期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 595, 期 15, 页码 5159-5174出版社
WILEY
DOI: 10.1113/JP274291
关键词
microcirculation; metabolic syndrome; skeletal muscle blood flow; venous function
资金
- American Heart Association [IRG 14330015, EIA 0740129N]
- National Institutes of Health [RR 2865AR, P20 RR 016477, R01 DK64668, R01 DK67582]
- Canadian Natural Sciences and Engineering Research Council [NSERC R4081A03, R4218A03]
While research into vascular outcomes of the metabolic syndrome has focused on arterial/arteriolar and capillary levels, investigation into venular function and how this impacts responses has received little attention. Using the in situ cremaster muscle of obese Zucker rats (OZR; with lean Zucker rats (LZR) as controls), we determined indices of venular function. At approximate to 17weeks of age, skeletal muscle post-capillary venular density was reduced by approximate to 20% in LZR vs. OZR, although there was no evidence of remodelling of the venular wall. Venular tone at approximate to 25m (post-capillary) and approximate to 75m (collecting) diameter was elevated in OZR vs. LZR. Venular dilatation to acetylcholine was blunted in OZR vs. LZR due to increased oxidant stress-based loss of nitric oxide bioavailability (post-capillary) and increased (1)- (and (2)-) mediated constrictor tone (collecting). Venular constrictor responses in OZR were comparable to LZR for most stimuli, although constriction to (1)-adrenoreceptor stimulation was elevated. In response to field stimulation of the cremaster muscle (0.5, 1, 3Hz), venular dilator and hyperaemic responses to lower frequencies were blunted in OZR, but responses at 3Hz were similar between strains. Venous production of TxA(2) was higher in OZR than LZR and significantly higher than PGI(2) production in either following arachidonic acid challenge. These results suggest that multi-faceted alterations to skeletal muscle venular function in OZR may contribute to alterations in upstream capillary pressure profiles and the transcapillary exchange of solutes and water under conditions of metabolic syndrome.
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