Review
Medicine, General & Internal
Puneet Agarwal, Snehal Balvant Lunge, Nandini Sundar Shetty, Priyanka Karagaiah, Steven Daveluy, Alex G. Ortega-Loayza, Thrasyvoulos Tzellos, Jacek C. Szepietowski, Christos C. Zouboulis, Stephan Grabbe, Mohamad Goldust
Summary: Hidradenitis suppurativa/acne inversa (HS) is a chronic inflammatory disease that causes painful, inflammatory nodules, abscesses, and tunnels in the apocrine gland-bearing areas of the skin. Pain and drainage are the main symptoms that affect the quality of life in HS patients. Itch, which is often overlooked in quality of life studies, is also an important symptom and is associated with reduced quality of life, depression, and impairment of social life. Mast cells and mTor signaling are elevated in both lesional and perilesional skin. Brodalumab, a monoclonal antibody against IL-17A receptor, has shown significant improvements in itch, pain, quality of life, and depression in patients with moderate to severe HS. Statins have shown some reduction in itch intensity score. Further studies are needed to better understand the etiopathogenesis and optimal therapeutic modalities for itch in HS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Chemistry, Medicinal
Qiang Cai, Guoqing Liu, Linsheng Huang, Yuting Guan, Huixia Wei, Zhiqian Dou, Dexi Liu, Yang Hu, Meiling Gao
Summary: The review describes the pharmacologic characteristics of dexmedetomidine, the tumor-progressive factors during the perioperative period, and the relationships between dexmedetomidine and tumor-progressive factors. Available evidence suggests that dexmedetomidine may reduce immune function suppression during cancer operations and decrease the level of proinflammatory cytokines. However, the role of dexmedetomidine in cancer cell behavior varies depending on the cell type. Currently, there is a lack of strong clinical evidence to determine whether dexmedetomidine influences cancer recurrence.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Nutrition & Dietetics
Luigi Barrea, Giovanna Muscogiuri, Gabriella Pugliese, Giulia de Alteriis, Maria Maisto, Marianna Donnarumma, Gian Carlo Tenore, Annamaria Colao, Gabriella Fabbrocini, Silvia Savastano
Summary: In this study, circulating TMAO levels were higher and adherence to the Mediterranean diet was lower in HS patients, with HS patients of higher severity showing higher BMI, waist circumference, and energy intake but lower PhA and MD adherence. Circulating TMAO levels were positively correlated with HS severity, and both circulating TMAO levels and PhA were main predictors of HS clinical severity.
Review
Dermatology
Ashley Riddle, Linnea Westerkam, Cynthia Feltner, Christopher Sayed
Summary: Hidradenitis suppurativa (HS) is a chronic dermatologic condition that often requires surgical treatment. This study summarizes the literature on HS surgery, comparing different surgical approaches and their efficacy in terms of recurrence rates. It was found that wide excision and flap-based reconstruction are associated with lower postsurgical recurrence, but this must be balanced against the potentially higher morbidity of extensive procedures.
DERMATOLOGIC SURGERY
(2021)
Article
Dermatology
Pengjun Zhou, Jingjing Liu, Tianxing Xu, Yanni Guo, Yue Han, Yanyan He, Lihang Lin, Xuemin Xiao
Summary: The effects of PSENEN mutations in patients with acne inversa are still not well understood, it may be insufficient to solely cause the development of the disease, or may only induce a mild phenotype. Further research is needed to fully comprehend the role of PSENEN mutations in acne inversa.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Surgery
Ulrich Eugen Ziegler, Petronela Sakova, Hans Bernd Reith
Summary: Post-bariatric surgical procedures in patients after massive weight loss are often associated with high rates of complications, especially if patients also have a long history of hydradenitis suppurativa. A differentiated therapy regime is necessary for these patients. A study on 12 patients who underwent abdominoplasty after massive weight loss showed a high complication rate, but the use of antibiotics prevented soft tissue infections.
ZENTRALBLATT FUR CHIRURGIE
(2023)
Review
Oncology
Xinming Wang, Chunlan Yang, Heinrich Korner, Chaoliang Ge
Summary: Tumor Necrosis Factor was initially thought to be deadly to cancer cells and tumors, but recent research reveals it primarily functions as a proinflammatory cytokine. Despite this, the search continues for a cytokine that can serve as a one-stop treatment for solid tumors and lymphomas.
Article
Dermatology
Carlos Cuenca-Barrales, Trinidad Montero-Vilchez, Manuel Sanchez-Diaz, Juan-Angel Rodriguez-Pozo, Pablo Diaz-Calvillo, Antonio Martinez-Lopez, Salvador Arias-Santiago, Alejandro Molina-Leyva
Summary: This study aimed to characterize the surgical recurrences in patients with hidradenitis suppurativa (HS) treated with wide excision and second-intention healing. It was found that the severity of Hurley stage II at the surgical site, obesity, and higher IHS4 scores after surgery and at week 68 increased the risk of recurrence. Tunnel recurrence originated in the depth of the surgical scar, while AN recurrence originated in the borders of the surgical scar and may benefit from preoperative ultrasound.
Review
Immunology
Nadia Peyravian, Sapna Deo, Sylvia Daunert, Joaquin J. Jimenez
Summary: Acne, a common skin condition, can be treated with conventional therapies such as retinoids and antibiotics, but these treatments may have side effects and risks of antibiotic resistance. Therefore, the use of natural plant-derived treatments like CBD as an alternative or adjunct therapy is attractive to patients due to their anti-inflammatory properties and minimal side effects.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Nutrition & Dietetics
Irene Lorite-Fuentes, Trinidad Montero-Vilchez, Salvador Arias-Santiago, Alejandro Molina-Leyva
Summary: There is limited scientific information available regarding the potential benefits of healthy lifestyles in patients with hidradenitis suppurativa (HS). This study aimed to explore the potential association between adherence to a Mediterranean diet (MD), physical activity, and HS severity. The results showed that higher adherence to a MD was associated with lower disease activity and severity, and increased levels of physical activity were also correlated with lower disease severity.
Article
Microbiology
Christine Podrini, Laetitia Schramm, Giulia Marianantoni, Jagienka Apolinarska, Colin McGuckin, Nico Forraz, Clement Milet, Anne-Laure Desroches, Pauline Payen, Maria D'Aguanno, Manuele Biazzo
Summary: The tailoring of the skin microbiome is a challenging research area in immune-mediated inflammatory skin diseases like acne. Common preservatives used in functional ingredients can impact the skin microbiota and hinder the survival of beneficial skin bacteria. This study investigated the viability of Lactiplantibacillus plantarum, formulated with natural enhancers for topical use, and found that it showed increased viability in vitro and a stable viability on healthy skin. The strain also showed promising results in reducing the viability and inflammation associated with acne on human skin models. Based on these findings, the researchers suggest that SkinDuo(TM) could be introduced as an acne-mitigating agent.
Article
Dermatology
Verena Gerlinde Frings, Boris Bauer, Roswitha Schuster, Matthias Goebeler, Dagmar Presser, Andreas Kerstan
Summary: In this study, the duration of complete secondary wound healing after surgical intervention for hidradenitis suppurativa/acne inversa was assessed. The anogenital/inguinal region showed significantly faster wound healing compared to the axillary region, possibly due to differences in pilosebaceous unit density and hair follicle progenitor cells as reflected by CK15 and CD200 expression.
EUROPEAN JOURNAL OF DERMATOLOGY
(2021)
Article
Neurosciences
Karissa Barthelson, Yang Dong, Morgan Newman, Michael Lardelli
Summary: Analysis of brain transcriptomes in young adult zebrafish revealed both similarities and differences in the effects of heterozygosity for psen1 mutations causing EOfAD or fAI. The contrasting effects observed may shed light on how these mutation types lead to distinct diseases.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Dermatology
Indrashis Podder, Komal Agarwal, Anubhav Anurag
Summary: Acne vulgaris has a significant impact on the quality of life of adolescents and may be associated with metabolic syndrome and obesity. However, despite a higher prevalence of MetS and obesity in acne patients, there is a lack of significant association between the two.
INDIAN JOURNAL OF DERMATOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Jian Ai, Weiwei Ma, Zhenghao Pan, Bingyong Mao, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Wei Chen, Shumao Cui
Summary: Oral ingestion of live Lactobacillus plantarum can alleviate acne by suppressing skin inflammation, normalizing hormone and skin lipid metabolism, and improving gut microbial ecosystem.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Dermatology
A. Sesti, K. Rappersberger, C. Posch
Letter
Dermatology
Bal Christina, Rappersberger Klemens, Posch Christian
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2017)
Article
Dermatology
Leo Richter, Igor Vujic, Alma Sesti, Babak Monshi, Martina Sanlorenzo, Christian Posch, Klemens Rappersberger
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2017)
Article
Dermatology
I. Vujic, R. Herman, M. Sanlorenzo, C. Posch, B. Monshi, K. Rappersberger, L. Richter
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2018)
Article
Dermatology
Georg Richtig, Markus Richtig, Wolfram Hoetzenecker, Werner Saxinger, Bernhard Lange-Asschenfeldt, Andreas Steiner, Robert Strohal, Christian Posch, Johann W. Bauer, Robert R. Muellegger, Teresa Deinlein, Norbert Sepp, Beatrix Volc-Platzer, Van Anh Nguyen, Matthias Schmuth, Christoph Hoeller, Gudrun Pregartner, Erika Richtig
ACTA DERMATO-VENEREOLOGICA
(2019)
Article
Multidisciplinary Sciences
Martina Sanlorenzo, Igor Vujic, Rosaura Esteve-Puig, Kevin Lai, Marin Vujic, Kevin Lin, Christian Posch, Michelle Dimon, Adrian Moy, Mitchell Zekhtser, Katia Johnston, Deborah Gho, Wilson Ho, Abhinay Gajjala, Juan Oses Prieto, Alma Burlingame, Adil Daud, Klemens Rappersberger, Susana Ortiz-Urda
SCIENTIFIC REPORTS
(2018)
Letter
Oncology
Alain Patrick Algazi, Julia Rotow, Christian Posch, Susana Ortiz-Urda, Alain Patrick Algazi, Pamela N. Munster, Adil Daud
PIGMENT CELL & MELANOMA RESEARCH
(2019)
Letter
Dermatology
P. Schmidle, T. Biedermann, C. Posch
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2020)
Editorial Material
Dermatology
C. Posch
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2020)
Letter
Oncology
H. Obermann, P. Schmidle, S. A. Steimle-Grauer, N. Pfarr, C. Posch
EUROPEAN JOURNAL OF CANCER
(2021)
Letter
Dermatology
M. Arenbergerova, A. Lallas, E. Nagore, L. Rudnicka, A. M. Forsea, M. Pasek, F. Meier, K. Peris, J. Olah, C. Posch
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Editorial Material
Dermatology
C. Posch
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Letter
Dermatology
R. Pirker, A. Fink, A. Stella, L. Stifter, C. Posch
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Medicine, General & Internal
Valentin Feichtenschlager, Felix Weihsengruber, Leo Richter, Igor vujic, Klemens Rappersberger, Christian Posch
WIENER MEDIZINISCHE WOCHENSCHRIFT
(2019)