Article
Biochemistry & Molecular Biology
Soichiro Ide, Noriaki Iwase, Kenichi Arai, Masahiro Kojima, Shigeru Ushiyama, Kaori Taniko, Kazutaka Ikeda
Summary: Despite the widespread use of opioids for pain management, opioid addiction and the overdose crisis are becoming increasingly serious. A new nonpeptide ligand, UD-030, has been found to be a selective mu-opioid receptor antagonist and shows promise as a treatment option for opioid use disorder, with different characteristics from traditional medications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Javier Ballester, Anne K. Baker, Ilkka K. Martikainen, Vincent Koppelmans, Jon-Kar Zubieta, Tiffany M. Love
Summary: This study found that chronic pain patients at high risk for opioid misuse showed higher baseline MOR availability in the right amygdala, while patients at low risk for opioid misuse showed less pain-induced activation of MOR-mediated, endogenous opioid neurotransmission in the nucleus accumbens.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Qingxiao Hong, Wenjin Xu, Zi Lin, Jing Liu, Weisheng Chen, Huaqiang Zhu, Miaojun Lai, Dingding Zhuang, Zemin Xu, Dan Fu, Wenhua Zhou, Huifen Liu
Summary: Epigenetic modifications, such as DNA methylation, play a crucial role in regulating gene expression and may influence neuroplasticity and drug-induced aberrant behaviors. The study in Sprague-Dawley rats showed that heroin self-administration led to hypomethylation of the GABRD gene and transcriptional upregulation in the NAc. Manipulations with DNMT inhibitor and MET affected heroin-seeking behavior, possibly through direct repression of DNMT1 and DNMT3A expression to alter the DNA methylation landscape of the GABRD gene.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Alessandro Bonifazi, Francisco O. Battiti, Julie Sanchez, Saheem A. Zaidi, Eric Bow, Mariia Makarova, Jianjing Cao, Anver Basha Shaik, Agnieszka Sulima, Kenner C. Rice, Vsevolod Katritch, Meritxell Canals, J. Robert Lane, Amy Hauck Newman
Summary: Novel drug design aims to retain analgesic effects while reducing addiction risks. Targeting D3R with antagonists/partial agonists can decrease self-administration behaviors in rodents. Bi- or multivalent ligands targeting MOR and D3R show potential in maintaining analgesia with reduced opioid abuse liability.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Neurosciences
Xiaohu Xie, Jun Gu, Dingding Zhuang, Wenwen Shen, Longhui Li, Yue Liu, Wenjin Xu, Qingxiao Hong, Weisheng Chen, Wenhua Zhou, Huifen Liu
Summary: The study suggests a potential association between the rs13303344 SNP in GABRD gene and susceptibility to heroin addiction, with the C allele at this locus linked to an increased risk. However, after Bonferroni correction, this association lost significance. Additionally, specific haplotypes in the GARBD gene also showed significant differences between heroin dependent patients and controls.
NEUROSCIENCE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Raphael Goutaudier, Fanny Joly, David Mallet, Magali Bartolomucci, Denis Guicherd, Carole Carcenac, Frederique Vossier, Thibault Dufourd, Sabrina Boulet, Colin Deransart, Benoit Chovelon, Sebastien Carnicella
Summary: This study provides evidence for the involvement of reduced dopamine levels in the dorsolateral striatum in compulsive alcohol use. The researchers showed that selective hypodopaminergia in this pathway leads to compulsive-like alcohol self-administration and alcohol withdrawal-like motivational impairments. Treatment with the monoamine stabilizer OSU6162 transiently decreased compulsive-like alcohol self-administration in vulnerable rats.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Rocio Guerrero-Bautista, Aurelio Franco-Garcia, Juana M. Hidalgo, Francisco Jose Fernandez-Gomez, Bruno Ribeiro Do Couto, M. Victoria Milanes, Cristina Nunez
Summary: Preventing relapse in cocaine addiction is a major challenge in treatment. Cocaine relapse activates memory-related nuclei, affecting emotional and episodic memories. D3 receptor antagonists are emerging as potential treatments for preventing drug relapse.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Timothy J. O'Neal, Mollie X. Bernstein, Derek J. MacDougall, Susan M. Ferguson
Summary: Pairing a drug with a neutral stimulus leads to drug-seeking behavior. The NAc plays a key role in the response to drug-associated stimuli. Neurons in the NAc regulate heroin-seeking behavior. Heroin alters the balance of signaling in the NAc. Dopamine signaling in the NAc is important for heroin reinforcement.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Qian Lv, Miao Zhang, Haifeng Jiang, Yilin Liu, Shaoling Zhao, Xiaomin Xu, Wenlei Zhang, Tianzhen Chen, Hang Su, Jiangtao Zhang, Heqiu Wang, Jianmin Zhang, Yuanjing Feng, Yongqiang Li, Biao Li, Min Zhao, Zheng Wang
Summary: Elevated impulsivity is commonly observed in individuals receiving methadone maintenance therapy (MMT) for opioid addiction. This study aimed to understand the underlying neural mechanisms and cognitive subprocesses associated with this impulsivity. The results showed that individuals receiving MMT exhibited higher self-reported impulsivity and had a tendency for impulsive decision-making without available evidence. The impulsive decision bias was associated with the dose and duration of methadone use, rather than the duration of heroin use. Furthermore, the hypoactivation in the left rostral middle frontal gyrus during a decision-making task was correlated with the impulsive decision bias. The findings suggest that elevated impulsivity in individuals receiving MMT is driven by deficits in top-down cognitive control, rather than reward sensitivity.
Article
Health Care Sciences & Services
Chieh-Liang Huang, Ping-Ho Chen, Hsien-Yuan Lane, Ing-Kang Ho, Chia-Min Chung
Summary: This study aimed to identify heroin addicts with specific genetic variants in their dopaminergic reward systems and found multiple genes associated with heroin use and craving scores. The results showed a dose-response relationship between the number of genetic risk alleles and heroin craving scores, suggesting potential implications for predicting relapse risk and developing targeted therapies for heroin addiction.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Kwang-Hyun Hur, Seong-Eon Kim, Shi-Xun Ma, Bo-Ram Lee, Yong-Hyun Ko, Jee-Yeon Seo, Seon-Kyung Kim, Young-Jung Kim, Su-Jeong Sung, Youyoung Lee, Young Hoon Jung, Yong-Sup Lee, Seok-Yong Lee, Choon-Gon Jang
Summary: The study demonstrates that methoxphenidine exhibits addictive and schizophrenia-like behaviors, inducing neurochemical changes in brain regions associated with these behaviors. These findings suggest that methoxphenidine could be utilized in developing animal disease models and calls for legal restrictions on its recreational use.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Liangpei Chen, Shihao Huang, Chang Yang, Feilong Wu, Qiuyao Zheng, He Yan, Jie Yan, Yixiao Luo, Ewa Galaj
Summary: Propranolol may reduce relapse by interfering with the reconsolidation of heroin memory, holding potential therapeutic value in opioid addiction treatment and relapse prevention.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Matthew T. Rich, Yanhua H. Huang, Mary M. Torregrossa
Summary: The protocol demonstrates the use of optogenetic tools to reverse cocaine-induced plasticity in thalamo-amygdala circuits and reduce subsequent cocaine seeking behaviors in rats. This manipulation induces long-term reduction in the ability of cues associated with cocaine to induce drug seeking actions.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Chemistry, Medicinal
Ying-Ting Hsu, Shen-Ren Chen, Yung-Chiao Chang, Hsiao-Fu Chang, Teng-Kuang Yeh, Jian-Ying Chuang, Horace H. Loh, Hsing-Pang Hsieh, Shau-Hua Ueng, Shiu-Hwa Yeh
Summary: The demand for a non-addictive analgesic medication is increasing due to clinical misuse. Compound 14 is a dual agonist of the mu opioid receptor (MOR) and nociceptin-orphanin FQ opioid peptide (NOP) receptor, providing pain relief at very small doses and reducing unwanted side effects. Evaluating its effects in wild type and humanized mice can help develop a safer prescription analgesic drug.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Sport Sciences
Yu Zhou, Graham Finlayson, Xudong Liu, Qichen Zhou, Tianze Liu, Chenglin Zhou
Summary: The study examined the effects of acute moderate-intensity dance and aerobic exercise on drug craving, appetite, prefrontal neural activation to food cues, and food reward in women with methamphetamine dependence. Results showed that both interventions reduced subjective craving for drugs and increased implicit wanting and relative preferences for high-calorie savory foods. The findings suggest that moderate-intensity exercise can be used as a therapeutic intervention to restore the balance between drug and nondrug rewards.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Neurosciences
Zhi-Bing You, Guo-Hua Bi, Ewa Galaj, Vivek Kumar, Jianjing Cao, Alexandra Gadiano, Rana Rais, Barbara S. Slusher, Eliot L. Gardner, Zheng-Xiong Xi, Amy Hauck Newman
NEUROPSYCHOPHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Krista J. Spiller, Guo-hua Bi, Yi He, Ewa Galaj, Eliot L. Gardner, Zheng-Xiong Xi
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Neurosciences
Lili Shan, Ewa Galaj, Yao-Ying Ma
NEUROPSYCHOPHARMACOLOGY
(2019)
Article
Neurosciences
E. Galaj, B. T. Kipp, S. B. Floresco, L. M. Savage
Article
Biochemistry & Molecular Biology
Guo-Hua Bi, Ewa Galaj, Yi He, Zheng-Xiong Xi
Article
Clinical Neurology
Ewa Galaj, Zheng-Xiong Xi
Article
Neurosciences
Ewa Galaj, Guo-Hua Bi, Hong-Ju Yang, Zheng-Xiong Xi
Article
Pharmacology & Pharmacy
Yi He, Ewa Galaj, Guo-Hua Bi, Xiao-Fei Wang, Eliot Gardner, Zheng-Xiong Xi
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Xiao-Fei Wang, Ewa Galaj, Guo-Hua Bi, Cindy Zhang, Yi He, Jia Zhan, Michael H. Bauman, Eliot L. Gardner, Zheng-Xiong Xi
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Review
Behavioral Sciences
Ewa Galaj, Eddy D. Barrera, Robert Ranaldi
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2020)
Article
Substance Abuse
Ewa Galaj, Eddy Barrera, Debra Morris, Yao-Ying Ma, Robert Ranaldi
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Ewa Galaj, Guo-Hua Bi, Eliot Gardner, Zheng-Xiong Xi
Article
Pharmacology & Pharmacy
Xi Shen, Rongji Hui, Yixiao Luo, Hailei Yu, Suiyuan Feng, Bing Xie, Haitao Bi, Ewa Galaj, Bin Cong, Chunling Ma, Di Wen
FRONTIERS IN PHARMACOLOGY
(2020)
Review
Behavioral Sciences
Ewa Galaj, Amy Hauck Newman, Zheng-Xiong Xi
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Meeting Abstract
Substance Abuse
B. T. Kipp, E. Galaj, S. Heide, K. Poynor, L. M. Savage
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)