期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 139, 期 20, 页码 6819-6822出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b02829
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资金
- University of California, San Diego
Herein we describe concise enantioselective chemical syntheses of (-)-viridin and (-)-viridiol.,Our convergent approach couples two achiral fragments of similar complexity and employs an enantioselective intramolecular Heck reaction to set the absolute stereo chemical configuration of an all-carbon quaternary stereo center. To complete the syntheses of these base- and nucleophile-sensitive natural products, we conduct carefully orchestrated site- and diastereoselective oxidations and other transformations. Our work is the first to generate these targets as single enantiomers.
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