Review
Nanoscience & Nanotechnology
Zhiren Wang, Karina Marie Gonzalez, Leyla Estrella Cordova, Jianqin Lu
Summary: Neurodegenerative diseases are prevalent among aging populations in the 21st century, resulting in the progressive loss of neuronal function and related complications. However, effective therapeutical strategies remain a challenge due to limited drug delivery to the central nervous system. Nanotechnology-enabled drug delivery systems offer a potential solution, providing targeted and efficient treatment with minimal side effects. This review outlines the current applications and progress in enhancing therapeutic efficacy for neurodegenerative diseases.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Jia Li, Meng Zheng, Olga Shimoni, William A. Banks, Ashley I. Bush, Jennifer R. Gamble, Bingyang Shi
Summary: The blood-brain barrier is a crucial neurovascular unit that prevents harmful substances from entering the brain and maintains normal neuronal function. Disruption of BBB in diseases can contribute to disease progression, while restoration of BBB integrity is a biomarker for better clinical outcomes. The BBB also plays a role in facilitating communication between neuronal and circulatory systems, showing promising results for brain-targeted drug delivery.
Review
Chemistry, Multidisciplinary
Abdul Waris, Asmat Ali, Atta Ullah Khan, Muhammad Asim, Doaa Zamel, Kinza Fatima, Abdur Raziq, Muhammad Ajmal Khan, Nazia Akbar, Abdul Baset, Mohammed A. S. Abourehab
Summary: Neurological disorders are a major global health concern and lack effective treatments. Nano-scale materials have shown promise in improving drug efficacy and bypassing the blood-brain barrier, and are widely used for the treatment and imaging studies of neurological disorders.
Review
Cell Biology
Md. Mominur Rhaman, Md. Rezaul Islam, Shopnil Akash, Mobasharah Mim, Md. Noor Alam, Eugenie Nepovimova, Martin Valis, Kamil Kuca, Rohit Sharma
Summary: In recent years, there has been a strong emphasis on using nanostructured materials technologies to improve medicine delivery to the central nervous system (CNS), particularly for the treatment of neurodegenerative diseases. Nanomaterials can target specific brain regions and enhance therapy success, offering advantages such as low toxicity and high stability. However, safety concerns need to be addressed before widespread clinical application can be realized.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Keerti Mishra, Rafquat Rana, Shourya Tripathi, Shumaila Siddiqui, Pavan K. Yadav, Prem N. Yadav, Manish K. Chourasia
Summary: The treatment of neurological disorders is challenging due to the blood-brain barrier (BBB) and adverse effects of current approaches. Nanotechnology and nanocarriers provide a potential solution by enhancing drug delivery and stability of phytochemicals. This review explores the use of nanocarriers in delivering phytochemicals for neurological disorders, discussing their mechanisms of drug transport across the BBB and future applications.
NEUROCHEMICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Qin Ouyang, Kai Liu, Qubo Zhu, Huiyin Deng, Yuan Le, Wen Ouyang, Xiaoxin Yan, Wenhu Zhou, Jianbin Tong
Summary: Alzheimer's disease (AD) is a common form of dementia in elderly individuals, with no effective treatment currently available. This study presents a novel DNA nanoflowers-based delivery system for AD therapy, which allows exogenous supplementation of miR-124 to ameliorate AD-like pathology. The nanosystem demonstrates promising results in increasing miR-124 levels in the brain and achieving robust therapeutic efficacy in a mouse model of AD.
Review
Neurosciences
Benjamin Nguyen, Gregory Bix, Yao Yao
Summary: This article focuses on the changes of the basal lamina (BL) during aging and in neurodegenerative disorders, and its impact on the blood-brain barrier and meningeal lymphatic/glymphatic system. Research has revealed the crucial role of the BL in the pathogenesis and progression of neurodegenerative disorders.
MOLECULAR NEURODEGENERATION
(2021)
Review
Pharmacology & Pharmacy
Alaa Raad Al Jayoush, Hatem A. F. M. Hassan, Hawraa Asiri, Maryam Jafar, Reem Saeed, Rania Harati, Mohamed Haider
Summary: Neurodegenerative diseases have a significant impact on morbidity and mortality worldwide. The effectiveness of current therapeutic approaches for these diseases is limited due to poor drug delivery to the brain. Intranasal delivery has been proposed as a non-invasive strategy for delivering drugs to the brain, and niosomes, a type of nano-sized carrier, show promise for drug delivery to the brain.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Amna Akhtar, Anisa Andleeb, Tayyba Sher Waris, Masoomeh Bazzar, Ali-Reza Moradi, Nasir Raza Awan, Muhammad Yar
Summary: The central nervous system (CNS) is considered the most vital part of the human body, with the blood-brain barrier (BBB) posing a significant hurdle for drug transport to the brain. Innovative approaches such as nano-fabricated smart drug delivery systems and implantable drug loaded biomaterials are being developed to overcome this challenge. Recent studies on neural drug discovery and injectable hydrogels show promise in providing new treatment options for neurological disorders and evaluating drug efficacy using induced pluripotent stem cells.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Biochemistry & Molecular Biology
Buddolla Anantha Lakshmi, Young-Joon Kim
Summary: Nanotechnology plays a crucial role in the treatment and diagnosis of glioblastoma. The multifunctional nanomaterials with specific features such as real-time tracking, in-depth tissue penetration, and drug-loading capacity offer effective theranostics for glioblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Liron L. Israel, Tao Sun, Oliver Braubach, Alysia Cox, Ekaterina S. Shatalova, Harun-Mohammad Rashid, Anna Galstyan, Zachary Grodzinski, Xue Ying Song, Oksana Chepurna, Vladimir A. Ljubimov, Antonella Chiechi, Sachin Sharma, Connor Phebus, Yizhou Wang, Julia Y. Ljubimova, Keith L. Black, Eggehard Holler
Summary: Delivery of therapeutic substances to the brain is challenging due to the blood-brain barrier, limited stability, and distribution in brain tissue. However, a study demonstrated efficient delivery of microRNA and antisense RNA specifically to neurons using a biodegradable, amphiphilic, and multivalent platform conjugated with a D3-peptide. This targeting approach, through the transcytosis pathway, shows promise in Alzheimer's disease mouse models.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Immunology
Behnaz Lahooti, Tanya Chhibber, Sounak Bagchi, Sree Pooja Varahachalam, Rahul D. Jayant
Summary: Neuroinflammation characterized by glial cell activation is a hallmark of several neurological and neurodegenerative disorders, with chronic inflammation being a critical contributing factor for disease manifestation in conditions like HIV-1-associated neurocognitive disorders, Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Involvement of inflammasomes, particularly the NLRP complex, has been implicated in the development of these diseases, leading to the development of potential NLRP-targeting small-molecule therapeutics for the treatment of chronic neurological diseases.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Urszula Kozlowska, Charles Nichols, Kalina Wiatr, Maciej Figiel
Summary: Studies on psychedelics, particularly psilocybin, are gaining interest in neuroscience research due to their potential therapeutic effects on psychiatric illnesses like depression. Recent research suggests that psychedelics may not only treat conditions like major depressive disorder, but also have benefits in treating brain injuries and neurodegenerative diseases. Their exact molecular mechanisms and interactions within the central nervous system during brain injuries and neurodegenerative diseases are still being investigated.
JOURNAL OF NEUROCHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Claudia Riccardi, Filomena Napolitano, Daniela Montesarchio, Simone Sampaolo, Mariarosa Anna Beatrice Melone
Summary: Neurodegenerative diseases are a group of aging-related disorders characterized by progressive impairment of motor and/or cognitive functions. Diseases like Alzheimer's, Parkinson's, and Huntington's are classified as protein misfolding diseases and currently lack effective treatment options. Nanotechnology offers promise in delivering therapeutic solutions for these diseases by crossing the blood-brain barrier to release active molecules in the brain.
Article
Pharmacology & Pharmacy
Hala N. ElShagea, Rana R. Makar, Alaa H. Salama, Nermeen A. Elkasabgy, Emad B. Basalious
Summary: This study focuses on delivering the hydrophilic drug, rasagiline mesylate (RSM), directly to the brain through intranasal administration. Transferosomes were formed to encapsulate RSM and incorporated into an in situ gel. The optimized transferosomal in situ gel showed safety and biocompatibility, with enhanced brain bioavailability and direct nose-to-brain drug delivery.
Review
Instruments & Instrumentation
Nidhi Aggarwal, Sachin, Bushra Nabi, Sumit Aggarwal, Sanjula Baboota, Javed Ali
Summary: Despite the benefits of HAART for AIDS patients, managing HIV infections remains a global health challenge. The inability of ARV drugs to cross the BBB has limited their effectiveness, but nano-based drug delivery strategies have shown promise in improving drug penetration and targeting viral reservoirs in the brain, offering a potential solution for treating NeuroAIDS.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Rubiya Khursheed, Sachin Kumar Singh, Bimlesh Kumar, Sheetu Wadhwa, Monica Gulati, A. Anupriya, Ankit Awasthi, Sukriti Vishwas, Jaskiran Kaur, Leander Corrie, K. R. Arya, Rajan Kumar, Niraj Kumar Jha, Piyush Kumar Gupta, Flavia Zacconi, Kamal Dua, Nitin Chitranshi, Gulam Mustafa, Ankit Kumar
Summary: The liquid self-nanoemulsifying drug delivery system (L-SNEDDS) of curcumin and quercetin was prepared and solidified into pellets, significantly enhancing the dissolution rate and permeability of the compounds. In diabetic rat experiments, the formulation was found to normalize blood glucose, lipids, antioxidant biomarkers, and tissue architecture of pancreas and liver.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Inorganic & Nuclear
Happy Garg, Saurabh Mittal, Muhammad Usama Ashhar, Shobhit Kumar, Shweta Dang, Kuldeep Nigam, Javed Ali, Sanjula Baboota
Summary: The study developed paroxetine-loaded SNEDDS to increase oral bioavailability. Optimized SNEDDS exhibited good particle morphology and transmittance. Results from permeability and behavioral studies demonstrated the enhanced therapeutic effects of paroxetine-loaded SNEDDS. Pharmacokinetic studies showed higher oral bioavailability of paroxetine SNEDDS.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Sabna Kotta, Abdul Wadood Khan, Shahid H. Ansari, Rakesh Kumar Sharma, Y. T. Kamal, Hibah Mubarak Aldawsari, Nabil Abdulhafiz Alhakamy, Sanjula Baboota, Javed Ali
Summary: The development of a nanoemulsion formulation of efavirenz has shown promising results in improving drug permeability and bioavailability, addressing the challenges of inaccurate dosing in pediatric antiretroviral therapy for HIV infection. The formulation has demonstrated an effective dose adjustable formulation for HIV therapy, especially in pediatric population.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Saurabh Mittal, Javed Ali, Sanjula Baboota
Summary: Temozolomide and resveratrol have synergistic effects in treating glioblastoma, and a newly developed HPLC method allows for simultaneous assessment of both compounds with high precision and accuracy.
JOURNAL OF AOAC INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Aftab Alam, Gulam Mustafa, Gopal Prasad Agrawal, Sana Hashmi, Riyaz Ahmed Khan, Faris F. Aba Alkhayl, Zabih Ullah, Md Sajid Ali, Ahmed F. Elkirdasy, Shamshir Khan
Summary: A new microemulsion-based topical treatment containing hydrogen-loaded isotretinoin and erythromycin estolate has been developed for acne management, showing promising drug permeation and skin retention effects in experiments.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ritam Bandopadhyay, Nainshi Mishra, Ruhi Rana, Gagandeep Kaur, Mohammed M. Ghoneim, Sultan Alshehri, Gulam Mustafa, Javed Ahmad, Nabil. A. Alhakamy, Awanish Mishra
Summary: This study focuses on the recent updates in molecular mechanisms and therapeutic approaches for the effective management of levodopa-induced dyskinesia (LID) in Parkinson's disease patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Farheen Fatima Qizilbash, Muhammad Usama Ashhar, Ameeduzzafar Zafar, Zufika Qamar, Annu, Javed Ali, Sanjula Baboota, Mohammed M. Ghoneim, Sultan Alshehri, Asgar Ali
Summary: In this study, a thymoquinone-enriched naringenin-loaded nanostructured lipid carrier was developed for nasal delivery in the treatment of depression. The optimized carrier exhibited excellent drug release and permeation properties, leading to improved therapeutic effect compared to traditional suspension and marketed formulation.
Article
Chemistry, Inorganic & Nuclear
Hani Z. Asfour, Nabil A. Alhakamy, Md Shoaib Alam, Mohammed W. Al-Rabia, Shadab Md
Summary: This study developed neem oil nanoemulsion of tea tree oil using a design of experiment. The optimized nanogel showed sustained drug release, maximum drug deposition, and skin safety. Additionally, the nanogel exhibited good stability after 6 months of storage.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Polymer Science
Mohamed A. Alfaleh, Anwar M. Hashem, Turki S. Abujamel, Nabil A. Alhakamy, Mohd Abul Kalam, Yassine Riadi, Md Shadab
Summary: A novel delivery system of lipid polymer hybrid nanoparticles has been developed for efficient management of colon cancer. The nanoparticles displayed promising drug entrapment and sustained release characteristics, leading to significant therapeutic efficacy against colon cancer. The mechanism behind the anticancer activity of the nanoparticles was explored by evaluating gene expressions involved in carcinogenic pathways, showing significant results. The expression of genes associated with chemoresistance also decreased, indicating the potential of the nanoparticles to overcome resistance.
Review
Biotechnology & Applied Microbiology
Javed Ahmad, Hassan A. Albarqi, Mohammad Zaki Ahmad, Mohamed A. A. Orabi, Md Shadab, Ritam Bandopadhyay, Faraha Ahmed, Mohammad Ahmed Khan, Javed Ahamad, Awanish Mishra
Summary: This manuscript discusses the pharmacological evidence of Nigella sativa and its active constituent, thymoquinone, for the management of osteoporosis. It highlights the anti-inflammatory effects of N. sativa, its positive effects on bone turnover markers, and its stimulation of bone regeneration. The manuscript also explores the potential use of nanotechnology-mediated drug delivery approach to enhance the therapeutic performance of N. sativa and thymoquinone in osteoporosis management.
BIOENGINEERING-BASEL
(2022)
Article
Pharmacology & Pharmacy
Bala Vikash, Shashi, Narendra Kumar Pandey, Bimlesh Kumar, Sheetu Wadhwa, Umesh Goutam, Aftab Alam, Faisal Al-Otaibi, Pramila Chaubey, Gulam Mustafa, Gaurav Gupta, Kamal Dua, Sachin Kumar Singh
Summary: The aim of this study was to develop an ocular Self-nanoemulsifying drug delivery system (SNEDDS) loaded with Brimonidine tartrate (BRT) and evaluate its ex-vivo permeability. The optimized SNEDDS loaded with BRT showed a droplet size of 118.3 nm, a PDI of 0.251, a pH of 6.34 +/- 0.31, and a viscosity of 12.39 +/- 2.31 cP. The optimized SNEDDS had excellent stability in the shelving period and a higher apparent permeability coefficient compared to the marketed formulation. These findings suggest that Brimonidine tartrate-loaded SNEDDS can be a promising nanocarrier for ocular drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shadab Md, Hatoon Abdul Rahman Mahrous, Nabil A. Alhakamy, Rasheed A. Shaik, Basma G. Eid
Summary: Icariin (ICR) is a flavonoid with various therapeutic properties. In this study, ICR nanoemulsions (ICR-NE) were developed and found to exhibit superior cardioprotective effects against doxorubicin-induced cardiotoxicity. The improved solubility, antioxidant, anti-inflammatory, and anti-apoptotic activity of ICR-NE contribute to its therapeutic efficacy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Javed Ahmad, Anuj Garg, Gulam Mustafa, Abdul Aleem Mohammed, Mohammad Zaki Ahmad
Summary: 3D printing technology in medicine is gaining attention for its ability to fabricate various types of dosage forms. Nanomedicine-based solid dosage forms utilizing 3D printing technology have overcome challenges and allowed for personalized medicine. Extrusion-based 3D printing techniques have been used to produce tablets and suppositories for oral and rectal administration. The impact of process parameters on the performance of 3D-printed solid dosage forms is critically analyzed.
Review
Computer Science, Information Systems
Javed Ahmad, Anuj Garg, Gulam Mustafa, Mohammad Zaki Ahmad, Mohammed Aslam, Awanish Mishra
Summary: Cancer remains a leading cause of death worldwide, and multidrug resistance is a major challenge in cancer treatment. Nanoparticulate systems offer promising approaches for accurate diagnosis and effective therapy, including theranostic strategies and targeted drug delivery using carbon-based and graphene-based quantum dots. This review highlights the use of hybrid quantum dots as a theranostic system in different cancers and discusses the role of biomolecule conjugation in enhancing their biopharmaceutical attributes and therapeutic outcomes in cancer.
