Article
Nutrition & Dietetics
Minkyung Bae, Mi-Bo Kim, Ji-Young Lee
Summary: We found that astaxanthin has an inhibitory effect on the activation of hepatic stellate cells, exerting its antifibrogenic effect through regulating the expression of miRNAs. Specifically, miR-382-5p is significantly upregulated in activated hepatic stellate cells, and this upregulation is inhibited by astaxanthin. Baz1a and Zfp462 may be target genes of miR-382-5p, and further investigation is needed to understand their roles in the activation of hepatic stellate cells and the antifibrogenic effect of astaxanthin.
Article
Plant Sciences
Rong Wang, Shengnan Li, Panpan Chen, Xin Yue, Shaozhan Wang, Yanqiu Gu, Yongfang Yuan
Summary: This study found that Sal B suppresses HSC activation and liver fibrosis by regulating the miR-6499-3p/LncRNA-ROR-mediated NF-kappa B signaling pathway, revealing a new molecular mechanism of Sal B in liver fibrosis.
Article
Medicine, Research & Experimental
Mohamed A. Morsy, Seham A. Abdel-Gaber, Rehab A. Rifaai, Mostafa M. Mohammed, Anroop B. Nair, Walaa Yehia Abdelzaher
Summary: Telmisartan demonstrates protective effects against hepatic I/R injury in rats by modulating oxidative stress parameters, myeloperoxidase levels, PPARγ and TLR4 mRNA expression, as well as NF-κB and caspase-3 immunoexpression.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Feixia Wang, Zhanghao Li, Li Chen, Ting Yang, Baoyu Liang, Zili Zhang, Jiangjuan Shao, Xuefen Xu, Guoping Yin, Shijun Wang, Hai Ding, Feng Zhang, Shizhong Zheng
Summary: ASCT2 plays an important role in liver fibrosis by controlling the senescence of hepatic stellate cells and modifying the proinflammatory senescence-associated secretory phenotype (SASP). Atractylenolide III, identified as an ASCT2 inhibitor, shows potential as a therapeutic candidate for liver fibrosis.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Multidisciplinary
Gen-long Xue, De-sheng Li, Zhi-yong Wang, Yang Liu, Ji-ming Yang, Chang-zhu Li, Xing-da Li, Jiu-dong Ma, Man-man Zhang, Yan-jie Lu, Yue Li, Bao-feng Yang, Zhen-wei Pan
Summary: IL-17 plays a crucial role in regulating cardiac diseases by affecting calcium handling processes and contributing to heart failure development. Inhibition of IL-17 represents a potential therapeutic strategy for the treatment of heart failure.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Pharmacology & Pharmacy
Liying Xu, Feng Ge, Yan Hu, Ying Yu, Kefang Guo, Changhong Miao
Summary: Sevoflurane postconditioning exerts hepatoprotective effects by inhibiting apoptosis, oxidative stress, and inflammatory response, improving survival rates in HIRI mice. Regulation of miR-142 and HMGB1 expression, as well as blocking the TLR4/NF-kappa B pathway activation, contribute to the protective effects of sevoflurane in hepatic I/R injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Tao Luo, Yile Wang, Hailin Tang, Fei Zhou, Ying Chen, Bing Pei, Jinke Wang
Summary: The study presents a recombinant adeno-associated virus (rAAV-DMP-miR533) that shows significant anti-inflammatory effect by directly targeting NF-κB. It also demonstrates the biosafety of the virus in mice.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Oncology
Harald Krenzlin, Mykola Zdioruk, Michal O. Nowicki, Tomer Finkelberg, Naureen Keric, Niels Lemmermann, Magdalena Skubal, E. Antonio Chiocca, Charles H. Cook, Sean E. Lawler
Summary: The study suggests that the CMV-induced upregulation of c-MET may be a potential mechanism involved in the effects of CMV on GBM growth.
Article
Immunology
Jing-yue Zhang, Yu Du, Li-ping Gong, Yi-ting Shao, Jing-yun Wen, Li-ping Sun, Dan He, Jin-rui Guo, Jian-ning Chen, Chun-kui Shao
Summary: This study showed that EBV upregulated CXCL8 expression and promoted VM formation in gastric carcinoma cells. Overexpression of CXCL8 increased cell proliferation and migration, while activation of NF-kappa B signaling was involved in VM formation. EBV-encoded lncRNA RPMS1 also activated the signaling cascade responsible for EBV-induced VM formation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Akouavi Julite I. Quenum, Akhil Shukla, Fjolla Rexhepi, Maryse Cloutier, Amit Ghosh, Thomas A. Kufer, Sheela Ramanathan, Subburaj Ilangumaran
Summary: NLRC5 deficiency disrupts hepatic inflammatory response following chemical injury, but does not significantly aggravate the fibrogenic response. Increased phosphorylation of the NF-kappa B subunit p65 was observed in fibrotic livers of NLRC5-deficient mice, indicating that NLRC5 is not a critical regulator of liver fibrosis pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rongzhi Li, Tomomi Sano, Akiko Mizokami, Takao Fukuda, Takanori Shinjo, Misaki Iwashita, Akiko Yamashita, Terukazu Sanui, Yusuke Nakatsu, Yusuke Sotomaru, Tomoichiro Asano, Takashi Kanematsu, Fusanori Nishimura
Summary: A well-tuned inflammatory response is crucial, and dysregulation of nuclear factor-kappa B (NF-kappa B) is associated with immune-related diseases. This study identified miR-582-5p as a miRNA that modulates NF-kappa B signaling during inflammation. It was found that miR-582-5p targets S-phase kinase-associated protein 1 (SKP1) and attenuates the NF-kappa B pathway, leading to reduced production of pro-inflammatory cytokines. This suggests that exogenous miR-582-5p could be a potential therapeutic strategy for inflammatory and immune diseases.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Pharmacology & Pharmacy
Hongyan Wu, Lixia Wu, Linxia Xiao, Yaqin Gu, Hongxia Liu, Lihu Zhang, Mingguang Zhang, Liang Qi
Summary: Inhibition of the senescence-associated secretory phenotype (SASP) by atractylenolide III (ATR III) promotes senescence in hepatic stellate cells (aHSCs) and reduces the release and expression of SASP factors. ATR III exerts its effect by regulating the cGAS/NF-kappa B signaling pathway. This study suggests that ATR III may be a potential therapeutic agent for liver fibrosis.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Dilaware Khan, Jan Frederick Cornelius, Sajjad Muhammad
Summary: This systematic review examines the role of NF-kappa B in the pathogenesis of intracranial aneurysms (IAs), finding that its activation is closely associated with the formation, progression, and rupture of IAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Guangwen Shu, Xiao Lei, Yecheng Lei, Tiantian Zhang, Hui Sun, Chuo Wang, Anning Song, Xukun Deng
Summary: Our study aimed to investigate the effects and mechanisms of characterized ethanol extract of Rosa rugosa (ERS) on hepatic stellate cells (HSCs) activation and liver fibrosis. ERS suppressed TGF-beta 1-induced activation of LX-2 HSCs by elevating Smad7 and inhibiting phosphorylation of Smad2/3. Knockdown of Smad7 or Hint1 abolished the protective effects of ERS on HSC activation. ERS also mitigated mouse liver fibrosis induced by CCl4 through regulating the Hint1/Smad7 axis.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Melis Olcum, Kemal Ugur Tufekci, Devrim Yagmur Durur, Bora Tastan, Irem Nur Gokbayrak, Kursad Genc, Sermin Genc
Summary: Ethyl pyruvate has anti-inflammatory and pro-metabolic effects, effectively suppressing NLRP3 inflammasome activation in microglial cells by regulating miR-223 and the NF-κB/HMGB1 axis.