期刊
DRUG DISCOVERY TODAY
卷 20, 期 7, 页码 848-855出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2015.04.004
关键词
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资金
- Czech Ministry of Education, Youth and Sports [CZ.1.07/2.3.00/30.0041, LO1304]
- Czech Ministry of Health [NT14282]
- Technological Agency of the Czech Republic [TE01020028]
- Italian Ministry of Health
- Ricerca Corrente [RF-2011-02346914]
The alarming rate of failure of clinical trials is a major hurdle in cancer therapy that partly results from the inadequate use of in vitro tumor models for the screening of promising hits and leads in preclinical studies. 2D cultures of cancer cell lines that are primarily used for drug screening do not adequately recapitulate tumor microenvironment (TME) complexities compared with 3D cancer cell cultures and tumor-derived primary cell cultures. In this review, we focus on the potential use of in vitro tumor models that reproduce in vivo tumor complexities for effective drug selection in the preclinical stages of drug development.
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