Cardiac action potential repolarization revisited: early repolarization shows all-or-none behaviour

A Dynamical Threshold for Cardiac Delayed Afterdepolarization-Mediated Triggered Activity

(2016) Michael B. Liu et al.   BIOPHYSICAL JOURNAL

Uncertainty and variability in computational and mathematical models of cardiac physiology

(2016) Gary R. Mirams et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cardiac late Na+ current: Proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress

(2015) Luiz Belardinelli et al.   HEART RHYTHM

A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+current

(2015) Pei-Chi Yang et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Early Repolarization Pattern

(2015) Peter W. Macfarlane et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Comprehensive T wave Morphology Assessment in a Randomized Clinical Study of Dofetilide, Quinidine, Ranolazine, and Verapamil

(2015) J. Vicente et al.   Journal of the American Heart Association

Sex Differences in Cardiac Electrophysiology and Clinical Arrhythmias: Epidemiology, Therapeutics, and Mechanisms

(2014) Rafik Tadros et al.   CANADIAN JOURNAL OF CARDIOLOGY

Screening for Acute I Kr Block Is Insufficient to Detect Torsades de Pointes Liability

(2014) Tao Yang et al.   CIRCULATION

In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome

(2014) Lucia Romero et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

Modulation of ventricular transient outward K+ current by acidosis and its effects on excitation-contraction coupling

(2013) Noriko Saegusa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Electrophysiological changes in heart failure and their implications for arrhythmogenesis

(2013) R. Coronel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Quantification of Transmembrane Currents during Action Potential Propagation in the Heart

(2013) Richard A. Gray et al.   BIOPHYSICAL JOURNAL

Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve

(2013) Zhilin Qu et al.   CARDIOVASCULAR RESEARCH

Ranolazine for Congenital and Acquired Late I Na -Linked Arrhythmias

(2013) Jonathan D. Moreno et al.   CIRCULATION RESEARCH

Subepicardial Action Potential Characteristics Are a Function of Depth and Activation Sequence in Isolated Rabbit Hearts

(2013) Allen Kelly et al.   Circulation-Arrhythmia and Electrophysiology

Critical appraisal of the mechanism underlying J waves

(2013) Mark G. Hoogendijk et al.   JOURNAL OF ELECTROCARDIOLOGY

Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs

(2013) Norbert Jost et al.   JOURNAL OF PHYSIOLOGY-LONDON

Revolution dawning in cardiotoxicity testing

(2013) Kelly Rae Chi   NATURE REVIEWS DRUG DISCOVERY

mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study

(2013) John Walmsley et al.   PLoS One

MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

(2013) James Kramer et al.   Scientific Reports

Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing

(2012) Gary R Mirams et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells

(2012) Zhenghang Zhao et al.   CARDIOVASCULAR RESEARCH

Genetic, Molecular and Cellular Mechanisms Underlying the J Wave Syndromes

(2012) Charles Antzelevitch   CIRCULATION JOURNAL

Beat-to-beat variability of repolarization as a new biomarker for proarrhythmia in vivo

(2012) Rosanne Varkevisser et al.   HEART RHYTHM

Exploiting mathematical models to illuminate electrophysiological variability between individuals

(2012) Amrita X. Sarkar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

(2012) Joanne Bowes et al.   NATURE REVIEWS DRUG DISCOVERY

Markov Models of Use-Dependence and Reverse Use-Dependence during the Mouse Cardiac Action Potential

(2012) Qinlian Zhou et al.   PLoS One

Cardiac ventricular repolarization reserve: a principle for understanding drug-related proarrhythmic risk

(2011) András Varró et al.   BRITISH JOURNAL OF PHARMACOLOGY

Risk of sudden death among young individuals with J waves and early repolarization: Putting the evidence into perspective

(2011) Raphael Rosso et al.   HEART RHYTHM

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis

(2011) Amrita X. Sarkar et al.   HEART RHYTHM

Refining repolarization reserve

(2011) Dan M. Roden et al.   HEART RHYTHM

Distinguishing “benign” from “malignant early repolarization”: The value of the ST-segment morphology

(2011) Raphael Rosso et al.   HEART RHYTHM

Early repolarization patterns: The good, the bad, and the ugly?

(2011) Mark G. Hoogendijk et al.   HEART RHYTHM

Late Phase of Repolarization is Autoregenerative and Scales Linearly with Action Potential Duration in Mammals Ventricular Myocytes: A Model Study

(2011) M. Zaniboni   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Rationale for the Use of the Terms J-Wave Syndromes and Early Repolarization

(2011) Charles Antzelevitch et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

3D current–voltage–time surfaces unveil critical repolarization differences underlying similar cardiac action potentials: A model study

(2011) M. Zaniboni   MATHEMATICAL BIOSCIENCES

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

Effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium

(2010) Rachel C. Myles et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Transmural heterogeneity of repolarization and Ca2+ handling in a model of mouse ventricular tissue

(2010) Vladimir E. Bondarenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

So Little Source, So Much Sink: Requirements for Afterdepolarizations to Propagate in Tissue

(2010) Yuanfang Xie et al.   BIOPHYSICAL JOURNAL

Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death

(2010) Elena Burashnikov et al.   HEART RHYTHM

Sudden Cardio Arrest: When normal ECG variants turn lethal

(2010) Stanley Nattel   NATURE MEDICINE

Drug-Induced Long QT Syndrome

(2010) P. Kannankeril et al.   PHARMACOLOGICAL REVIEWS

Impact of ionic current variability on human ventricular cellular electrophysiology

(2009) Lucía Romero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

J wave syndromes

(2009) Charles Antzelevitch et al.   HEART RHYTHM

Long-Term Outcome Associated with Early Repolarization on Electrocardiography

(2009) Jani T. Tikkanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Feedback Remodeling of Cardiac Potassium Current Expression

(2008) Ling Xiao et al.   CIRCULATION

Repolarization Reserve

(2008) Dan M. Roden   CIRCULATION

Early Repolarization Revisited

(2008) Hein J. Wellens   NEW ENGLAND JOURNAL OF MEDICINE

Sudden Cardiac Arrest Associated with Early Repolarization

(2008) Michel Haïssaguerre et al.   NEW ENGLAND JOURNAL OF MEDICINE

Double pharmacological challenge on repolarization opens new avenues for drug safety research

(2007) M B Thomsen   BRITISH JOURNAL OF PHARMACOLOGY