Article
Surgery
Lisa Dominowski, Michael Kirsch
Summary: The combined application of beta-alanine and aprotinin in an acute mesenteric ischemia and reperfusion rat model provided synergistic protection with reduced tissue damage, inflammatory response, stabilized blood pressure and blood glucose levels, ultimately leading to improved survival rates.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Immunology
Zhen Cao, Silong Mu, Maihuan Wang, Yun Zhang, Guijun Zou, Xinpu Yuan, Yun Huang, Siwang Yu, Jinming Zhang, Chaojun Zhang
Summary: Intestinal ischemia-reperfusion (I/R) injury disrupts the intestinal barrier composed of tight junction proteins, leading to the entry of bacteria and endotoxins into the bloodstream and causing distant organ damage. This study investigated the role of succinate, an intermediate product of the tricarboxylic acid cycle, in intestinal I/R injury, and found that pretreatment with succinate reduced tissue damage, necroptosis, and inflammation. The protective effect of succinate was associated with the upregulation of the inflammatory protein KLF4 and was diminished after inhibition of KLF4.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Fernanda Yamamoto Ricardo-da-Silva, Evelyn Thais Fantozzi, Sara Rodrigues-Garbin, Helori Vanni Domingos, Ricardo Martins Oliveira-Filho, Bernardo Boris Vargaftig, Yanira Riffo-Vasquez, Ana Cristina Breithaupt-Faloppa, Wothan Tavares-de-Lima
Summary: The study found that estradiol treatment can improve the deleterious effects of ischemia and reperfusion injury on the intestine, enhance intestinal motility, reduce intestinal permeability, and increase the expression of key proteins. Estradiol treatment also reduces levels of injury markers and inflammatory mediators.
Article
Medicine, Research & Experimental
Abolfazl Badripour, Mohamad Behzadi, Amin Hassanipour, Pasha Reza Shams Azar, Alireza Rahbar, Zhaleh Abbaslou, Elnaz Ehghaghi, Ashkan Piranviseh, Mohammad Mahdi Khavandi, Seyed Mohsen Ahmadi-Tafti, Mohammad Ashouri, Zahra Ebrahim Soltani, Ahmadreza Dehpour
Summary: This study aimed to evaluate the effects of Albendazole pretreatment on mesenteric ischemia reperfusion (MIR) injury. The findings demonstrated that Albendazole could ameliorate the inflammatory response and enhance the ischemia threshold following MIR injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Tamara Merz, Oscar McCook, Cosima Brucker, Christiane Waller, Enrico Calzia, Peter Radermacher, Thomas Datzmann
Summary: The discovery of endogenous H2S with cytoprotective properties has led to efforts in developing H2S as a therapeutic agent. H2S's ability to regulate various processes makes it potentially useful in managing critical illnesses. However, current methods of delivering H2S are not feasible for clinical use. Na2S2O3, a clinically approved compound, shows promise in pre-clinical studies for managing critical illnesses. Clinical trials are investigating its potential in myocardial infarction, and it may also be relevant for pre-eclampsia and COVID-19 pneumonia.
Article
Biochemistry & Molecular Biology
Viktorija Zitkute, Mindaugas Kvietkauskas, Vygante Maskoliunaite, Bettina Leber, Diana Ramasauskaite, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Summary: The study showed that melatonin, glycine, and their combination can significantly reduce ischemia/reperfusion injury in a rat model, potentially by protecting tissue from oxidative stress and inflammation. Further clinical studies are needed to evaluate the protective effects of these substances in uterine IRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Wenjing Lv, Junqi Jiang, Yi Xu, Zhiyuan Chen, Zixuan Wang, Ang Xing, Xueping Zheng, Tingting Qu, Qi Wan
Summary: By using a comprehensive analysis approach, including DEG analysis, WGCNA, and pathway analysis, the genetic transcription profile of brain ischemic and reperfusion injury was studied. It was found that there were 58 upregulated DEGs and some validated core genes associated with stroke in mouse and rat models. Factors such as ischemic treatment and reperfusion time were important confounding factors in gene profile changes. Additionally, modules related to reperfusion time, inflammation, and thrombo-inflammation were identified, and core hub genes within these modules were identified as well. Overall, these findings expand our understanding of the genetic profile involved in brain ischemia and reperfusion, emphasizing the crucial role of inflammatory disequilibrium.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wen-hui Tao, Xi-sheng Shan, Jia-xin Zhang, Hua-yue Liu, Bi-ying Wang, Xiang Wei, Mian Zhang, Ke Peng, Jun Ding, Shang-xian Xu, Lin-gui Li, Jun-kai Hu, Xiao-wen Meng, Fu-hai Ji
Summary: This study revealed that dexmedetomidine protects against acute kidney injury caused by ischemia-reperfusion (I/R) through inhibiting the ACSL4-mediated ferroptosis and inflammation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Jinyan Zhang, Liwei Liu, Zhen Dong, Xicun Lu, Wenxuan Hong, Jin Liu, Xiaoyi Zou, Jinfeng Gao, Hao Jiang, Xiaolei Sun, Kai Hu, Youjun Yang, Junbo Ge, Xiao Luo, Aijun Sun
Summary: This study utilizes a peroxynitrite-triggered carbon monoxide donor to generate a biomimetic carbon monoxide nanogenerator, which is coated with macrophage membrane for targeted delivery to the ischemic area and neutralization of proinflammatory cytokines, effectively improving myocardial ischemia-reperfusion injury. This research provides a new perspective on the safe therapeutic use of carbon monoxide for myocardial ischemia-reperfusion injury by utilizing a novel carbon monoxide donor combined with biomimetic technology. The M/PCOD@PLGA nanogenerator offers targeted delivery of carbon monoxide to the ischemic area, minimizing potential toxicity and enhancing therapeutic efficacy.
BIOACTIVE MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Young Sook Lee, Hadi Javan, Jo-Anna Reems, Ling Li, Jessica Lusty, Christine Schaaf, Jan Pierce, John D. Phillips, Craig H. Selzman
Summary: Cell-free human amniotic fluid, a naturally derived cocktail composed of thousands of proteins involved with innate immunity and anti-inflammation, significantly reduces injury and preserves cardiac function in a model of rodent myocardial ischemia-reperfusion, suggesting its potential as a cardioprotective adjunct.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu-Qiong Lei, Yan-Tong Wan, Guang-Tao Liang, Yu-hao Huang, Peng Dong, Si-dan Luo, Wen-juan Zhang, Wei-Feng Liu, Ke-Xuan Liu, Xi-Yang Zhang
Summary: This study evaluated the effects of extracellular RNAs/TLR3 signaling in intestinal I/R injury. The results showed that extracellular RNAs, especially double-stranded RNAs, were significantly increased and TLR3 knockout attenuated intestinal I/R injury. The extracellular RNAs/TLR3 signaling is a key mechanism that regulates intestinal I/R injury in adult mice.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Immunology
Yuanyuan Wu, Zinah D. Zwaini, Nigel J. Brunskill, Xinyue Zhang, Hui Wang, Ravinder Chana, Cordula M. Stover, Bin Yang
Summary: The study showed that mice lacking Properdin exhibited more severe renal injury during the repair phase post IR, with Properdin playing a crucial role in optimizing damaged cells and regulating phagocytic ability to effectively clear apoptotic cells and reduce inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Qihong Wu, Rong Xu, Kun Zhang, Ran Sun, Mengxi Yang, Kuan Li, Hanrui Liu, Yiyuan Xue, Huayan Xu, Yingkun Guo
Summary: This study comprehensively characterized the physiopathologic changes of myocardial injury after ischemia-reperfusion. It found that the early stage of reperfusion injury is mainly characterized by edema rather than inflammation, and suggested that edema may be a crucial factor contributing to myocardial injury.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Feng Chen, Yi-hong Chai, Fa Zhang, Yong-qiang Liu, Yan Zhang, Ya-jing Shi, Jian-ming Zhang, Yu-fang Leng
Summary: This study investigated the pharmacological mechanism of action of salidroside, a natural product in Rhodiola rosea, on intestinal ischemia-reperfusion (IR) injury. The results showed that salidroside may target AMPK and TXNIP domains to exert its anti-intestinal IR injury effect.
BIOSCIENCE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Hyeonbin Shin, Seungwon Jeong, Yeongjong Lee, Chanhee Jeon, Gayoung Kwon, Sooyeon Kim, Dongwon Lee
Summary: Renal ischemia-reperfusion (IR) injury is a common complication in clinical settings and currently lacks effective treatment. This study developed a novel nanoparticle drug that can protect the kidneys from IR injury by eliminating hydrogen peroxide (H2O2), exerting anti-inflammatory and anti-apoptotic effects. These nanoparticles have potential therapeutic value not only for renal IR injury but also for other inflammatory diseases associated with reactive oxygen species (ROS).
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)