Article
Surgery
Assi Drobot, Maxim Bez, Ibrahim Abu Shakra, Fahed Merei, Kamal Khatib, Amitai Bickel, Samer Ganam, Grigori Bogouslavski, Nour Karra, Badran Mahran, Walid Kassis, Leonid Kogan, Denis Drobot, Michael Weiss, Isao Koshima, Eli Kakiashvili
Summary: A retrospective analysis of 70 patients with lymphedema who underwent lymphaticovenular anastomosis (LVA) surgery showed that LVA is a safe and effective method for reducing lymphedema severity, especially in early-stage upper extremity lymphedema. The mean number of lymphovenous bypasses was 3.9 and the reduction in limb volume at 3, 6, and 12 months was significant, with early-stage patients showing higher volume reductions compared to late-stage patients.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Ankita Poojari, Kapil Dev, Atefeh Rabiee
Summary: Lipedema is a fat and fascia disorder primarily affecting women. The mechanisms underlying this condition and its treatment options are not well understood. This review explores the morphological phenotype of lipedema fat, its pathophysiology, and potential biomarkers, while emphasizing the importance of technological interventions in the future.
Article
Dermatology
Kristina D. Rojas, Mariana E. Perez, Michael A. Marchetti, Anna J. Nichols, Frank J. Penedo, Natalia Jaimes
Summary: Skin cancer is the most common diagnosed cancer globally, and understanding its natural history is crucial for developing effective prevention and control strategies. These strategies include health promotion, primary prevention, secondary prevention, and tertiary prevention.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Kristina D. Rojas, Mariana E. Perez, Michael A. Marchetti, Anna J. Nichols, Frank J. Penedo, Natalia Jaimes
Summary: This article discusses the natural history of skin cancer and strategies for prevention and control, including health promotion, prevention, treatment, etc.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Jin A. Yoon, Myung Jun Shin, Yong Beom Shin, Byeong Ju Lee, Kyung Un Choi, Joo Hyoung Kim
Summary: The article reported three cases of angiosarcoma secondary to post-irradiation and lymphedema. One patient underwent surgery with a good outcome, while the other two refused treatment. It is important to perform biopsy and imaging studies promptly for patients with clinical findings suggestive of angiosarcoma in the setting of radiation and chronic lymphedema.
Article
Medicine, General & Internal
Akitatsu Hayashi, Giuseppe Visconti, Chia-Shen (Johnson) Yang, Nobuko Hayashi, Hidehiko Yoshimatsu
Summary: This study investigated the efficacy of lymphaticovenular anastomosis (LVA) on the posterior side of the lower leg for the treatment of primary lymphedema. The results showed that performing LVA on the posterior side in addition to the anterior and medial sides resulted in further improvement of lower extremity lymphedema with a reduced number of anastomoses.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Charissa Kim, Hamza Ali, Leo L. Tsai, Julie Bulman, Dhruv Singhal, Brett Carroll, Muneeb Ahmed, Jeffrey Weinstein
Summary: This retrospective study identified common groin IL findings in primary LED patients, including irregular lymph node morphology, lymphovenous shunting, contrast passage across midline, and failure to opacify the cisterna chyli and thoracic duct. These findings highlight patterns that interventional radiologists should be aware of when addressing primary LED.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cynthia Sung, Wan Jiao, Sun Young Park, Michael Cooper, Antoun Bouz, Dahae Choi, Eunson Jung, Gene Kim, Young Kwon Hong, Alex K. K. Wong
Summary: Secondary lymphedema is a debilitating disease caused by dysfunction of the lymphatic system, characterized by abnormal soft tissue swelling. Despite its high prevalence, there are no approved therapeutic agents that can prevent disease progression. Previous studies have shown that 9-cis-retinoic acid (9-cisRA) has the potential to be repurposed for lymphedema by promoting lymphangiogenesis. This study demonstrates that the nuclear receptor RXR alpha plays a critical role in the therapeutic efficacy of 9-cisRA in treating postsurgical lymphedema.
Article
Radiology, Nuclear Medicine & Medical Imaging
Michaela Cellina, Daniele Gibelli, Carlo Martinenghi, Denisa Giardini, Massimo Soresina, Andrea Menozzi, Giancarlo Oliva, Gianpaolo Carrafiello
Summary: Cancer-related secondary lymphedema is a common issue affecting patients' quality of life. Currently, there is no consensus on the best imaging technique for its assessment, making diagnosis mainly clinical. Treatment has traditionally been conservative, but new surgical techniques are proving effective in disease management. Non-contrast magnetic resonance lymphography is becoming increasingly important for diagnosis confirmation, grading, and treatment planning.
Review
Immunology
Yoshiki Tokura, Pawit Phadungsaksawasdi, Kazuo Kurihara, Toshiharu Fujiyama, Tetsuya Honda
Summary: Skin T-RM cells are long-term resident immune cells in the skin that can be reactivated upon reinfection with the same antigen, and play different functions in various pathological conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yuuki Shimizu, Yiyang Che, Toyoaki Murohara
Summary: Secondary lymphedema is a result of lymphatic insufficiency following surgery or radiation for breast or pelvic cancer. It leads to reduced quality of life, skin ulcers, pain, and infection. Current countermeasures mainly involve physical therapy, but there is a need for a fundamental and effective treatment. Therapeutic lymphangiogenesis shows promise in reconstructing the lymphatic network and recovering lymphatic vessel function, offering a potential cure for lymphedema. This review focuses on the translational research and prospects of therapeutic lymphangiogenesis for lymphedema.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Liting Sun, Yuzhen Sun, Wuyan Xin, Jiangman He, Yuan Hu, Hanyin Zhang, Jianbin Yu, Jiang-An Zhang
Summary: This study reported a case of cutaneous diffuse large B-cell lymphoma (DLBCL) associated with chronic lymphedema of the lower limbs. Histopathological and immunohistochemical studies confirmed the association between this cutaneous lymphoma and lymphedema, especially the expression of CD5.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2022)
Article
Surgery
Jin Geun Kwon, Seongsu Jeong, Changsik John Pak, Hyunsuk Peter Suh, Joon Pio Hong
Summary: This study compared the efficacy of end-to-end and side-to-end lymphaticovenous anastomosis in different stages of lymphedema, revealing significantly better volume reduction in the side-to-end group for advanced-phase lymphedema patients. No difference was found in early-phase patients.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Surgery
Maureen Beederman, Rebecca M. Garza, Shailesh Agarwal, David W. Chang
Summary: The long-term impact of VLNT and LVB surgeries on secondary lymphedema patients was examined in this study. The results showed that most UEL patients and some LEL patients experienced a reduction in affected limb volume after surgery. UEL patients had a more substantial reduction in limb volume differential compared to LEL patients.
Review
Cardiac & Cardiovascular Systems
Muhammed Gercek, Volker Rudolph
Summary: Tricuspid regurgitation can be divided into primary and secondary origins, with the natural cause of secondary TR not well-understood and likely underdiagnosed. Assessment of TR is challenging due to late manifestation of symptoms and requires a multiparametric approach.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Dermatology
Giovanni Damiani, Laura C. Gironi, Ayman Grada, Khalaf Kridin, Renata Finelli, Alessandra Buja, Nicola L. Bragazzi, Paolo D. M. Pigatto, Paola Savoia
Summary: Wearing masks during lockdown may exacerbate acne and rosacea, leading to a decrease in patients' quality of life. Further studies are needed to explore this phenomenon.
DERMATOLOGIC THERAPY
(2021)
Review
Infectious Diseases
Christopher G. Bunick, Jonette Keri, S. Ken Tanaka, Nika Furey, Giovanni Damiani, Jodi L. Johnson, Ayman Grada
Summary: Sarecycline, a narrow-spectrum third-generation tetracycline-class antibiotic approved by the FDA for treating moderate-to-severe acne, exhibits activity against Gram-positive bacteria, particularly Staphylococcus aureus, with reduced efficacy against Gram-negative bacteria like Escherichia coli. Its unique C7 moiety interacts with bacterial ribosomes to block translation and prevent resistance, showing promising results in in vivo studies of infection and inflammation.
Review
Pharmacology & Pharmacy
Diem-Phuong D. Dao, Vikram Nath Sahni, Dev Ram Sahni, Esther A. Balogh, Ayman Grada, Steven R. Feldman
Summary: Tirbanibulin is a new topical treatment for AKs with a favorable safety profile and shorter duration, leading to effective reduction of AK burden with mild adverse events. Compared to other treatments, tirbanibulin has fewer side effects and better efficacy.
ANNALS OF PHARMACOTHERAPY
(2022)
Letter
Dermatology
Alessia Pacifico, Paolo D. M. Pigatto, Antonio Cristaudo, Diego Orsini, Alessandra Buja, Dennis Linder, Ayman Grada, Giovanni Damiani
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Ayman Grada, James Q. Del Rosso, Emmy Graber, Christopher G. Bunick, Linda Stein Gold, Angela Y. Moore, Hilary Baldwin, Zaidal Obagi, Giovanni Damiani, Timothy Carrothers, Brian McNamee, Eva Hanze
Summary: The study investigated the impact of food intake on the absorption and clinical efficacy of sarecycline, a new oral narrow-spectrum third-generation tetracycline-class antibiotic approved for acne vulgaris treatment. Co-administration with high-fat food was found to decrease exposure by 21.7%, but had limited impact on clinical efficacy, allowing for weight-based dosing and flexibility in administration.
DERMATOLOGIC THERAPY
(2022)
Article
Infectious Diseases
Mahmoud A. Ghannoum, Lisa Long, Christopher G. Bunick, James Q. Del Rosso, Ahmed Gamal, Stephen K. Tyring, Thomas S. McCormick, Ayman Grada
Summary: This study evaluated the impact of sarecycline on gut microbiota and found that it had reduced antimicrobial activity compared to minocycline against a wide range of microorganisms. This suggests that sarecycline is less disruptive to gut microbiota.
Article
Infectious Diseases
Ayman Grada, Mahmoud A. Ghannoum, Christopher G. Bunick
Summary: We evaluated the clinical effectiveness of oral sarecycline against cutaneous staphylococcal infections, eyelid stye, and mucous membrane pemphigoid and found that sarecycline is a viable option for clinicians to practice improved antibiotic stewardship. Our findings demonstrate the superiority of sarecycline over broad-spectrum tetracyclines in treating staphylococcal skin infections and inflammatory skin diseases.
Article
Infectious Diseases
Patrick O. Perche, Gabrielle M. Peck, Lillian Robinson, Ayman Grada, Alan B. Fleischer Jr, Steven R. Feldman
Summary: Acne vulgaris is a common reason for patients to seek care from dermatologists in the US, but referring providers may be hesitant to prescribe acne treatments or certain medications. A study analyzed prescription rates for acne therapies from 1993 to 2016 and found that younger patients and privately insured patients were more likely to receive prescription treatments. Dermatologists were more likely to recommend prescription medications compared to family medicine and pediatric providers. Oral minocycline and oral doxycycline were the most commonly prescribed antibiotics, while benzoyl peroxide was the most utilized and recommended over-the-counter drug for acne.
Article
Dermatology
Todd Schlesinger, Eggert Stockfleth, Ayman Grada, Brian Berman
Summary: This article summarizes the preclinical and clinical evidence of tirbanibulin as an effective and safe treatment option for actinic keratosis. Tirbanibulin significantly inhibits cell proliferation, tumor growth, and down-regulates Src signaling. Early phase and Phase III trials have shown high lesion clearance, compliance, and few side effects of once daily tirbanibulin treatment.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2022)
Review
Rheumatology
Eleni Pilitsi, Brooke Kennamer, Nicole Trepanowski, Reina Gonzalez, Marcin Trojanowski, Tania Phillips, Christina S. Lam
Summary: TAO is a non-atherosclerotic inflammatory disease strongly associated with tobacco use in young adults. CA, a subtype of TAO, shares similar clinical and pathological features and is described in marijuana users. Distinguishing between TAO and CA is challenging due to concurrent tobacco and marijuana use.
CLINICAL RHEUMATOLOGY
(2023)
Letter
Dermatology
Julie C. Harper, April Armstrong, Richard G. Fried, Evan A. Rieder, Andrew F. Alexis, Raidah J. Salem, Ismail Kasujee, Ayman Grada
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ivan B. Lomakin, Swapnil C. Devarkar, Shivali Patel, Ayman Grada, Christopher G. Bunick
Summary: Acne vulgaris is a chronic skin disease that negatively affects the physical and mental health of approximately 1 billion people worldwide. Through cryogenic electron microscopy, we discovered that sarecycline, an antibiotic against Cutibacterium acnes, can inhibit two active sites on the ribosome of this bacterium, unlike the previously detected one site on a model ribosome. The structure also revealed unique features of the ribosomal RNA and proteins in Cutibacterium acnes.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Infectious Diseases
Rachel E. Tao, Stuti Prajapati, Jessica N. Pixley, Ayman Grada, Steven R. Feldman
Summary: Tetracycline-class drugs are commonly used in dermatology for treating skin diseases. This study reviewed the available evidence on whether taking these drugs with food affects their absorption and clinical efficacy. The study found that co-administration with food decreased systemic absorption of tetracycline, while the impact on doxycycline and minocycline varied. Oral sarecycline showed decreased absorption with food. Only sarecycline demonstrated limited or no impact of food intake on clinical efficacy. The study suggested considering patient adherence when choosing to take doxycycline, minocycline, and sarecycline with food.
Review
Infectious Diseases
Faraz Yousefian, Roksana Hesari, Taylor Jensen, Sabine Obagi, Ala Rgeai, Giovanni Damiani, Christopher G. Bunick, Ayman Grada
Summary: Wound management is a significant challenge in clinical practice, and antimicrobial dressings have emerged as a promising approach to control bioburden and promote wound healing. The selection of suitable dressings depends on factors such as cost, wound type, and local microbial burden.
Article
Dermatology
Alessandra Buja, Andrea Miatton, Claudia Cozzolino, Lorenzo Monasta, Ayman Grada, Chante Aksut Karimkhani, Mohsen Naghavi, Giovanni Damiani
Summary: Seborrheic dermatitis is a chronic skin disease that affects infants, adolescents, and adults. The prevalence of the disease varies between geographical regions, but the overall age-standardized prevalence has remained stable over a 30-year period.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)