Zonation of hepatic fat accumulation: insights from mathematical modelling of nutrient gradients and fatty acid uptake

Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems

(2017) Felipe T Lee-Montiel et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease

(2017) Zoe Hall et al.   HEPATOLOGY

Unbound free fatty acid profiles in human plasma and the unexpected absence of unbound palmitoleate

(2017) Andrew H. Huber et al.   JOURNAL OF LIPID RESEARCH

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

(2017) Keren Bahar Halpern et al.   NATURE

Metabolic zonation of the liver: The oxygen gradient revisited

(2017) Thomas Kietzmann   Redox Biology

Combined defects in oxidative phosphorylation and fatty acid  -oxidation in mitochondrial disease

(2016) A. Nsiah-Sefaa et al.   BIOSCIENCE REPORTS

Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases

(2016) Ahmed Ghallab et al.   JOURNAL OF HEPATOLOGY

A physiologically-based flow network model for hepatic drug elimination III: 2D/3D DLA lobule models

(2016) Vahid Rezania et al.   Theoretical Biology and Medical Modelling

A Computational Model of Hepatic Energy Metabolism: Understanding Zonated Damage and Steatosis in NAFLD

(2016) William B. Ashworth et al.   PLoS Computational Biology

Effects of high fat diets on rodent liver bioenergetics and oxidative imbalance

(2016) Pâmela A. Kakimoto et al.   Redox Biology

Optimality in the zonation of ammonia detoxification in rodent liver

(2015) Martin Bartl et al.   ARCHIVES OF TOXICOLOGY

Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation

(2015) Wudelehu Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Zonation of hepatic fatty acid metabolism — The diversity of its regulation and the benefit of modeling

(2015) J. Schleicher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A systems biology approach reveals the physiological origin of hepatic steatosis induced by liver X receptor activation

(2015) Brenda S. Hijmans et al.   FASEB JOURNAL

β-Catenin Links Hepatic Metabolic Zonation with Lipid Metabolism and Diet-Induced Obesity in Mice

(2014) Jaideep Behari et al.   AMERICAN JOURNAL OF PATHOLOGY

An in vitro hepatic zonation model with a continuous oxygen gradient in a microdevice

(2014) Asako Sato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modeling function–perfusion behavior in liver lobules including tissue, blood, glucose, lactate and glycogen by use of a coupled two-scale PDE–ODE approach

(2014) T. Ricken et al.   Biomechanics and Modeling in Mechanobiology

Pathological Features of Fatty Liver Disease

(2014) Matthew M. Yeh et al.   GASTROENTEROLOGY

Beta-catenin signaling in murine liver zonation and regeneration: A Wnt-Wnt situation!

(2014) Jing Yang et al.   HEPATOLOGY

Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration

(2014) Freimut Schliess et al.   HEPATOLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

A theoretical study of lipid accumulation in the liver—implications for nonalcoholic fatty liver disease

(2013) J. Schleicher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Zonation of glucose and fatty acid metabolism in the liver: Mechanism and metabolic consequences

(2013) Brenda S. Hijmans et al.   BIOCHIMIE

Metabolic gradients as key regulators in zonation of tumor energy metabolism: A tissue-scale model-based study

(2013) Matthias König et al.   Biotechnology Journal

Cell-to-Cell Heterogeneity in Lipid Droplets Suggests a Mechanism to Reduce Lipotoxicity

(2013) Albert Herms et al.   CURRENT BIOLOGY

Differential effects of high-carbohydrate and high-fat diets on hepatic lipogenesis in rats

(2013) Alessandra Ferramosca et al.   EUROPEAN JOURNAL OF NUTRITION

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

(2013) Karima Begriche et al.   HEPATOLOGY

Diet-Sensitive Sources of Reactive Oxygen Species in Liver Mitochondria: Role of Very Long Chain Acyl-CoA Dehydrogenases

(2013) Ariel R. Cardoso et al.   PLoS One

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

(2012) Zheng Sun et al.   NATURE MEDICINE

A Krill Oil Supplemented Diet Suppresses Hepatic Steatosis in High-Fat Fed Rats

(2012) Alessandra Ferramosca et al.   PLoS One

Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease

(2011) Ingrid C. Gaemers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

(2011) Anabela P. Rolo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C

(2011) M. E. Miquilena-Colina et al.   GUT

Short-term inhibition of SREBP-1c expression reverses diet-induced non-alcoholic fatty liver disease in mice

(2011) Marisa JS Frederico et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxia

(2010) Julieta Carabelli et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lipidomics reveals a remarkable diversity of lipids in human plasma,

(2010) Oswald Quehenberger et al.   JOURNAL OF LIPID RESEARCH

Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity

(2010) Shahab Sheikh-Bahaei et al.   JOURNAL OF THEORETICAL BIOLOGY

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

(2010) Jan F. C. Glatz et al.   PHYSIOLOGICAL REVIEWS

Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis

(2009) Koji Fujita et al.   HEPATOLOGY

Transcription dynamics in a physiological process: β-Catenin signaling directs liver metabolic zonation

(2009) Cyril Torre et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism

(2009) E. B. Rankin et al.   MOLECULAR AND CELLULAR BIOLOGY

Gene expression in human NAFLD

(2008) Dario Greco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Construction of a Biological Tissue Model Based on a Single-Cell Model: A Computer Simulation of Metabolic Heterogeneity in the Liver Lobule

(2008) Hiroshi Ohno et al.   ARTIFICIAL LIFE

High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial functionin vivo

(2008) Sudheer K. Mantena et al.   BIOCHEMICAL JOURNAL

Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease

(2008) Naga Chalasani et al.   JOURNAL OF HEPATOLOGY