Article
Orthopedics
Elizabeth Dylke
Summary: This article discusses the measurement methods and techniques for breast cancer-related lymphoedema and evaluates and compares them. The results of the study provide effective methods for assessing patients' lymphoedema and guiding appropriate treatment measures.
JOURNAL OF PHYSIOTHERAPY
(2022)
Article
Physiology
Daichi Shima, Yukihide Nishimura, Takamasa Hashizaki, Yuta Minoshima, Tatsuya Yoshikawa, Yasunori Umemoto, Tokio Kinoshita, Ken Kouda, Fumihiro Tajima, Yoshi-Ichiro Kamijo
Summary: The study investigated whether arm and leg ergometer exercises could be used for core strengthening and whether different exercise sites would affect the results. The results showed that both arm and leg ergometer exercises effectively increased muscle activity in the erector spinae and multifidus. This provides an alternative method for individuals who are unable to perform traditional core strengthening exercises.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Nursing
Patricia Martinez-Jaimez, Miriam Armora Verdu, Carlos G. Forero, Samantha Alvarez Salazar, Pilar Fuster Linares, Cristina Monforte-Royo, Jaume Masia
Summary: This study aimed to identify risk factors for lymphoedema following ALND in a European sample and propose a prediction model. The model included factors such as lymph node dissection level, status, post-operative complications, BMI, and number of lymph nodes extracted, showing good sensitivity in predicting lymphoedema risk. Nurses play a key role in providing holistic care and the model offers a tool for assessing lymphoedema risk in women undergoing ALND.
JOURNAL OF ADVANCED NURSING
(2022)
Article
Medicine, General & Internal
Figen Dag, Ozlem Bolgen Cimen, Okan Dogu
Summary: The study revealed that an 8-week arm crank ergometer training led to significant improvements in aerobic capacity, physical performance, and Parkinson's disease-related disabilities in patients.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Yuma Fuse, Ryo Karakawa, Tomoyuki Yano, Hidehiko Yoshimatsu
Summary: The study evaluated the efficacy of lymph-venous anastomosis (LVA) for breast cancer-related lymphoedema (BCRL) patients with a history of docetaxel use. Results showed that LVA was comparably effective for patients who had undergone docetaxel-based chemotherapy before or after axillary lymph node dissection (ALND).
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Aomei Shen, Qian Lu, Liyuan Zhang, Jingru Bian, Fei Zhu, Zijuan Zhang, Wanmin Qiang
Summary: The aim of this study is to identify factors predicting the development of breast cancer-related lymphoedema (BCRL), clarify the predicting mechanism, and determine the credibility of risk factors. The researchers will conduct a comprehensive systematic search in multiple databases and assess the methodological quality of included studies. Based on the results and associated factors, they will provide suggestions for clinical practice and future research.
Article
Oncology
Yang Yang Huang, Pei Yinn Toh, Catherine Hunt, Joshua Tzi Wei Lin, Roshi Kamyab, Ananda Kallyani Ponniah
Summary: Immediate and delayed axillary lymph node dissections have comparable outcomes in terms of arm lymphoedema and morbidity compared to sentinel lymph node biopsies alone. Preoperative appropriate patient selection for axillary surgery treatment may improve lymphoedema outcomes in breast cancer patients.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Sandra C. Hayes, Matthew Dunn, Melanie L. Plinsinga, Hildegard Reul-Hirche, Yumeng Ren, E-Liisa Laakso, Melissa A. Troester
Summary: This study found that upper-body symptoms are common in women with invasive breast cancer and are associated with poorer upper-body function, lower physical activity levels, and lower quality of life. Furthermore, the presence of these symptoms may predict an increased risk of developing breast cancer-related lymphoedema (BCRL).
Article
Oncology
Sacha A. Roberts, Tessa C. Gillespie, Amy M. Shui, Cheryl L. Brunelle, Kayla M. Daniell, Joseph J. Locascio, George E. Naoum, Alphonse G. Taghian
Summary: This study aimed to determine the relationship between postoperative weight change and breast cancer-related lymphedema. The findings suggest that weight loss alone may not decrease the risk of developing BCRL.
Article
Oncology
Louise A. Koelmeyer, Emma Moloney, John Boyages, Kerry A. Sherman, Catherine M. Dean
Summary: The study found that the prospective surveillance model in the home with BIS is feasible and leads to increased self-management. A Phase II randomized trial is needed, as well as research into the costs of implementing this model of care for high-risk individuals.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Review
Oncology
S. Fresno-Alba, A. Denche-Zamorano, R. Pastor-Cisneros, D. Pereira-Payo, J. M. Franco-Garcia, R. Jimenez-Castuera
Summary: Breast cancer is a significant global health issue that has a profound impact on various aspects of a woman's life. Physical exercise is a non-pharmacological treatment that can improve self-esteem, quality of life, fatigue, and psychological factors associated with breast cancer. It is also associated with a reduction in treatment side effects.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Vesile Yildiz Kabak, Ceren Gursen, Ayca Aytar, Turkan Akbayrak, Tulin Duger
Summary: The study found that female patients with BCRL have lower physical activity levels compared to healthy controls, but a higher percentage of BCRL patients engage in regular exercise. The most common exercise barriers were fatigue, other responsibilities, and weather-related factors. Most participants preferred supervised, structured, combined-type, and moderate intensity exercise programs, and preferred to be informed by a physiotherapist at the time of cancer diagnosis.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Oncology
Bolette S. Rafn, Jan Christensen, Anders Larsen, Kira Bloomquist
Summary: The study found that participation in prospective surveillance with early management can reduce the risk of chronic lymphedema in breast cancer patients. Only a small number of patients who are at high risk of lymphedema due to axillary surgery develop chronic lymphedema. More research is needed to determine whether prospective surveillance with early management can reduce the risk of chronic lymphedema, especially for cancer survivors other than breast cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Miwako Deguchi, Hisayo Yokoyama, Nobuko Hongu, Atsuya Toya, Takahiro Matsutake, Yuta Suzuki, Daiki Imai, Yuko Yamazaki, Masanori Emoto, Kazunobu Okazaki, Elena Amaricai, Roxana Ramona Onofrei, Oana Suciu, Alexandru Florian Crisan
Summary: This study evaluated whether exercise testing with the upper limbs can be used equivalently to that of the lower limbs in assessing exercise capacity. The results suggested that exercise capacity assessed by exercise testing with the upper limbs is underestimated, regardless of the training status of the upper limbs.
APPLIED SCIENCES-BASEL
(2023)
Review
Oncology
Emma Byrne, Jane Gaffey, Lucy Hayden, Adam Daly, Pamela Gallagher, Simon Dunne
Summary: This systematic review aims to explore the state of the science concerning body image in cancer-related lymphoedema, including measurement methods and associated variables. Nine studies with 977 participants were included, and it was found that higher body integrity beliefs, physical changes, and appearance-related thoughts, feelings, and emotions were associated with increased body image concerns. Behavioral and psychological interventions were found to have a positive impact on body image outcomes in individuals with lymphoedema.
Article
Gastroenterology & Hepatology
Huy Duc Le, Theresa Pflaum, Johannes Labrenz, Soner Sari, Fabienne Bretschneider, Florian Tran, Arne Lassen, Susanna Nikolaus, Silke Szymczak, Diana Kormilez, Philip Rosenstiel, Stefan Schreiber, Konrad Aden, Christoph Roecken
Summary: This study evaluated histological disease activity in UC patients and found that the Nancy index is a reliable measure. However, there was poor agreement in the assessment of NI grade 1. It is important to specify histological characteristics leading to NI grade 1.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Oncology
Magnus Kock Am Brink, Laura Sophie Dunst, Hans-Michael Behrens, Sandra Krueger, Thomas Becker, Christoph Roecken
Summary: The study investigates the problem of intratumoral heterogeneity (ITH) in gastric cancer (GC), and tests the effects of Ki67 and tumor regression on ITH after neoadjuvant/perioperative chemotherapy. The results suggest that Ki67 is significantly associated with tumor regression and may serve as a predictor for chemotherapy sensitivity and an indicator of ITH.
BRITISH JOURNAL OF CANCER
(2023)
Article
Clinical Neurology
Ulf Jensen-Kondering, Nils G. Margraf, Caroline Weiler, Walter Maetzler, Justina Dargvainiene, Kim Falk, Sarah Philippen, Thorsten Bartsch, Charlotte Flueh, Christoph Roecken, Bettina Moeller, Georg Royl, Alexander Neumann, Norbert Brueggemann, Benjamin Roeben, Claudia Schulte, Benjamin Bender, Daniela Berg, Gregor Kuhlenbaeumer
Summary: This study compared the clinical, radiological, and cerebrospinal fluid marker data of patients with CAA, MLH, AD, and healthy controls. The results showed that cSS was more common in CAA, and MLH with cSS was associated with ICH. The concentrations of cerebrospinal fluid markers differed among the groups.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Cell Biology
Claudia Geismann, Charlotte Hauser, Frauke Grohmann, Christian Schneeweis, Nico Boelter, Jan-Paul Gundlach, Gunter Schneider, Christoph Roecken, Christian Meinhardt, Heiner Schaefer, Stefan Schreiber, Alexander Arlt
Summary: The resistance to systemic therapies in PDAC remains a major challenge in clinical practice, and NF-kappa B activity plays a crucial role in this process. A20, identified as an NF-kappa B target gene, is associated with elevated RelA expression in PDAC patients. Elevated A20 expression leads to resistance to TRAIL-induced apoptosis but not to chemotherapeutic-induced cell death, mediated by its E3-ligase activity-mediating Zink finger domain. Additionally, p62 is found to be indispensable for the TRAIL-mediated apoptosis-inducing pathway affected by A20.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Michaela Kuhlen, Marina Kunstreich, Stefan A. Wudy, Paul-Martin Holterhus, Lienhard Lessel, Dominik T. Schneider, Ines B. Brecht, Denis M. Schewe, Guido Seitz, Christoph Roecken, Christian Vokuhl, Pascal D. Johann, Michael C. Fruehwald, Peter Vorwerk, Antje Redlich
Summary: This study analyzes the clinical characteristics and prognosis of 161 pediatric ACT patients. The findings indicate that age, initial biopsy, tumor spillage, incomplete tumor resection, and unfavorable histology are associated with overall survival and event-free survival.
Letter
Biochemistry & Molecular Biology
J. C. Purrucker, C. Roecken, D. Reuss
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Christian Treitz, Neelis Mueller-Marienburg, Rolf Ruediger Meliss, Peter Urban, Hans-Detlef Axmann, Frank Siebert, Karsten Becker, Klaus Martens, Hans-Michael Behrens, Eva Gericke, Andreas Tholey, Christoph Roecken
Summary: This study found unclassifiable amyloid deposits in the annular ligament during surgical treatment of trigger finger. Using comprehensive analysis methods, it was determined that there are two different types of amyloid affecting the annular ligament, ATTR amyloid and AFib amyloid, with distinct patient characteristics and deposition patterns. The unknown amyloid was identified as most likely of fibrinogen origin.
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2023)
Article
Oncology
Wiebke Siemsen, Christine Halske, Hans-Michael Behrens, Sandra Krueger, Christoph Becker-Pauly, Christoph Roecken
Summary: In this study, the expression of meprin beta in gastric cancer was found to be differentially regulated and correlated with clinicopathological characteristics and patient survival. It may function as either a tumor suppressor or promotor depending on the histological site and context.
Article
Oncology
Dita Ulase, Hans-Michael Behrens, Sandra Krueger, Steffen M. Heckl, Ulrike Ebert, Thomas Becker, Christoph Roecken
Summary: This study analyzed the spatial distribution of LAG3 + cells in gastric cancer and its correlation with clinicopathological and survival data. The results demonstrated significant differences in the spatial distribution of LAG3 + cells and their association with prognosis. The findings highlight the importance of LAG3 as a potential prognostic factor and suggest its role in clinical outcomes and treatment responses.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tim A. Steiert, Genis Parra, Marta Gut, Norbert Arnold, Jean-Remi Trotta, Raul Tonda, Alice Moussy, Zuzana Gerber, Peter M. Abuja, Kurt Zatloukal, Christoph Roecken, Trine Folseraas, Marit M. Grimsrud, Arndt Vogel, Benjamin Goeppert, Stephanie Roessler, Sebastian Hinz, Clemens Schafmayer, Philip Rosenstiel, Jean-Francois Deleuze, Ivo G. Gut, Andre Franke, Michael Forster
Summary: Formalin fixation with paraffin-embedding (FFPE) was developed in the late 19th century and is still commonly used in clinical practice. However, FFPE samples can undergo DNA damage, leading to potential errors in sequencing and analysis. This review discusses mitigation strategies in sample quality control, DNA repair treatments, sample preparation, and bioinformatic analysis of FFPE-DNA.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Clinical Neurology
Hajrullah Ahmeti, Amke Caliebe, Nourane Trigui, Ilay Alati, Christoph Roecken, Olav Jansen, Michael Synowitz, Maximilian H. Mehdorn
Summary: A systematic investigation of 210 patients with convexity meningiomas revealed that large tumor volume and brain infiltration were significant factors for postoperative complications. The clinical conditions of patients significantly improved postoperatively and further during the follow-up period.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Biochemistry & Molecular Biology
Florian Richter, Clara Henssen, Tim Alexander Steiert, Tobias Meissner, Anne-Sophie Mehdorn, Christoph Roecken, Andre Franke, Jan-Hendrik Egberts, Thomas Becker, Susanne Sebens, Michael Forster
Summary: Esophageal cancer (EC) has a high mortality rate, and optimizing therapies and dynamically adapting to individuals is crucial. Liquid biopsy is an increasingly important method for residual disease monitoring, but conflicting detection rates and varying levels of circulating tumor DNA (ctDNA) have been observed in previous studies. This study aims to resolve this discrepancy and found that ctDNA in blood can be used for therapy monitoring of EC patients. A combination of solid and liquid samples should be used to guide individualized EC therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Samir Abdullazade, Hans-Michael Behrens, Sandra Krueger, Jochen Haag, Christoph Roecken
Summary: The study validated gene amplification, protein expression, and tumor biological function of MDM2 in gastric cancer, and found a significant correlation between MDM2 amplification and protein expression. However, MDM2 amplification and expression were not associated with patient survival.
Article
Geriatrics & Gerontology
Patricia Huebbe, Stephanie Bilke, Johanna Rueter, Anke Schloesser, Graeme Campbel, Claus-C. Glueer, Ralph Lucius, Christoph Roecken, Andreas Tholey, Gerald Rimbach
Summary: Recent studies have found that the human APOE epsilon 4 allele protects against non-alcoholic fatty liver disease (NAFLD), while epsilon 3 promotes hepatic steatosis and steatohepatitis. In this study, mice expressing the APOE3 or APOE4 protein isoforms were fed a high-fat and high-sucrose diet to induce obesity. The results showed that APOE3 mice had higher liver weights and exhibited more severe hepatic steatosis compared to APOE4 mice. Proteome analysis also revealed differences in proteins related to inflammation, damage response, and lipid storage between APOE3 and APOE4 mice. These findings support the association of increased NAFLD risk with the APOE epsilon 3 allele and suggest potential mechanisms of protection conferred by APOE epsilon 4.
Article
Medicine, Research & Experimental
Hajrullah Ahmeti, Amke Caliebe, Christoph Rocken, Olav Jansen, Maximilian H. Mehdorn, Michael Synowitz
Summary: This study systematically examined 696 patients with primary intracranial meningiomas to assess the effect of preoperative peritumoral brain edema (PTBE) on preoperative symptoms, neurological deficits, postoperative complications, and long-term outcomes. Results showed that PTBE significantly increased the incidences of specific preoperative symptoms, neurological deficits, and postoperative complications. Patients with preoperative PTBE required more medical support after surgery, but all patients had favorable outcomes.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
