Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth

Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth

(2016) Fredrick J. Rosario et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Down-Regulation of Placental Transport of Amino Acids Precedes the Development of Intrauterine Growth Restriction in Maternal Nutrient Restricted Baboons

(2016) P. Pantham et al.   BIOLOGY OF REPRODUCTION

Expression and correlation of sex hormone-binding globulin and insulin signal transduction and glucose transporter proteins in gestational diabetes mellitus placental tissue

(2016) Bao Zhang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Low Oxygen Tension Modulates the Insulin-Like Growth Factor-1 or -2 Signaling via Both Insulin-Like Growth Factor-1 Receptor and Insulin Receptor to Maintain Stem Cell Identity in Placental Mesenchymal Stem Cells

(2016) Amer Youssef et al.   ENDOCRINOLOGY

Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes

(2016) J. Martino et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Placental Origins of Chronic Disease

(2016) Graham J. Burton et al.   PHYSIOLOGICAL REVIEWS

Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation

(2016) Amanda N. Sferruzzi-Perri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocorticoid receptor-mediated insulin-like growth factor-I transcriptional regulation in BeWo trophoblast cells before and after syncytialisation

(2016) Bin He et al.   STEROIDS

Role of IGF Binding Proteins in Regulating Metabolism

(2016) David R. Clemmons   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Insulin-like growth factor axis in pregnancies affected by fetal growth disorders

(2016) Aamod R. Nawathe et al.   Clinical Epigenetics

Placental Nutrient Transport and Intrauterine Growth Restriction

(2016) Francesca Gaccioli et al.   Frontiers in Physiology

The Programming Power of the Placenta

(2016) Amanda N. Sferruzzi-Perri et al.   Frontiers in Physiology

Tumor-homing peptides as tools for targeted delivery of payloads to the placenta

(2016) A. King et al.   Science Advances

Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy

(2015) Paula Díaz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Reduced placental amino acid transport in response to maternal nutrient restriction in the baboon

(2015) Priyadarshini Pantham et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling

(2015) Liam C. Hunt et al.   GENES & DEVELOPMENT

Maternal insulin-like growth factor 1 and 2 differentially affect the renin–angiotensin system during pregnancy in the guinea pig

(2015) Prue Standen et al.   GROWTH HORMONE & IGF RESEARCH

Intraplacental Gene Therapy with Ad-IGF-1 Corrects Naturally Occurring Rabbit Model of Intrauterine Growth Restriction

(2015) Sundeep G. Keswani et al.   HUMAN GENE THERAPY

Placenta nutrient transport-related gene expression: the impact of maternal obesity and excessive gestational weight gain

(2015) Kendra Elizabeth Brett et al.   Journal of Maternal-Fetal & Neonatal Medicine

Morphological and molecular changes in the murine placenta exposed to normobaric hypoxia throughout pregnancy

(2015) Hannah Matheson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hypoxia, AMPK activation and uterine artery vasoreactivity

(2015) K. L. Skeffington et al.   JOURNAL OF PHYSIOLOGY-LONDON

Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy

(2015) J. S. Higgins et al.   JOURNAL OF PHYSIOLOGY-LONDON

Corticosterone alters materno-fetal glucose partitioning and insulin signalling in pregnant mice

(2015) O. R. Vaughan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth

(2015) Fredrick J. Rosario et al.   Obesity

Prenatal physical activity and diet composition affect the expression of nutrient transporters and mTOR signaling molecules in the human placenta

(2015) K.E. Brett et al.   PLACENTA

Development of Non-Viral, Trophoblast-Specific Gene Delivery for Placental Therapy

(2015) Noura Abd Ellah et al.   PLoS One

Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth

(2015) Irving L. M. H. Aye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal distress associates with placental genes regulating fetal glucocorticoid exposure and IGF2: Role of obesity and sex

(2015) Theresia H. Mina et al.   PSYCHONEUROENDOCRINOLOGY

Pre-gestational vs gestational exposure to maternal obesity differentially programs the offspring in mice

(2014) Isaac E. Sasson et al.   DIABETOLOGIA

Low-Oxygen Tension and IGF-I Promote Proliferation and Multipotency of Placental Mesenchymal Stem Cells (PMSCs) from Different Gestations via Distinct Signaling Pathways

(2014) Amer Youssef et al.   ENDOCRINOLOGY

Mid- to late term hypoxia in the mouse alters placental morphology, glucocorticoid regulatory pathways and nutrient transporters in a sex-specific manner

(2014) J. S. M. Cuffe et al.   JOURNAL OF PHYSIOLOGY-LONDON

Insulin-like growth factor I induces proliferation and migration of porcine trophectoderm cells through multiple cell signaling pathways, including protooncogenic protein kinase 1 and mitogen-activated protein kinase

(2014) Wooyoung Jeong et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Statins inhibit insulin-like growth factor action in first trimester placenta by altering insulin-like growth factor 1 receptor glycosylation

(2014) Karen Forbes et al.   MOLECULAR HUMAN REPRODUCTION

Diabetes-associated changes in the fetal insulin/insulin-like growth factor system are organ specific in rats

(2014) Verónica White et al.   PEDIATRIC RESEARCH

IGF-IR Signal Transduction Protein Content and Its Activation by IGF-I in Human Placentas: Relationship with Gestational Age and Birth Weight

(2014) Germán Iñiguez et al.   PLoS One

Regulation of Human Trophoblast GLUT1 Glucose Transporter by Insulin-Like Growth Factor I (IGF-I)

(2014) Marc U. Baumann et al.   PLoS One

Diet reduction to requirements in obese/overfed ewes from early gestation prevents glucose/insulin dysregulation and returns fetal adiposity and organ development to control levels

(2013) Nuermaimaiti Tuersunjiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Maternal Overweight Induced by a Diet with High Content of Saturated Fat Activates Placental mTOR and eIF2alpha Signaling and Increases Fetal Growth in Rats1

(2013) Francesca Gaccioli et al.   BIOLOGY OF REPRODUCTION

An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory

(2013) Amanda N. Sferruzzi-Perri et al.   FASEB JOURNAL

Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon

(2013) Jovita V. Kavitha et al.   FASEB JOURNAL

Recapitulation of characteristics of human placental vascular insufficiency in a novel mouse model

(2013) M. Habli et al.   PLACENTA

The effects of an obesogenic diet during pregnancy on fetal growth and placental gene expression are gestation dependent

(2013) V. King et al.   PLACENTA

Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta

(2013) E.M. Gårdebjer et al.   PLACENTA

Regulation of amino acid transporters by adenoviral-mediated human insulin-like growth factor-1 in a mouse model of placental insufficiency in vivo and the human trophoblast line BeWo in vitro

(2013) H. Jones et al.   PLACENTA

Mild Gestational Hyperglycemia in Rat Induces Fetal Overgrowth and Modulates Placental Growth Factors and Nutrient Transporters Expression

(2013) Ouma Cisse et al.   PLoS One

Adenoviral-Mediated Placental Gene Transfer of IGF-1 Corrects Placental Insufficiency via Enhanced Placental Glucose Transport Mechanisms

(2013) Helen N. Jones et al.   PLoS One

Sildenafil Citrate Increases Fetal Weight in a Mouse Model of Fetal Growth Restriction with a Normal Vascular Phenotype

(2013) Mark Robert Dilworth et al.   PLoS One

Gestational Protein Restriction Reduces Expression of Hsd17b2 in Rat Placental Labyrinth1

(2012) Haijun Gao et al.   BIOLOGY OF REPRODUCTION

Improvement of insulin sensitivity promotes extravillous trophoblast cell migration stimulated by insulin-like growth factor-I

(2012) Reiko Mayama et al.   ENDOCRINE JOURNAL

Insulin-like growth factor-II and heparin are anti-apoptotic survival factors in human villous cytotrophoblast

(2012) Frank A. Hills et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non-native women at high altitude

(2012) Hong Wa Yung et al.   FASEB JOURNAL

Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development

(2012) Lindsey N. Kent et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Phosphatase of Regenerating Liver 2 (PRL2) Is Essential for Placental Development by Down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and Activating Akt Protein

(2012) Yuanshu Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Effect of Insulin Like Growth Factor-I on Constriction of Human Uterine and Placental Arteries

(2012) Jemma J. Corcoran et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Activation of Placental mTOR Signaling and Amino Acid Transporters in Obese Women Giving Birth to Large Babies

(2012) Nina Jansson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Endoplasmic reticulum stress disrupts placental morphogenesis: implications for human intrauterine growth restriction

(2012) Hong wa Yung et al.   JOURNAL OF PATHOLOGY

Maternal corticosterone regulates nutrient allocation to fetal growth in mice

(2012) Owen R. Vaughan et al.   JOURNAL OF PHYSIOLOGY-LONDON

The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r

(2012) Andrew Keniry et al.   NATURE CELL BIOLOGY

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

The emerging role of mTORC1 signaling in placental nutrient-sensing

(2012) T. Jansson et al.   PLACENTA

Weekly Intra-Amniotic IGF-1 Treatment Increases Growth of Growth-Restricted Ovine Fetuses and Up-Regulates Placental Amino Acid Transporters

(2012) Jibran A. Wali et al.   PLoS One

Metabolic Induction and Early Responses of Mouse Blastocyst Developmental Programming following Maternal Low Protein Diet Affecting Life-Long Health

(2012) Judith J. Eckert et al.   PLoS One

Maternal Diets Trigger Sex-Specific Divergent Trajectories of Gene Expression and Epigenetic Systems in Mouse Placenta

(2012) Anne Gabory et al.   PLoS One

Placental adaptations to the maternal–fetal environment: implications for fetal growth and developmental programming

(2012) Ionel Sandovici et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Endostatin Suppresses IGF-II-Mediated Signaling and Invasion of Human Extravillous Trophoblasts

(2011) Jürgen Pollheimer et al.   ENDOCRINOLOGY

Fetal Programming of Gene Expression in Growth-Restricted Rats Depends on the Cause of Low Birth Weight

(2011) Kai-Dietrich Nüsken et al.   ENDOCRINOLOGY

Placental-SpecificIgf2Deficiency Alters Developmental Adaptations to Undernutrition in Mice

(2011) A. N. Sferruzzi-Perri et al.   ENDOCRINOLOGY

Maternal Protein Restriction in the Rat Inhibits Placental Insulin, mTOR, and STAT3 Signaling and Down-Regulates Placental Amino Acid Transporters

(2011) Fredrick J. Rosario et al.   ENDOCRINOLOGY

Gene expression patterns of insulin-like growth factor 1, 2 (IGF-1, IGF-2) and insulin-like growth factor binding protein 3 (IGFBP-3) in human placenta from preterm deliveries: influence of additional factors

(2011) Csaba Demendi et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth

(2011) Emily Angiolini et al.   FASEB JOURNAL

Biology and significance of signalling pathways activated by IGF-II

(2011) Lynda K. Harris et al.   GROWTH FACTORS

Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction

(2011) Balázs Börzsönyi et al.   JOURNAL OF PERINATAL MEDICINE

Dietary composition programmes placental phenotype in mice

(2011) P. M. Coan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Igf2 ligand dependency of Pten+/− developmental and tumour phenotypes in the mouse

(2011) D N Church et al.   ONCOGENE

Upregulation of growth signaling and nutrient transporters in cotyledons of early to mid-gestational nutrient restricted ewes☆

(2011) Y. Ma et al.   PLACENTA

Sex specific changes in placental growth and MAPK following short term maternal dexamethasone exposure in the mouse

(2011) J.S.M. Cuffe et al.   PLACENTA

System A activity and vascular function in the placental-specific Igf2 knockout mouse

(2011) L.C. Kusinski et al.   PLACENTA

A maternal high-fat diet in rat pregnancy reduces growth of the fetus and the placental junctional zone, but not placental labyrinth zone growth

(2011) P. J. Mark et al.   Journal of Developmental Origins of Health and Disease

Maternal obesity and overnutrition alter fetal growth rate and cotyledonary vascularity and angiogenic factor expression in the ewe

(2010) Yan Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Maternal obesity markedly increases placental fatty acid transporter expression and fetal blood triglycerides at midgestation in the ewe

(2010) Mei J. Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

IGF2 Actions on Trophoblast in Human Placenta Are Regulated by the Insulin-Like Growth Factor 2 Receptor, Which Can Function as Both a Signaling and Clearance Receptor1

(2010) Lynda K. Harris et al.   BIOLOGY OF REPRODUCTION

Tumor Necrosis Factor-α (TNF-α) Inhibits Insulin-like Growth Factor-I (IGF-I) Activities in Human Trophoblast Cell Cultures Through IGF-I/Insulin Hybrid Receptors

(2010) Reiko HASHIMOTO et al.   ENDOCRINE JOURNAL

Impairment of insulin receptor signal transduction in placentas of intra-uterine growth-restricted newborns and its relationship with fetal growth

(2010) M E Street et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Effect of pituitary growth hormone and insulin-like growth factor type-I on proliferation, apoptosis and hormone secretion of the placental cell line JEG-3

(2010) Agnieszka Rak-Mardyła et al.   GYNECOLOGICAL ENDOCRINOLOGY

The neglected role of insulin-like growth factors in the maternal circulation regulating fetal growth

(2010) A. N. Sferruzzi-Perri et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sex- and Diet-Specific Changes of Imprinted Gene Expression and DNA Methylation in Mouse Placenta under a High-Fat Diet

(2010) Catherine Gallou-Kabani et al.   PLoS One

Placental-specific Igf2 knockout mice exhibit hypocalcemia and adaptive changes in placental calcium transport

(2010) M. R. Dilworth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

eNOS, NO, and the Activation of ERK and AKT Signaling at Mid-Gestation and Near-Term in an Ovine Model of Intrauterine Growth Restriction

(2010) Juan A. Arroyo et al.   Systems Biology in Reproductive Medicine

Placental gene transfer: transgene screening in mice for trophic effects on the placenta

(2009) Anna B. Katz et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Placental mammalian target of rapamycin and related signaling pathways in an ovine model of intrauterine growth restriction

(2009) Juan A. Arroyo et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Insulin-like growth factor-II regulates maternal hemodynamic adaptation to pregnancy in rats

(2009) Tim Van Mieghem et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Raised Late Pregnancy Glucose Concentrations in Mice Carrying Pups With Targeted Disruption of H19 13

(2009) C. J. Petry et al.   DIABETES

The Protein-Tyrosine Phosphatase, Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2, Is a Crucial Mediator of Exogenous Insulin-Like Growth Factor Signaling to Human Trophoblast

(2009) Karen Forbes et al.   ENDOCRINOLOGY

Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus

(2009) Michelle Colomiere et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Placental efficiency and adaptation: endocrine regulation

(2009) A. L. Fowden et al.   JOURNAL OF PHYSIOLOGY-LONDON

Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice

(2009) P. M. Coan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of Placental Growth Hormone Secretion in a Human Trophoblast Model—The Effects of Hormones and Adipokines

(2009) Willibald Zeck et al.   PEDIATRIC RESEARCH

Prenatal stress programming of offspring feeding behavior and energy balance begins early in pregnancy

(2009) Diana E. Pankevich et al.   PHYSIOLOGY & BEHAVIOR

Placental Glycogen Stores are Increased in Mice with H19 Null Mutations but not in those with Insulin or IGF Type 1 Receptor Mutations

(2009) Diego R. Esquiliano et al.   PLACENTA

Down-Regulation of Growth Signaling Pathways Linked to a Reduced Cotyledonary Vascularity in Placentomes of Over-Nourished, Obese Pregnant Ewes

(2009) M.J. Zhu et al.   PLACENTA

Human placental IGF-I and IGF-II expression: correlating maternal and infant anthropometric variables and micronutrients at birth in the Pakistani population

(2008) SK Akram et al.   ACTA PAEDIATRICA

Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

(2008) Hong-wa Yung et al.   AMERICAN JOURNAL OF PATHOLOGY

Insulin-like growth factor I and II regulate the life cycle of trophoblast in the developing human placenta

(2008) Karen Forbes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Insulin-Like Growth Factor II Activates Phosphatidylinositol 3-Kinase-Protooncogenic Protein Kinase 1 and Mitogen-Activated Protein Kinase Cell Signaling Pathways, and Stimulates Migration of Ovine Trophectoderm Cells

(2008) Jinyoung Kim et al.   ENDOCRINOLOGY

Disproportional effects ofIgf2knockout on placental morphology and diffusional exchange characteristics in the mouse

(2008) P. M. Coan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice

(2008) P. M. Coan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Maternal Insulin-like Growth Factor-II Promotes Placental Functional Development Via the Type 2 IGF Receptor in the Guinea Pig

(2008) A.N. Sferruzzi-Perri et al.   PLACENTA

Peroxisome proliferator-activated receptor α activation regulates lipid metabolism in the feto-placental unit from diabetic rats

(2008) N Martínez et al.   REPRODUCTION