Article
Biochemistry & Molecular Biology
Honoka Tanno, Takayuki Sassa, Megumi Sawai, Akio Kihara
Summary: Branched-chain fatty acids are important components in the meibum lipids secreted from the meibomian glands. Enzymes such as ELOVL1, ELOVL3, and ELOVL7 are responsible for elongating branched-chain acyl-CoAs. Liquid chromatography-tandem mass spectrometry has revealed the predominance of branched-chain lipids in mouse meibomian glands, demonstrating the significance of ELOVL1 in elongating branched-chain VLC acyl-CoAs in vivo.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Biochemical Research Methods
Helena Beatriz Ferreira, Cristina Barros, Tania Melo, Artur Paiva, M. Rosario Domingues
Summary: This study comprehensively assessed oxCE derivatives and identified their detailed structural features and isomer differentiation using high-resolution lipidomic approaches. The results showed that oxCE can be modified in either the fatty acyl moiety or the cholesterol ring, and specific fragmentation patterns were found to distinguish different oxCE isomers. These findings are important for identifying oxCE in biological samples and understanding their role in biological conditions and diseases.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Pharmacology & Pharmacy
Yan-Jhih Shen, Yan-Cheng Shen, Wen-Sen Lee, Kun-Ta Yang
Summary: The study demonstrated that methyl palmitate (MP) exerts significant cardioprotective effects against ischemia/reperfusion (I/R) injury by activating the GPR40-mediated PI3K/AKT signaling pathway. These findings suggest the potential therapeutic application of MP in the treatment of I/R-induced heart injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Brandon M. Roberts, Sarah E. Deemer, Daniel L. Smith, James A. Mobley, Nicolas Musi, Eric P. Plaisance
Summary: Exogenous ketone ester supplementation can reduce weight and fat mass gains in aged mice, while improving transcriptional and proteomic characteristics of skeletal muscle.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Applied
Jia Li, Haibo Yuan, Yuting Rong, Michael C. Qian, Fuqiao Liu, Jinjie Hua, Qinghua Zhou, Yuliang Deng, Jun Zeng, Yongwen Jiang
Summary: This study analyzed the lipid composition and metabolic changes of ripened Pu-erh tea (RPT) during pile fermentation. A total of 362 lipid species were significantly altered during fermentation, and fatty acid ester of hydroxy fatty acid (FAHFA) was detected in tea for the first time. The enrichment of FAHFA could serve as a marker compound associated with microbial fermentation in RPT.
Article
Pharmacology & Pharmacy
Zhikai Xiahou, Jun Han
Summary: This study revealed the molecular mechanism by which dehydroabietic acid affects HepG2 cells, showing its influence on pathways such as ferroptosis, oxidative phosphorylation, and protein processing. It was also found that dehydroabietic acid affects lipid metabolism in HepG2 cells, particularly the metabolism of glyceryl phosphatide.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Sarah Riesbeck, Hannes Petruschke, Ulrike Rolle-Kampczyk, Christian Schori, Christian H. Ahrens, Christian Eberlein, Hermann J. Heipieper, Martin von Bergen, Nico Jehmlich
Summary: Bisphenols can disturb the gut microbiome and inhibit the growth of human commensal bacteria, leading to changes in physiological and functional state of cells. These findings help to better understand the impact of bisphenols on host health and disease development.
Article
Cell Biology
Sora Q. Kim, Rodrigo Mohallem, Jackeline Franco, Kimberly K. Buhman, Kee-Hong Kim, Uma K. Aryal
Summary: This study utilized a multi-omics approach to investigate the effects of high fat and low fat diets on the livers of mice, revealing that high fat diet led to a decrease in protein phosphorylation levels and impacted lipolysis and lipid-mediated signaling pathways.
Article
Biochemistry & Molecular Biology
Khaled I. Alatibi, Stefan Tholen, Zeinab Wehbe, Judith Hagenbuchner, Daniela Karall, Michael J. Ausserlechner, Oliver Schilling, Sarah C. Gruenert, Jerry Vockley, Sara Tucci
Summary: The study found that treatment with medium-chain fatty acids had limited impact on certain proteomic changes but induced remodeling of complex lipids. Especially, C7 appeared to have a protective effect by improving protein homeostasis in LCHADD under control conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Miguel Cosenza-Contreras, Agnes Schafer, Justin Sing, Lena Cook, Maren N. Stillger, Chia-Yi Chen, Jose Villacorta Hidalgo, Niko Pinter, Larissa Meyer, Tilman Werner, Darleen Bug, Zeno Haberl, Oliver Kuebeck, Kai Zhao, Susanne Stei, Anca Violeta Gafencu, Radu Ionita, Felix M. Brehar, Jaime Ferrer-Lozano, Gloria Ribas, Leo Cerda-Alberich, Luis Marti-Bonmati, Christopher Nimsky, Alexis Van Straaten, Martin L. Biniossek, Melanie Foll, Nina Cabezas-Wallscheid, Jorg Buscher, Hannes Rost, Armelle Arnoux, Jorg W. Bartsch, Oliver Schilling
Summary: This study utilized proteomics and lipidomics to analyze patient-matched initial and recurrent glioblastoma specimens, revealing increased immune cell infiltration and extracellular matrix reorganization in recurrent glioblastoma. ASAH1 and SYNM were identified as potential plasma markers for the progression of recurrent glioblastoma.
Article
Agriculture, Multidisciplinary
Xiuxiu Zhang, Lu Liu, Lina Wang, Yue Pan, Xinyue Hao, Gengxu Zhang, Xiaodong Li, Muhammad Hussain
Summary: The study analyzed and compared the lipidome and fatty acid composition of human milk and infant formulas with different fat sources, finding common lipid species but significant variations in fatty acid composition, especially depending on the fat source used in the formulas. Overall, the results provide valuable insights for designing new milk formulas that better replicate human milk.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Iku Sazaki, Toshihiro Sakurai, Arisa Yamahata, Sumire Mogi, Nao Inoue, Koutaro Ishida, Ami Kikkai, Hana Takeshita, Akiko Sakurai, Yuji Takahashi, Hitoshi Chiba, Shu-Ping Hui
Summary: Oxidized low-density lipoproteins (oxLDLs) induce oxidative stress in liver tissue, leading to hepatic steatosis, inflammation, and fibrosis. This study investigated the effects of oxLDL on lipid metabolism, lipid droplet formation, and gene expression in a human liver cell line. The results showed that oxLDL increased lipid droplets enriched with CE hydroperoxides (CE-OOH) and altered the expression of certain genes involved in lipid metabolism. These findings suggest that oxLDL may play a crucial role in the development of NAFLD and NASH and could be a potential therapeutic target and biomarker for these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Jie Gu, Anqi Kong, Chuanzhi Guo, Junlin Liu, Kongdong Li, Zhen Ren, Yang Zhou, Min Tang, Haifeng Shi
Summary: This study demonstrates that exposure to cadmium ion (Cd2+) is associated with dyslipidemia and contributes to the development of nonalcoholic fatty liver disease (NAFLD). By analyzing the differential metabolites in serum, phosphatidylcholines (PCs) were identified as important metabolites, specifically participating in the Arachidonic Acid (AA) metabolism pathway, which may serve as potential biomarkers for NAFLD. Furthermore, the study suggests that Cd2+ exposure induces PC synthesis and remodeling, leading to increased AA levels through the fatty acid desaturase 1 (FADS1) pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cardiac & Cardiovascular Systems
Desmond K. Li, Lauren E. Smith, Alexander W. Rookyard, Shivanjali J. Lingam, Yen C. Koay, Holly P. McEwen, Stephen M. Twigg, Anthony S. Don, John F. O'Sullivan, Stuart J. Cordwell, Melanie Y. White
Summary: The study investigates the impact of high-fat diet and streptozotocin on the metabolome and proteome in diabetic hearts, revealing changes in metabolism and protein expression that contribute to poor cardiovascular outcomes in type 2 diabetes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Energy & Fuels
Ke Li, Jie Chen, Xiao-an Nie
Summary: The study shows that glycerol in pre-esterification of waste oil can reduce the acid value to a lower level in one step, and the optimized process conditions obtained through orthogonal experiment can achieve high conversion rate and good environmental protection, making it easier to realize the continuous synthesis of biodiesel from waste oil with high acid.
Review
Cardiac & Cardiovascular Systems
Sean M. Davidson, Chantal M. Boulanger, Elena Aikawa, Lina Badimon, Lucio Barile, Christoph J. Binder, Alain Brisson, Edit Buzas, Costanza Emanueli, Felix Jansen, Miroslava Katsur, Romaric Lacroix, Sai Kiang Lim, Nigel Mackman, Manuel Mayr, Philippe Menasche, Rienk Nieuwland, Susmita Sahoo, Kaloyan Takov, Thomas Thum, Pieter Vader, Marca H. M. Wauben, Kenneth Witwer, Joost P. G. Sluijter
Summary: This article provides an overview of the techniques and technologies available for the separation and characterization of EVs from different sources. It discusses methods for determining the protein, RNA, and lipid content of EVs. The guidance provided in this document is important for investigating the role of EVs in cardiovascular diseases and highlights key methodological issues to consider.
CARDIOVASCULAR RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Frank Lezoualc'h, Lina Badimon, Hana Baker, Monique Bernard, Gabor Czibik, Rudolf A. de Boer, Thomas D'Humieres, Micheline Kergoat, Mark Kowala, Jennifer Rieusset, Gemma Vilahur, Maximin Detrait, Chris Watson, Genevieve A. Derumeaux
Summary: Diabetic cardiomyopathy is a distinct, multifactorial disease that leads to ventricular hypertrophy and abnormal myocardial contractility. Animal models provide opportunities to study its mechanisms, but there are limitations when extrapolating findings to humans.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Raffaele Bugiardini, Stefano Nava, Gaetano Caramori, Jinsung Yoon, Lina Badimon, Maria Bergami, Edina Cenko, Antonio David, Ilir Demiri, Maria Dorobantu, Oana Fronea, Radmilo Jankovic, Sasko Kedev, Nebojsa Ladjevic, Ratko Lasica, Goran Loncar, Giuseppe Mancuso, Guiomar Mendieta, Davor Milicic, Petra Mjehovic, Marijan Pasalic, Milovan Petrovic, Lidija Poposka, Marialuisa Scarpone, Milena Stefanovic, Mihaela van der Schaar, Zorana Vasiljevic, Marija Vavlukis, Maria Laura Vega Pittao, Vladan Vukomanovic, Marija Zdravkovic, Olivia Manfrini
Summary: This retrospective cross-sectional study in 17 hospitals across 5 European countries found that women were at higher risk of in-hospital mortality and acute heart failure compared to men, but sex was not associated with mortality risk in patients receiving intensive care treatment for COVID-19.
CARDIOVASCULAR RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Marina Canyelles, Carla Borras, Noemi Rotllan, Mireia Tondo, Joan Carles Escola-Gil, Francisco Blanco-Vaca
Summary: Trimethylamine-N-oxide (TMAO), the main metabolite produced by gut microbiota, is mainly eliminated through renal excretion. Elevated levels of TMAO have been associated with increased risk of atherosclerotic cardiovascular disease (ASCVD) and related complications. However, the causal relationship between TMAO and CVD remains inconclusive, with conflicting findings in prospective studies and potential mediating role of renal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Emiel P. C. van der Vorst, Lina Badimon
CARDIOVASCULAR RESEARCH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Lina Badimon, Guiomar Mendieta, Gemma Vilahur
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Maria Carmen Garcia-Gomez, Teresa Padro, Natalia Munoz-Garcia, Maria Bianchi, Lorenzo Alvarez, Lina Badimon, Emili Corbella, Xavier Pinto
Summary: This study investigated the HDL antioxidant function in patients with rheumatoid arthritis (RA). The results showed that RA patients had lower HDL antioxidant capacity and a lower resistance of LDL particles to oxidation, mainly related to the degree of inflammation.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Alberto Cordero, Natalia Munoz-Garcia, Teresa Padro, Gemma Vilahur, Vicente Bertomeu-Gonzalez, David Escribano, Emilio Flores, Pilar Zuazola, Lina Badimon
Summary: This study investigated the role of lipoprotein functionality as well as particle number and size in patients with acute coronary syndrome (ACS) and on-target LDL-C levels. It was found that ACS patients had higher susceptibility to LDL oxidation and lower HDL-antioxidant capacity. They also had lower HDL-C and Apolipoprotein A-I levels compared to non-ACS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lasse Sprankel, David Vizarraga, Jesus Martin, Sina Manger, Jakob Meier-Credo, Marina Marcos, Josep Julve, Noemi Rotllan, Margot P. Scheffer, Joan Carles Escola-Gil, Julian D. Langer, Jaume Pinol, Ignacio Fita, Achilleas S. Frangakis
Summary: This study reveals the structural and functional analysis of the previously uncharacterized protein P116. P116 plays a crucial role in extracting essential lipids from the host environment, offering a potential target for controlling Mycoplasma infection.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2023)
Article
Hematology
Alba Vilella-Figuerola, Alberto Cordero, Sonia Mirabet, Natalia Munoz-Garcia, Rosa Suades, Teresa Padro, Lina Badimon
Summary: This study investigated platelet-derived extracellular vesicles (pEVs) in patients with chronic heart failure (CHF) and first-onset acute coronary syndrome (ACS). It was found that CHF patients had reduced pEVs carrying specific antigens, while ACS patients had increased pEVs with phosphatidylserine (PS) exposure. The background etiology of CHF or ACS type did not affect pEV levels.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cardiac & Cardiovascular Systems
Jeanine E. Roeters van Lennep, Lale S. Tokgozoglu, Lina Badimon, Sandra M. Dumanski, Martha Gulati, Connie N. Hess, Kirsten B. Holven, Maryam Kavousi, Meral Kayikcioglu, Esther Lutgens, Erin D. Michos, Eva Prescott, Jane K. Stock, Anne Tybjaerg-Hansen, Marieke J. H. Wermer, Marianne Benn
Summary: Cardiovascular disease is the leading cause of death globally, with atherosclerotic cardiovascular disease (ASCVD) being the main contributor. ASCVD mortality is currently increasing, especially in middle-aged women. Sex-specific factors, such as hypertensive disorders of pregnancy, premature menopause, and polycystic ovary syndrome, are associated with higher cardiovascular risk.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Rosa Suades, Alba Vilella-Figuerola, Teresa Padro, Sonia Mirabet, Lina Badimon
Summary: In this study, circulating extracellular microvesicles (cEVs) from chronic heart failure patients were phenotypically and quantitatively characterized. It was found that PS--cEVs were predominantly present in both chronic heart failure patients and non-HF subjects, but the proportions of PS-cEVs varied depending on the parental markers. PS+-cEVs were mainly derived from platelets and increased in the non-HF group, while PS--cEVs were mainly derived from endothelium and connexin 43-rich sources and significantly increased in chronic heart failure patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Giovanna Revilla, Nuseibah Al Qtaish, Pablo Caruana, Myriam Sainz-Ramos, Tania Lopez-Mendez, Francisco Rodriguez, Veronica Paez-Espinosa, Changda Li, Nuria Fucui Vallverdu, Maria Edwards, Antonio Moral, Jose Ignacio Perez, Juan Carlos Escola-Gil, Jose Luis Pedraz, Idoia Gallego, Rosa Corcoy, Maria Virtudes Cespedes, Gustavo Puras, Eugenia Mato
Summary: This study produced and assessed lenvatinib-loaded PLGA nanoparticles (NPs) as a novel therapeutic approach for aggressive thyroid tumors. The decorated NPs showed better cytotoxicity and therapeutic efficacy in vitro and in vivo compared to NPs without decoration, suggesting a promising strategy for targeted and effective administration of TKIs.
Article
Cardiac & Cardiovascular Systems
Jeanine E. Roeters van Lennep, Lale S. Tokgozoglu, Lina Badimon, Sandra M. Dumanski, Martha Gulati, Connie N. Hess, Kirsten B. Holven, Maryam Kavousi, Meral Kayikcioglu, Esther Lutgens, Erin D. Michos, Eva Prescott, Jane K. Stock, Anne Tybjaerg-Hansen, Marieke J. H. Wermer, Marianne Benn
Summary: Cardiovascular disease is the leading cause of death globally, with women experiencing the fastest relative increase in middle-aged mortality. In addition to missed or delayed diagnosis and undertreatment, sex-specific factors contribute to increased cardiovascular risk in women. The European Atherosclerosis Society's position statement focuses on the impact of gender-specific factors and the effects of these factors on women's lifelong lipid profiles, including lipoprotein(a). Sociocultural components further compound these effects. Early identification and treatment of modifiable cardiovascular risk factors in women, especially those related to sex-specific conditions, are necessary to reduce the high burden of cardiovascular disease in women.
EUROPEAN HEART JOURNAL
(2023)
Article
Food Science & Technology
Maria-Carmen Lopez de las Hazas, Andrea del Saz-Lara, Lidia Cedo, Maria Carmen Crespo, Joao Tome-Carneiro, Luis A. Chapado, Alba Macia, Francesco Visioli, Joan C. Escola-Gil, Alberto Davalos
Summary: HT supplementation in humanized mice resulted in systemic dyslipidemia, impaired glucose metabolism, increased body weight, and accumulation of triacylglycerols in different tissues. The expression of genes related to lipid metabolism, such as Pltp or Lpl, was also modulated by HT. Further studies are needed to fully understand the potential effects of HT consumption.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)