Taking chances and making mistakes: non-genetic phenotypic heterogeneity and its consequences for surviving in dynamic environments

Autonomous Metabolic Oscillations Robustly Gate the Early and Late Cell Cycle

(2017) Alexandros Papagiannakis et al.   MOLECULAR CELL

Generation and filtering of gene expression noise by the bacterial cell cycle

(2016) Noreen Walker et al.   BMC BIOLOGY

Complex Interplay of Physiology and Selection in the Emergence of Antibiotic Resistance

(2016) Wei-Hsiang Lin et al.   CURRENT BIOLOGY

Slowdown of growth controls cellular differentiation

(2016) Jatin Narula et al.   Molecular Systems Biology

Non‐genetic diversity modulates population performance

(2016) Adam James Waite et al.   Molecular Systems Biology

Bacterial persistence is an active σSstress response to metabolic flux limitation

(2016) Jakub Leszek Radzikowski et al.   Molecular Systems Biology

Synchronous long-term oscillations in a synthetic gene circuit

(2016) Laurent Potvin-Trottier et al.   NATURE

Toxin-antitoxin systems in bacterial growth arrest and persistence

(2016) Rebecca Page et al.   Nature Chemical Biology

Response of single bacterial cells to stress gives rise to complex history dependence at the population level

(2016) Roland Mathis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dealing with Gene-Dosage Imbalance during S Phase

(2016) Raz Bar-Ziv et al.   TRENDS IN GENETICS

Stochastic Switching of Cell Fate in Microbes

(2015) Thomas M. Norman et al.   Annual Review of Microbiology

The yeast galactose network as a quantitative model for cellular memory

(2015) Sarah R. Stockwell et al.   Molecular BioSystems

Growth-dependent bacterial susceptibility to ribosome-targeting antibiotics

(2015) P. Greulich et al.   Molecular Systems Biology

Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria

(2015) S. Hui et al.   Molecular Systems Biology

HipBA–promoter structures reveal the basis of heritable multidrug tolerance

(2015) Maria A. Schumacher et al.   NATURE

Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals “aging factors” and mechanism of lifespan asymmetry

(2015) Jing Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic links between cellular trade-offs, gene expression, and growth

(2015) Andrea Y. Weiße et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of stationary phase respiration impairs persister formation in E. coli

(2015) Mehmet A. Orman et al.   Nature Communications

Population Diversification in a Yeast Metabolic Program Promotes Anticipation of Environmental Shifts

(2015) Ophelia S. Venturelli et al.   PLOS BIOLOGY

Expression noise facilitates the evolution of gene regulation

(2015) Luise Wolf et al.   eLife

Contributions of Cell Growth and Biochemical Reactions to Nongenetic Variability of Cells

(2014) Anne Schwabe et al.   BIOPHYSICAL JOURNAL

Bacterial growth: global effects on gene expression, growth feedback and proteome partition

(2014) Stefan Klumpp et al.   CURRENT OPINION IN BIOTECHNOLOGY

Probing the effect of promoters on noise in gene expression using thousands of designed sequences

(2014) Eilon Sharon et al.   GENOME RESEARCH

Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations

(2014) Ofer Fridman et al.   NATURE

Stochasticity of metabolism and growth at the single-cell level

(2014) Daniel J. Kiviet et al.   NATURE

Transcript level and sequence determinants of protein abundance and noise in Escherichia coli

(2014) Joao C. Guimaraes et al.   NUCLEIC ACIDS RESEARCH

Bet-hedging during bacterial diauxic shift

(2014) A. Solopova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promoter architecture dictates cell-to-cell variability in gene expression

(2014) Daniel L. Jones et al.   SCIENCE

Lost in Transition: Start-Up of Glycolysis Yields Subpopulations of Nongrowing Cells

(2014) J. H. van Heerden et al.   SCIENCE

Contribution of RNA polymerase concentration variation to protein expression noise

(2014) Sora Yang et al.   Nature Communications

Single yeast cells vary in transcription activity not in delay time after a metabolic shift

(2014) Anne Schwabe et al.   Nature Communications

Different Levels of Catabolite Repression Optimize Growth in Stable and Variable Environments

(2014) Aaron M. New et al.   PLOS BIOLOGY

Memory and Fitness Optimization of Bacteria under Fluctuating Environments

(2014) Guillaume Lambert et al.   PLoS Genetics

Adaptability of non-genetic diversity in bacterial chemotaxis

(2014) Nicholas W Frankel et al.   eLife

Evolution in Microbes

(2013) Edo Kussell   Annual Review of Biophysics

Regulation of Noise in Gene Expression

(2013) Alvaro Sanchez et al.   Annual Review of Biophysics

Partitioning of RNA Polymerase Activity in Live Escherichia coli from Analysis of Single-Molecule Diffusive Trajectories

(2013) Somenath Bakshi et al.   BIOPHYSICAL JOURNAL

RETRACTED: (p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin Activity

(2013) Etienne Maisonneuve et al.   CELL

How Biochemical Constraints of Cellular Growth Shape Evolutionary Adaptations in Metabolism

(2013) J. Berkhout et al.   GENETICS

Metabolic Control of Persister Formation in Escherichia coli

(2013) Stephanie M. Amato et al.   MOLECULAR CELL

Promoter decoding of transcription factor dynamics involves a trade-off between noise and control of gene expression

(2013) A. S. Hansen et al.   Molecular Systems Biology

Memory and modularity in cell-fate decision making

(2013) Thomas M. Norman et al.   NATURE

Single-Cell Dynamics Reveals Sustained Growth during Diauxic Shifts

(2013) Sarah Boulineau et al.   PLoS One

Functioning of a metabolic flux sensor in Escherichia coli

(2013) K. Kochanowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth feedback as a basis for persister bistability

(2013) J. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Innate Growth Bistability and Fitness Landscapes of Antibiotic-Resistant Bacteria

(2013) J. B. Deris et al.   SCIENCE

Robust Circadian Oscillations in Growing Cyanobacteria Require Transcriptional Feedback

(2013) S.-W. Teng et al.   SCIENCE

Dynamic Persistence of Antibiotic-Stressed Mycobacteria

(2013) Y. Wakamoto et al.   SCIENCE

Cell-Cycle Dependence of Transcription Dominates Noise in Gene Expression

(2013) C. J. Zopf et al.   PLoS Computational Biology

Noise-mean relationship in mutated promoters

(2012) G. Hornung et al.   GENOME RESEARCH

Ageing in Escherichia coli requires damage by an extrinsic agent

(2012) C. U. Rang et al.   MICROBIOLOGY-SGM

A conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes

(2012) Nikolai Slavov et al.   MOLECULAR BIOLOGY OF THE CELL

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

(2012) Adam L. Hughes et al.   NATURE

Using Gene Expression Noise to Understand Gene Regulation

(2012) B. Munsky et al.   SCIENCE

Bet Hedging in Yeast by Heterogeneous, Age-Correlated Expression of a Stress Protectant

(2012) Sasha F. Levy et al.   PLOS BIOLOGY

Pulsed Feedback Defers Cellular Differentiation

(2012) Joe H. Levine et al.   PLOS BIOLOGY

A Genome-Wide Analysis of Promoter-Mediated Phenotypic Noise in Escherichia coli

(2012) Olin K. Silander et al.   PLoS Genetics

Natural selection. I. Variable environments and uncertain returns on investment*

(2011) S. A. FRANK   JOURNAL OF EVOLUTIONARY BIOLOGY

The Value of Information for Populations in Varying Environments

(2011) Olivier Rivoire et al.   JOURNAL OF STATISTICAL PHYSICS

Adaptation by stochastic switching of a monostable genetic circuit in Escherichia coli

(2011) S. Tsuru et al.   Molecular Systems Biology

Central dogma at the single-molecule level in living cells

(2011) Gene-Wei Li et al.   NATURE

Random partitioning of molecules at cell division

(2011) D. Huh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of gene expression noise on organismal fitness and the efficacy of natural selection

(2011) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Delineation of a Bacterial Starvation Stress Response Network Which Can Mediate Antibiotic Tolerance Development

(2010) D. K. C. Fung et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Robust Growth of Escherichia coli

(2010) Ping Wang et al.   CURRENT BIOLOGY

Exact Results for the Evolution of Stochastic Switching in Variable Asymmetric Environments

(2010) B. Gaal et al.   GENETICS

Functional roles for noise in genetic circuits

(2010) Avigdor Eldar et al.   NATURE

Non-genetic heterogeneity from stochastic partitioning at cell division

(2010) Dann Huh et al.   NATURE GENETICS

The fitness value of information

(2010) Matina C. Donaldson-Matasci et al.   OIKOS

Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence

(2010) Eitan Rotem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noise Can Induce Bimodality in Positive Transcriptional Feedback Loops Without Bistability

(2010) T.-L. To et al.   SCIENCE

Interdependence of Cell Growth and Gene Expression: Origins and Consequences

(2010) M. Scott et al.   SCIENCE

Bacterial Chromosome Organization and Segregation

(2010) E. Toro et al.   Cold Spring Harbor Perspectives in Biology

Connecting Variability in Global Transcription Rate to Mitochondrial Variability

(2010) Ricardo Pires das Neves et al.   PLOS BIOLOGY

Shifts in growth strategies reflect tradeoffs in cellular economics

(2009) Douwe Molenaar et al.   Molecular Systems Biology

Experimental evolution of bet hedging

(2009) Hubertus J. E. Beaumont et al.   NATURE

Using movies to analyse gene circuit dynamics in single cells

(2009) James C. W. Locke et al.   NATURE REVIEWS MICROBIOLOGY

Noise Management by Molecular Networks

(2009) Frank J. Bruggeman et al.   PLoS Computational Biology

The yeast lysosome-like vacuole: Endpoint and crossroads

(2008) Sheena Claire Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

(2008) Arjun Raj et al.   CELL

Chromatin decouples promoter threshold from dynamic range

(2008) Felix H. Lam et al.   NATURE

Self-destructive cooperation mediated by phenotypic noise

(2008) Martin Ackermann et al.   NATURE

Stochastic switching as a survival strategy in fluctuating environments

(2008) Murat Acar et al.   NATURE GENETICS

Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation

(2008) A. B. Lindner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Molecular Memory and Bursting on Fluctuations in Gene Expression

(2008) J. M. Pedraza et al.   SCIENCE

A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell

(2008) P. J. Choi et al.   SCIENCE

Regulatory Control and the Costs and Benefits of Biochemical Noise

(2008) Sorin Tănase-Nicola et al.   PLoS Computational Biology