Article
Chemistry, Analytical
Yingying Mi, Wei Zheng, Xiangpei Zhao, Xun Zhang, Kang Yang, Gangyi Shen, Weizhi Liu, Wenrui Li, Baiping Ma, Dan Zhu
Summary: In this study, novel qualitative and quantitative methods were established to analyze the compounds in Panzerina lanata. A total of 20 compounds were identified, with five being identified for the first time. The results of the experiment provided valuable information for quality evaluation.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Food Science & Technology
Weili Li, Yushu Liu, Yuxin Ye, Zhengming Che, Tao Wu
Summary: This paper presents a comprehensive chemical profiling of Pixian doubanjiang during fermentation, identifying 99 key metabolites and their association with various metabolic pathways. The metabolite changes are expected to provide insights into the formation of taste and flavor components in PXDB production.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yang Yu, Changliang Yao, De-an Guo
Summary: Liquid chromatography combined with mass spectrometry has greatly contributed to the qualitative analysis of traditional Chinese medicine (TCM) in recent decades, with new approaches continuously introduced to improve analytical performance. The introduction of large data acquisition and post-processing tools has made data processing more efficient and accurate.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Biochemical Research Methods
Ya-Liu Fan, Run-Zhou Liu, Qin Tan, Heng-Li Zhao, Min Song, Rui Wang, Ping Li, Hua Yang
Summary: This study proposed a comprehensive chemical profiling method for traditional Chinese medicine, utilizing a self-built component database and integrated identification strategy to quickly locate potential components and eliminate interfering ions, facilitating in-depth analysis of compounds.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Review
Integrative & Complementary Medicine
Lieyan Huang, Lixing Nie, Zhong Dai, Jing Dong, Xiaofei Jia, Xuexin Yang, Lingwen Yao, Shuang-Cheng Ma
Summary: Mass spectrometry imaging is an advanced technique that allows visualization of chemicals in tissues. It has various applications in traditional Chinese medicine research, including searching for marker components, discovering new compounds, and revealing pharmacological and toxicological mechanisms.
Article
Chemistry, Analytical
Fan Huang, Ziying Wang, Lulu Wang, Ruxia Liu, Chi Ma, Yanzhong Che, Yiwen He, Ji Ye
Summary: This study comprehensively investigated the chemical ingredients and metabolites of Lingbao Huxin Dan (LBHX) using advanced analytical techniques. The researchers identified 53 volatile compounds and 191 non-volatile chemical components in LBHX. In addition, potential active compounds targeting proteins associated with sick sinus syndrome were identified. This study provides important insights for further understanding the mechanism of LBHX in treating cardiovascular diseases.
JOURNAL OF SEPARATION SCIENCE
(2023)
Review
Spectroscopy
Chung-Yu Chen, Yen-Hsien Li, Zuguang Li, Maw-Rong Lee
Summary: Traditional Chinese medicines (TCMs) have been widely used in clinical and healthcare applications. The characterization of the phytochemical components in TCMs is important for studying their therapeutic mechanism. Chromatography combined with mass spectrometry techniques, such as gas chromatography-MS and liquid chromatography-MS, are commonly used for the analysis of trace components in TCM samples. This article also introduces a new ambient ionization MS method for rapid and high-throughput analysis of TCM components.
MASS SPECTROMETRY REVIEWS
(2022)
Review
Plant Sciences
Akhila Ajith, Phillip J. Milnes, Giles N. Johnson, Nicholas P. Lockyer
Summary: The detection and spatial localisation of chemical species in plant tissues are important in plant science. Mass spectrometry imaging combines mass spectrometry with 2D analysis to detect and locate numerous chemical species. This article provides a detailed overview of mass spectrometry imaging methodologies, sample preparation, and data analysis methods. It also reviews the applications of this technique in spatial profiling of metabolites, detection of agrochemicals, and disease diagnosis in plants. The article discusses the challenges in analyzing plant tissues and suggests an integrated approach to maximize the information obtained from samples.
Article
Biochemical Research Methods
Yue-Hua Chen, Si-Yu Li, Dan Wang, Wei Yuan, Kun Xu, Jia-Wei Wang, Ting-Guo Kang, Hui Zhang
Summary: This study analyzed the constituents of different parts of Marsdenia tenacissima using a combinatorics-based chemical characterization strategy. The roots, stems, and leaves of M. tenacissima showed similar antioxidant activity but differed in their α-glucosidase inhibitory activity. The study also identified tenacissoside H as a critical indicator component for quality evaluation, with significantly higher levels in the roots compared to the stems.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Chemistry, Analytical
Yujia Tu, Linnan Li, Zhengtao Wang, Li Yang
Summary: Traditional Chinese medicine injections (TCMIs) are a new form of pharmaceuticals in the modernization of traditional Chinese medicines, with rapid efficacy and improved curative effects. Chemical and biological analysis methods are widely used in the quality control of TCMIs, with emerging techniques being introduced for better control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Review
Medicine, General & Internal
Feng Xie, Tiantian Zhang, Pu Zhang, Xinliang Qu, Min Li, Wei Lan
Summary: The objective of this study was to evaluate the clinical efficacy and safety of Shenkang injection combined with alprostadil in treating chronic renal failure. The results showed that the treatment group had a higher overall response rate compared to the control group, and also showed significant improvements in creatinine clearance rate, serum creatinine, quantitative urine protein, and blood urea nitrogen. There was no statistical difference in the incidence of adverse reactions between the two groups. Further large-scale clinical trials are needed to verify its specific efficacy and safety.
FRONTIERS IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Zhenhao Li, Xiaohui Zhang, Jie Liao, Xiaohui Fan, Yiyu Cheng
Summary: The study introduced a novel fingerprinting method based on multiple reaction monitoring (MRM) for simultaneous detection of approximately 100 constituents for quality assessment of traditional Chinese medicine. Compared to conventional ultraviolet-based fingerprints, the MRM fingerprints demonstrated better discriminatory capacity and robustness under different chromatographic conditions. This approach provides a sensitive, robust, and comprehensive analytical tool for quality assessment of traditional Chinese medicine.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Review
Plant Sciences
Yuan-yuan Ren, Xiao-rui Zhang, Ting-na Li, Yi-jia Zeng, Jin Wang, Qin-wan Huang
Summary: Galla chinensis is a traditional Chinese medicine with diverse pharmacological properties used for over 1400 years. Research has focused on its traditional uses, botanical characteristics, chemical composition, pharmacology, and toxicology, showing potential therapeutic benefits for various diseases. Further studies are needed on the relationship between its components and biological activities, as well as quality control and dynamics of chemical accumulation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Kejun Li, Haiyan Yang, Xin Yuan, Mei Zhang
Summary: This paper provides a brief and systematic review of the determination of heavy metals in traditional Chinese medicine using recently developed atomic techniques, and also discusses the future outlook in this field.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Atikanmu Wahefu, Rahima Abdulla, Xueying Lu, Yongqiang Liu, Haji Akber Aisa
Summary: Caraway, a traditional Uyghur medicine, has been used to treat vitiligo for centuries. In this study, the chemical components present in caraway were comprehensively characterized using ultra-high performance liquid chromatography coupled with hybrid quadrupole orbitrap mass spectrometry. Additionally, a tandem mass spectrometry method was developed and validated for quantitative analysis of specific components in rat plasma.
JOURNAL OF SEPARATION SCIENCE
(2022)
