期刊
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
卷 77, 期 1, 页码 1-13出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2016.10.048
关键词
chemical leukoderma; confetti depigmentation; halo nevi; leukoderma; segmental vitiligo; vitiligo; vitiligo pathogenesis
类别
资金
- National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health [AR061437, AR069114]
- Kawaja Vitiligo Research Initiative
- Vitiligo Research Foundation
- Dermatology Foundation Stiefel Scholar Award
Vitiligo is a common autoimmune disease that progressively destroys melanocytes in the skin, resulting in the appearance of patchy depigmentation. This disfiguring condition frequently affects the face and other visible areas of the body, which can be psychologically devastating. The onset of vitiligo often occurs in younger individuals and progresses for life, resulting in a heavy burden of disease and decreased quality of life. Presentation patterns of vitiligo vary, and recognition of these patterns provides both diagnostic and prognostic clues. Recent insights into disease pathogenesis offer a better understanding of the natural history of the disease, its associations, and potential for future treatments. The first article in this continuing medical education series outlines typical and atypical presentations of vitiligo, how they reflect disease activity, prognosis, and response to treatment. Finally, we discuss disease associations, risk factors, and our current understanding of disease pathogenesis.
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