期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 139, 期 23, 页码 7693-7696出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b02951
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资金
- Association for Research on Cancer, French Ministry Enseignement Superieure et Recherche
- Rhone-Alpes region (Contrat de projets Etat-Region Exploration du vivant, Imagerie biomedicale)
Fluorescent probes that are able to directly measure viscosity are attractive candidates for the study of intracellular environments. We report a new class of luminescent rotors, based on the sensitized emission of a terbium(III) complex. A 4-fold increase in both quantum yield and luminescence lifetime was observed in viscous media for the studied complexes, with, a lifetime ranging from 0.23 to 0.89 ms over a broad range of viscosities (0.6-1200 cP). The presented approach, relying on the millisecond-scale luminescence lifetime of the lanthanide ions, was applied to fixed T24 cancer cells using temporal sampling lifetime imaging microscopy.
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