Article
Materials Science, Multidisciplinary
Angela Barreda, Chengjun Zou, Artem Sinelnik, Evgenii Menshikov, Ivan Sinev, Thomas Pertsch, Isabelle Staude
Summary: This study proposes the use of phase change materials to tune the properties of light-emitting metasurfaces designed to support quasi-bound states in the continuum. Numerical simulations demonstrate the different functionalities of the metasurface depending on the selected phase change material. The research provides concrete design blueprints for switchable metasurfaces, offering new opportunities for nanophotonics devices or integrated photonic circuits.
OPTICAL MATERIALS EXPRESS
(2022)
Article
Environmental Sciences
Samuel Sainz-Villegas, Camino Fernandez de la Hoz, Jose A. Juanes, Araceli Puente
Summary: Modelling the distribution of introduced seaweed species is challenging. This study examines the use of simplified models and the tuning of algorithm configurations to improve predictions. The results show that models with more predictors generally perform better, with Random Forest and Generalized Boosting Models scoring the highest. However, these models may have unrealistic or overfitting response curves. Generalized Linear Models and MAXENT, despite lower scores, produce smoother curves. It is important to consider both quantitative and qualitative methods when selecting optimal model configurations.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Diego R. Abujetas, Nuno de Sousa, Antonio Garcia-Martin, Jose M. Llorens, Jose A. Sanchez-Gil
Summary: In this study, the properties of quasi-BICs in magneto-optic all-dielectric metasurfaces are analyzed, showing the impact of applied magnetic field in the BIC parameter space and demonstrating the manifestation of magneto-optical activity in the optical regime. A design for fast magneto-optical switch of Brewster quasi-BIC is proposed by simply reversing the driving magnetic field.
Article
Biology
Amit Kumar, Oscar Vadas, Nicolas Dos Santos Pacheco, Xu Zhang, Kin Chao, Nicolas Darvill, Helena O. Rasmussen, Yingqi Xu, Gloria Meng-Hsuan Lin, Fisentzos A. Stylianou, Jan Skov Pedersen, Sarah L. Rouse, Marc L. Morgan, Dominique Soldati-Favre, Stephen Matthews
Summary: The intracellular parasites belonging to the phylum of Apicomplexa employ substrate-dependent gliding motility to invade host cells. The glideosome-associated connector (GAC), a conserved protein, plays a crucial role in this process. The crystal structure of Toxoplasma gondii GAC reveals a unique armadillo repeat region that adopts a closed ring conformation. The properties of GAC suggest that it can adopt multiple conformations from closed to open and extended, and a multi-conformational model is proposed for its assembly and regulation within the glideosome.
Article
Nanoscience & Nanotechnology
Ekaterina E. Maslova, Mikhail Rybin, Andrey A. Bogdanov, Zarina F. Sadrieva
Summary: This study investigates the impact of structural disorder on the transition from bound states in the continuum to quasi-BICs in periodic photonic structures. The robustness of symmetry protected and accidental BICs against various types of structural disorder is uncovered, with analysis revealing how spatial mode localization induced by disorder reduces system length and limits the Q factor of quasi-BICs. These findings are crucial for practical implementation of BICs, particularly in natural and self-assembled photonic structures where structural disorder plays a significant role.
Review
Chemistry, Multidisciplinary
Kevin Jooss, John P. McGee, Neil L. Kelleher
Summary: Biology is driven by molecular interactions, and the language of protein-level biology is still largely undiscovered or inferred. Mass spectrometry has evolved to preserve and characterize protein complexes, allowing for a better understanding of protein interactions and their roles in human diseases. The future of native mass spectrometry includes advancements in separations, top-down mass spectrometry, and integration with structural biology, enabling the study of larger and more complex bioassemblies.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Hyounghan Kwon, Tianzhe Zheng, Andrei Faraon
Summary: This study demonstrates experimental nano-electromechanical tuning of both GMR and quasi-BIC modes in the telecom wavelength range, leading to impressive results that suggest a direct route toward optical modulators through the engineering of these resonances.
Article
Cardiac & Cardiovascular Systems
Darnel Prakoso, Shiang Y. Lim, Jeffrey R. Erickson, Rachel S. Wallace, Jarmon G. Lees, Mitchel Tate, Helen Kiriazis, Daniel G. Donner, Darren C. Henstridge, Jonathan R. Davey, Hongwei Qian, Minh Deo, Laura J. Parry, Amy J. Davidoff, Paul Gregorevic, John C. Chatham, Miles J. De Blasio, Rebecca H. Ritchie
Summary: Elevated protein O-GlcNAc modification is observed in diabetic human myocardium, and selectively targeting cardiac protein O-GlcNAcylation may offer a new therapeutic approach for diabetes-induced heart failure. In non-diabetic mice, rAAV6-OGT impairs LV diastolic function and induces maladaptive cardiac remodelling, while rAAV6-OGA rescues LV diastolic function and adverse cardiac remodelling in diabetic mice.
CARDIOVASCULAR RESEARCH
(2022)
Article
Chemistry, Physical
Irene Badia-Dominguez, Sofia Canola, Victor Hernandez Jolin, Juan T. Lopez Navarrete, Juan C. Sancho-Garcia, Fabrizia Negri, M. Carmen Ruiz Delgado
Summary: The study explores the efficiency of structural isomerism and substitution position in controlling the optical and electronic properties of ICz-based systems, with meta-substituted systems with a V-shaped structure displaying the largest diradical character. This work contributes to elucidating the chemical reactivity and physical properties of diradicaloid systems, guiding experimental chemists to produce new molecules with desirable properties.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Physics, Multidisciplinary
Adam Overvig, Nanfang Yu, Andrea Alu
Summary: The study introduces quasi-bound states in the continuum (QBICs) born of chiral perturbations, encoding arbitrary elliptical polarization states and enabling geometric phase engineering. Metasurfaces with ultrasharp spectral features are designed as a result, shaping impinging wave fronts with near-unity efficiency. The findings extend Fano resonances beyond their conventional limits, opening opportunities for nanophotonics, classical and quantum optics, and acoustics.
PHYSICAL REVIEW LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Artem V. Peretokin, Dmitry V. Yurasov, Margarita V. Stepikhova, Mikhail V. Shaleev, Artem N. Yablonskiy, Dmitry V. Shengurov, Sergey A. Dyakov, Ekaterina E. Rodyakina, Zhanna V. Smagina, Alexey V. Novikov
Summary: Detailed studies were conducted on the luminescent properties of Si-based 2D photonic crystal (PhC) slabs with air holes of various depths. Ge self-assembled quantum dots were used as the internal light source. It was found that changing the air hole depth can significantly influence the optical properties of the PhC, with a maximal increase in the photoluminescence (PL) signal obtained for intermediate depths of the air holes. Furthermore, specific bound states in continuum (BIC) with flat dispersion curves were engineered, resulting in sharp peaks in the PL spectra and higher Q-factors compared to other BIC modes without such flat dispersion characteristics.
Article
Biology
Nathanael A. Caveney, Naotaka Tsutsumi, K. Christopher Garcia
Summary: Membrane receptor guanylyl cyclases play important roles in human physiology. This study reveals the structural and functional mechanisms of the interaction between guanylyl cyclase and Hsp90-Cdc37 complex, shedding light on the potential development of therapeutics for related conditions.
Article
Materials Science, Multidisciplinary
Amir M. Jazayeri
Summary: PT symmetry has attracted much attention in both non-Hermitian electronic and electromagnetic models. In this study, we explore one-dimensional PT-symmetric non-Hermitian electromagnetic models and introduce the concept of fixed points in the band structure. These fixed points lead to bidirectional reflection zeros and allow for the observation of extended states in the bandgap and ideal superluminal tunneling. The results of this work provide novel insights into the behavior of PT-symmetric electromagnetic models.
Editorial Material
Chemistry, Physical
Jorge A. Vila
Summary: By assessing the amide hydrogen exchange protection factor, it is concluded that structural fluctuations in the native state of proteins are consistent with metamorphism. Therefore, the presence of metamorphism in the native state is more probable than previously thought based on preliminary results.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Carlos Pena-Varas, Christa Kanstrup, Ariela Vergara-Jaque, Mariela Gonzalez-Avendano, Christoph Crocoll, Osman Mirza, Ingo Dreyer, Hussam Nour-Eldin, David Ramirez
Summary: In this study, computational simulation approaches were used to investigate how the plant glucosinolate transporter GTR1 transports specific substrates. By docking and analyzing a range of GTR1 conformations, key residues essential for substrate transport were identified. The incorporation of structural bioinformatics accelerated the understanding of plant transporter functions and optimized the use of time and resources.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Encarnacion Medina-Carmona, Isabel Betancor-Fernandez, Jaime Santos, Noel Mesa-Torres, Silvia Grottelli, Cristina Batlle, Athi N. Naganathan, Elisa Oppici, Barbara Cellini, Salvador Ventura, Eduardo Salido, Angel L. Pey
HUMAN MOLECULAR GENETICS
(2019)
Article
Chemistry, Physical
Abhishek Narayan, Athi N. Naganathan
JOURNAL OF PHYSICAL CHEMISTRY B
(2018)
Article
Biochemistry & Molecular Biology
Sneha Munshi, Soundhararajan Gopi, Gitanjali Asampille, Sandhyaa Subramanian, Luis A. Campos, Hanudatta S. Atreya, Athi N. Naganathan
NUCLEIC ACIDS RESEARCH
(2018)
Review
Biochemistry & Molecular Biology
Athi N. Naganathan
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Sneha Munshi, Sandhyaa Subramanian, Samyuktha Ramesh, Hemashree Golla, Divakar Kalivarathan, Madhurima Kulkarni, Luis A. Campos, Ashok Sekhar, Athi N. Naganathan
Article
Biochemistry & Molecular Biology
Abhishek Narayan, Kabita Bhattacharjee, Athi N. Naganathan
Article
Multidisciplinary Sciences
Abhishek Narayan, Soundhararajan Gopi, David Fushman, Athi N. Naganathan
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Abhishek Narayan, Soundhararajan Gopi, Bincy Lukose, Athi N. Naganathan
JOURNAL OF MOLECULAR BIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Rafayel Petrosyan, Abhishek Narayan, Michael T. Woodside
Summary: Single-molecule force spectroscopy (SMFS) is a powerful tool for studying protein folding dynamics, uncovering energy landscapes of folding, complex folding pathways, mechanisms of chaperones in assisting folding, effects of ribosomes on co-translational folding, and monitoring membrane protein folding.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Krishna Neupane, Meng Zhao, Aaron Lyons, Sneha Munshi, Sandaru M. Ileperuma, Dustin B. Ritchie, Noel Q. Hoffer, Abhishek Narayari, Michael T. Woodside
Summary: The RNA pseudoknot of SARS-CoV-2 that induces programmed ribosomal frameshifting is a potential drug target. Through optical tweezer experiments, researchers identified two pseudoknotted conformers with distinct topologies and revealed the folding mechanism of the frameshift signal, shedding light on its conformational heterogeneity and implications for drug discovery based on structure.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Jose L. Neira, Athi N. Naganathan, Noel Mesa-Torres, Eduardo Salido, Angel L. Pey
Summary: The mutations G170R and I244T are the most common disease causes in primary hyperoxaluria type I. This study found that phosphorylation of T9 may affect the conformation of NTT-AGT and synergize with PH1-causing mutations to promote aggregation in a genotype-specific manner.
Article
Biochemical Research Methods
Soundhararajan Gopi, Devanshu Devanshu, Praveen Krishna, Athi N. Naganathan