Article
Clinical Neurology
Ashley C. Guest, Kevin J. O'Neill III, Dakota Graham, Zaman Mirzadeh, Francisco A. Ponce, Bradley Greger
Summary: This study investigates the electrophysiological relationships within the cortico-basal ganglia network in Parkinson's disease (PD) using intraoperative recordings from microelectrodes in the subthalamic nucleus (STN) and a micro-electrocorticography grid on the motor association cortex during deep brain stimulation (DBS) electrode placement. The results show functional connections between STN neurons and local field potential (LFP) in the STN, as well as cortical LFP. These connections exhibit differential topography on the cortex for each neuron. Significance: The cortico-basal ganglia circuit on a sub-centimeter scale plays an important role in the mechanisms of PD and DBS.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Marco Heerdegen, Monique Zwar, Denise Franz, Julia Hoernschemeyer, Valentin Neubert, Franz Plocksties, Christoph Niemann, Dirk Timmermann, Christian Bahls, Ursula van Rienen, Maria Paap, Stefanie Perl, Anika Luettig, Angelika Richter, Rudiger Koehling
Summary: DBS can increase cortico-striatal evoked responses in healthy tissue, but not in dystonic tissue. It also enhances inhibitory control in dystonic tissue and decreases inhibitory control in healthy tissue, suggesting modulation of presynaptic mechanisms.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Multidisciplinary Sciences
Brian D. Kangas, Ann M. Iturra-Mena, Mykel A. Robble, Oanh T. Luc, David Potter, Stefanie Nickels, Jack Bergman, William A. Carlezon, Diego A. Pizzagalli
Summary: This study integrated electrophysiological recordings with rodent touchscreen-based cognitive testing, creating a rat flanker task that aligns with human cognitive control research. Purple and green photographic stimuli were found to efficiently train rats and elicit expected flanker interference effects.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Brian R. Lee, Agata Budzillo, Kristen Hadley, Jeremy A. Miller, Tim Jarsky, Katherine Baker, DiJon Hill, Lisa Kim, Rusty Mann, Lindsay Ng, Aaron Oldre, Ram Rajanbabu, Jessica Trinh, Sara Vargas, Thomas Braun, Rachel A. Dalley, Nathan W. Gouwens, Brian E. Kalmbach, Tae Kyung Kim, Kimberly A. Smith, Gilberto Soler-Llavina, Staci Sorensen, Bosiljka Tasic, Jonathan T. Ting, Ed Lein, Hongkui Zeng, Gabe J. Murphy, Jim Berg
Summary: Patch-seq is a powerful technique for characterizing individual neurons, allowing for a comprehensive view of their electrophysiological, morphological, and transcriptomic features. By refining key factors for efficient data collection and developing specialized software, high-quality data can be generated at scale. The protocol is versatile, suitable for different species and brain regions, and the resources are available for diverse mammalian research.
Article
Neurosciences
Daisuke Koketsu, Satomi Chiken, Tatsuhiro Hisatsune, Shigehiro Miyachi, Atsushi Nambu
Summary: This study used a photodynamic technique to selectively eliminate the cortico-subthalamo projection in male mice, and found that after elimination, cortically evoked early excitation in the substantia nigra pars reticulata was diminished, while the cortically evoked inhibition and late excitation delivered through the direct and indirect pathways remained unchanged. In addition, locomotor activity was significantly increased after bilateral cortico-subthalamo elimination.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Ann M. Iturra-Mena, Brian D. Kangas, Oanh T. Luc, David Potter, Diego A. Pizzagalli
Summary: Blunted reward learning and reward-related activation in the corticostriatal-midbrain circuitry are linked to anhedonia and depression. This study used event-related potentials and spectral analyses to identify the electrophysiological signatures of reward learning in rats. The findings suggest that these approaches could be used to evaluate novel therapeutics targeting anhedonia.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Audiology & Speech-Language Pathology
Alexandria M. H. Lesicko, Maria N. Geffen
Summary: This article discusses the ascending and descending connections in sensory processing, focusing on the anatomical organization and physiological properties of the auditory cortico-collicular pathway. It highlights the role of this pathway in high-level cognitive processes, acoustico-motor behaviors, and auditory plasticity.
Article
Neurosciences
Marc Deffains, Tho Hai Nguyen, Hugues Orignac, Nathalie Biendon, Sandra Dovero, Erwan Bezard, Thomas Boraud
Summary: The study recorded and examined the inhibition of pallidal neurons using DREADD technology in the NHP model, demonstrating its effectiveness in this context.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Jose David Celdran, Lawrence Humphreys, Desiree Gonzalez, Cristina Soto-Sanchez, Gema Martinez-Navarrete, Ivan Maldonado, Idoia Gallego, Ilia Villate-Beitia, Myriam Sainz-Ramos, Gustavo Puras, Jose Luis Pedraz, Eduardo Fernandez
Summary: Gene therapy and optogenetics show promise for treating nervous system pathologies, but viral vectors used in these approaches pose risks. Non-viral nanoparticles such as niosomes offer a potential alternative, and our study tested three niosome formulations with optogenetic plasmids in rat cortical neurons. We found successful expression of optogenetic channels, but observed changes in cell morphology and electrophysiological properties, particularly at higher concentrations of niosomes. Our results highlight the potential and the need for careful optimization in the use of niosomes for optogenetic applications.
Article
Multidisciplinary Sciences
Chunyu A. Duan, Yuxin Pan, Guofen Ma, Taotao Zhou, Siyu Zhang, Ning-long Xu
Summary: The study reveals dynamic coding of choice information in SC-projecting M2 neurons during motor planning and execution, with disruption of this information impairing decision maintenance. Excitatory and inhibitory SC neurons both receive synaptic inputs from M2, but display differential temporal patterns in choice coding during behavior.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Alexander Yu Rotov, Arsenii A. Goriachenkov, Roman Cherbunin, Michael L. Firsov, Nikita Chernetsov, Luba A. Astakhova
Summary: The nasal quadrant of the avian retina is sensitive to magnetic field, which may be related to its morphology and the optical properties of oil droplets.
Article
Developmental Biology
Tian Tian, Idoia Quintana-Urzainqui, Zrinko Kozic, Thomas Pratt, David J. Price
Summary: This study used conditional mutagenesis to delete Pax6 at the onset of neurogenesis and investigated the long-term consequences. The results showed that Pax6 loss affected the rates of neurite elongation, location and length of axon initial segments, and electrophysiological properties of prethalamic neurons. These findings broaden our understanding of the cell-autonomous effects of Pax6 deletion on structural and functional development of certain neurons in the developing mouse forebrain.
Article
Neurosciences
Chia-wei Chang, Meiling Zhao, Samantha Grudzien, Max Oginsky, Yexin Yang, Sung Eun Kwon
Summary: The primary somatosensory cortex (S1) plays an important role in movement control by encoding sensory input and receiving inputs from other sensorimotor areas. In this study, silencing the non-whisker S1 area disrupted hind paw movement during locomotion in mice. Furthermore, the S2 and M1 areas were found to provide major inputs to the non-whisker S1 area, with S2 projections preferentially targeting inhibitory interneurons.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Medicine, General & Internal
Tsun-Kang Chiang, Minzhong Yu
Summary: Macular dystrophies are a group of genetic disorders that seriously threaten bilateral central vision. Despite advances in molecular genetics, there is still significant phenotypical variation among patients. Electrophysiological testing is important for differential diagnosis, understanding pathophysiology, monitoring treatment effect, and potentially advancing therapy. This review summarizes the application of electrophysiological testing in various macular dystrophies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Marek Balaz, Jiri Buril, Tereza Jurkova, Eva Koritakova, Dusan Hrabovsky, Jonas Kunst, Petra Bartova, Jan Chrastina
Summary: This study aims to compare the preplanned trajectories for deep brain stimulation (DBS) with the final trajectories selected after electrophysiological monitoring, and to discuss the factors responsible for the differences. The results showed significant differences between the preplanned and final trajectories, but no predictors for these differences were identified. There was also no association between the anatomical-electrophysiological differences and clinical outcome.
FRONTIERS IN SURGERY
(2023)