduce unnecessary calcium replacement and length of stay.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Endocrinology & Metabolism
Wenfei Xia, Jinjun Zhang, Wenzhuang Shen, Zhi Zhu, Zhifang Yang, Xingrui Li
Summary: A novel immunochromatographic test strip method was developed for rapid intraoperative identification of parathyroid glands based on tissue PTH detection using the immune colloidal gold technique. The method showed high accuracy and efficiency compared to traditional inspection methods, with faster detection times and improved diagnostic rates for both parathyroid and non-parathyroid tissues. The use of PTH-ICGT assay also resulted in better postoperative outcomes compared to direct visual inspection, with higher serum calcium and blood PTH levels at 1 and 3 months post-surgery and lower incidence of transient hypocalcemia.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Guido Zavatta, Paola Altieri, Giulia Vandi, Valentina Vicennati, Uberto Pagotto, Fabio Vescini
Summary: New insights into phosphate metabolism present challenges for endocrinologists to rethink pathophysiology. Studying rare mineral metabolism diseases can provide valuable new information about phosphate and other minerals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Fiona Riordan, Catherine Brophy, Matthew S. Murphy, Patrick Sheahan
Summary: Early parathyroid hormone (PTH) levels after total thyroidectomy can predict patients at low risk of hypocalcaemia who can be discharged early without calcium supplementation. PTH levels >= 15 pg/ml along with calcium >= 2.0 mmol/l are associated with low risk of symptomatic hypocalcaemia, and represent a safe criterion for discharge of most patients without calcium supplementation.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Saeyoung Park, Sung-Chul Jung
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Jiwon Park, Ju Kwang Choi, Kyeong Eun Lee, Da Hyeon Choi, Yoon Shin Park
Summary: The study found that isolated MEFs were morphologically similar to McCoy regardless of the storage period, and the population doubling time was similar to non-cryopreserved MEFs. However, gene expression levels showed significant changes after cryopreservation, with different genes exhibiting different expression patterns depending on the storage period.
TOXICOLOGY AND ENVIRONMENTAL HEALTH SCIENCES
(2021)
Article
Cell Biology
Jiwon Park, Ju Kwang Choi, Da Hyeon Choi, Kyeong Eun Lee, Yoon Shin Park
Summary: This study optimized the isolation and purification methods for skeletal muscle-derived fibroblasts. The results showed that the characteristics of these fibroblasts were maintained up to passage 5 regardless of preplating, and even after cryopreservation, fibroblast-specific properties remained unchanged.
CELL AND TISSUE BANKING
(2022)
Article
Biochemistry & Molecular Biology
Ji Yeon Kim, Saeyoung Park, Se-Young Oh, Yu Hwa Nam, Young Min Choi, Yeonzi Choi, Ha Yeong Kim, Soo Yeon Jung, Han Su Kim, Inho Jo, Sung-Chul Jung
Summary: In this study, the authors standardized the differentiation rate of Tonsil-derived MSCs (T-MSCs) into parathyroid-hormone (PTH)-releasing cells (T-MSC-PTHCs) to overcome donor-dependent variation and provide a potential solution for treating hypoparathyroidism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yeonsil Yu, Se-Young Oh, Ha Yeong Kim, Ji-Young Choi, Sangmee Ahn Jo, Inho Jo
Summary: Our study found that the level of CCN1 increases as osteogenic differentiation progresses in tonsil-derived mesenchymal stem cells (TMSCs). We investigated how CCN1 is regulated through HDAC inhibition in TMSCs and their relationship with osteogenesis. Valproic acid (VPA), a well-known HDAC inhibitor, was found to inhibit TMSC proliferation and increase osteogenic differentiation, while decreasing adipogenesis and chondrogenesis. The effects of VPA on CCN1 were mediated through the stability of the CCN1 protein instead of gene expression. These findings demonstrate the potential of VPA as an inhibitor of HDAC1 to promote osteogenic differentiation in TMSCs.
Article
Cell & Tissue Engineering
Da Hyeon Choi, Kyeong Eun Lee, Yoon Shin Park
Summary: Mesenchymal stem cells (MSCs) are widely used in tissue regeneration and stem cell therapy, and research on senescence-related changes in MSC properties has attracted attention. A study established a senescent MSC model and identified novel biomarkers for old, senescent tonsil-derived MSCs (TMSCs) using transcriptomics. The expression of CDK1, CDK2, and TGFB2 was significantly higher in old TMSCs compared to young TMSCs, suggesting CDK1 could be a selective senescence biomarker of MSCs to broaden the research criteria for senescent mechanisms.
STEM CELLS INTERNATIONAL
(2022)
Article
Cell & Tissue Engineering
Saeyoung Park, Soyeon Jeong, Yu Hwa Nam, Yoonji Yum, Sung-Chul Jung
Summary: Skeletal muscles are important in the human body and any dysfunction can reduce the quality of life. Duchenne muscular dystrophy (DMD) is a common hereditary form of muscular dystrophy with no clear treatment. Mesenchymal stem cells have the potential to differentiate into skeletal muscle cells and could be a resource for DMD treatment.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Sung-Chul Jung, Saeyoung Park
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Yeonzi Choi, Yu Hwa Nam, Soyeon Jeong, Hee-Yoon Lee, Se-Young Choi, Saeyoung Park, Sung-Chul Jung
Summary: This study found that skeletal muscle cells derived from tonsil mesenchymal stem cells exhibit functional characteristics of skeletal muscle cells, including insulin reactivity, neuromuscular junction formation, and changes in cell membrane action potential. This has potential clinical applications for the treatment of skeletal muscle disorders.
Article
Biochemistry & Molecular Biology
Jiwon Park, Eunseok Seo, Yang-Hoon Kim, Ji-Young Ahn, Da Hyeon Choi, Kyeong Eun Lee, Yoon Shin Park
Summary: An oleamide-polydimethylsiloxane (OPC) copolymer was synthesized to prevent biofilm infection on biomedical devices. The OPC showed anti-adhesion and anti-biofilm activities against Escherichia coli and Staphylococcus aureus. It was also found to have high biocompatibility and low hemolytic properties, making it suitable for medical device applications.
MOLECULAR & CELLULAR TOXICOLOGY
(2023)
Article
Geriatrics & Gerontology
Yi-Jun Kim, Yongho Jee, Sholhui Park, Eun-Hee Ha, Inho Jo, Hyang Woon Lee, Myung Seon Song
Summary: The study showed that COVID-19 patients with dementia have a significantly higher risk of early death within 14 days compared to non-dementia patients, even after propensity score matching.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Gyungah Kim, Eun-Ji Choi, Han-Seung Park, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Lee
Summary: This case report describes a patient who developed ITP after receiving the AstraZeneca vaccine, with symptoms appearing 3 days after vaccination. Prompt clinical suspicion and appropriate treatment are essential for vaccine-related ITP.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Urology & Nephrology
Sungjin Chung, Mina Son, Yura Chae, Songhee Oh, Eun Sil Koh, Yong Kyun Kim, Seok Joon Shin, Cheol Whee Park, Sung-Chul Jung, Ho-Shik Kim
Summary: The study investigated the pathogenic mechanism leading to fibrosis in kidneys of Fabry disease mice with unilateral ureteral obstruction (UUO). The results showed an increased presence of lamellar inclusion bodies and fibrosis in the kidneys of diseased mice. Impaired autophagy and enhanced apoptosis were identified as probable mechanisms involved in the enhanced renal fibrosis observed under the stimulus of UUO in Fabry disease.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Cell & Tissue Engineering
Hee-Yeon Kim, Younghay Lee, Hee-Soo Yoon, Yu-Hee Kim, Kyong-A Cho, So-Youn Woo, Han Sun Kim, Bo-Young Park, Sung-Chul Jung, Inho Jo, Woo-Jae Park, Joo-Won Park, Kyung-Ha Ryu
Summary: Tonsil-derived mesenchymal stem cells (TMSCs) have the potential to differentiate into estrogen-secreting cells, offering a novel cell therapy for estrogen deficiency.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
