Article
Health Care Sciences & Services
Jonas D. Senft, Thomas Fleischhauer, Regina Poss-Doering, Jona Frasch, Manuel Feisst, Sinclair Awounvo, Uwe Muller-Buhl, Attila Altiner, Joachim Szecsenyi, Gunter Laux
Summary: Despite the proven effectiveness of compression therapy for venous leg ulceration, it is only applied in a small percentage of patients, leading to unnecessary complications. The Ulcus Cruris Care project aims to develop a new disease-management concept to support evidence-based treatment. This study shows that the intervention has led to more frequent application of guideline-conform compression therapy and improved patient self-help and education.
Article
Dermatology
Benjamin Juntermanns, Knut Kroeger, Peter Waldhausen, Gabor Gaebel
Summary: Venous ulcus cruris is a chronic disease caused by chronic venous insufficiency. Conservative treatment includes compression treatment and exudate management, while surgical treatment involves resolving pathological venous reflux, ulcer surgery, and fascia surgery in rare cases.
Article
Medicine, Research & Experimental
Jonas D. Senft, Thomas Fleischhauer, Jona Frasch, Wiebke van Rees, Manuel Feisst, Simon Schwill, Christine Fink, Regina Poss-Doering, Michel Wensing, Uwe Mueller-Buehl, Joachim Szecsenyi
Summary: The UCC trial aims to evaluate the effectiveness of the Ulcus Cruris Care intervention for patients with VLU. The trial will assess outcomes such as wound healing time, health-related quality of life, and utilization of medical resources. If the intervention proves to be effective, comprehensive implementation in primary care may be considered.
Article
Cell Biology
Hai P. Nguyen, Frances Lin, Danielle Yi, Ying Xie, Jennie Dinh, Pengya Xue, Hei Sook Sul
Summary: Adipose tissue mass and adiposity change throughout lifespan, with visceral adipose tissue (VAT) increasing and subcutaneous adipose tissue (SAT) decreasing with aging. A regulatory cell population called ARCs emerges in aging SAT, expressing progenitor markers but lacking adipogenic capacity, inhibiting proliferation and differentiation of neighboring adipose precursors. Pu.1 is identified as a driving factor for ARC development, correlating with aging-associated loss of SAT.
DEVELOPMENTAL CELL
(2021)
Article
Peripheral Vascular Disease
Benjamin Juntermanns, Knut Kroeger, Peter Waldhausen, Gabor Gaebel
Summary: Venous ulcus cruris is a chronic disease caused by chronic venous insufficiency. Adequate treatment, including conservative and surgical options, is necessary to manage the condition.
Article
Biochemistry & Molecular Biology
Francesca Favaretto, Chiara Compagnin, Elisa Cogliati, Giulia Montagner, Francesco Dell'Antonia, Giorgio Berna, Roberto Vettor, Gabriella Milan, Diletta Trojan
Summary: This study aimed to characterize and validate the storage effectiveness of cryopreserved adipose tissue (AT) for up to three years for clinical applications. AT components were isolated from fresh and cryopreserved samples and cell viability was assessed. Adipogenic and endothelial precursors and mature cells were measured. The differentiation potential and cellular composition of cryopreserved AT were maintained. Two patients successfully underwent autologous cryopreserved AT transplants without complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Liang Li, Anya M. Gunewardena, Tenzin Nyima, Brian J. Feldman
Summary: This article describes a method and procedure for quantifying oxygen consumption rates of primary human cells from adipose tissue. By using this method, we can further understand the functional properties of primary cells isolated from adipose tissue.
Article
Multidisciplinary Sciences
Connor D. Johnson, Lylybell Y. Zhou, Daniel Kopinke
Summary: This article introduces a rigorous method that preserves the morphology of intramuscular adipocytes, allowing for visualization, imaging, and quantification. The method can also be used for genetic lineage tracing to study adipogenic conversion. The analysis pipeline consistently yields high-resolution and morphologically accurate immunofluorescent images of adipocytes, confirmed by RT-qPCR.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Cell & Tissue Engineering
Benjamin Debuc, Nicolas Gendron, Audrey Cras, Jeanne Rancic, Aurelien Philippe, Curtis L. L. Cetrulo Jr, Alexandre G. Lellouch, David M. Smadja
Summary: Autologous fat transplantation, known as lipofilling, is a promising technique in aesthetic and reconstructive surgery with applications in breast reconstruction, facial and hand rejuvenation. However, the unpredictable and low graft survival rate limits its use. This study reviews the current evidence for the efficacy of regenerative strategies and cellular factors, such as platelet-rich plasma (PRP), stromal vascular fraction (SVF), and adipose-derived stem cells (ADSCs), to improve fat graft retention and discusses the potential role of angiogenic cell enrichment in promoting early vascularization. The addition of stem or progenitor cells to fat transplantation may revolutionize lipofilling, but further research and development are needed.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Medicine, General & Internal
Lorenzo Svolacchia, Claudia Prisco, Federica Giuzio, Fabiano Svolacchia
Summary: This study demonstrates that combining microfiltered adipose tissue cells with cross-linked hyaluronic acid can effectively improve visible imperfections of the skin, clinically observable wrinkles, and the extracellular matrix. The technique proves to be a safe and efficient method for treating soft tissue defects such as deep wrinkles.
MEDICINA-LITHUANIA
(2022)
Review
Allergy
Ioana Agache, Yang Song, Margarita Posso, Pablo Alonso-Coello, Claudio Rocha, Ivan Sola, Jessica Beltran, Cezmi Akdis, Mubeccel Akdis, Knut Brockow, Tomas Chivato, Stefano del Giacco, Thomas Eiwegger, Kilian Eyerich, Ana Gimenez-Arnau, Jan Gutermuth, Emma Guttman-Yassky, Marcus Maurer, Graham Ogg, Peck Y. Ong, Liam O'Mahony, Jurgen Schwarze, Thomas Werfel, Carlos Canelo-Aybar, Oscar Palomares, Marek Jutel
Summary: This review evaluated the efficacy, safety, and economic impact of dupilumab compared to standard care for uncontrolled moderate-to-severe atopic dermatitis. Dupilumab showed significant improvements in symptoms and quality of life for both adult and adolescent patients. Long-term safety data is needed for both children and adults, along with more efficacy data for the pediatric population.
Article
Allergy
Ioana Agache, Cezmi Akdis, Mubeccel Akdis, Knut Brockow, Tomas Chivato, Stefano del Giacco, Thomas Eiwegger, Kilian Eyerich, Ana Gimenez-Arnau, Jan Gutermuth, Emma Guttman-Yassky, Marcus Maurer, Graham Ogg, Peck Y. Ong, Liam O'Mahony, Juergen Schwarze, Amena Warner, Thomas Werfel, Oscar Palomares, Marek Jutel
Summary: Chronic spontaneous urticaria (CSU) poses a significant burden on patients, families and healthcare systems, but a stratified approach to management supported by better understanding of mechanisms allows for targeted treatment with omalizumab.
Editorial Material
Dermatology
Valerie PEETERS, Sherief R. JANMOHAMED, Samira BAHARLOU, Jan GUTERMUTH, Ria WILLEMSEN
ACTA DERMATO-VENEREOLOGICA
(2021)
Review
Allergy
Inge Kortekaas Krohn, Joeri L. Aerts, Karine Breckpot, Cleo Goyvaerts, Edward Knol, Femke Van Wijk, Jan Gutermuth
Summary: T lymphocytes play a crucial role in the adaptive immune response, with different subsets exhibiting specific functions in a variety of inflammatory skin disorders. Some T-cell subsets show similarities or opposing functions across different skin diseases.
Article
Dermatology
J. Gutermuth, A. E. Pink, M. Worm, L. Soldbro, C. Bjerregard Oland, S. Weidinger
Summary: The study evaluated the efficacy and safety of tralokinumab plus TCS in adult patients with severe AD not adequately controlled with CSA or with contraindications to oral CSA, showing the treatment was effective and well tolerated.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
E. Van den Steen, D. Ramaekers, M. Horlait, J. Gutermuth
Summary: This study aimed to identify relevant items for patient's experience in immunodermatology and develop a concise questionnaire to assess patient's experience in routine clinical care. By conducting a literature search, patient interviews, and a multi-stakeholder focus group, a Patient-Reported Experience Measure (PREM) questionnaire with 11 items was developed. This user-friendly tool can be used in scientific and routine care settings to improve care for patients with chronic inflammatory skin diseases.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Letter
Dermatology
S. Nguyen, E. van de Perre, B. Velkeniers, L. Pierret, J. Gutermuth, M. Grosber
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Review
Immunology
Yves Piette, Valerie Reynaert, Amber Vanhaecke, Carolien Bonroy, Jan Gutermuth, Alberto Sulli, Maurizio Cutolo, Vanessa Smith
Summary: This systematic review examines the value of nailfold videocapillaroscopy (NVC) in idiopathic inflammatory myopathies (IIM). The study finds significant differences in NVC outcomes between (juvenile) dermatomyositis, other inflammatory myopathies, healthy controls, and systemic sclerosis patients. Reduced capillary density and scleroderma pattern appear to be associated with active disease in (juvenile) dermatomyositis, while immunosuppressive treatment seems to reduce NVC abnormalities.
AUTOIMMUNITY REVIEWS
(2022)
Article
Immunology
Fariza Mishaal Saiema Badloe, Shauni De Vriese, Tina De Bruyn Carlier, Elise Vandersichel, Joerg Scheffel, Marcus Maurer, Johannes Ring, Jan Gutermuth, Inge Kortekaas Krohn
Summary: In this study, a novel method for the purification of total IgE from human serum was established using specific antibodies and beads, resulting in high purity of IgE. This highly effective and widely accessible approach can improve the use of IgE-based models and contribute to allergy research.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Dermatology
Jonathan Silverberg, David N. Adam, Matthew Zirwas, Sunil Kalia, Jan Gutermuth, Andreas Pinter, Andrew E. Pink, Andrea Chiricozzi, Sebastien Barbarot, Thomas Mark, Ann-Marie Tindberg, Stephan Weidinger
Summary: This study analyzed the efficacy and safety of tralokinumab combined with topical corticosteroids in the treatment of atopic dermatitis. The results showed that continued tralokinumab treatment plus corticosteroids provided progressive and sustained improvements in AD signs, symptoms, and health-related quality of life over 32 weeks period.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2022)
Review
Geriatrics & Gerontology
Lene Salimans, Keliane Liberman, Rose Njemini, Inge Kortekaas Krohn, Jan Gutermuth, Ivan Bautmans
Summary: This review provides a systematic analysis of the impact of resistance exercise on immune cells in the blood circulation. The findings suggest that resistance exercise activates specific signaling pathways in immune cells and improves antioxidant enzyme expression. Additionally, there are age-related differences in natural killer cell activity after resistance exercise.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Dermatology
Niels Timo Hilhorst, Elfie Deprez, Deepak Mukesh Wieshwaykumar Balak, Nanja Van Geel, Jan Gutermuth, Isabelle Hoorens, Jo Lydie Wilfried Lambert
Summary: This study aims to develop an actionable value-based outcome set (VOS) for evaluating psoriasis care. Through four phases of a mixed method approach, the study identified the outcomes deemed important by patients and selected suitable instruments to measure these outcomes. This VOS allows for the evaluation and improvement of current care processes, increasing value for patients.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Dermatology
V Reynaert, J. Gutermuth, A. Wollenberg
Summary: The nipple is an important part of the human breast and serves various purposes. Nipple eczema can have negative effects on the patient's quality of life. This article discusses the different types of nipple eczema and provides information on diagnosis and treatment options.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
A. Jadoul, L. Huygen, G. Leemans, M. Grosber, I. Kortekaas Krohn, J. Gutermuth
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
L. De Brucker, L. Seyler, G. Leemans, J. Gutermuth, M. Grosber
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)