Termination of re-entrant atrial tachycardia via optogenetic stimulation with optimized spatial targeting: insights from computational models

Optogenetics gets to the heart: A guiding light beyond defibrillation

(2017) Claudia Crocini et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Patient-derived models link re-entrant driver localization in atrial fibrillation to fibrosis spatial pattern

(2016) Sohail Zahid et al.   CARDIOVASCULAR RESEARCH

Feasibility of using patient-specific models and the “minimum cut” algorithm to predict optimal ablation targets for left atrial flutter

(2016) Sohail Zahid et al.   HEART RHYTHM

Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations

(2016) Tobias Bruegmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Opsin spectral sensitivity determines the effectiveness of optogenetic termination of ventricular fibrillation in the human heart: a simulation study

(2016) Thomas V. Karathanos et al.   JOURNAL OF PHYSIOLOGY-LONDON

Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial

(2016) Barry Greenberg et al.   LANCET

Optogenetics design of mechanistically-based stimulation patterns for cardiac defibrillation

(2016) Claudia Crocini et al.   Scientific Reports

Systemic gene transfer enables optogenetic pacing of mouse hearts

(2015) C. C. Vogt et al.   CARDIOVASCULAR RESEARCH

Computational modeling of cardiac optogenetics: Methodology overview & review of findings from simulations

(2015) Patrick M. Boyle et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Optogenetics for in vivo cardiac pacing and resynchronization therapies

(2015) Udi Nussinovitch et al.   NATURE BIOTECHNOLOGY

Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics

(2015) Sung Il Park et al.   NATURE BIOTECHNOLOGY

Optical control of excitation waves in cardiac tissue

(2015) Rebecca A. B. Burton et al.   Nature Photonics

“Beauty is a light in the heart”: The transformative potential of optogenetics for clinical applications in cardiovascular medicine1

(2015) Patrick M. Boyle et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Optogenetics-enabled assessment of viral gene and cell therapy for restoration of cardiac excitability

(2015) Christina M. Ambrosi et al.   Scientific Reports

Virtual Electrophysiological Study of Atrial Fibrillation in Fibrotic Remodeling

(2015) Kathleen S. McDowell et al.   PLoS One

Modulation of cardiac tissue electrophysiological properties with light-sensitive proteins

(2014) Udi Nussinovitch et al.   CARDIOVASCULAR RESEARCH

Light-induced termination of spiral wave arrhythmias by optogenetic engineering of atrial cardiomyocytes

(2014) Brian O. Bingen et al.   CARDIOVASCULAR RESEARCH

Optogenetics-enabled dynamic modulation of action potential duration in atrial tissue: feasibility of a novel therapeutic approach

(2014) T. V. Karathanos et al.   EUROPACE

Voltage mapping for delineating inexcitable dense scar in patients undergoing atrial fibrillation ablation: A new end point for enhancing pulmonary vein isolation

(2014) Fabien Squara et al.   HEART RHYTHM

Ablation of Rotor and Focal Sources Reduces Late Recurrence of Atrial Fibrillation Compared With Trigger Ablation Alone

(2014) Sanjiv M. Narayan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Sodium Current Reduction Unmasks a Structure-Dependent Substrate for Arrhythmogenesis in the Normal Ventricles

(2014) Patrick M. Boyle et al.   PLoS One

Cardiac optogenetics

(2013) Emilia Entcheva   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mechanistic Inquiry into the Role of Tissue Remodeling in Fibrotic Lesions in Human Atrial Fibrillation

(2013) Kathleen S. McDowell et al.   BIOPHYSICAL JOURNAL

Magnetic resonance image intensity ratio, a normalized measure to enable interpatient comparability of left atrial fibrosis

(2013) Irfan M. Khurram et al.   HEART RHYTHM

Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics

(2013) T.-i. Kim et al.   SCIENCE

A comprehensive multiscale framework for simulating optogenetics in the heart

(2013) Patrick M. Boyle et al.   Nature Communications

Computational Optogenetics: Empirically-Derived Voltage- and Light-Sensitive Channelrhodopsin-2 Model

(2013) John C. Williams et al.   PLoS Computational Biology

How to Approach Reentrant Atrial Tachycardia After Atrial Fibrillation Ablation

(2012) Shinsuke Miyazaki et al.   Circulation-Arrhythmia and Electrophysiology

Mechanisms of Human Atrial Fibrillation Initiation

(2012) David E. Krummen et al.   Circulation-Arrhythmia and Electrophysiology

Image-Based Estimation of Ventricular Fiber Orientations for Personalized Modeling of Cardiac Electrophysiology

(2012) F. Vadakkumpadan et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Methodology for patient-specific modeling of atrial fibrosis as a substrate for atrial fibrillation

(2012) Kathleen S. McDowell et al.   JOURNAL OF ELECTROCARDIOLOGY

Treatment of Atrial Fibrillation by the Ablation of Localized Sources

(2012) Sanjiv M. Narayan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Multiscale Computational Models for Optogenetic Control of Cardiac Function

(2011) Oscar J. Abilez et al.   BIOPHYSICAL JOURNAL

Stimulating Cardiac Muscle by Light

(2011) Zhiheng Jia et al.   Circulation-Arrhythmia and Electrophysiology

An Intuitive Safety Factor for Cardiac Propagation

(2010) Patrick M. Boyle et al.   BIOPHYSICAL JOURNAL

Waterproof AlInGaP optoelectronics on stretchable substrates with applications in biomedicine and robotics

(2010) Rak-Hwan Kim et al.   NATURE MATERIALS

Pacing lightly: optogenetics gets to the heart

(2010) Björn C Knollmann   NATURE METHODS

Optogenetic control of heart muscle in vitro and in vivo

(2010) Tobias Bruegmann et al.   NATURE METHODS

Changes in Connexin Expression and the Atrial Fibrillation Substrate in Congestive Heart Failure

(2009) Brett Burstein et al.   CIRCULATION RESEARCH

Catheter Ablation of Atrial Tachycardia Following Atrial Fibrillation Ablation

(2009) RUKSHEN WEERASOORIYA et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Atrial Tachycardia After Ablation of Persistent Atrial Fibrillation

(2008) Anshul M. Patel et al.   Circulation-Arrhythmia and Electrophysiology