Editorial Material
Chemistry, Physical
Michael Lang
Summary: An approach to analyze the deformation behavior of polymer networks provides valuable structural information, enhancing our understanding of the elasticity of soft materials.
Article
Multidisciplinary Sciences
Matthew D. Davidson, Margaret E. Prendergast, Ehsan Ban, Karen L. Xu, Gabriel Mickel, Patricia Mensah, Abhishek Dhand, Paul A. Janmey, Vivek B. Shenoy, Jason A. Burdick
Summary: Fibrous hydrogel assemblies stabilized with photocrosslinking display strain-responsive properties that mimic natural ECM, allowing for applications in cell culture and tissue engineering. These materials can be processed into constructs with programmed shape changes through various methods, such as microtissue formation, bioprinting, and photopatterning.
Review
Biochemistry & Molecular Biology
Aleksandr Popov, Emma Kozlovskaya, Tatyana Rutckova, Olga Styshova, Aleksey Vakhrushev, Elena Kupera, Ludmila Tekutyeva
Summary: Recent research has shown that matrix metalloproteinase-generated functional proteins (MKs) can be a valuable source of nutrition and therapy, reducing the risk of serious diseases such as cancer. MKs have antitumor properties and can be used in combination therapy without toxic side effects. This review summarizes the data on the antitumor activity of MKs from various sources and discusses their potential and challenges in therapeutic use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Mechanics
John E. Bolander, Jan Elias, Gianluca Cusatis, Kohei Nagai
Summary: Discrete models of solids have been developed to study the discontinuous and heterogeneous nature of material structure and its breakdown under loading, offering novel means for investigating material structure-property relationships. However, lack of comprehensive understanding of both the advantages and disadvantages of discrete models limits their further development and applications. This paper reviews the application of discrete approaches in modeling the mechanical behavior of geomaterials, particularly concrete, classifying the models based on their form and abilities to represent elastic and fracture behaviors in the presence of large-scale material heterogeneity.
ENGINEERING FRACTURE MECHANICS
(2021)
Article
Engineering, Multidisciplinary
Samuel Burbulla, Luca Formaggia, Christian Rohde, Anna Scotti
Summary: We propose a novel model for fluid-driven fracture propagation in poro-elastic media, which combines ideas from dimensionally reduced discrete fracture models with diffuse phase-field models. Our thermodynamically consistent model is solved numerically using a mixed-dimensional discontinuous Galerkin scheme. The diffuse phase-field acts as an indicator to identify new fracture facets as the fracture propagates, and our approach reproduces classical scenarios for fracturing porous media.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Article
Mechanics
Nosaibeh Esfandiary, Michael Zaiser, Paolo Moretti
Summary: This study introduces a three-dimensional model for interface failure of hierarchical materials on heterogeneous substrates. The hierarchical structure induces scale invariant detachment patterns, preventing interface failure by crack propagation in cases of low interface disorder. In cases of high interface disorder, hierarchical patterns ensure enhanced work of failure. These findings suggest that hierarchical patterns can be useful for tuning and optimizing adhesion properties in engineering scenarios.
JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT
(2022)
Article
Physics, Fluids & Plasmas
Amir Suhail, Anuradha Banerjee, R. Rajesh
Summary: In this paper, a kinetic model for collagen fibrils is developed, which reproduces well the characteristic features of cyclic response. The approach to the steady state is found to be controlled by a characteristic cycle number for both residual strain and energy dissipation.
Article
Materials Science, Multidisciplinary
Gavin A. Buxton
Summary: The Born lattice spring model is implemented on an irregular network to capture an elastically uniform system and allow for variable node density. This model can be refined around areas of interest and captures the spatial cooperative effects of isotropic fracture propagation in heterogeneous materials.
MODELLING AND SIMULATION IN MATERIALS SCIENCE AND ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Brandon G. Gerberich, Amy J. Wood-Yang, Afsane Radmand, Lauren M. Nichols, Amir Hejri, Elisa Schrader Echeverri, Hannah G. Gersch, Mark R. Prausnitz
Summary: A computational model was developed to predict the crosslinking efficiency of visible/near infrared photosensitizers in the sclera for the treatment of myopia and glaucoma. The study validated photocrosslinking against riboflavin corneal crosslinking experimental studies and simulated the treatment using methylene blue administered by retrobulbar injection and irradiated with a transpupillary light beam. Optimal ranges for treatment parameters were determined and the sensitivity of crosslinking to various parameters was quantified, with oxygen concentration in the injection solution, scleral thickness, and injection volume being the most sensitive parameters.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Physical
Di Lu, Bin Chen
Summary: In this study, a nonaffine constitutive theory was developed to explain the large stretch behavior of slide-ring hydrogels by considering the molecular frictions induced by sliding of rings on polymer chains. The theory was validated by predicting the viscoelastic behaviors of several hydrogels, which were in agreement with experiments. The analysis showed that the sliding of rings is critical for their high fracture energy, and the molecular friction coefficient for ring sliding might strongly depend on the normal force occurring at the interface between rings and polymer chains.
Article
Physics, Fluids & Plasmas
Oran Szachter, Eytan Katzav, Mokhtar Adda-Bedia, Michael Moshe
Summary: The stress function method in elasticity theory is a powerful tool for analyzing physical systems. However, it has limitations in dealing with nonlinear elasticity. This paper develops a formalism for nonlinear stress functions, allowing for better analysis of nonlinear deformation.
Article
Computer Science, Software Engineering
Chengguizi Han, Tao Xue, Mridul Aanjaneya
Summary: This study introduces a Lagrangian particle-based formulation to simulate deformation, fracture, and diffusion in thin membranelike structures, resulting in a unified framework for simulating deformation-diffusion coupled phenomena. The end-to-end 3D simulations demonstrate the detailed fracture growth patterns captured by the deformation-diffusion coupling framework, including realistically wrinkled slit edges and heterogeneity induced by diffusion.
COMPUTER GRAPHICS FORUM
(2021)
Article
Mechanics
Weicheng Huang, Longhui Qin, Mohammad Khalid Jawed
Summary: Elastic gridshells are lightweight structures covering large areas through a net-like design, with a numerical framework studying geometric nonlinear deformations and solving form-finding problems. By utilizing physically-based simulation and contact algorithms, successful solutions were achieved for form-finding and inverse problems.
JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME
(2021)
Article
Mechanics
Andrew Choi, Dezhong Tong, Mohammad K. Jawed, Jungseock Joo
Summary: This article introduces a new contact model with high convergence properties for simulating knots and tangles, allowing for large time steps without compromising accuracy. By using a new contact potential and enhancing the modeling of contact forces, this model addresses issues with numerical convergence from explicit implementations and inefficiency in iteratively solving for contact forces.
JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME
(2021)
Review
Chemistry, Medicinal
Igor Yu. Dolmatov, Vladimir A. Nizhnichenko
Summary: This review examines the composition of the extracellular matrix (ECM) in echinoderms, highlighting its complex organization and presence of various proteins, proteases, and proteoglycans. The ECM in echinoderms differs significantly from that of vertebrates, lacking certain glycoproteins and elastin. Echinoderms also possess a wide range of proteinases and their inhibitors, contributing to the complexity of the mechanical properties in their connective tissue.
Article
Materials Science, Paper & Wood
Hakimeh Koochi, Jonatan Mac Intyre, Leevi Viitanen, Antti Puisto, Nahid Maleki-Jirsaraei, Mikko Alava
Summary: The aging behavior of TEMPO-CNF suspensions, which are fundamentally different from low-density gels, is investigated using rheological measurements and experiments. The aging effect is found to result in the logarithmic growth of the elastic modulus and a decrease in particle velocity. Based on experimental evidence, it is proposed that the aging effect in TEMPO-CNFs occurs due to the restructuring of fibrous elements and does not develop homogeneously across the whole sample.
Article
Multidisciplinary Sciences
Maria Rita Fumagalli, Stella Maria Saro, Matteo Tajana, Stefano Zapperi, Caterina A. M. La Porta
Summary: STELLA is a computational method used to derive the spectrum of metabolites associated with an individual's microbiome. By comparing the results with healthy individuals, individual metabolic alterations can be identified.
Article
Materials Science, Paper & Wood
Leevi Viitanen, Isaac Y. Miranda-Valdez, Juha Koivisto, Antti Puisto, Mikko Alava
Summary: A more sustainable future requires bio-based alternatives to replace plastic foams for various applications. Research has shown that bio-based foams, fabricated using liquid foam templating and methyl cellulose as main constituents, have potential in packaging, insulation, and cushioning. However, scaling up production requires a comprehensive understanding of the foam's rheology during shaping and drying processes.
Article
Materials Science, Paper & Wood
Ari Jasberg, Antti Puisto, Ilona Leppaenen, Antti I. Koponen, Mikko J. Alava
Summary: The article discusses a method using polarization-sensitive optical coherence tomography as an online measurement tool for determining particle orientation in materials such as filaments and films. This tool enables better control and optimization of the manufacturing process.
Article
Biochemistry & Molecular Biology
Stefano Zapperi, Caterina A. M. La Porta
Summary: Finding prognostic and predictive markers for TNBC is highly desirable, and the recently developed transcriptomic test ARIADNE shows promising capabilities in this regard.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mrinmoy Mukherjee, Oleksandr Chepizhko, Maria Chiara Lionetti, Stefano Zapperi, Caterina A. M. La Porta, Herbert Levine
Summary: In recent years, there has been a growing interest in understanding the role of the adaptive immune system in controlling tumor progression. Studies have shown that the density of adaptive immune cells inside solid tumors is a favorable prognostic marker for various types of cancer, although the exact mechanisms behind immune cell infiltration are not fully understood. In this study, the researchers quantified the temporal dynamics of immune cell density around a solid tumor spheroid and developed a computational model that could reproduce the experimentally measured infiltration profile. Studying the density distribution of immune cells inside solid tumors can provide insights into immune trafficking in the tumor microenvironment and potentially guide the development of novel immunotherapeutic strategies.
Article
Microbiology
Marianna Dourou, Caterina Anna Maria La Porta
Summary: The nucleation dynamic assay is used to identify microbial behaviors, such as the interactions between Trichoderma fungi and other members of soil microflora. Trichoderma-based fungicides are being researched as an alternative to synthetic ones, but the impact on the soil microbiome is not well-studied. In this study, twelve fungi were isolated from Italian vineyards, including three Trichoderma strains and nine other plant-associated fungi. Through a dual nucleation assay, it was observed that Trichoderma strains exhibited both neutral and antagonistic interactions with different fungi, including plant pathogens. The findings emphasize the importance of studying fungal interactions to understand the impact of fungal-based biological fungicides on soil communities.
Article
Materials Science, Multidisciplinary
E. Wyszkowska, C. Mieszczynski, L. Kurpaska, A. Azarov, W. Chrominski, I Jozwik, A. Esfandiarpour, A. Kosinska, D. Kalita, R. Diduszko, J. Jagielski, S. T. Nori, M. Alava
Summary: The radiation resistance of NixFe1-x single crystals was studied by irradiating them with Ni-58 ions and analyzing the resulting damage. It was found that the addition of iron reduced the formation of damage and increased the hardness of the alloy. Simulations showed that the presence of FeNi3 (L1(2)) phase contributed to the high hardness of the Ni0.62Fe0.38 alloy.
JOURNAL OF NUCLEAR MATERIALS
(2023)
Article
Mechanics
Juha Savolainen, Mikko Alava
Summary: The average velocity of an interface under sinusoidal driving in the creep region was studied, considering both short-range elastic systems and long-range elastic systems. For short-range elastic systems, a modified version of creep velocity with approximate power-law behavior and a material-dependent exponent was obtained, while simpler behavior was observed for long-range elasticity. The applicability of the model to fatigue fractures and the necessity of additional physics were discussed.
JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT
(2023)
Article
Mathematics, Interdisciplinary Applications
Caterina A. M. La Porta, Stefano Zapperi
Summary: Inequalities in wealth, income, access to food and healthcare have been increasing worldwide. This study explores the relationship between wealth inequality and mobility, comparing surveys conducted in the USA and Italy. It is found that greater wealth inequality in the USA is associated with poorer health conditions than in Italy. Additionally, mobility becomes slower at the extremes of the wealth distribution in both countries. Households trapped in persistent lack of wealth experience greater food insecurity and poorer health. A simple agent based model of wealth condensation driven by random returns and exchanges is used to explain the association between inequality and immobility. The model accurately describes survey data qualitatively, but overestimates mobility. The discrepancy is attributed to the model's incorrect representation of income generation for low-wealth households. On the other hand, the model effectively describes wealth dynamics within the ultra-wealthy class. The results highlight the interconnectedness of different forms of inequality and the need to address them collectively.
JOURNAL OF PHYSICS-COMPLEXITY
(2023)
Article
Materials Science, Multidisciplinary
Amir H. Naghdi, Kamran Karimi, Axel E. Poisvert, Amin Esfandiarpour, Rene Alvarez, Pawel Sobkowicz, Mikko Alava, Stefanos Papanikolaou
Summary: Recent experiments and atomistic simulations have shown that equiatomic NiCoCr solid solutions exhibit exceptional mechanical properties that may be linked to nanostructural short-range order (SRO) arising from thermal treatments. This study uses hybrid Monte Carlo-molecular dynamics simulations to further understand the thermal effects on SRO formation and edge dislocation plasticity mechanisms in equiatomic NiCoCr solid solutions. The results suggest that the presence of SROs enhances the roughening mechanism and leads to significant improvements in dislocation glide resistance, ultimately improving alloy strength through the interplay between nanoscopic SROs and atomic-level misfit properties.
Article
Chemistry, Applied
Isaac Y. Miranda-Valdez, Jesus G. Puente-Cordova, Flor Y. Renteria-Baltierrez, Lukas Fliri, Michael Hummel, Antti Puisto, Juha Koivisto, Mikko J. Alava
Summary: This paper explores the potential of using fractional calculus models to describe the viscoelastic properties of soft solids, focusing on methylcellulose aqueous systems. The results show that fractional calculus can accurately describe the rheological behavior of methylcellulose, particularly the frequency- and temperature-dependent rheology. Additionally, the study showcases how the use of one springpot can replace multiple spring-dashpot arrangements, simplifying the model. Lastly, the study finds that the thermogelation of methylcellulose involves the cooperative mobility of polymer chains and can be compared to the glass transition in polymers.
FOOD HYDROCOLLOIDS
(2024)
Article
Energy & Fuels
Isaac Y. Miranda-Valdez, Maryam Roza Yazdani, Tero Makinen, Sebastian Coffeng, Leevi Viitanen, Juha Koivisto, Mikko J. Alava
Summary: This study demonstrates that cellulose foams can exhibit solid-liquid phase change functionality by adding a phase change material during the foam forming process. The resulting cellulose phase change foams have low density, high Young's modulus, and excellent dimensional stability and thermal absorption capacity at specific temperatures. This opens up broad applications for the cellulose phase change foams as thermal insulators.
JOURNAL OF ENERGY STORAGE
(2023)
Article
Engineering, Biomedical
Xinyao Zhu, Yifan Liu, Jing Ye, Wei Xu, Xuexia Zhao, Tianyan Liu
Summary: This study reveals the adverse effect of acid on dentin in terms of degradation of its fracture toughness. The peritubular dentin plays a significant role in enhancing the dentin's fracture resistance capability. The findings highlight the importance of structural integrity for dentin.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Priya Ranganathan, Vijayakumari Sugumaran, Bargavi Purushothaman, Ajay Rakkesh Rajendran, Balakumar Subramanian
Summary: The study aims to design and fabricate an ultra-easier multi-functional biomedical polymeric scaffold loaded with unique equimolar Ca:P phasic bioactive glass material. The results showed that the G:BG (1:2) ratio is the more appropriate composition for enhanced bio-mineralization and higher surface area. The scaffold can induce mitogenesis in osteoblast cells for hard tissue regeneration and rapid collagen secretion in fibroblast cells for soft tissue regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ziad Guerfi, Oum keltoum Kribaa, Hanane Djouama
Summary: Hydroxyapatite, a biocompatible and bioactive ceramic material, has been widely studied in fields such as orthopedics and plastic surgery. The use of computational tools, especially density functional theory, has become increasingly important in research. In this study, Hydroxyapatite was synthesized using the double decomposition method and quantum mechanical computations were performed using density functional theory. The experimental and computational results confirmed the successful synthesis of Hydroxyapatite and showed good agreement in spectroscopic characterizations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Sally AbdulHussain Kadhum, Nassier A. Nassir
Summary: In this research, porous composites were successfully prepared and reinforced for bone scaffold applications. The functional groups, pore structure, and composition distribution of the materials were characterized using techniques such as FTIR, Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM).
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Veronika Geiger, Felicitas Mayinger, Moritz Hoffmann, Marcel Reymus, Bogna Stawarczyk
Summary: The study investigated the mechanical properties of four additively manufactured denture base resins in different measurement environments, and found that the measurement environment impacts the strength and fracture toughness of the materials.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Junxiao Wang, Amatjan Sawut, Rena Simayi, Huijun Song, Xueying Jiao
Summary: The development of cost-effective and eco-friendly conductive hydrogels with excellent mechanical properties, self-healing capabilities, and non-toxicity is of great significance in the field of biosensors.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Yijun Zhou, Lisa Ho, Ayan Samanta, Philip Procter, Cecilia Persson
Summary: In this study, soft, non-setting biomaterials based on Hyalectin gels and different morphological parameters of hydroxyapatite (HA) particles were evaluated as potential augmentation materials for orthopaedic implant fixation. The results showed that constructs reinforced with irregularly shaped nano-HA particles and spherically shaped micro-HA particles had significantly higher pull-out force compared to the control group.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Mehdi Jahandardoost, Donald Ricci, Abbas S. Milani, Mohsen Jahandardoost, Dana Grecov
Summary: Tubular flow diverters are important for treating cerebral aneurysms. A new design called VR-eCLIPs has been developed to cover the neck of challenging bifurcation aneurysms. A finite element model has been used to simulate the implantation processes of VR-eCLIPs and assess potential plastic deformation.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marek Traczynski, Adam Patalas, Katarzyna Roslan, Marcin Suszynski, Rafa l Talar
Summary: This article evaluates the forces acting on intravenous needles during insertion into the skin and selects the most suitable model for future research. The experimental results show that needle size, insertion angle, and insertion speed have an influence on the measured force values.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chester Jar, Andrew Archibald, Monica Gibson, Lindsey Westover
Summary: This study evaluates the ASIST technique for assessing the stability of dental implants. The results show that the ASIST technique can reliably measure the interfacial stiffness of dental implants, which is not significantly influenced by different abutment types. This method may provide an improved non-invasive way to measure the stability of dental implants.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ali Kamali, Kaveh Laksari
Summary: In this paper, a UNet-based neural network model (El-UNet) is developed to infer the spatial distributions of mechanical parameters. The El-UNet shows superior performance in terms of accuracy and computational cost compared to other neural network models. A self-adaptive spatial loss weighting approach is proposed, which achieves the most accurate reconstructions in equal computation times.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chunyan Yu, Yanju Lu, Jinhui Pang, Lu Li
Summary: In this study, a safe and effective hemostatic composite sponge was developed by combining chitosan and hydroxypropylmethylcellulose (HPMC). The sponge exhibited excellent flexibility and rapid hemostatic ability in vitro. In vivo assessments showed that the sponge had the shortest clotting time and minimal blood loss.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Zhongliang Yu, Lin Yu, Junjie Liu
Summary: The study proposes incorporating functionally graded tablets into nacreous composites to enhance both stiffness and damping properties. Analytical formulae and numerical experiments demonstrate the effectiveness of this design, surpassing existing homogeneous composites in performance.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marc Graham, Sandra Klinge
Summary: This study investigates the macroscopic diffusion behavior of heterogeneous gels using a homogenization method in a finite element framework. Two materials, calcifying PDMA and PAAm, were studied, and the results show that the diffusivity of PDMA has a strong nonlinear dependence on the solute molecule radius.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Abdur-Rasheed Alao
Summary: This study aimed to find the optimal sandblasting parameters for roughening YTZP surfaces. Through experimental and statistical analysis, the best setting was found to be IA = 45 degrees, AP = 110 μm, ST = 20 s, and P = 400 kPa, which resulted in the maximum surface roughness, phase transformation, and shear bond strength.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
