Article
Oncology
Lucia Celada, Tamara Cubiella, Jaime San-Juan-Guardado, Andres San Jose Martinez, Nuria Valdes, Paula Jimenez-Fonseca, Ignacio Diaz, Jose Maria Enguita, Aurora Astudillo, Enol Alvarez-Gonzalez, Luisa Maria Sierra, Maria-Dolores Chiara
Summary: The expression level of HIF2 alpha differs in pheochromocytoma and head and neck paraganglioma and is associated with VHL and SDH dysfunctions. Selective HIF2 alpha inhibitors may be effective in treating pheochromocytoma.
Article
Pharmacology & Pharmacy
Harisa Ferizovic, Natasa Spasojevic, Milica Jankovic, Bojana Stefanovic, Sladjana Dronjak
Summary: The study investigated the effects of the fatty acid amide hydrolase inhibitor URB597 on plasma catecholamine levels and their synthesis and degradation in the adrenal medulla of male and female rats under chronic unpredictable stress. Results showed that URB597 reduced catecholamine content and synthesis in stressed female rats, while females had higher adrenal weights and catecholamine levels before stress than males, and stress further increased these levels in females compared to males. Additionally, the inhibitor reduced plasma norepinephrine levels and restored content in the adrenal medulla in male rats under stress. The findings suggest a potential role for endocannabinoids in modulating stress response in both male and female subjects.
Article
Endocrinology & Metabolism
Jonathan Weber, Veeraya K. Tanawattanacharoen, Amy Seagroves, Mark C. Liang, Christina M. Koppin, Heather M. Ross, Tania A. S. S. Bachega, Mitchell E. Geffner, Monica Serrano-Gonzalez, Gagandeep Bhullar, Mimi S. Kim
Summary: The study found that lower epinephrine levels in infants with classical CAH are associated with increased risk of illness in the first year of life. Measuring epinephrine levels and assessing genotype may help predict acute illness in these infants.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Helena Hanschell, Salvador Diaz-Cano, Alfredo Blanes, Nadia Talat, Gabriele Galata, Simon Aylwin, Klaus Martin Schulte
Summary: In this study, a simple and reliable tool, the SIZEPASS criterion, was developed to predict the malignant behavior of PPGLs based on the size of the tumors. The SIZEPASS criterion showed high accuracy and sensitivity in predicting malignancy in PPGLs.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Andrej Tillinger, Boris Mravec
Summary: The corticotropin-releasing hormone family of peptides and the vagus nerve play important roles in regulating the neuroendocrine stress response and transmitting immune-related signals to the brain. The study showed that Ucn2 may be involved in regulating the HPA axis in response to immune challenge, and this regulation is mediated by vagal pathways.
NEUROCHEMICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Anna-Karin Akerman, Ase Bjorvatn Saevik, Per Medboe Thorsby, Paal Methlie, Marcus Quinkler, Anders Palmstrom Jorgensen, Charlotte Hoybye, Aleksandra J. Debowska, Bjorn Gunnar Nedrebo, Anne Lise Dahle, Siri Carlsen, Aneta Tomkowicz, Stina Therese Sollid, Ingrid Nermoen, Kaja Gronning, Per Dahlqvist, Guri Grimnes, Jakob Skov, Trine Finnes, Jeanette Wahlberg, Synnove Emblem Holte, Katerina Simunkova, Olle Kampe, Eystein Sverre Husebye, Marianne Oksnes, Sophie Bensing
Summary: Residual adrenocortical function (RAF) affects the levels of plasma metanephrines in patients with autoimmune Addison's disease (AAD), according to this study. Patients with RAF had a higher likelihood of detectable metanephrines compared to patients without RAF. There was a positive correlation between detectable metanephrines and cortisol levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Roderick J. Clifton-Bligh
Summary: Diagnosis of pheochromocytoma or paraganglioma (PPGL) during pregnancy has historically led to high rates of maternal and fetal morbidity and mortality. Recent evidence suggests that early recognition of PPGL and appropriate medical management can improve outcomes. The need for antepartum surgery and the mode of delivery in PPGL cases are still controversial. It is important to offer genetic counseling and testing to women with PPGL in pregnancy, as they are often associated with heritable syndromes.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Endocrinology & Metabolism
Jose R. Lopez Ruiz, Stephen A. Ernst, Ronald W. Holz, Edward L. Stuenkel
Summary: This study continuously monitored the electrical activity of cortical chromaffin cells in the adrenal medulla, revealing the activity patterns and connections between cells under basal and physiological stress conditions. The results showed that adrenal medulla chromaffin cell networks have specific activation patterns under different stressors, reflecting the dynamic nature of neuroendocrine output.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Luise Eckardt, Maria Prange-Barczynska, Emma J. Hodson, James W. Fielding, Xiaotong Cheng, Joanna D. C. C. Lima, Samvid Kurlekar, Gillian Douglas, Peter J. Ratcliffe, Tammie Bishop
Summary: The study revealed the importance of the PHD2/HIF-2α pathway in adrenal development in pseudohypoxic PPGL, with combined inactivation of Phd2 and Hif-2α resulting in changes in gene expression patterns and morphological abnormalities in adrenal medullary cells.
ENDOCRINE-RELATED CANCER
(2021)
Review
Physiology
Andrew P. Holmes, Agnieszka Swiderska, Demitris Nathanael, Hayyaf S. Aldossary, Clare J. Ray, Andrew M. Coney, Prem Kumar
Summary: It is widely recognized that the mitochondria in type I cells of the carotid body (CB) are unique, as they can be inhibited by relatively small decreases in PaO2 compared to other cell types. This characteristic allows the CB to function as an acute oxygen sensor, being stimulated and activating protective reflexes before other cells' metabolism is compromised. However, the exact mechanism of how a decrease in mitochondrial activity leads to depolarization of type I cells is still unclear. This review explores the significance of various signaling pathways in mediating the overall CB response to hypoxia, suggesting that multiple mitochondria-related signaling pathways are likely involved at different oxygen levels (P(a)O(2)s) during hypoxia. Additionally, it remains to be determined whether mitochondrial signaling acts independently or in collaboration with extramitochondrial oxygen sensors.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Jessica E. Baker, Samuel W. Plaska, Zhaoping Qin, Chia-Jen Liu, Juilee Rege, William E. Rainey, Aaron M. Udager
Summary: This study demonstrates the application of targeted RNA sequencing to FFPE normal adrenal gland specimens, capturing distinct transcriptomic differences among adrenal zones. The data obtained will improve the understanding of transcriptomic patterns and potentially identify novel pathways controlling zone-specific steroid production.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Cell Biology
Austin E. Gillen, L. Elaine Epperson, David J. Orlicky, Rui Fu, Sandra L. Martin
Summary: This study utilized RNA-seq to analyze the gene expression dynamics of adrenal glands in hibernating ground squirrels and found that seasonal differentiation affected the expression of multiple genes involved in steroidogenesis. Additionally, during each short arousal period, an immediate early response gene was activated, which further activated a cellular stress response program to restore protein homeostasis and tissue-specific gene expression.
PHYSIOLOGICAL GENOMICS
(2023)
Article
Endocrinology & Metabolism
Fengchao Lang, Abhishek Jha, Leah Meuter, Karel Pacak, Chunzhang Yang
Summary: Carotid body paragangliomas are rare neuroendocrine tumors that account for about 65% of head and neck paragangliomas. A somatic mutation in the gene encoding isocitrate dehydrogenase 2 (IDH2) was reported in a case of carotid body PGL, leading to a specific amino acid substitution and production of a specific metabolic product.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Anatomy & Morphology
Javier Villadiego, Roberto Garcia-Swinburn, Diego Garcia-Gonzalez, Rafael Lebron-Galan, Veronica Murcia-Belmonte, Ernesto Garcia-Roldan, Nela Suarez-Luna, Cristina Nombela, Miguel Marchena, Fernando de Castro, Juan Jose Toledo-Aral
Summary: The protein Anosmin-1 (A1) plays a crucial role in regulating the development and survival of dopaminergic neurons in both the central and peripheral nervous systems. Overexpression of A1 leads to an increase in the number of dopaminergic neurons in the substantia nigra pars compacta and alters the organization of the striatum. However, A1 overexpression also results in a significant reduction in the number of dopaminergic chemosensitive carotid body glomus cells.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Physiology
Ryan J. Rakoczy, Clay M. Schiebrel, Christopher N. Wyatt
Summary: This study presents preliminary evidence supporting a new oxygen-sensing hypothesis that suggests CB Type I cell hypoxic signaling may be partly mediated by mitochondria-generated thermal transients in TASK-channel-containing microdomains. The data shows the existence of oxygen-sensing microdomains in CB Type I cells and suggests that hypoxic inhibition of mitochondrial thermogenesis may play a role in oxygen chemotransduction in the CB.
FRONTIERS IN PHYSIOLOGY
(2022)
