Article
Dermatology
Muazzez Cigdem Oba, Ozge Askin, Mehmet Guven Gunver, Gokce Kocaarslan, Deniz Can Alis, Burhan Engin
Summary: This study aimed to assess changes in biochemical parameters and carotid intima-media thickness (CIMT) values in HS patients undergoing TNF inhibitor therapy. The results showed that CIMT values of HS patients significantly exceeded those of healthy controls. After TNF inhibitor therapy, fasting blood glucose levels significantly decreased, while total cholesterol levels and CIMT values significantly increased.
SKIN RESEARCH AND TECHNOLOGY
(2023)
Review
Allergy
Kelsey R. van Straalen, Errol P. Prens, Johann E. Gudjonsson
Summary: Hidradenitis suppurativa is a chronic, inflammatory skin disorder that affects around 1% of the population and significantly impacts patients' quality of life. It is characterized by inflammatory lesions such as nodules, abscesses, and sinus tracts in areas like the armpits, groin, and buttocks, typically appearing during or after puberty. The development and maintenance of the disease involve a complex interplay of genetic predisposition, hormonal factors, obesity, and smoking. It is believed to stem from a defect in the hair follicle, leading to follicular plugging, cyst formation, and subsequent acute inflammation. Over time, acute lesions progress to a chronic condition with draining sinus tracts and extensive fibrosis. Hidradenitis suppurativa is associated with other immune-mediated inflammatory diseases, metabolic and cardiovascular disorders, and psychiatric comorbidities.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Pediatrics
Colleen H. H. Cotton, Stella X. X. Chen, Sadaf H. H. Hussain, Irene Lara-Corrales, Andrea L. L. Zaenglein
Summary: Hidradenitis suppurativa is a chronic inflammatory skin disorder mainly affecting areas with apocrine glands. It is common in Western populations, occurring in up to 2% of people, and its incidence is increasing in children and adults. Pediatric cases represent about one-third of all cases, with initial symptoms often appearing in childhood. Limited clinical studies and guidelines exist for pediatric hidradenitis suppurativa. This review covers the epidemiology, clinical presentation, comorbidities, and management of the disease in children. It also discusses the barriers to timely diagnosis and the significant physical and emotional impact on children and adolescents.
Letter
Dermatology
Gretchen Bellefeuille, Briana Paiewonsky, Bisma Khalid, Rebecca L. Freese, Michelle A. Lowes, Joslyn S. Kirby, Afsaneh Alavi, Noah Goldfarb
Summary: This study aimed to evaluate the relationship between skin thickness and HS severity. The study found that inflammatory induration has a moderate association with HS severity, thickest lesion measurement (mm) demonstrates known-validity across Hurley stages, and cut-offs for thickest lesion measurement (mm) were determined for inflammatory induration grading for the purpose of HASI-R training.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Medicine, General & Internal
Ratnakar Shukla, Priyanka Karagaiah, Anant Patil, Katherine Farnbach, Alex G. Ortega-Loayza, Thrasivoulos Tzellos, Jacek C. Szepietowski, Mario Giulini, Hadrian Schepler, Stephan Grabbe, Mohamad Goldust
Summary: HS is a chronic inflammatory disease that typically begins in puberty and presents with painful nodules and sinus tracts. The disease may impact quality of life and management often requires a multidisciplinary approach. Medical treatment can be used in early stages while surgical intervention may be necessary in advanced stages.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Dermatology
Ellie Choi, Xue Ting Ooi, Nisha Suyien Chandran
Summary: Interest and research in hidradenitis suppurativa (HS) have grown in the past decade, expanding knowledge about associated comorbidities and treatment efficacy. Limited understanding exists about pediatric-onset HS, but with increasing prevalence of childhood obesity and awareness of HS, physicians may encounter younger HS patients more frequently.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Dermatology
Kelsey R. van Straalen, John R. Ingram, Matthias Augustin, Christos C. Zouboulis
Summary: Research interest in Hidradenitis Suppurativa (HS) has grown rapidly, and several new scores and tools are being developed to address the limitations of current assessment methods. These new measures have the potential to become the primary outcome measures in HS clinical trials and practice.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Amit Garg, Carla Zema, Valerie Ciaravino, Robert Rolleri, Luke Peterson, Llenalia Garcia, Tyler Massaro, Gregor B. E. Jemec, Joslyn S. Kirby, Linnea Thorlacius, John R. Ingram
Summary: This study evaluated the psychometric properties of the HS-IGA score and found that it has good validity and reliability. The HS-IGA score may be considered as an endpoint in clinical trials for HS.
Article
Dermatology
K. Navrazhina, Y. Renert-Yuval, J. W. Frew, D. Grand, J. Gonzalez, S. C. Williams, S. Garcet, J. G. Krueger
Summary: Hidradenitis suppurativa (HS) and psoriasis share significant similarities in Th1/Th17 enrichment and upregulation of atherosclerosis-related proteins, with HS patients exhibiting a greater serum inflammatory burden despite psoriasis involving a larger body surface area.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Genetics & Heredity
Bruna De Felice, Concetta Montanino, Marta Mallardo, Graziella Babino, Edi Mattera, Giovanni Ragozzino, Giuseppe Argenziano, Aurora Daniele, Ersilia Nigro
Summary: This study analysed the expression profiles of miRNA in the blood of HS patients and found significantly different expression of miR-24-1-5p, miR-146a-5p, miR26a-5p, miR-206, miR338-3p, and miR338-5p compared to healthy controls. MiR-338-5p was closely related to the invasiveness of HS lesions and cytokine production, showing atypical overexpression.
Article
Dermatology
Amit Garg, Neeta Malviya, Andrew Strunk, Shari Wright, Afsaneh Alavi, Raed Alhusayen, Ali Alikhan, Steven D. Daveluy, Isabelle Delorme, Noah Goldfarb, Wayne Gulliver, Iltefat Hamzavi, Tarannum Jaleel, Alexa B. Kimball, Joslyn S. Kirby, Mark G. Kirchhof, Janice Lester, Hadar Lev-Tov, Michelle A. Lowes, Robert Micheletti, Lauren A. Orenstein, Vincent Piguet, Christopher Sayed, Jerry Tan, Haley B. Naik
Summary: This study aims to provide evidence-based screening recommendations for comorbidities associated with HS. Screening recommendations were made based on the consistency and quality of existing studies, disease prevalence and magnitude of association, as well as benefits, harms, and feasibility of screening. A total of 30 comorbidities were recommended for screening in order to improve patients' quality of life and health status.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Immunology
Kelly Z. Z. Young, Peter Dimitrion, Li Zhou, Indra Adrianto, Qing-Sheng Mi
Summary: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by abscesses, sinus tracts, and scarring. HS has a strong female sex bias, and this article reviews the role of intrinsic and extrinsic factors in sex-related differences in immunity and their potential role in HS pathophysiology. Hormones, X chromosome dosage, genetics, the microbiome, and smoking are discussed as possible factors contributing to sex-related differences in immunity and HS disease presentations.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
T. Gambichler, S. Hessam, M. Skrygan, M. Bakirtzi, D. Kasakovski, F. G. Bechara
Summary: The study found significantly elevated expression of NOD2 and related factors in Hidradenitis suppurativa (HS) skin samples and keratinocyte cultures. Moreover, there were correlations between NOD2 and other factors. The response of HS keratinocytes to stimuli differed from normal keratinocytes.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Amelia Glowaczewska, Radomir Reszke, Jacek C. Szepietowski, Lukasz Matusiak
Summary: HS is a chronic and debilitating skin condition that affects patients' quality of life. Indirect self-destructiveness, such as addictions and risky behaviors, can impede positive clinical effects in HS patients. This study assessed indirect self-destructive behaviors in 100 adult HS patients, revealing higher scores in smokers, particularly in the class of Helplessness and Passivity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Erin M. Taylor, Ryoko Hamaguchi, Kimberly M. Kramer, Alexa B. Kimball, Dennis P. Orgill
Summary: After studying this article, participants will be able to understand the pathogenesis of hidradenitis suppurativa, perioperative multimodal therapy, and surgical planning, as well as the importance of multidisciplinary teamwork for successful treatment.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Review
Dermatology
Farnam Barati Sedeh, Thorunn Elisabet Michaelsdottir, Mattias Arvid Simon Henning, Gregor Borut Ernst Jemec, Kristina Sophie Ibler
Summary: The aim of this study was to compare the efficacy and safety of Janus kinase inhibitors for alopecia areata, using change in Severity of Alopecia Tool (SALT) score as the measure. A systematic review following PRISMA guidelines was conducted, including all studies investigating the efficacy of treatments for alopecia areata. A meta-analysis of randomized controlled trials was performed, and the findings suggest that baricitinib and deuruxolitinib show promising results for the treatment of alopecia areata, with response varying based on dosage.
ACTA DERMATO-VENEREOLOGICA
(2023)
Editorial Material
Dermatology
Sofia H. C. Botvid, Lone Storgaard Hove, Dorra Bouazzi, Rune Kjaersgaard Andersen, Simon Francis Thomsen, Ditte Marie Saunte, Gregor B. E. Jemec
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Dermatology
Sylvia Van Beugen, Christina Schut, Joerg Kupfer, Anthony P. Bewley, Andrew Y. Finlay, Uwe Gieler, Andrew R. Thompson, Tamara Gracia-Cazana, Flora Balieva, Barbara R. Ferreira, Gregor B. Jemec, Lars Lien, Laurent Misery, Servando E. Marron, Sonja Staender, Claudia Zeidlerl, Csanad Szabo, Jacek C. Szepietowski, Adam Reich, Amna Elyas, Ilknur K. Altunay, Franz J. Legat, Vesna Grivcheva-Panovska, Dmitry V. Romanov, Andrey N. Lvov, Geraldine Titeca, Francesca Sampogna, Nienke C. Vulink, Lucia Tomas-Aragones, Andrea W. M. Evers, Florence J. Dalgard
Summary: An observational cross-sectional study quantified perceived stigmatization and identified its predictors among patients with a wide range of skin diseases. Patients experienced higher levels of perceived stigmatization compared to controls, and factors such as age, gender, general health, and disease severity were associated with stigmatization.
ACTA DERMATO-VENEREOLOGICA
(2023)
Review
Immunology
Christoffer Kursawe Larsen, Rune Kjaersgaard Andersen, Ditte Marie Lindhardt Saunte, Gregor Borut Ernst Jemec
Summary: An abscess is a pus-filled cavity in the tissue, commonly perceived as an infection. However, this diagnosis does not always require an infection. This study aims to review the microbiome of bacteria-positive primary skin abscesses to explore the reported microbiota.
Letter
Immunology
Dorra Bouazzi, Pernille Lindso Andersen, Ester Weihe Jacobsen, Maiken Cavling Arendrup, Gregor B. E. Jemec, Ditte M. L. Saunte
Letter
Dermatology
Amit Garg, Sahil Rawal, Oleg Akilov, Afsaneh Alavi, Christine Ardon, Falk G. Bechara, Arnon D. Cohen, Steven R. Cohen, Steven Daveluy, Veronique del Marmol, Maia Delage, Solveig Esmann, Shani Fisher, Evangelos J. Giamarellos-Bourboulis, Amelia Glowaczewska, Noah Goldfarb, Elena Gonzalez Brant, Oystein Grimstad, Sandra Guilbault, Iltefat Hamzavi, Rosalind Hughes, John R. Ingram, Gregor B. E. Jemec, Qiang Ju, Naomi Kappe, Brian Kirby, Joslyn S. Kirby, Michelle A. Lowes, Lukasz Matusiak, Stella Micha, Robert G. Micheletti, Angela P. Miller, Dagfinn Moseng, Haley B. Naik, Aude Nassif, Georgios Nikolakis, So Yeon Paek, Jose Carlos Pascual, Errol Prens, Barry Resnik, Hassan Riad, Christopher Sayed, Saxon D. Smith, Yssra Soliman, Jacek C. Szepietowski, Jerry Tan, Linnea Thorlacius, Thrasyvoulos Tzellos, Hessel H. van der Zee, Bente Villumsen, Lanqi Wang, Christos C. Zouboulis, Andrew Strunk
Summary: Patients with hidradenitis suppurativa are greatly affected in their lives. Factors such as younger age, Black race, high BMI, active smoking, flares, depression, anxiety, high comorbidity burden, disability, and difficult access to a dermatologist have a negative impact on their quality of life. Attention should be given to these factors, especially those that can be modified, to reduce the overall impact of the disease.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Rami Nabil Al-Chaer, Dorra Bouazzi, Gregor Jemec, Mette Mogensen
Summary: Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) can provide high-resolution diagnosis and treatment evaluation for common skin disorders such as acne vulgaris, rosacea, and folliculitis. These imaging techniques have the ability to assess the characteristics and quantitative features of hair follicles in various skin disorders, supporting clinical diagnosis and treatment evaluation. However, larger and better-designed studies are needed to implement RCM and OCT in clinical practice.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
K. B. E. Holm, L. J. Nielsen, J. Lock-Andersen, N. Behrendt, M. S. Svensson, L. Themstrup, G. B. E. Jemec
Summary: This study compared the effectiveness of clinical examination, histopathology, and optical coherence tomography (OCT) in delineating the tumor margins of facial basal cell carcinomas (BCC) before surgery. The results showed that OCT and histopathology were in agreement in 86.6% of the data points collected. The study supports the use of OCT in clinical practice for aiding clinicians in preoperative delineation of BCC lesions.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Article
Dermatology
Amit Garg, Carla Zema, Valerie Ciaravino, Robert Rolleri, Luke Peterson, Llenalia Garcia, Tyler Massaro, Gregor B. E. Jemec, Joslyn S. Kirby, Linnea Thorlacius, John R. Ingram
Summary: This study evaluated the psychometric properties of the HS-IGA score and found that it has good validity and reliability. The HS-IGA score may be considered as an endpoint in clinical trials for HS.
Review
Medicine, General & Internal
Mathieu Daoud, Mariano Suppa, Farida Benhadou, Mathilde Daxhelet, Hassane Njimi, Jonathan White, Gregor Jemec, Veronique del Marmol
Summary: Due to its clinical heterogeneity, hidradenitis suppurativa (HS) is difficult to score accurately, as shown by the large number of disease scores. The aim of this study is to provide a concise but detailed narrative review of the scores used to date and to compare these scores for individual patients.
FRONTIERS IN MEDICINE
(2023)
Review
Clinical Neurology
Mattias A. S. Henning, Farnam Barati, Gregor B. E. Jemec
Summary: This study compared the health-related quality of life (HRQOL) in individuals with and without hyperhidrosis. The findings indicate that individuals with hyperhidrosis have higher Dermatology Life Quality Index scores and lower mental component summary scores. There was no significant difference in the physical component summary scores.
CLINICAL AUTONOMIC RESEARCH
(2023)
Article
Medicine, General & Internal
Silvia Otero-Rodriguez, Cristina Guillen, Maria Mataix, Pilar Gonzalez-de-la-Aleja, Elisabeth Cruces-Fuentes, Alix Juliette Mantilla-Pinilla, Oscar Moreno-Perez, Rosario Sanchez-Martinez, Esperanza Merino, Jose-Manuel Ramos-Rincon
Summary: This retrospective study included 2450 hospitalized COVID-19 patients, among whom 20 patients developed severe spontaneous intramuscular bleeding, with a higher prevalence compared to non-COVID-19 inpatients. These patients were predominantly elderly with multiple comorbidities, receiving high doses of heparin, and had cough as a preceding symptom. Most patients required transfusion and embolization, with a mortality rate of 45%.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2023)
Article
Dermatology
Ehiaghe Lonia Anaba, Dorra Bouazzi, Pelumi Victor Ajayi, Oluwapelumi Olumide Aro, Jurr Boer, Gregor Jemec
Summary: This study aimed to uncover the prevalence of Hidradenitis Suppurativa (HS) in Lagos, Nigeria, validate an HS screening questionnaire, and contribute to the Global Hidradenitis Suppurativa Atlas (GHiSA). The study found a prevalence of 2.2% for HS in the sample, with no gender predominance. BMI did not appear to be a risk factor, and the axilla was the most affected site. All patients had mild disease severity (Hurley Score I).
Article
Pharmacology & Pharmacy
A. S. Byrd, A. Z. Rosenberg, W. D. Shipman, U. J. Okoh, M. Mazhar, G. A. Okoye, N. L. Bragazzi, C. Mortellaro, G. B. E. Jemec, G. Damiani
Summary: A study investigated the prevalence and morbidity of hidradenitis suppurativa (HS) in Black and White patients. The research found that although there were no significant differences in clinical presentation, Black patients had more severe diseases. It is speculated that these ethnic differences may be related to social factors.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Dermatology
Pernille Lindso Andersen, Bente Villumsen, Ditte Marie Lindhardt Saunte, Kristoffer Solvsten Burgdorf, Maria Didriksen, Sisse Rye Ostrowski, Lise Wegner Thorner, Christian Erikstrup, Khoa Manh Dinh, Kaspar Rene Nielsen, Thorsten Brodersen, Mie Topholm Bruun, Karina Banasik, Thomas Folkmann Hansen, Ole Birger Pedersen, Gregor Borut Jemec
Summary: This study explores the possible association between HS and ADHD, and finds a positive correlation between ADHD and HS. This result has significant implications for the research on psychiatric comorbidity of HS.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
