Article
Biochemistry & Molecular Biology
Soroush Ahmadi, Ahmad Hivechi, S. Hajir Bahrami, Peiman B. Milan, Seyedeh Sara Ashraf
Summary: This study developed chitosan/gelatin nanofiber membranes with sustained release capacity to prevent infection by delivering cinnamon extract (CE) in the implanted site. The incorporation of CE enhanced the properties of the nanofibers, including degradation behavior, antibacterial activity, and biocompatibility. The extract release profile showed a burst release in the first 6 hours, followed by a controlled release in the next 138 hours.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Poornima Ramburrun, Pradeep Kumar, Elias Ndobe, Yahya E. Choonara
Summary: This study evaluated a biosimulated nerve repair system providing three types of regenerative cues in a peripheral nerve injury model. The nanofibers supported PC12 proliferation, preserved muscle mass, and gradually improved functional recovery. The combination of physical guidance, chemical cues, and therapeutic cues offers a promising strategy for the regeneration of severed peripheral nerves.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Kai Liu, Lesan Yan, Ruotao Li, Zhiming Song, Jianxun Ding, Bin Liu, Xuesi Chen
Summary: Nerve autograft is currently the preferred treatment for peripheral nerve defects but has limitations. Emerging nerve guide conduits (NGCs), especially those made through 3D printing, offer effective platforms for repairing peripheral nerve defects.
Article
Food Science & Technology
Mengxia Duan, Jishuai Sun, Yequn Huang, Haixin Jiang, Yaqin Hu, Jie Pang, Chunhua Wu
Summary: This study developed active and intelligent packaging nanofibers based on gelatin/chitosan with curcumin. The incorporation of curcumin enhanced the thermal stability, tensile strength, antioxidant activity, and antimicrobial activity of the nanofibers. The nanofibers also showed high sensitivity to ammonia, indicating their potential for protecting and monitoring the freshness of protein-rich animal foods.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Chemistry, Multidisciplinary
Binghui Jin, Yiling Yu, Chenghao Lou, Xiaodi Zhang, Bowen Gong, Jinghao Chen, Xiangxiang Chen, Zihan Zhou, Liqun Zhang, Jian Xiao, Jiajia Xue
Summary: A multi-functional nerve guidance conduit (NGC) is constructed to promote nerve regeneration by integrating ordered topological structure, density gradient of biomacromolecular nanoparticles, and controlled delivery of biological effectors. The NGC promotes the proliferation of Schwann cells and directional extension of neurites, achieving both anatomical and functional regeneration of the nerve. It provides a favorable microenvironment for peripheral nerve regeneration and holds great promise for nerve repair.
Review
Polymer Science
Sangjoon Lee, Madhumita Patel, Rajkumar Patel
Summary: This review presents the challenges associated with autologous nerve grafting and the potential of artificial nerve guidance conduits (NGCs) as an alternative treatment method for peripheral nerve injuries (PNIs). The tubular NGCs provide guidance and protection for nerve growth and elongation. Novel designs of electrospun NGCs offer promising prospects for functional recovery.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Materials Science, Biomaterials
Hongyu Liu, Yanan Zhao, Jun Tong, Xiaowen Shi, Yun Chen, Yumin Du
Summary: The study demonstrates that a new type of chitosan-based nerve-guide hydrogel conduit fabricated using one-step electrofabrication technology has enhanced mechanical flexibility. The CNHC shows cytocompatibility by promoting cell proliferation and adhesion, and is able to guide axon growth to reach a distal stump, indicating great potential in peripheral nerve regeneration.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Engineering, Multidisciplinary
Renliang Zhao, Lianghua Jiang, Juan Du, Bitong Xu, Ang Li, Wei Wang, Shichang Zhao, Xiaolin Li
Summary: The biomimetic electrospun conduit Gel@PLGA/Col showed outstanding nerve regeneration performance in a sciatic nerve defect implantation model, inducing axon growth and facilitating nerve continuity recovery. This structure holds great potential for peripheral nerve repair and functional recovery after injury.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Feng Xiong, Shuo Wei, Shuyuan Wu, Wei Jiang, Biyun Li, Hongyun Xuan, Ye Xue, Huihua Yuan
Summary: In this study, a biomimetic piezoelectric and conductive nanofiber scaffold was constructed for the repair of large peripheral nerve deficits, which promoted nerve cell differentiation and nerve fiber extension. The application of the scaffold in rat sciatic nerve injury prevented autotomy and facilitated nerve regeneration and functional recovery.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Xianhao Dong, Siyang Liu, Yueyue Yang, Shan Gao, Wenlei Li, Jiasong Cao, Ye Wan, Ziqi Huang, Guanwei Fan, Quan Chen, Hongjun Wang, Meifeng Zhu, Deling Kong
Summary: Research on nerve conduits composed of oriented microfiber-bundle cores and randomly organized nanofiber sheaths has shed light on the regulatory role of microfiber orientation in promoting peripheral nerve regeneration, elucidating a cascade of biological responses and ultimately enhancing nerve regeneration outcomes.
Review
Biochemistry & Molecular Biology
Luke Juckett, Tiam Mana Saffari, Benjamin Ormseth, Jenna-Lynn Senger, Amy M. M. Moore
Summary: Peripheral nerve injuries (PNI) often result in lifelong disability with rare complete functional recovery. Intraoperative electrical stimulation (ES) is a promising surgical adjunct that can augment the intrinsic molecular pathways of nerve regeneration. Clinical trials have shown that ES can be an efficacious therapy to improve patient outcomes following PNIs.
Review
Cell Biology
Jingxin Zhang, Binjing Zhang, Jinglan Zhang, Weimin Lin, Shiwen Zhang
Summary: Magnesium as a suitable material for promoting peripheral nerve regeneration has both challenges and potentials, but there is currently limited research on this topic, requiring further exploration to address the shortcomings and challenges identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Xiaolan Li, Xiang Zhang, Ming Hao, Dongxu Wang, Ziping Jiang, Liqun Sun, Yongjian Gao, Ye Jin, Peng Lei, Yue Zhuo
Summary: This review summarizes the importance of collagen in peripheral nerve regeneration, focusing on its characteristics, role, and optimization methods. Collagen, as a biomaterial, plays a crucial role in peripheral nerve repair and can be further optimized by adjusting its structure and physical properties, as well as combining it with bioactive components.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Runyi Mao, Bin Yu, Jinjie Cui, Zeying Wang, Xintai Huang, Hongbo Yu, Kaili Lin, Steve G. F. Shen
Summary: This study developed a piezoelectric nerve conduit using a composite of PCL/ZnO nanofiber, which demonstrated faster and superior sciatic nerve repair compared to conventional materials. The piezoelectric stimulation from PZNF increased the expression of nerve growth factor/vascular endothelial growth factor and activated downstream pathways, leading to accelerated nerve repair and function recovery. This novel strategy offers potential for rapid peripheral nerve regeneration.
Review
Clinical Neurology
Teodoro Martin-Noguerol, Rafael Barousse, Antonio Luna, Mariano Socolovsky, Juan M. Gorriz, Manuel Gomez-Rio
Summary: This article reviews the physical basis of DTI and DCE-MRI for Peripheral Nerves (PNs) evaluation and provides practical tips for implementing these advanced sequences into clinical practice. It also summarizes the clinical applications of these techniques for PN assessment and introduces the potential use of AI algorithms for PNs evaluation.