期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 139, 期 49, 页码 17787-17790出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b11663
关键词
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资金
- University of Illinois
- National Science Foundation [CHE-1654110]
- NIH/National Institute of General Medical Sciences [R01 GM122891]
- Honjo International Scholarship Foundation
A dearomative 1,4-carboamination of arenes has been achieved using arenophile cycloaddition and subsequent palladium-catalyzed substitution with non stabilized lithium enolates. This protocol delivers products with exclusive syn-1,4-selectivity and can be also conducted in an asymmetric fashion. The method allows rapid dearomative difunctionalization of simple aromatic compounds into functional small molecules amenable to further diversification.
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