期刊
AIDS RESEARCH AND HUMAN RETROVIRUSES
卷 31, 期 6, 页码 636-640出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2014.0325
关键词
-
资金
- Carlos Julio Montoya from Universidad de Antioquia and Walter Osorio from Fundacion Antioquena de Infectologia
- CODI-Universidad de Antioquia convocatoria mediana cuantia
- Estrategia de Sostenibilidad de la Universidad de Antioquia
- CIHR IID&GH Program of the University of Manitota
- Colciencias Convocatoria Nacional 511 para el estudio de Doctorado en Colombia ano
- Canadian Institutes for Health Research [MOP-86721]
Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion, and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules on natural killer (NK) and CD4(+) T cells and plasma levels of proinflammatory cytokines in individuals exhibiting viral control: a cohort of HIV-1-exposed-seronegative individuals (HESN) and a cohort of HIV controllers. There was lower expression of CD69, LAG-3, PD-1, and TIM-3 in both cohorts when compared to a low-risk population or HIV progressors. In addition, HIV controllers exhibited lower plasma levels of proinflamatory molecules TNF- and IP-10. These findings suggest that individuals exhibiting viral control have lower basal expression of markers associated with cellular activation and particularly immune exhaustion.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据