Article
Cardiac & Cardiovascular Systems
A. John Camm, Keith A. A. Fox, Saverio Virdone, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Berchuck, Bernard J. Gersh, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Frank Misselwitz, Karen S. Pieper, Alexander G. G. Turpie, Freek W. A. Verheugt, Riccardo Cappato, Ajay K. Kakkar
Summary: In patients with atrial fibrillation at risk of stroke, non-vitamin K antagonist oral anticoagulants (NOACs) showed lower risks of all-cause mortality and major bleeding compared to vitamin K antagonists (VKAs), with similar risks of non-haemorrhagic stroke/systemic embolism.
Article
Cardiac & Cardiovascular Systems
John de Heide, Andre de Wit, Rohit E. Bhagwandien, Amira Assaf, Jaleesa Gros-Bisdom, Koen C. van der Meer, Sip A. Wijchers, Felix Zijlstra, Tamas Szili-Torok, Mattie J. Lenzen, Sing-Chien Yap
Summary: The study evaluated the outcomes of patients with atrial tachyarrhythmia undergoing elective electrical cardioversion (ECV) with DOAC or VKA treatment in a tertiary referral center. Results showed that the rates of thromboembolism and major bleeding events were low after ECV, even without routine TEE, in patients treated with DOAC or VKA.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Fabrice F. F. Darche, Lisa C. C. Fabricius, Matthias Helmschrott, Ann-Kathrin Rahm, Philipp Ehlermann, Tom Bruckner, Wiebke Sommer, Gregor Warnecke, Norbert Frey, Rasmus Rivinius
Summary: Little is known about the post-transplant use of direct oral anticoagulants (DOACs) in patients after heart transplantation (HTX). We investigated the frequency, indications, and complications of DOACs and vitamin K antagonists (VKAs) in HTX recipients. The results showed that DOACs were associated with significantly fewer bleeding complications compared to VKAs, but there were no differences in the risk of ischemic stroke, thromboembolic events, or OAC-related death between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Chun-Li Wang, Victor Chien-Chia Wu, Yu-Tung Huang, Yu-Ling Chen, Pao-Hsien Chu, Chang-Fu Kuo, Ming-Shien Wen, Shang-Hung Chang
Summary: After experiencing hematuria, it is unclear to what extent patients resume VKA or NOAC. A cohort study in Taiwan revealed that patients resuming NOAC had similar risks of ischemic stroke/systemic embolism and major bleeding compared to those resuming VKA. Over time, the proportion of patients resuming NOAC has increased, while VKA resumption and non-resumption have decreased.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Cardiac & Cardiovascular Systems
Norman Mangner, Miriam Brinkert, Lukas S. Keller, Noriaki Moriyama, Daniel Hagemeyer, Stephan Haussig, Lisa Crusius, Richard Kobza, Mohamed Abdel-Wahab, Mika Laine, Stefan Stortecky, Thomas Pilgrim, Fabian Nietlispach, Frank Ruschitzka, Holger Thiele, Stefan Toggweiler, Axel Linke
Summary: This study aimed to investigate the safety and effectiveness of continued non-vitamin K antagonist oral anticoagulant (NOAC) therapy compared with continued vitamin K antagonist (VKA) therapy during transcatheter aortic valve implantation (TAVI). The study found that continued NOAC therapy led to comparable outcomes to continued VKA therapy, suggesting that both drugs can be used for long-term oral anticoagulation in TAVI patients.
Article
Medicine, General & Internal
Enrico Guido Spinoni, Chiara Ghiglieno, Simona Costantino, Eleonora Battistini, Gabriele Dell'Era, Stefano Porcellini, Matteo Santagostino, Federica De Vecchi, Giulia Renda, Giuseppe Patti
Summary: This study compares the occurrence of post-procedural bleeding complications between patients with atrial fibrillation undergoing cardiac implantable electronic device (CIED) intervention who were treated with non-vitamin K antagonist anticoagulants (NOACs) or vitamin K antagonist anticoagulants (VKAs). The results suggest that NOACs may be associated with a lower incidence of post-intervention pocket hematoma compared to VKAs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Menno Huisman, Christine Teutsch, Shihai Lu, Hans-Christoph Diener, Sergio J. Dubner, Jonathan L. Halperin, Chang-Sheng Ma, Kenneth J. Rothman, Ragna Lohmann, Venkatesh Kumar Gurusamy, Dorothee B. Bartels, Gregory Y. H. Lip
Summary: This study compared the safety and effectiveness of dabigatran versus vitamin K antagonists in newly diagnosed atrial fibrillation patients. The results showed that dabigatran was associated with a reduced risk of major bleeding and all-cause death compared to VKA. The risks of stroke and myocardial infarction were similar between the two groups. These findings confirm a more favorable benefit-risk profile for dabigatran compared to VKA in clinical practice.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Maxim Grymonprez, Cynthia Simoens, Stephane Steurbaut, Tine L. De Backer, Lies Lahousse
Summary: The introduction of NOACs has significantly increased the use of oral anticoagulants among atrial fibrillation patients worldwide. However, there is still room for improvement as a portion of patients are not receiving anticoagulation therapy or are only being treated with antiplatelet monotherapy.
Article
Medicine, General & Internal
Raffaele De Caterina, Young-Hoon Kim, Yukihiro Koretsune, Chun-Chieh Wang, Takeshi Yamashita, Cathy Chen, Paul-Egbert Reimitz, Martin Unverdorben, Paulus Kirchhof
Summary: The study found that among patients with atrial fibrillation, those treated with edoxaban had low rates of stroke, intracranial hemorrhages, and other major bleeding events, but cardiovascular death remained common.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Songnan Wen, Cristina Pislaru, Kristi H. Monahan, Stephanie M. Barnes, David O. Hodge, Douglas L. Packer, Sorin Pislaru, Samuel J. Asirvatham
Summary: This study found that overall atrial fibrillation recurrence after ablation was similar with NOACs or warfarin use, but in patients with persistent AF, NOACs use was associated with a higher probability of arrhythmia recurrence and was an independent risk factor for recurrence in long-term follow-up.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Clinical Neurology
Josefine Grundtvig, Christian Ovesen, Thorsten Steiner, Cheryl Carcel, David Gaist, Louisa Christensen, Jacob Marstrand, Per Meden, Sverre Rosenbaum, Helle K. Iversen, Christina Kruuse, Thomas Christensen, Karen AEgidius, Inger Havsteen, Hanne Christensen
Summary: This study explores the similarities and differences in risk factors, acute presentation, treatments, and outcomes between men and women with oral anticoagulant-related intracerebral hemorrhage (ICH). The results show significant differences in age, risk factors, access to treatment, and do-not-resuscitate (DNR) orders between genders, but no significant differences in comorbidity burden, stroke severity, or hematoma volume. These findings support the presence of gender differences in risk factors and care, but not in presentation and outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Katharina Platzbecker, Helge Mueller-Fielitz, Ronja Foraita, Matthias J. Koepp, Annemarie Voss, Rene Pflock, Roland Linder, Iris Pigeot, Tania Schink, Markus Schwaninger
Summary: This study aimed to investigate whether treatment of atrial fibrillation (AF) with direct oral anticoagulants (DOACs) affects the risk of epilepsy compared to treatment with the vitamin K antagonist phenprocoumon (PPC). The results showed that patients with AF treated with DOACs had a higher risk of epilepsy compared to PPC treatment.
Article
Cardiac & Cardiovascular Systems
Joris J. Komen, Anton Pottegard, Aukje K. Mantel-Teeuwisse, Tomas Forslund, Paul Hjemdahl, Bjorn Wettermark, Jesper Hallas, Morten Olesen, Marion Bennie, Tanja Mueller, Raymond Carragher, Oystein Karlstad, Lars J. Kjerpeseth, Olaf H. Klungel
Summary: Observational data suggests that NOAC treatment may have a positive net clinical benefit compared with no treatment or VKA treatment in low stroke risk patients.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Walter Ageno, Ivan B. Casella, Kok Han Chee, Sebastian Schellong, Sam Schulman, Daniel E. Singer, Marc Desch, Wenbo Tang, Isabelle Voccia, Kristina Zint, Samuel Z. Goldhaber
Summary: In this study, a higher percentage of elderly patients and those with renal impairment were found compared to randomized clinical trials for acute VTE. The use of NOACs decreased with worsening renal impairment, while not significantly associated with older age.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Medicine, General & Internal
Mette Sogaard, Flemming Skjoth, Peter Bronnum Nielsen, Jan Beyer-Westendorf, Torben Bjerregaard Larsen
Summary: According to a Danish study, fetal risk was lowest in pregnant women who were unexposed to any medications or exposed to low-molecular-weight heparin (LMWH). Compared to unexposed women, those exposed to vitamin K antagonists (VKA) had an increased risk of preterm and very preterm births, as well as lower mean gestational age and birthweight.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Miney Paquette, Lionel Riou Franca, Christine Teutsch, Hans-Christoph Diener, Shihai Lu, Sergio J. Dubner, Chang Sheng Ma, Kenneth J. Rothman, Kristina Zint, Jonathan L. Halperin, Brian Olshansky, Menno Huisman, Gregory Y. H. Lip, Robby Nieuwlaat
AMERICAN JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
James A. Reiffel, Atul Verma, Peter R. Kowey, Jonathan L. Halperin, Bernard J. Gersh, Mitchell S. Elkind, Paul D. Ziegler, Rachelle E. Kaplon, Lou Sherfesee, Rolf Wachter
AMERICAN HEART JOURNAL
(2020)
Article
Medicine, General & Internal
Giuseppe Boriani, Menno Huisman, Christine Teutsch, Sabrina Marler, Lionel Riou Franca, Shihai Lu, Gregory Y. H. Lip
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2020)
Article
Medicine, General & Internal
Irene Escudero-Martinez, Michael Mazya, Christine Teutsch, Norbert Lesko, Zuzana Gdovinova, Leonardo Barbarini, Waldemar Fryze, Michal Karlinski, Adam Kobayashi, Georgi Krastev, Ana Paiva Nunes, Katarina Pasztoova, Andre Peeters, Piotr Sobolewski, Aleksandras Vilionskis, Danilo Toni, Niaz Ahmed
Article
Medicine, General & Internal
Monika Koziel, Michal Mazurek, Christine Teutsch, Hans-Christoph Diener, Sergio J. Dubner, Jonathan L. Halperin, Chang-Sheng Ma, Kenneth J. Rothman, Axel Brandes, Miney Paquette, Kristina Zint, Lionel Riou Franca, Shihai Lu, Dorothee B. Bartels, Menno V. Huisman, Gregory Y. H. Lip
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Sergio J. Dubner, Christine Teutsch, Menno V. Huisman, Hans-Christoph Diener, Jonathan Halperin, Kenneth J. Rothman, Chang-Sheng Ma, Eduardo Chuquiure-Valenzuela, Jutta Bergler-Klein, Kristina Zint, Lionel Riou Franca, Shihai Lu, Miney Paquette, Gregory Y. H. Lip
Article
Cardiac & Cardiovascular Systems
George Ntaios, Menno Huisman, Hans-Christoph Diener, Jonathan L. Halperin, Christine Teutsch, Sabrina Marler, Venkatesh K. Gurusamy, Milla Thompson, Gregory Y. H. Lip, Brian Olshansky
Summary: The study analyzed the actual prescription patterns of oral anticoagulants based on SAMe-TT2R2 scores in atrial fibrillation patients, finding that patients with higher scores did not necessarily receive more VKA prescriptions. There is currently no clear evidence that the SAMe-TT2R2 score has a significant impact on the selection of anticoagulant therapy.
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Monika Koziel, Christine Teutsch, Jonathan L. Halperin, Kenneth J. Rothman, Hans-Christoph Diener, Chang-Sheng Ma, Sabrina Marler, Shihai Lu, Venkatesh K. Gurusamy, Menno Huisman, Gregory Y. H. Lip
Summary: This study described the baseline characteristics, patterns of antithrombotic therapy, and factors associated with oral anticoagulant prescription in patients with atrial fibrillation and multi-comorbid conditions.
Article
Medicine, General & Internal
Sake J. van der Wall, Gregory Y. H. Lip, Christine Teutsch, Oskars Kalejs, Philippe Lyrer, Christian Hall, Sergio J. Dubner, Hans-Christoph Diener, Jonathan L. Halperin, Chang Sheng Ma, Kenneth J. Rothman, Kristina Zint, Dongmei Zhai, Menno Huisman
Summary: This study evaluated the safety and effectiveness of uninterrupted dabigatran therapy during cardiovascular interventions, with low major bleeding and stroke/systemic embolism risks. Uninterrupted dabigatran therapy showed a favorable safety and effectiveness profile in clinical practice-based settings.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Monika Koziel, Christine Teutsch, Valentina Bayer, Shihai Lu, Venkatesh K. Gurusamy, Jonathan L. Halperin, Kenneth J. Rothman, Hans-Christoph Diener, Chang-Sheng Ma, Menno Huisman, Gregory Y. H. Lip
Summary: Over a period of 4 years after the approval of the first NOAC, the use of NOACs increased while the use of Vitamin K antagonists decreased across all regions.
JOURNAL OF ARRHYTHMIA
(2021)
Article
Cardiac & Cardiovascular Systems
Gregory Y. H. Lip, Agnieszka Kotalczyk, Christine Teutsch, Hans-Christoph Diener, Sergio J. Dubner, Jonathan L. Halperin, Chang-Sheng Ma, Kenneth J. Rothman, Sabrina Marler, Venkatesh Kumar Gurusamy, Menno Huisman
Summary: This study compared the safety and effectiveness of different non-vitamin K antagonists (NOACs) in newly diagnosed atrial fibrillation (AF) patients. The results showed that dabigatran had a lower risk of major bleeding compared to rivaroxaban, but similar risks of stroke, myocardial infarction (MI), and death. Patients treated with dabigatran had similar risks of stroke, major bleeding, MI, and death compared to apixaban. Rivaroxaban had an increased risk of major bleeding compared to apixaban, but similar risks of stroke, MI, and death.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Menno Huisman, Christine Teutsch, Shihai Lu, Hans-Christoph Diener, Sergio J. Dubner, Jonathan L. Halperin, Chang-Sheng Ma, Kenneth J. Rothman, Ragna Lohmann, Venkatesh Kumar Gurusamy, Dorothee B. Bartels, Gregory Y. H. Lip
Summary: This study compared the safety and effectiveness of dabigatran versus vitamin K antagonists in newly diagnosed atrial fibrillation patients. The results showed that dabigatran was associated with a reduced risk of major bleeding and all-cause death compared to VKA. The risks of stroke and myocardial infarction were similar between the two groups. These findings confirm a more favorable benefit-risk profile for dabigatran compared to VKA in clinical practice.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Valentina Bayer, Agnieszka Kotalczyk, Bory Kea, Christine Teutsch, Peter Larsen, Dana Button, Menno Huisman, Gregory Y. H. Lip, Brian Olshansky
Summary: This study investigated the use of oral anticoagulants (OACs) in patients with atrial fibrillation (AF) in different regions and types of healthcare sites. The findings showed significant geographic variability and suboptimal implementation of guideline recommendations in the initiation of OAC treatment. Optimizing OAC use in AF patients could lead to better outcomes and cost reduction in healthcare.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Rabih R. Azar, Hany Ragy, Omer Kozan, Maurice El Khuri, Nooshin Bazergani, Sabrina Marler, Christine Teutsch, Mohamed Ibrahim, Gregory Y. H. Lip, Menno Huisman
Summary: In Africa and the Middle East region, dabigatran was the most commonly used antithrombotic agent in newly diagnosed patients with nonvalvular atrial fibrillation, with high persistence rate and low incidence rates of stroke, myocardial infarction, major bleeding, and all-cause mortality after 2 years of follow-up. The data from GLORIA-AF indicate a positive impact on stroke prevention in this region, consistent with global findings and randomized clinical trials.
IJC HEART & VASCULATURE
(2021)
Article
Cardiac & Cardiovascular Systems
Sergio Dubner, Jose Francisco Kerr Saraiva, Juan Carlos Nunez Fragoso, Gonzalo Baron-Esquivias, Christine Teutsch, Venkatesh Kumar Gurusamy, Sabrina Marler, Menno Huisman, Gregory Y. H. Lip, Cecilia Zeballos
IJC HEART & VASCULATURE
(2020)