Review
Chemistry, Physical
Daan Zillen, Max Beugeling, Wouter L. J. Hinrichs, Henderik W. Frijlink, Floris Grasmeijer
Summary: Pulmonary drug delivery using dry powder formulations offers advantages such as improved dosing reproducibility and aerosolization performance. However, the pulmonary toxicity of many of the excipients used in these formulations remains largely unknown and requires further research attention.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2021)
Review
Biotechnology & Applied Microbiology
Helena H. W. B. Hansen, Haotian Cha, Lingxi Ouyang, Jun Zhang, Bo Jin, Helen Stratton, Nam-Trung Nguyen, Hongjie An
Summary: Nanobubbles, suspended gaseous entities in liquids, have versatile biomedical applications such as aiding in drug delivery, serving as imaging agents, and allowing controlled and targeted delivery. This review provides an overview of their preparation, characterization, current research focuses, and their potential impact on the future of biomedicine.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Chemistry, Medicinal
Monica R. Swinney, Amy L. Cox, Eric D. Hawkins, Jie Xue, Parag Garhyan, James R. L. Stanley, Shantanu Sule, Kofi Adragni, M. Dodson Michael
Summary: Prolonged wear of insulin infusion sets may increase the risk of unexplained hyperglycemia, potentially due to an inflammatory response to preservatives like m-cresol. However, exposure to m-cresol did not affect pharmacokinetics and pharmacodynamics endpoints, while the inflammatory response peaked at Day 7 and remained stable thereafter.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Nanoscience & Nanotechnology
Ran Chen, Tingting Wang, Jie Song, Daojun Pu, Dan He, Jianjun Li, Jie Yang, Kailing Li, Cailing Zhong, Jingqing Zhang
Summary: Antiviral drugs play a crucial role in fighting viruses, including COVID-19, but their use is often limited by poor oral bioavailability and low efficacy. Studying the metabolism and pharmacokinetic characteristics of AvDs can help improve their effectiveness and combat drug resistance.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Pharmacology & Pharmacy
Kei Xian Tan, Michael K. Danquah, Jaison Jeevanandam, Ahmed Barhoum
Summary: Janus particles have emerged as a novel and smart material for improving pharmaceutical formulation, drug delivery, and therapeutics. They have two distinct compartments that can accommodate opposing pharmaceutical agents and allow for controlled drug release. This article discusses the development of Janus particles and their potential applications in diabetes treatment and antimicrobial therapy. It highlights the advances in synthesizing Janus particles from different materials using various approaches and evaluates their potential for improving conventional drug delivery systems.
Review
Chemistry, Medicinal
Jiao Qu, Qianqian Liu, Guoquan You, Ling Ye, Yiguang Jin, Lingdong Kong, Wenjie Guo, Qiang Xu, Yang Sun
Summary: Andrographolide, a natural lactone with a range of pharmacological actions in traditional Chinese medicine, shows promising potential in treating inflammatory diseases and cancers. Its effects have been studied extensively in preclinical use and clinical trials, highlighting advancements in both disease categories.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Sara A. A. Valente, Guido R. R. Lopes, Isabel Ferreira, Miguel F. F. Galrinho, Margarida Almeida, Paula Ferreira, Maria T. T. Cruz, Manuel A. A. Coimbra, Claudia P. Passos
Summary: Non-invasive routes for insulin delivery are being developed to replace painful subcutaneous injections. Polysaccharides from roasted coffee beans and spent coffee grounds, specifically galactomannans and arabinogalactans, were utilized to prepare insulin-loaded microparticles. The polysaccharides were obtained through purification and ethanol precipitation or microwave-assisted extraction and ultrafiltration.
Article
Chemistry, Medicinal
Mingzhi Xu, Gang Chen, Yanan Dong, Jing Yang, Yongxue Liu, Haijing Song, Haifeng Song, Yi Wang
Summary: Bovine milk contains mEVs, which can serve as an orally bioavailable drug delivery vehicle. Sublingual administration of mEVs was found to result in systemic uptake, whereas gavage administration showed lower absorption levels. Furthermore, mEVs loaded with an antidiabetic drug demonstrated efficacy in reducing blood glucose levels when given sublingually but not via gavage.
Article
Chemistry, Multidisciplinary
Boram Gu, Yu Huang, Emily Louise Manchester, Alun D. Hughes, Simon A. McG Thom, Rongjun Chen, Xiao Yun Xu
Summary: This study establishes a multiphysics simulation platform for evaluating the effects of therapeutic parameters on thrombolysis dynamics and side effects. Results show that tPA-NV offers advantages in reducing bleeding risk, lowering tPA dosage, and accelerating recanalisation, making it a potential new thrombolytic strategy.
PHARMACEUTICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ellen Niederberger, Michael J. Parnham
Summary: Lifestyle changes, particularly through exercise and diet, can impact physiological functions in the human body. Physiological changes induced by exercise and modified diet have the potential to affect the efficacy and toxicity of drugs. This impact may play an important role in common drugs with a narrow therapeutic window.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Engineering, Biomedical
A. Zaghmi, J. Drouin-Ouellet, D. Brambilla, M. A. Gauthier
Summary: The presence of impermeable blood-brain barriers restricts access of protein therapeutics to the brain, making treating brain disorders a great challenge. Exploring new approaches to deliver proteins to the brain by circumventing physiological barriers is of great interest and importance.
Review
Pharmacology & Pharmacy
Xingchen Bian, Xingyi Qu, Jing Zhang, Sue C. Nang, Phillip J. Bergen, Qi Tony Zhou, Hak-Kim Chan, Meiqing Feng, Jian Li
Summary: Antimicrobial resistance poses a major global health challenge, and peptide antibiotics serve as important therapeutic options for multidrug-resistant pathogen infections. Optimizing the exposure of peptide antibiotics at the infection site is crucial for improving treatment efficacy and reducing the emergence of resistance.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Danielle van Staden, Richard K. K. Haynes, Joe M. M. Viljoen
Summary: Self-emulsification is a formulation technique that improves oral drug delivery by enhancing solubility and bioavailability. It provides a simplified method for delivering lipophilic drugs by producing emulsions upon moderate agitation and dilution. It is also a promising approach for topical drug delivery, offering simplified production procedures and unlimited upscaling possibilities.
Article
Pharmacology & Pharmacy
Merve Celik-Tekeli, Nevin Celebi, M. Yasin Tekeli, Yesim Aktas
Summary: This study aimed to develop a new self-nanoemulsifying system with exendin-4 and/or enzyme inhibitor chymostatin, and evaluate its effects on plasma exendin-4, insulin levels, and blood glucose. The system was found to increase the bioavailability of regulatory hormones and insulin, showing promising results for the treatment of diabetic rats.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Medicinal
Elena Presas, Sulay Tovar, Juan Cunarro, Joseph P. O'Shea, Caitriona M. O'Driscoll
Summary: This study describes the pre-clinical development of a cyclodextrin-based NP formulation containing the GLP-1 analogue liraglutide for intestinal administration, demonstrating its potential for further development.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemical Research Methods
Benjamin Moeller, Brenna Espelien, Waylon Weber, Philip Kuehl, Melanie Doyle-Eisele, C. Edwin Garner, Jacob D. McDonald, Efrain Garcia, Robert Raulli, Judith Laney
DRUG TESTING AND ANALYSIS
(2019)
Article
Respiratory System
James Verco, William Johnston, Michael Baltezor, Philip J. Kuehl, Andrew Gigliotti, Steven A. Belinsky, Anita Lopez, Ronald Wolff, Lauren Hylle, Gere diZerega
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
(2019)
Article
Chemistry, Medicinal
Jie Shao, Mong-Jen Chen, Philip J. Kuehl, Guenther Hochhaus
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2019)
Article
Respiratory System
Timothy J. Gregory, Hammad Irshad, Ramesh Chand, Philip J. Kuehl
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
(2020)
Article
Toxicology
Matthew A. Nystoriak, Peter J. Kilfoil, Pawel K. Lorkiewicz, Bhargav Ramesh, Philip J. Kuehl, Jacob McDonald, Aruni Bhatnagar, Daniel J. Conklin
TOXICOLOGY IN VITRO
(2019)
Article
Oncology
Philip J. Kuehl, Carmen S. Tellez, Marcie J. Grimes, Thomas H. March, Mathewos Tessema, David A. Revelli, Larry M. Mallis, Wendy W. Dye, Tyler Sniegowski, Aaron Badenoch, Michael Burke, Devon Dubose, David T. Vodak, Maria A. Picchi, Steven A. Belinsky
BRITISH JOURNAL OF CANCER
(2020)
Review
Respiratory System
James B. Fink, Stephan Ehrmann, Jie Li, Patricia Dailey, Paul McKiernan, Chantal Darquenne, Andrew R. Martin, Barbara Rothen-Rutishauser, Philip J. Kuehl, Sabine Haeussermann, Ronan MacLoughlin, Gerald C. Smaldone, Bernhard Muellinger, Timothy E. Corcoran, Rajiv Dhand
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
(2020)
Article
Pharmacology & Pharmacy
Kimberly B. Shepard, David T. Vodak, Philip J. Kuehl, David Revelli, Yue Zhou, Amanda M. Pluntze, Molly S. Adam, Julia C. Oddo, Lauren Switala, Jonathan L. Cape, John M. Baumann, Michael Banks
Summary: Spray drying was used to manufacture a dry powder pulmonary formulation of bevacizumab, reducing side effects, lowering doses, and improving patient compliance.
Article
Cell Biology
Meghan S. Vermillion, Eisuke Murakami, Bin Ma, Jared Pitts, Adrian Tomkinson, Davin Rautiola, Darius Babusis, Hammad Irshad, Dustin Seigel, Cynthia Kim, Xiaofeng Zhao, Congrong Niu, Jesse Yang, Andrew Gigliotti, Nani Kadrichu, John P. Bilello, Scott Ellis, Roy Bannister, Raju Subramanian, Bill Smith, Richard L. Mackman, William A. Lee, Philip J. Kuehl, Jim Hartke, Tomas Cihlar, Danielle P. Porter
Summary: The pharmacokinetics and efficacy of inhaled Remdesivir (RDV) were investigated in African green monkeys (AGM). Inhalation RDV dosing produced comparable concentrations of the active triphosphate in lower respiratory tract tissues compared to intravenous RDV dosing but resulted in lower systemic exposures. An efficacy study in AGM showed reductions in viral replication in respiratory tract tissues with inhaled RDV dosing, which was similar to intravenous RDV dosing.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Mellissa Gomez, Mushtaq Ahmed, Shibali Das, Joseph McCollum, Leah Mellett, Rosemary Swanson, Ananya Gupta, Nicholas B. Carrigy, Hui Wang, David Barona, Shital Bachchhav, Alana Gerhardt, Chris Press, Michelle C. Archer, Hong Liang, Emilie Seydoux, Ryan M. Kramer, Philip J. Kuehl, Reinhard Vehring, Shabaana A. Khader, Christopher B. Fox
Summary: Converting vaccines into thermostable dry powders offers advantages in reducing resource burden and providing flexibility in dosage and administration. This study evaluates the immunogenicity and protective efficacy of a promising TB vaccine candidate when administered via different routes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Jayne E. Hastedt, Per Backman, Antonio Cabal, Andy Clark, Carsten Ehrhardt, Ben Forbes, Anthony J. Hickey, Guenther Hochhaus, Wenlei Jiang, Stavros Kassinos, Philip J. Kuehl, David Prime, Yoen-Ju Son, Simon Teague, Ulrika Tehler, Jennifer Wylie
Summary: This manuscript outlines the foundational principles and framework for a classification system for inhaled drugs, aimed at facilitating an understanding of the technical challenges associated with the development of these drugs based on key attributes of the drug substance and drug product.
MOLECULAR PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
Per Baeckman, Antonio Cabal, Andy Clark, Carsten Ehrhardt, Ben Forbes, Jayne Hastedt, Anthony Hickey, Guenther Hochhaus, Wenlei Jiang, Stavros Kassinos, Philip J. Kuehl, David Prime, Yoen-Ju Son, Simon P. Teague, Ulrika Tehler, Jennifer Wylie
Summary: This work explores the sensitivity of primary biopharmaceutics functional outputs to biopharmaceutics-relevant input attributes for inhaled drugs, and reveals the non-linear relationship between these attributes, leading to the classification of inhaled drugs into different risk levels.
MOLECULAR PHARMACEUTICS
(2022)
Article
Cell Biology
Stephanie N. Langel, Susan Johnson, Clarissa Martinez, Sarah N. Tedjakusuma, Nadine Peinovich, Emery G. Dora, Philip J. Kuehl, Hammad Irshad, Edward G. Barrett, Adam D. Werts, Sean N. Tucker
Summary: Vaccination through oral or intranasal routes can generate strong antibody responses, reduce viral load in the nose and lungs, and mitigate lung pathology caused by SARS-CoV-2. Mucosally vaccinated hamsters transmitted fewer viruses with less severity to naive hamsters, suggesting that mucosal immunization can reduce viral transmission. In a clinical trial, the same platform also induced mucosal cross-reactive antibody responses.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Conor A. Ruzycki, Derek Montoya, Hammad Irshad, Jason Cox, Yue Zhou, Jacob D. Mcdonald, Philip J. Kuehl
Summary: Developing clinically-efficacious inhaled gene therapies has proven difficult due to numerous challenges. Fit-for-purpose experimental and analytical methods are necessary for determining biologically relevant doses in preclinical animal models. Further advancements in disease-specific animal models may improve the translatability of results for future work, and we expect to see increased interest in inhalation gene therapies for various diseases. Early and frequent discussions among sponsors, researchers, and regulators are encouraged, and the dissemination of preclinical methodologies would greatly help in avoiding common pitfalls.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Pharmacology & Pharmacy
Philip J. Kuehl, Christin M. Yingling, Devon Dubose, Michael Burke, David A. Revelli, Wenshu Chen, Wendy W. Dye, Steven A. Belinsky, Mathewos Tessema
Summary: Topotecan, a potent anti-cancer drug, was explored for inhalation delivery in this study to overcome hematopoietic toxicities and improve efficacy. Results showed that inhaled topotecan significantly increased drug exposure and improved tumor burden reduction, especially at distant lung tumor sites, compared to standard IV delivery.