期刊
JOURNAL OF PROTEOMICS
卷 188, 期 -, 页码 97-106出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jprot.2017.08.010
关键词
Predictive, preventive, and personalized medicine; Cancer; Omics strategy; Biomarker discovery
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT and future Planning [NRF-2015R1C1A1A02036315, NRF-2017R1A2B4007859]
Cancer is a global health issue as a multi-factorial complex disease, and early detection and novel therapeutic strategies are required for more effective cancer management. With the development of systemic analytical -omics strategies, the therapeutic approach and study of the molecular mechanisms of carcinogenesis and cancer progression have moved from hypothesis-driven targeted investigations to data-driven untargeted investigations focusing on the integrated diagnosis, treatment, and prevention of cancer in individual patients. Predictive, preventive, and personalized medicine (PPPM) is a promising new approach to reduce the burden of cancer and facilitate more accurate prognosis, diagnosis, as well as effective treatment. Here we review the fundamentals of, and new developments in,-omics technologies, together with the key role of a variety of practical-omics strategies in PPPM for cancer treatment and diagnosis. Biological significance: In this review, a comprehensive and critical overview of the systematic strategy for predictive, preventive, and personalized medicine (PPPM) for cancer disease was described in a view of cancer prognostic prediction, diagnostics, and prevention as well as cancer therapy and drug responses. We have discussed multi-dimensional data obtained from various resources and integration of multisciplinary omics strategies with computational method which could contribute the more effective PPPM for cancer. This review has provided the novel insights of the current applications of each and combined-omics technologies, which showed their powerful potential for the establishment of PPPM for cancer
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