Review
Medicine, Research & Experimental
Madhu Rani, Rashmi Kumari, Shashi Prakash Singh, Annu Devi, Preeti Bansal, Aisha Siddiqi, Mohammed A. Alsahli, Saleh A. Almatroodi, Arshad Husain Rahmani, M. Moshahid Alam Rizvi
Summary: MicroRNAs play a critical role in regulating genes, including FOXO transcription factors, which are important tumor suppressors. FOXO family members modulate various cellular processes and their abnormal expression due to microRNA down-regulation has been linked to tumor initiation, chemo-resistance, and progression. Chemo-resistance is a major challenge in cancer treatment, with a high percentage of cancer-related deaths associated with it. This article discusses the structure, functions, and posttranslational modifications of FOXO, as well as the role of microRNAs in carcinogenesis by regulating FOXOs at the post-transcriptional level. The miRNA-FOXO axis can be a potential target for novel cancer therapy to overcome chemo-resistance.
Review
Biochemistry & Molecular Biology
Maura Rojas-Pirela, Diego Andrade-Alviarez, Lisvaneth Medina, Christian Castillo, Ana Liempi, Jesus Guerrero-Munoz, Yessica Ortega, Juan Diego Maya, Veronica Rojas, Wilfredo Quinones, Paul A. Michels, Ulrike Kemmerling
Summary: MicroRNAs (miRNAs) are a group of small non-coding RNA molecules that regulate gene expression. They play a crucial role in the pathogenesis of diseases, including those caused by parasitic protists. Additionally, miRNAs have the potential to be used as targets for drug design and as diagnostic and prognostic markers for parasitic diseases.
Article
Gastroenterology & Hepatology
Xiaolin Wang, Yong He, Bryan Mackowiak, Bin Gao
Summary: MicroRNAs are small, non-coding RNAs that play crucial roles in regulating liver functions and are associated with various liver diseases, making them promising for early diagnosis and treatment strategies. Continued research on miRNAs in the liver may lead to the identification of biomarkers and therapeutic targets for liver diseases in the future.
Review
Immunology
Jose A. Canas, Jose M. Rodrigo-Munoz, Beatriz Sastre, Marta Gil-Martinez, Natalia Redondo, Victoria del Pozo
Summary: Chronic respiratory diseases (CRDs) such as asthma and chronic obstructive pulmonary disease (COPD) are important factors in global mortality and morbidity, accounting for approximately 6% of total deaths worldwide. MicroRNAs (miRNAs) have emerged as promising diagnostic and therapeutic biomarkers for CRDs, playing crucial roles in inflammation-related pathways in asthma and COPD. Their deregulation in various biofluids and cells of patients, as well as their involvement in histopathological changes and treatment response, highlight the potential of miRNAs as prognostic tools and therapeutic targets in these respiratory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Genetics & Heredity
Linda Koch
Summary: Wagner et al. present a comprehensive map of non-coding RNA expression in ageing and rejuvenated mice, highlighting a group of widely dysregulated microRNAs that could function as systemic regulators of ageing.
NATURE REVIEWS GENETICS
(2023)
Review
Cell Biology
Wojciech Gierlikowski, Barbara Gierlikowska
Summary: MiRNAs, short non-coding RNAs, play a crucial role in regulating gene expression and cellular function. They can influence phagocytosis at various levels, including macrophage polarization, phagosome maturation, reactive oxygen species production, and cytokine synthesis.
Review
Cell Biology
Aurelio Balsalobre, Jacques Drouin
Summary: Pioneer factors are transcription factors that can initiate the opening of closed chromatin. They play crucial roles in determining cell fate and cellular reprogramming, but their misexpression can have pathological consequences.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Honghu Li, Qian Luo, Wei Shan, Shuyang Cai, Ruxiu Tie, Yulin Xu, Yu Lin, Pengxu Qian, He Huang
Summary: Hematopoietic stem cells (HSCs) can perceive both soluble signals and biomechanical inputs, with mechanotransduction playing a critical role in regulating their functions. However, the underlying molecular details of biomechanical regulation in HSCs are still poorly understood.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sonia Aguila, Ascension M. de los Reyes-Garcia, Maria P. Fernandez-Perez, Laura Reguilon-Gallego, Laura Zapata-Martinez, Inmaculada Ruiz-Lorente, Vicente Vicente, Rocio Gonzalez-Conejero, Constantino Martinez
Summary: This article summarizes the formation mechanism and regulatory elements of Neutrophil extracellular traps (NETs), as well as the role of miRNAs associated with various inflammatory pathologies. miRNAs, as small non-coding RNAs, play important regulatory roles in various pathological processes and may become therapeutic targets for preventing inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Nadia Flores-Huerta, Macrina B. Silva-Cazares, Lourdes A. Arriaga-Pizano, Jessica L. Prieto-Chavez, Cesar Lopez-Camarillo
Summary: Breast cancer stem cells (bCSC), as a small subset of tumor cells with self-renewal properties and tumorigenic characteristics, play a key role in the development of breast cancer. Studies have shown that non-coding RNAs such as lncRNAs and miRNAs play important roles in regulating the stemness of bCSC.
Review
Plant Sciences
Meiying He, Xiangjin Kong, Yueming Jiang, Hongxia Qu, Hong Zhu
Summary: MiRNAs, as a major class of endogenous small RNAs in plants, play critical roles in regulating the development and growth of horticultural crops.
TRENDS IN PLANT SCIENCE
(2022)
Article
Physics, Fluids & Plasmas
Andreas Kramer
Summary: Cell type-specific gene expression patterns are represented as memory states of a Hopfield neural network model, where order parameters can be interpreted as concentrations of master transcription regulators forming positive feedback loops. The order parameter free energy defines an epigenetic landscape with stable cell states corresponding to local minima. The model is applied to gene expression data in the context of hematopoiesis.
Review
Health Care Sciences & Services
Natarajaseenivasan Suriya Muthukumaran, Prema Velusamy, Charles Solomon Akino Mercy, Dianne Langford, Kalimuthusamy Natarajaseenivasan, Santhanam Shanmughapriya
Summary: Cancer cells rapidly reprogram their metabolism to adapt to the tumor environment or escape chemotherapy. Recent studies have shown that cancer cells rely on glutamine, lipid, and mitochondrial metabolism for energy. Some miRNAs play a key role in regulating these metabolic changes. Additionally, miRNAs can regulate mitochondrial calcium stores and energy metabolism, promoting cancer cell survival, growth, and metastasis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Oncology
Juliana Maria Motta, Hebatallah Hassan, Sherif Abdelaziz Ibrahim
Summary: In this review, we emphasize the key roles of Syndecans (SDCs) in breast cancer pathogenesis, including their dysregulation of pivotal signaling pathways involved in biological and molecular functions, prognostic value, critical molecular regulators, and therapeutic perspectives.
Review
Biochemistry & Molecular Biology
Hai-Hui Zhuang, Qiang Qu, Xin-Qi Teng, Ying-Huan Dai, Jian Qu
Summary: Transcriptional deregulation, driven by epigenetic abnormalities, plays a significant role in brain tumors. Superenhancers (SEs), as novel epigenetic regulatory elements, are involved in tumorigenesis of various tumors, including brain tumors. SEs can be inhibited by key components, offering potential targets for antitumor therapy. This review summarizes the characteristics and identification of SEs in tumors, as well as their activation mechanisms and clinical applications in tumor therapy and prognostication.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Cell & Tissue Engineering
Piera Trionfini, Osele Ciampi, Elena Romano, Ariela Benigni, Susanna Tomasoni
STEM CELL RESEARCH
(2020)
Review
Urology & Nephrology
Marina Noris, Ariela Benigni, Giuseppe Remuzzi
KIDNEY INTERNATIONAL
(2020)
Review
Pediatrics
Ariela Benigni, Simona Buelli, Donald E. Kohan
Summary: Chronic kidney disease is a leading cause of end-stage renal disease globally, often associated with diabetes, obesity, and hypertension. The endothelin system plays a key role in the progression of CKD, with evidence supporting the effectiveness of ET receptor antagonists in improving renal function and fibrosis. Clinical trials have shown beneficial effects of these antagonists on a wide range of kidney disorders.
PEDIATRIC NEPHROLOGY
(2021)
Article
Multidisciplinary Sciences
Monica Locatelli, Carlamaria Zoja, Cristina Zanchi, Daniela Corna, Sebastian Villa, Silvia Bolognini, Rubina Novelli, Luca Perico, Giuseppe Remuzzi, Ariela Benigni, Paola Cassis
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Manuel Chiusa, Wen Hu, Jozef Zienkiewicz, Xiwu Chen, Ming-Zhi Zhang, Raymond C. Harris, Roberto M. Vanacore, Jennifer A. Bentz, Giuseppe Remuzzi, Ariela Benigni, Agnes B. Fogo, Wentian Luo, Stavroula Mili, Matthew H. Wilson, Roy Zent, Jacek Hawiger, Ambra Pozzi
JOURNAL OF CELL BIOLOGY
(2020)
Article
Cell & Tissue Engineering
Elena Romano, Piera Trionfini, Osele Ciampi, Ariela Benigni, Susanna Tomasoni
STEM CELL RESEARCH
(2020)
Article
Medicine, Research & Experimental
Andrea Remuzzi, Sara Conti, Bogdan Ene-Iordache, Susanna Tomasoni, Paola Rizzo, Ariela Benigni, Giuseppe Remuzzi
Review
Urology & Nephrology
Luca Perico, Ariela Benigni, Federica Casiraghi, Lisa F. P. Ng, Laurent Renia, Giuseppe Remuzzi
Summary: This review provides insights into the pathogenic mechanisms and clinical manifestations of COVID-19, highlighting the critical role of the immunological hyper-response induced by SARS-CoV-2 infection. The authors emphasize the importance of early diagnosis and intervention in controlling disease progression.
NATURE REVIEWS NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lorena Longaretti, Piera Trionfini, Valerio Brizi, Christodoulos Xinaris, Caterina Mele, Matteo Breno, Elena Romano, Roberta Giampietro, Giuseppe Remuzzi, Ariela Benigni, Susanna Tomasoni
Summary: A study on a patient with familial steroid-resistant FSGS identified a PAX2 mutation, suggesting a dual effect of the mutation in the onset of FSGS. Fixing the mutation improved the functionality of podocytes, providing insight into the development of proteinuria in FSGS.
Article
Multidisciplinary Sciences
Anna Pezzotta, Luca Perico, Daniela Corna, Marina Morigi, Giuseppe Remuzzi, Ariela Benigni, Barbara Imberti
Summary: SIRT3 plays a crucial regulatory role in the kidney, and its dysregulation may lead to vascular dysfunction and progression of kidney disease. In the presence of nephrotoxic stimulus, Sirt3-deficient mice exhibit aggravated endothelial rarefaction and oxidative stress, resulting in more severe kidney injury.
Article
Biochemistry & Molecular Biology
Monica Locatelli, Daniela Rottoli, Rayan Mahmoud, Mauro Abbate, Daniela Corna, Domenico Cerullo, Susanna Tomasoni, Giuseppe Remuzzi, Carlamaria Zoja, Ariela Benigni, Daniela Macconi
Summary: In BTBR ob/ob mice with type 2 diabetic nephropathy, peritubular capillaries show endothelial cell abnormalities and basement membrane thickening. Remodeling and focal loss of the endothelial glycocalyx were observed in diabetic kidneys, and ACEi treatment preserved the glycocalyx and attenuated the ultrastructural abnormalities of peritubular capillaries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Urology & Nephrology
Luca Perico, Ariela Benigni, Giuseppe Remuzzi
Article
Medicine, General & Internal
Rossella Piras, Paraskevas Iatropoulos, Elena Bresin, Marta Todeschini, Sara Gastoldi, Elisabetta Valoti, Marta Alberti, Caterina Mele, Miriam Galbusera, Paola Cuccarolo, Ariela Benigni, Giuseppe Remuzzi, Marina Noris
FRONTIERS IN MEDICINE
(2020)
Article
Medicine, General & Internal
Luca Perico, Susanna Tomasoni, Tobia Peracchi, Annalisa Perna, Anna Pezzotta, Giuseppe Remuzzi, Ariela Benigni