Article
Immunology
Xiao-fei He, Li-li Li, Wen-biao Xian, Ming-yue Li, Li-ying Zhang, Jing-hui Xu, Zhong Pei, Hai-qing Zheng, Xi-quan Hu
Summary: Neuroinflammation plays a significant role in age-related brain degeneration, especially in conditions such as Alzheimer's disease. Inflammatory bowel diseases (IBDs) can induce neuroinflammation and worsen cognitive impairment in elderly individuals. The NLRP3 inflammasome may contribute to glymphatic dysfunction and cognitive impairment in aging mice with IBD, suggesting that targeting this pathway could have protective effects against colitis-induced neurodegeneration.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Endocrinology & Metabolism
Jialing Zhang, Aihua Zhang
Summary: The relationship between Klotho and cognitive function in chronic kidney disease patients with albuminuria is examined in this study. The findings suggest that increased levels of Klotho are associated with improved cognitive function in CKD patients with microalbuminuria. Further research is needed to investigate if Klotho could serve as a beneficial biomarker for cognitive health and neurodegeneration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Elora Basu, Manaav Mehta, Cenai Zhang, Chen Zhao, Russell Rosenblatt, Elliot B. Tapper, Neal S. Parikh
Summary: This study examined the association of chronic liver disease with cognition and brain imaging markers of cognitive impairment. The results showed that there were no consistent associations between liver disease and cognitive performance or brain volumes among individuals with diabetes and hypertension.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Neurosciences
Peter J. Duquette, Debbie S. Gipson, Stephen R. Hooper
Summary: Children with chronic kidney disease may have specific deficits in multiple attention dimensions, particularly for those with more severe disease.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Clinical Neurology
Marion Pepin, Aleksandra Klimkowicz-Mrowiec, Olivier Godefroy, Pilar Delgado, Sol Carriazo, Ana Carina Ferreira, Aleksandra Golenia, Jolanta Malyszko, Tomasz Grodzicki, Konstantinos Giannakou, Giuseppe Paolisso, Michelangela Barbieri, Liliana Garneata, Carmen Antonia Mocanu, Sophie Liabeuf, Goce Spasovski, Carmine Zoccali, Annette Bruchfeld, Ana Farinha, Mustafa Arici, Giovambattista Capasso, Andrzej A. Wiecek, Ziad Massy
Summary: Cognitive impairment is common in patients with chronic kidney disease (CKD). This article reviews interventions for the complications of CKD and prevention of vascular events, which may potentially also be protective against cognitive impairment. Nonpharmacological and pharmacological methods to prevent cognitive impairment and/or minimize its impact on CKD patients' daily lives are discussed. It is necessary to conduct studies assessing the effect of interventions on the cognitive function of patients with CKD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Emilie Pupier, Alicia Santos, Nicole Etchamendy, Aurelie Lavielle, Amandine Ferriere, Aline Marighetto, Eugenia Resmini, Daniela Cota, Susan M. Webb, Antoine Tabarin
Summary: Cognitive impairments and altered quality of life may persist in patients with long-term remission of Cushing's disease, even in the absence of other comorbidities. Memory tests revealed similar performance between patients and controls, but patients had worse quality of life despite no depression or residual clinical symptoms of Cushing's disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Transplantation
Helene Levassort, Julie Boucquemont, Natalia Alencar de Pinho, Oriane Lambert, Catherine Helmer, Marie Metzger, Laurent Teillet, Luc Frimat, Christian Combe, Denis Fouque, Maurice Laville, Christian Jacquelinet, Sophie Liabeuf, Benedicte Stengel, Ziad A. Massy, Marion Pepin
Summary: This study found that a lower glomerular filtration rate (eGFR) in chronic kidney disease (CKD) patients is associated with early impairments in specific cognitive domains. Early detection of cognitive impairments in CKD patients using tests assessing executive, attentional, and language functions before obvious cognitive decline could lead to better management of cognitive impairment and its impact on CKD treatment.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Neurosciences
Lei Huang, Yang Zhang, Yongwei Wang, Yajia Lan
Summary: Degenerative dementia, including Alzheimer's disease, is characterized by gradual deterioration of cognitive function. Chronic noise exposure has been identified as a potential risk factor for cognitive impairment and degenerative dementia, accelerating cognitive dysfunction and pathological changes in the brain. Epidemiological studies are increasingly investigating the association between external noise exposure and dementia, highlighting the need for further research in this area.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Neurosciences
Asam Murtaza, Indranil Dasgupta
Summary: Chronic kidney disease is closely associated with cognitive impairment, with vascular and metabolic factors playing a role. Cognitive impairment in CKD leads to reduced functional capacity, decreased quality of life, and increased mortality. Further research is needed to develop therapeutic interventions for cognitive decline in CKD patients, especially those undergoing hemodialysis.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Psychology, Multidisciplinary
Selma Delgado-Gallen, M. Dolors Soler, Sergiu Albu, Catherine Pachon-Garcia, Vanessa Alviarez-Schulze, Javier Solana-Sanchez, David Bartres-Faz, Josep M. Tormos, Alvaro Pascual-Leone, Gabriele Cattaneo
Summary: Chronic pain is commonly reported in middle-aged adults, with those suffering from it being older and in poorer health. The presence of chronic pain affects working memory, mental health, and daily life activities, and cognitive reserve can moderate the impact of pain intensity on mental health.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Medicine, General & Internal
Jin-Young Min, Sang-Won Ha, Soo-Hyun Yang, Min-Ju Kang, Da-Eun Jeong, Kyoung-Bok Min, Beom Kim
Summary: A study investigated the association between serum albumin levels and cognitive performance in older adults, and explored how the APOE genotype influences this association. The findings suggest that lower serum albumin levels are associated with lower cognitive performance, and this association may be modified by APOE polymorphisms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Huan Yu, Chaoyang Zhang, Yan Cai, Ning Wu, Xiuqin Jia, Jiaojiao Wu, Feng Shi, Rui Hua, Qi Yang
Summary: This study investigated the morphological brain-tissue changes in patients with dialysis- and non-dialysis-dependent chronic kidney disease (CKD), and analyzed the effects of CKD on brain cortical thickness, volume, surface area, and curvature. The results showed that CKD patients exhibited significant and widespread decrease in cortical thickness and volume compared to normal controls. The extent of brain atrophy was further increased in dialysis-dependent CKD patients. The findings suggest that blood urea nitrogen and dialysis may play a role in brain morphological changes in CKD patients.
METABOLIC BRAIN DISEASE
(2023)
Article
Clinical Neurology
Ryul Kim, Nyeonju Kang, Kyeongho Byun, Kiwon Park, Jin-Sun Jun
Summary: This study examined the association between peripheral blood neutrophils and lymphocytes and longitudinal motor and cognitive decline in early Parkinson's disease (PD) patients, as well as the disease-specific mechanisms underlying these associations.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Can Sun, Jian Fu, Zhenzhen Qu, Lijing Jia, Dongxiao Li, Junli Zhen, Weiping Wang
Summary: The study found that chronic intermittent hypobaric hypoxia treatment can rescue cognitive deficits in epileptic rats by activating the Wnt/β-catenin pathway, providing a potential therapeutic approach for epilepsy-induced cognitive impairments.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Esmee Verburgt, Esther Janssen, Mina Jacob, Mengfei Cai, Annemieke Ter Telgte, Kim Wiegertjes, Roy P. C. Kessels, David G. Norris, Jose Marques, Marco Duering, Anil M. Tuladhar, Frank-Erik De Leeuw
Summary: Small hyperintense lesions on diffusion-weighted imaging (DWI) in patients with sporadic small vessel disease (SVD) are found to be associated with the radiological progression of SVD and cognitive decline.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)