Article
Surgery
Jolanta Kowalewska, Ismail El Moudden, Agnieszka Perkowska-Ptasinska, Meghan E. Kapp, Agnes B. Fogo, Mercury Y. Lin, Alamgir Mirza, Dean A. Troyer, Magdalena Durlik, Rana Sandhu, Michal Ciszek, Dominika Deborska-Materkowska, Daniel Kuczynski, Thomas R. McCune
Summary: The proposed classification of PyVAN did not effectively stratify patients according to risk, especially with no significant difference between classes 1 and 2. Additionally, timing post-transplantation and inflammation in areas of interstitial fibrosis and tubular atrophy may contribute to unfavorable allograft outcomes in patients with PyVAN.
TRANSPLANT INTERNATIONAL
(2021)
Article
Surgery
Volker Nickeleit, Harsharan K. Singh, Darshana Dadhania, Virgilius Cornea, Amr El-Husseini, Ana Castellanos, Vicki G. Davis, Thomas Waid, Surya Seshan
Summary: This study validated the PVN classification scheme published by the Banff Working Group in 2018, confirming the independent association of PVN classification with clinical presentation, allograft function, and therapeutic intervention. The results demonstrated that the PVN classification can help predict the risk of transplant failure and functional decline in patients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Kalaivani S. Subramanian, Bheemanathi Hanuman Srinivas, Rajesh Nachiappa Ganesh, Debasis Gochhait, Priyamvada Ps, Sreejith Parameswaran, Sathish Haridasan
Summary: This study aimed to analyze the clinical and histopathological characteristics and outcomes of different classifications of PVN. The results showed that PVN class 1 had early presentation and better outcomes.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Immunology
Hannah Imlay, Paul Baum, Daniel C. Brennan, Kimberly E. Hanson, Michael R. Hodges, Aimee C. Hodowanec, Takashi E. Komatsu, Per Ljungman, Veronica Miller, Yoichiro Natori, Volker Nickeleit, Jules O'Rear, Andreas Pikis, Parmjeet S. Randhawa, Deirdre Sawinski, Harsharan K. Singh, Gabriel Westman, Ajit P. Limaye
Summary: BK polyomavirus infection and nephropathy are significant complications in renal transplant recipients. However, the lack of standardized outcome measures hampers clinical trials. To address this, experts have developed definitions of BK polyomavirus infection and disease, providing a framework for clinical research and drug development.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Nada Alachkar, Marco Delsante, Ross S. Greenberg, Abbal Koirala, Tarek Alhamad, Basmah Abdalla, Manish Anand, Ben Boonpheng, Christopher Blosser, Umberto Maggiore, Serena M. Bagnasco
Summary: The modified Oxford classification (MEST-C) was validated as a predictor of graft failure in Asians with recurrent IgAN. The study showed that IgAN recurrence was associated with younger age at transplantation and increased the risk of death-censored graft failure. Additionally, the MEST-C score and its individual components were found to be significantly associated with graft failure.
Article
Surgery
Alton B. Farris, Mariam P. Alexander, Ulysses G. J. Balis, Laura Barisoni, Peter Boor, Roman D. Bulow, Lynn D. Cornell, Anthony J. Demetris, Evan Farkash, Meyke Hermsen, Julien Hogan, Renate Kain, Jesper Kers, Jun Kong, Richard M. Levenson, Alexandre Loupy, Maarten Naesens, Pinaki Sarder, John E. Tomaszewski, Jeroen van der Laak, Dominique van Midden, Yukako Yagi, Kim Solez
Summary: The Banff Digital Pathology Working Group aims to establish a digital pathology repository and promote collaborations through the development, validation, and sharing of image analysis models, as well as regular videoconferencing. AI-based support systems for transplantation pathology were presented during the discussions, and potential collaborations in competitions/trials on AI applied to kidney transplant specimens were also discussed.
TRANSPLANT INTERNATIONAL
(2023)
Article
Rheumatology
Sara K. Tedeschi, Fabio Becce, Tristan Pascart, Ali Guermazi, Jean-Francois Budzik, Nicola Dalbeth, Georgios Filippou, Annamaria Iagnocco, Minna J. Kohler, Jean-Denis Laredo, Stacy E. Smith, F. Joseph Simeone, Janeth Yinh, Hyon Choi, Abhishek Abhishek
Summary: This study aims to develop definitions for imaging features of calcium pyrophosphate deposition (CPPD) disease as potential classification criteria, and provide example images of CPPD on different imaging modalities. An international team of experts reached consensus through surveys and voting, providing a reference for future clinical research.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Immunology
Meifang Wang, Qin Zhou, Huiping Wang, Ying Chen, Jianghua Chen
Summary: This study retrospectively analyzed the data of 53 patients with BKVN and found that BKVN mostly occurs within 1 year post-transplantation. There was no correlation between BK virus load in blood and urine and pathological damage at the time of diagnosis. The 2018 Banff Classification for BKVN showed a better predictive value for graft prognosis.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Chemistry, Analytical
Lin Zhao, Liwen Tang, Marion S. Greene, Yu Sa, Wenjin Wang, Jiahong Jin, Heng Hong, Jun Q. Lu, Xin-Hua Hu
Summary: This study investigates the structure-function relationship of CD4+ and CD8+ T cell subtypes by analyzing their morphologic features and surface CD markers. The results show a strong correlation between the structure and function of these two major T cell subtypes. Diffraction imaging flow cytometry proves to be a potential method for accurate and label-free classification of T cell subtypes.
ANALYTICAL CHEMISTRY
(2022)
Review
Immunology
Edmund Huang, Michael Mengel, Marian C. Clahsen-van Groningen, Annette M. Jackson
Summary: With the advancements in minimally invasive biomarkers in kidney transplantation, new strategies for monitoring allograft health are emerging. However, the current available data does not support the use of blood and urine-based biomarkers as stand-alone diagnostic tests. More studies are needed to evaluate their ability to distinguish different types of rejection and serve as adjuncts to histology, in order to elevate these biomarkers to diagnostic tests.
Article
Immunology
Matteo Bassetti, Elie Azoulay, Bart-Jan Kullberg, Markus Ruhnke, Shmuel Shoham, Jose Vazquez, Daniele Roberto Giacobbe, Thierry Calandra
Summary: The EORTC/MSGERC recently revised the definitions of invasive fungal disease, focusing on cancer and transplant patients but not ICU patients. The challenges in diagnosing IFD in the ICU setting vary for different types of fungal infections.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Surgery
Marjan Afrouzian, Nicolas Kozakowski, Helen Liapis, Verena Broecker, Luon Truong, Carmen Avila-Casado, Heinz Regele, Surya Seshan, Josephine M. Ambruzs, Alton Brad Farris, David Buob, Praveen N. Chander, Lukman Cheraghvandi, Marian C. Clahsen-van Groningen, Stanley de Almeida Araujo, Dilek Ertoy Baydar, Mark Formby, Danica Galesic Ljubanovic, Loren Herrera Hernandez, Eva Honsova, Nasreen Mohamed, Yasemin Ozluk, Marion Rabant, Virginie Royal, Heather L. Stevenson, Maria Fernanda Toniolo, Diana Taheri
Summary: The study used the Delphi method to develop minimum diagnostic criteria (MDC) and recommendations for renal transplant TMA (Tx-TMA) diagnosis. After multiple rounds of revisions and validations, MDC including pathological, clinical, laboratory criteria, and differential diagnoses were established with good consensus among the panelists. The study's findings are important for the transplantation community.
TRANSPLANT INTERNATIONAL
(2023)
Review
Peripheral Vascular Disease
Kosuke Masutani
Summary: Advancements in immunosuppressive therapy, posttransplant management, and measures against diseases have greatly improved kidney transplant success and patient survival. Kidney allograft biopsy is a crucial tool for diagnosing various transplant injuries, and the Banff Conference has established diagnostic criteria used worldwide. Many transplant centers also perform protocol biopsies to detect and treat early graft injuries. Preimplantation biopsy provides valuable information on donor kidney health and can guide subsequent management. This review discusses the latest Banff classification, protocol biopsies, and future perspectives on kidney allograft pathology.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Immunology
Daniele Zama, Andrea Zanaroli, Agnese Corbelli, Andrea Lo Vecchio, Margherita Del Bene, Antonella Colombini, Francesca Compagno, Angelica Barone, Ilaria Fontanili, Maria Rosaria D'Amico, Maria Rosaria Papa, Maria Grazia Petris, Elisabetta Calore, Shana Montalto, Linda Meneghello, Letizia Brescia, Rosamaria Mura, Milena La Spina, Paola Muggeo, Simona Rinieri, Cristina Meazza, Katia Perruccio, Monica Cellini, Manuela Spadea, Federico Mercolini, Valeria Petroni, Raffaella De Santis, Elena Soncini, Massimo Provenzi, Nagua Giurici, Ottavio Ziino, Gloria Tridello, Simone Cesaro
Summary: This study assessed the clinical impact and outcome of SARS-CoV-2 infection on children with cancer or those who received hematopoietic stem cell transplantation. The results showed that SARS-CoV-2 infection had a mild course in the Italian pediatric oncohematology population during the pandemic, and its main consequence was the discontinuation of cancer-directed therapies.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Pathology
James B. Maurice, Akudo Nwaogu, Mahmoud Gouda, Olivia Shaw, Alberto Sanchez-Fueyo, Yoh Zen
Summary: This study aimed to examine the clinical utility and impact of the 2016 Banff criteria for acute antibody-mediated rejection (acute AMR) in patients with liver transplantation. The results showed that only a small percentage of DSA-positive patients met the Banff criteria for acute AMR, and combined acute AMR/TCMR cases were more common than isolated acute AMR.
Article
Urology & Nephrology
Satoru Kudose, Dominick Santoriello, Hanna Debiec, Pietro A. Canetta, Andrew S. Bomback, M. Barry Stokes, Ibrahim Batal, Pierre Ronco, Vivette D. D'Agati, Glen S. Markowitz
Summary: Segmental membranous glomerulopathy (sMGN) is a rare PLA2R-negative variant of MGN with favorable prognosis, even in the absence of immunosuppressive treatment. During follow-up, most patients had stable/improved kidney function.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Dominick Santoriello, Andrew S. Bomback, Satoru Kudose, Ibrahim Batal, M. Barry Stokes, Pietro A. Canetta, Jai Radhakrishnan, Gerald B. Appel, Vivette D. D'Agati, Glen S. Markowitz
Summary: Hydralazine therapy can lead to hydralazine-associated ANCA-GN, presenting with overlapping clinical and pathologic features of mild immune complex glomerulonephritis resembling lupus nephritis. Discontinuation of hydralazine and immunosuppression can lead to outcomes similar to primary ANCA-GN.
KIDNEY INTERNATIONAL
(2021)
Article
Pathology
Ibrahim Batal, Geo Serban, Sumit Mohan, Syed A. Husain, Elena-Rodica Vasilescu, Russel J. Crew, Geoffrey Dube, P. Rodrigo Sandoval, Shana M. Coley, Dominick Santoriello, Michael B. Stokes, Vivette D. D'Agati, David J. Cohen, Glen Markowitz, Mark A. Hardy, Lloyd E. Ratner
Summary: The study revealed that deceased donor kidney allografts with baseline chronic histologic changes have increased immunogenicity, leading to a higher risk of severe acute rejection episodes and decreased allograft survival. Enhancing immunosuppression in recipients of deceased donor kidneys with baseline chronic histologic changes may be necessary to minimize acute rejection and prolong allograft survival.
Letter
Urology & Nephrology
Satoru Kudose, Miroslav Sekulic, Collette J. Mehring, Dominick Santoriello, Ibrahim Batal, M. Barry Stokes, Vivette D. D'Agati, Glen S. Markowitz
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Urology & Nephrology
Satoru Kudose, Pietro Canetta, Nicole K. Andeen, M. Barry Stokes, Ibrahim Batal, Glen S. Markowitz, Vivette D. D'Agati, Dominick Santoriello
Summary: This study successfully reclassified glomerulonephritis with fibrillar IgG deposits into different subtypes using various immunofluorescence and ancillary techniques, providing important information for diagnosis and treatment.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Neurosciences
Alexander Jacob, Lauren Nina Peralta, Deja Pegues, Kazuki Okamura, Anthony Chang, Daniel McSkimming, Jessy Alexander
Summary: Exercise can alleviate CNS lupus in mice by promoting neuron growth, reducing inflammatory responses, and improving behavioral performance. This study demonstrates for the first time that a supervised exercise regimen could serve as an intervention strategy to enhance the quality of life for lupus patients.
Letter
Urology & Nephrology
Satoru Kudose, Geetha Jagannathan, Dominick Santoriello, Miroslav Sekulic, Ibrahim Batal, M. Barry Stokes, Vivette D. D'Agati, Glen S. Markowitz
KIDNEY INTERNATIONAL REPORTS
(2022)
Editorial Material
Urology & Nephrology
Kelly V. Liang, Brigid K. Ellis, Michael B. Stokes, Richard J. Smith, Xin Gu, Daniel P. Gale
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Urology & Nephrology
Satoru Kudose, Ibrahim Batal, John Lucia, Purvi Patel, Rajesh K. Soni, Glen S. Markowitz, Vivette D. D'Agati, M. Barry Stokes
Summary: Rare cases of IgG-dominant immune complex-mediated glomerulonephritis without light chain restriction may represent PGNMID, in which monotypic IgG3 kappa is obscured by coexisting polytypic IgM. This case highlights the importance of considering PGNMID in the differential diagnosis and demonstrates the potential utility of IgG subclass staining and HLC-IF in detecting hidden monotypic immunoglobulin.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Medicine, General & Internal
Ronald Valdez Imbert, Nang San Hti Lar Seng, Michael B. Stokes, Belinda Jim
Summary: Nephropathic apolipoprotein L1 (APOL1) risk alleles (G1/G2) have been associated with various glomerulonephritides and protection against Trypanosoma brucei infections. This study presents a case of a young woman with obesity-related glomerulopathy who harbored two high-risk APOL1 alleles (G1/G2). The presence of APOL1 risk alleles may impact both renal disease and cardiovascular health in these patients.
Article
Urology & Nephrology
Samih H. Nasr, Satoru Kudose, Vincent Javaugue, Stephanie Harel, Samar M. Said, Virginie Pascal, M. Barry Stokes, Julie A. Vrana, Surendra Dasari, Jason D. Theis, George A. Osuchukwu, Insara Jaffer Sathick, Arjun Das, Ali Kashkouli, Elliot J. Suchin, Yaakov Liss, Zalman Suldan, Jerome Verine, Bertrand Arnulf, Alexis Talbot, Sanjeev Sethi, Mohamad Zaidan, Jean-Michel Goujon, Anthony M. Valeri, Ellen D. Mcphail, Christophe Sirac, Nelson Leung, Frank Bridoux, Vivette D. D'Agati
Summary: This study presents the first clinicopathological series of monoclonal light chain crystalline podocytopathy (LCCP), including 25 patients. The majority of patients presented with proteinuria and chronic kidney disease, with some also experiencing nephrotic syndrome, crystalline keratopathy, and Fanconi syndrome. The early diagnosis and subsequent clone-directed therapy are crucial for kidney survival.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Patricia Hirt-Minkowski, Joelle Handschin, Susanne Stampf, Helmut Hopfer, Thomas Menter, Lisa Senn, Gideon Hoenger, Caroline Wehmeier, Patrizia Amico, Jurg Steiger, Michael Koller, Michael Dickenmann, Stefan Schaub
Summary: This study aimed to investigate the clinical utility of urine CXCL10 monitoring in renal allografts. The results showed that urine CXCL10 monitoring did not have a significant beneficial effect on 1-year outcomes in renal transplantation.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Immunology
Ibrahim Batal, Pascale Khairallah, Astrid Weins, Nicole K. Andeen, Michael B. Stokes
Summary: Primary focal segmental glomerulosclerosis (FSGS) is a disease characterized by diffuse podocyte foot process effacement and nephrotic syndrome. It can recur after transplantation and is associated with immunogenetic factors. This study retrospectively investigated a cohort of kidney allograft recipients with primary FSGS and found a higher frequency of HLA-A30 antigen in patients with primary FSGS compared to healthy controls and deceased kidney donors. The study also revealed an association between donor HLA-A30 and recurrent FSGS in transplant patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Jagan Mohan Rao Vanjarapu, Jose Iglesias, Rumana Ahmed, Pratiksha Singh, Gabrielle Gerbino, Michael Barry Stokes
Summary: Proliferative glomerulonephritis with monoclonal immunoglobulin (mlg) deposits (PGNMID) is a rare glomerular disease characterized by glomerular deposits of mlg. In this case, the patient presented with multiple episodes of acute kidney injury, nephritic syndrome, and hypocomplementemia associated with self-limited febrile illnesses or COVID-19 vaccination. Sequential kidney biopsies revealed evolving morphologic and immunohistologic features, with monotypic IgG lambda deposits identified only in the third biopsy. Despite the need for dialysis, renal dysfunction and hypocomplementemia resolved after each episode with corticosteroid therapy.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Urology & Nephrology
Michael B. Stokes, Jacob S. Stevens