期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 139, 期 17, 页码 6038-6041出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b01410
关键词
-
资金
- NIH [R01GM102403]
- Welch Foundation [I-1612]
Boronic esters react with 2-lithiated indoles to form boronate intermediates. The boronate reacts with allylic acetates in the presence of (BINAP)Pd catalysts to allylate C3 concurrent with alkyl migration from B to C2 of the indole. Overall, the process is a three-component coupling that joins an allylic acetate, and indole and an organo-B(pin) species to provide substituted indoles and indolines with high enantio-, regio-, and diastereoselectivity.
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