Article
Ophthalmology
Yuhong Gan, Xiongze Zhang, Yongyue Su, Mei Shen, Yuting Peng, Feng Wen
Summary: This study compared the performance of optical coherence tomography angiography (OCTA) and dye angiography in detecting and evaluating choroidal neovascularisation (CNV) in punctate inner choroidopathy (PIC). The results showed that OCTA had high diagnostic accuracy and could provide morphological information of CNV to determine its activity. Although OCTA cannot replace dye angiography, it can serve as a feasible method for monitoring and guiding treatment decisions for patients with CNV secondary to PIC.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Jasleen Kaur Jolly, Moreno Menghini, Piers A. Johal, Thomas M. W. Buckley, Holly Bridge, Robert E. Maclaren
Summary: The study revealed alterations in inner retinal layers associated with photoreceptor disease, impacting microperimetry thresholds. Photoreceptor layer thickness and inner retinal thickness were found to be correlated with microperimetry threshold measurements.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Matthew L. O'Sullivan, Gui-Shuang Ying, Shwetha Mangalesh, Vincent Tai, Heena R. Divecha, Katrina P. Winter, Cynthia A. Toth, Xi Chen
Summary: The development of fovea in extremely preterm infants is altered, with the foveal pit depth and inner retinal layer thickness inversely related to gestational age. This developmental disruption occurs early after birth and persists through term equivalent age.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Neurosciences
Peter D. Lukasiewcz, Gregory W. Bligard, James D. DeBrecht
Summary: Glutamate transporters play a crucial role in removing glutamate from the synaptic cleft, with different types of transporters having varying chloride conductances affecting their efficiency. In the retina, EAAT5-mediated chloride currents have a significant impact on synaptic transmission.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Ophthalmology
Kristina Hess, Kristin Raming, Peter Charbel Issa, Philipp Herrmann, Frank G. Holz, Maximilian Pfau
Summary: This study revealed a significant association between aging and ONHD with GCL thinning in patients with PXE, but not with the number of anti-VEGF injections.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Neurosciences
Koushik Mondal, Hunter Porter, Jerome Cole, Hemang K. Pandya, Sandip K. Basu, Sufiya Khanam, Chi-Yang Chiu, Vinay Shah, Daniel J. Stephenson, Charles E. Chalfant, Nawajes Mandal
Summary: This article investigates the toxic effects of hydroxychloroquine (HCQ) on the inner retina and its impact on visual functions. Through a clinical study and a mouse model, the researchers found that chronic HCQ toxicity results in the loss of inner retinal neurons and retinal ganglion cells, leading to compromised visual functions. They also provided insights into the underlying molecular mechanisms involving autophagy-lysosomal defects and alterations in sphingolipid metabolism.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Ophthalmology
Jay Wang, Ying Cui, Filippos Vingopoulos, Megan Kasetty, Rebecca F. Silverman, Raviv Katz, Leo Kim, John B. Miller
Summary: This study found that the extent of disorganisation of retinal inner layers (DRIL) is associated with reduced contrast sensitivity (CS) in patients with retinal vein occlusion (RVO), indicating the important implications of DRIL for visual function.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Weijing Cheng, Wei Wang, Yunhe Song, Fengbin Lin, Yongbo Duan, Liu Xie, Kai Jin, Robert N. Weinreb, Xiulan Zhang
Summary: This study explores the relationship between choriocapillaris flow deficit percentage (FD%) and ganglion cell-inner plexiform layer (GCIPL) thickness in a non-glaucomatous population. The results show a significant correlation between CC FD% and GCIPL thickness, which could provide insights on the development and progression of glaucoma.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Sainan Xiao, Wenmin Sun, Xueshan Xiao, Shiqiang Li, Hualei Luo, Xiaoyun Jia, Jiamin Ouyang, Xueqing Li, Yingwei Wang, Yi Jiang, Panfeng Wang, Qingjiong Zhang
Summary: Almost all rare RS1 variants were found to be potential pathogenic, with all patients with RS1 pathogenic variants showing detectable characteristics in the macula and/or peripheral retina. These findings may be valuable for clinical diagnosis and genetic testing of retinoschisis.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ziwen Hui, Xiao Guo, Gabriella Bulloch, Meng Yuan, Kun Xiong, Shiran Zhang, Yifan Chen, Yuting Li, Huan Liao, Wenyong Huang, Zhuoting Zhu, Wei Wang
Summary: This study investigated the longitudinal changes in choroid and ganglion cell-inner plexiform layer (GCIPL) in type 2 diabetes mellitus (T2DM) patients and healthy populations over 2 years. The results showed that progressive thinning of choroid and GCIPL occurs in both healthy individuals and T2DM patients, with accelerated loss seen in NPDR patients.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Environmental Sciences
Yuzhou Gu, Shengjie Hao, Kaiyuan Liu, Mengqin Gao, Bing Lu, Feiyin Sheng, Li Zhang, Yili Xu, Di Wu, Yu Han, Shuying Chen, Wei Zhao, Xiaoming Lou, Xiaofeng Wang, Peng Li, Zhijian Chen, Ke Yao, Qiuli Fu
Summary: This study explored the effects of PM2.5 on the inner blood-retinal barrier, finding that exposure to PM2.5 resulted in retinal inflammation, vascular dilation, and damage to the iBRB.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Medicine, General & Internal
Clara Pfaeffle, Hendrik Spahr, Katharina Gercke, Leo Puyo, Svea Hoehl, David Melenberg, Yoko Miura, Gereon Huettmann, Dierck Hillmann
Summary: Non-invasive spatially resolved functional imaging in the human retina has attracted considerable attention. Using phase-sensitive optical coherence tomography, researchers have successfully imaged the activity of different layers of neuronal cells in the retina, allowing for the separation of functional signals from different cell types.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Linnet Rodriguez, Diva R. Salomao, James P. Dunn, Adnan Tufail, Jose S. Pulido
Summary: This study describes new histological findings of the inner retina in birdshot chorioretinopathy. The study found focal perivascular lymphocytic infiltration at the optic nerve head, extending into the adjacent inner retina, particularly affecting the ganglion and nerve fiber layers. This may result in bipolar and Muller cell dysfunction, leading to an electronegative electroretinogram.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Philipp Bartel, Takeshi Yoshimatsu, Filip K. Janiak, Tom Baden
Summary: The study reveals that retinal bipolar cells are mainly influenced by red cone inputs when integrating cone cell signals, while UV cone inputs are not correlated with those of other cones. The results show several notable integration rules in the inner retina.
Article
Multidisciplinary Sciences
Jennings C. Luu, Aicha Saadane, Henri Leinonen, Elliot H. Choi, Fangyuan Gao, Dominik Lewandowski, Maximilian Halabi, Christopher L. Sander, Arum Wu, Jacob M. Wang, Rupesh Singh, Songqi Gao, Emma M. Lessieur, Zhiqian Dong, Grazyna Palczewska, Robert F. Mullins, Neal S. Peachey, Philip D. Kiser, Marcin Tabaka, Timothy S. Kern, Krzysztof Palczewski
Summary: Chronic, progressive retinal diseases result from disruptions in cellular and tissue homeostasis, leading to vision impairment and blindness. Existing therapeutic options are limited for these diseases, especially in the early stages. A systems pharmacology approach was used to identify molecular mechanisms and develop targeted pharmacological inhibition of cyclic nucleotide phosphodiesterases (PDEs), resulting in enhanced resilience and preservation of retinal structure and function. This approach shows promise for the treatment and prevention of common causes of blindness.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Onkar S. Dhande, Benjamin K. Stafford, Katrin Franke, Rana El-Danaf, Kumiko A. Percival, Ann H. Phan, Peichao Li, Bryan J. Hansen, Phong L. Nguyen, Philipp Berens, W. Rowland Taylor, Edward Callaway, Thomas Euler, Andrew D. Huberman
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Anna L. Vlasits, Thomas Euler, Katrin Franke
CURRENT OPINION IN NEUROBIOLOGY
(2019)
Article
Biochemical Research Methods
Luke E. Rogerson, Zhijian Zhao, Katrin Franke, Thomas Euler, Philipp Berens
PLOS COMPUTATIONAL BIOLOGY
(2019)
Article
Biology
Katrin Franke, Andre Maia Chagas, Zhijian Zhao, Maxime J. Y. Zimmermann, Philipp Bartel, Yongrong Qiu, Klaudia P. Szatko, Tom Baden, Thomas Euler
Article
Multidisciplinary Sciences
Yanli Ran, Ziwei Huang, Tom Baden, Timm Schubert, Harald Baayen, Philipp Berens, Katrin Franke, Thomas Euler
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Zhijian Zhao, David A. Klindt, Andre Maia Chagas, Klaudia P. Szatko, Luke Rogerson, Dario A. Protti, Christian Behrens, Deniz Dalkara, Timm Schubert, Matthias Bethge, Katrin Franke, Philipp Berens, Alexander S. Ecker, Thomas Euler
SCIENTIFIC REPORTS
(2020)
Editorial Material
Multidisciplinary Sciences
Katrin Franke, Anna Vlasits
Article
Multidisciplinary Sciences
Klaudia P. Szatko, Maria M. Korympidou, Yanli Ran, Philipp Berens, Deniz Dalkara, Timm Schubert, Thomas Euler, Katrin Franke
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Yongrong Qiu, Zhijian Zhao, David Klindt, Magdalena Kautzky, Klaudia P. Szatko, Frank Schaeffel, Katharina Rifai, Katrin Franke, Laura Busse, Thomas Euler
Summary: An experiment using UV-green-sensitive cameras to record footage from mouse habitats revealed significant differences in chromatic contrast between the upper and lower visual fields, suggesting that environmental influences play a key role in the adaptability of the mouse retina.
Article
Biochemistry & Molecular Biology
Christian Behrens, Shubhash Chandra Yadav, Maria M. Korympidou, Yue Zhang, Silke Haverkamp, Stephan Irsen, Anna Schaedler, Xiaoyu Lu, Zhuohe Liu, Jan Lause, Francois St-Pierre, Katrin Franke, Anna Vlasits, Karin Dedek, Robert G. Smith, Thomas Euler, Philipp Berens, Timm Schubert
Summary: The study revealed the existence of two synaptic strata in the outer plexiform layer of the mouse retina, where horizontal cells provide global signaling to CBCs through bulbs and local, cone-specific feedback to cones through dendritic tips. This spatial arrangement of synaptic contacts allows for simultaneous different modes of signaling by horizontal cells.
Article
Biology
Saad Idrees, Matthias-Philipp Baumann, Maria M. Korympidou, Timm Schubert, Alexandra Kling, Katrin Franke, Ziad M. Hafed, Felix Franke, Thomas A. Muench
Summary: Visual perception remains stable across saccades because of the reduction in visual sensitivity known as saccadic suppression. This suppression is achieved through three independent mechanisms in the retina.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhuohe Liu, Xiaoyu Lu, Vincent Villette, Yueyang Gou, Kevin L. Colbert, Shujuan Lai, Sihui Guan, Michelle A. Land, Jihwan Lee, Tensae Assefa, Daniel R. Zollinger, Maria M. Korympidou, Anna L. Vlasits, Michelle M. Pang, Sharon Su, Changjia Cai, Emmanouil Froudarakis, Na Zhou, Saumil S. Patel, Cameron L. Smith, Annick Ayon, Pierre Bizouard, Jonathan Bradley, Katrin Franke, Thomas R. Clandinin, Andrea Giovannucci, Andreas S. Tolias, Jacob Reimer, Stephane Dieudonne, Francois St-Pierre
Summary: Researchers developed a high-throughput platform to optimize genetically encoded voltage indicators for two-photon microscopy. They identified a new indicator, JEDI-2P, which is faster, brighter, more sensitive, and more photostable than previous indicators. JEDI-2P can be used to monitor voltage dynamics in various applications.
Article
Multidisciplinary Sciences
Katrin Franke, Konstantin F. Willeke, Kayla Ponder, Mario Galdamez, Na Zhou, Taliah Muhammad, Saumil Patel, Emmanouil Froudarakis, Jacob Reimer, Fabian H. Sinz, Andreas S. Tolias
Summary: Behavioural state modulates stimulus selectivity in the mouse visual cortex, enhancing sensitivity to coloured stimuli. This modulation is caused by pupil dilation, which results in a switch from rod to cone photoreceptors.
Article
Multidisciplinary Sciences
Sarah Strauss, Maria M. Korympidou, Yanli Ran, Katrin Franke, Timm Schubert, Tom Baden, Philipp Berens, Thomas Euler, Anna L. Vlasits
Summary: Motion sensing is a crucial aspect of vision. Research on mouse retinal bipolar cells has revealed the presence of radial direction selectivity, with some cells preferring the origin of small object motion trajectories. This selectivity relies on the properties of the center-surround receptive field. By studying these cells and using connectomics, biophysical models were developed to understand how their selectivity contributes to downstream cells. It was found that bipolar cells pass radial direction selective excitation to starburst amacrine cells, contributing to their directional tuning and potentially impacting motion processing throughout the visual system.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Jonathan Oesterle, Christian Behrens, Cornelius Schroder, Thoralf Hermann, Thomas Euler, Katrin Franke, Robert G. Smith, Gunther Zeck, Philipp Berens