Article
Cardiac & Cardiovascular Systems
Dandan Yang, Xiaoping Wan, Adrienne T. Dennis, Emre Bektik, Zhihua Wang, Mauricio G. S. Costa, Charline Fagnen, Catherine Venien-Bryan, Xianyao Xu, Daniel H. Gratz, Thomas J. Hund, Peter J. Mohler, Kenneth R. Laurita, Isabelle Deschenes, Ji-Dong Fu
Summary: This study reveals a novel biophysical action of endogenous miRs in modulating cardiac electrophysiology through noncanonical mechanisms. Endogenous miR1 physically binds with cardiac membrane protein Kir2.1, suppressing I-K1 and affecting action potential of cardiomyocytes. The findings suggest that miRs may be involved in the pathogenesis of cardiac arrhythmias by regulating ion channel physiology and pathology.
Review
Multidisciplinary Sciences
Federico Bertagna, Rebecca Lewis, S. Ravi P. Silva, Johnjoe McFadden, Kamalan Jeevaratnam
Summary: Research in recent decades has focused on the effects of different electromagnetic fields on the electrical properties of neurons, particularly voltage-gated ion channels. Changes in voltage-gated calcium channels have been found to be the most commonly reported result of electromagnetic field exposure. The effects of electromagnetic fields on the neuronal landscape appear to be diverse and highly dependent on factors such as the field's frequency, exposure time, and intrinsic properties of the irradiated tissue.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Chemistry, Medicinal
Juan Antonio Contreras Vite, Carlos Vega Valle, Happi Biekeu Mbem, Sarah-Maude Boivin, Robert Dumaine
Summary: Lamotrigine is commonly used for treating bipolar disorder and epilepsy. The US FDA has recently issued a warning regarding the drug's potential to cause conduction anomalies and Brugada syndrome in epileptic patients. In this study, researchers used patch clamp technique on rat cardiomyocytes to investigate the effect of Lamotrigine on cardiac sodium current (I-Na). The results showed that Lamotrigine inhibited I-Na peak amplitude, reduced cardiac excitability, and prolonged the action potential refractory period in epileptic rats.
Article
Biology
Christian J. G. Tessier, Raymond M. Sturgeon, Johnathon R. Emlaw, Gregory D. McCluskey, F. Javier Perez-Areales, Corrie J. B. daCosta
Summary: Human adult muscle-type acetylcholine receptors are heteropentameric ion channels formed from different subunits, but they share a common ancestral homopentameric origin. A reconstructed ancestral muscle-type beta-subunit can form spontaneously open homopentameric ion channels, demonstrating that the function of the receptor is independent of agonist and does not require complex heteropentameric architecture.
Article
Pharmacology & Pharmacy
Ji-Yue Wen, Jie Zhang, Shuo Chen, Ye Chen, Yang Zhang, Zi-Yao Ma, Fang Zhang, Wei-Ming Xie, Yi-Fei Fan, Jing-Si Duan, Zhi-Wu Chen
Summary: This study demonstrates that hydrogen sulfide acts as endothelium-derived hyperpolarizing factor (EDHF) and exerts neuroprotective effects by activating BKCa channels in hippocampal neurons.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Biology
Carol Ann Remme
Summary: The influx of sodium ions through voltage-gated sodium channels is crucial for proper electrical conduction in the heart. Dysfunction of sodium channels can lead to life-threatening arrhythmias in acquired conditions and inherited disorders. Recent research has revealed the complex nature of sodium channel distribution and function, as well as its impact on cardiac structural integrity. Moreover, sodium channels and their role in various extracardiac tissues are being increasingly recognized. This review provides an overview of these novel insights and their contribution to our understanding of sodium channelopathies and dysfunction.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Loryn J. Bohne, Hailey J. Jansen, Tristan W. Dorey, Irene M. Daniel, K. Lockhart Jamieson, Darrell D. Belke, Megan D. Mcrae, Robert A. Rose
Summary: This study demonstrates that GLP-1 and its analogues can reduce the incidence of atrial fibrillation and prevent atrial remodeling in patients with type 2 diabetes.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Yevheniia Kravenska, Vanessa Checchetto, Ildiko Szabo
Summary: Potassium ions can enter and exit mitochondria through various channels in the outer and inner membranes, with the ATP-dependent potassium channel being the most studied and playing a crucial role in protecting cells against ischemic and neuronal damage.
Article
Pharmacology & Pharmacy
Min Li, Haibo Yu
Summary: WP1066 is identified as a K(V)1.3 channel blocker with open-state-dependent property, blocking the channels in a dose-dependent manner with hyperpolarizing shift of steady-state inactivation curve, and interacting preferentially with channels in open state rather than closed or inactivated state.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Physical
Junben Weng, Anhui Wang, Dinglin Zhang, Chenyi Liao, Guohui Li
Summary: The study used an antiparallel alignment double bilayer model to investigate the movement and regulation of GIRK2 channels in different environments, revealing significant impacts of the binding of phosphatidylinositol-4,5-bisphosphate and G-protein beta gamma subunits on ion conduction and energy basis of the channel, as well as functional rocking motions of GIRK2 in a nonequilibrium environment.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Cardiac & Cardiovascular Systems
Pietro Mesirca, Shu Nakao, Sarah Dalgas Nissen, Gabriella Forte, Cali Anderson, Tariq Trussell, Jue Li, Charlotte Cox, Min Zi, Sunil Logantha, Sana Yaar, Helena Cartensen, Isabelle Bidaud, Luke Stuart, Luca Soattin, Gwilym M. Morris, Paula A. da Costa Martins, Elizabeth J. Cartwright, Delvac Oceandy, Matteo E. Mangoni, Thomas Jespersen, Rikke Buhl, Halina Dobrzynski, Mark R. Boyett, Alicia D'Souza
Summary: The study found that atrioventricular block in athletes is mainly caused by electrical remodeling. Trained animals and mice showed atrioventricular node dysfunction, characterized by prolonged PR intervals and reduced expression of key ion channels. miRNAs such as miR-211-5p and miR-432 were identified as direct regulators of Ca(V)1.2 and HCN4.
CIRCULATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Clifford TeBay, Jeffrey R. McArthur, Melissa Mangala, Nicholas Kerr, Stewart Heitmann, Matthew D. Perry, Monique J. Windley, Jamie Vandenberg, Adam P. Hill
Summary: Hydroxychloroquine, chloroquine, and azithromycin have been proposed as drugs to treat COVID-19, but they carry a risk of proarrhythmia. Factors such as electrolyte imbalances, acidosis, and temperature can alter the potency of these drugs and increase the risk of proarrhythmia. In vitro screening and in silico simulations can help guide the preclinical screening and clinical management of patients receiving these drugs.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Rosalia Moreddu
Summary: Bioelectricity plays a critical role in regulating cellular function and communication, and has potential uses in cancer diagnosis, prognosis, and treatment. Cancer cells exhibit abnormal electrical properties compared to healthy cells, and nanotechnology holds promise for understanding and exploiting these differences.
Review
Chemistry, Multidisciplinary
Ishan Ghai
Summary: Gram-negative bacteria can resist antibiotics by altering the permeability of their outer membrane, which contains protein channels called porins or nanopores that allow the entry of hydrophilic compounds. To address the challenge of understanding membrane permeability, this assessment builds on previous research to comprehend the role of porins in antibiotic influx and investigate the bacterial response to membrane permeability. By expanding our knowledge of these mechanisms, novel approaches to mitigate antibiotic resistance can be developed.
APPLIED SCIENCES-BASEL
(2023)
Article
Cardiac & Cardiovascular Systems
Giovanna Nasilli, Loukia Yiangou, Chiara Palandri, Elisabetta Cerbai, Richard P. Davis, Arie O. Verkerk, Simona Casini, Carol Ann Remme
Summary: SCN5A mutations are associated with various cardiac phenotypes. The study found that mexiletine can improve the mixed phenotype caused by the SCN5A-1795insD mutation. This study demonstrates for the first time the therapeutic benefit of mexiletine in a human cardiomyocyte model of SCN5A overlap syndrome.
Article
Pharmacology & Pharmacy
Jacqueline Naylor, Aisling Minard, Hannah J. Gaunt, Mohamed S. Amer, Lesley A. Wilson, Marco Migliore, Sin Y. Cheung, Hussein N. Rubaiy, Nicola M. Blythe, Katie E. Musialowski, Melanie J. Ludlow, William D. Evans, Ben L. Green, Hongjun Yang, Yun You, Jing Li, Colin W. G. Fishwick, Katsuhiko Muraki, David J. Beech, Robin S. Bon
BRITISH JOURNAL OF PHARMACOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Melanie J. Ludlow, Hannah J. Gaunt, Hussein N. Rubaiy, Katie E. Musialowski, Nicola M. Blythe, Naveen S. Vasudev, Katsuhiko Muraki, David J. Beech
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Hussein N. Rubaiy, Melanie J. Ludlow, Matthias Henrot, Hannah J. Gaunt, Katarina Miteva, Sin Ying Cheung, Yasuyuki Tanahashi, Nurasyikin Hamzah, Katie E. Musialowski, Nicola M. Blythe, Hollie L. Appleby, Marc A. Bailey, Lynn McKeown, Roger Taylor, Richard Foster, Herbert Waldmann, Peter Nussbaumer, Mathias Christmann, Robin S. Bon, Katsuhiko Muraki, David J. Beech
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Pharmacology & Pharmacy
Hussein N. Rubaiy, Melanie J. Ludlow, Karsten Siems, Katherine Norman, Richard Foster, Dietmar Wolf, John A. Beutler, David J. Beech
BRITISH JOURNAL OF PHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Hussein N. Rubaiy, Tobias Seitz, Sven Hahn, Axel Choidas, Peter Habenberger, Bert Klebl, Klaus Dinkel, Peter Nussbaumer, Herbert Waldmann, Mathias Christmann, David J. Beech
BRITISH JOURNAL OF PHARMACOLOGY
(2018)
Review
Cell Biology
Aisling Minard, Claudia C. Bauer, David J. Wright, Hussein N. Rubaiy, Katsuhiko Muraki, David J. Beech, Robin S. Bon
Review
Pharmacology & Pharmacy
Hussein N. Rubaiy
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Pengyun Li, Hussein N. Rubaiy, Gui-Lan Chen, Thomas Hallett, Nawel Zaibi, Bo Zeng, Rahul Saurabh, Shang-Zhong Xu
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Sean Brennan, Hussein N. Rubaiy, Saba Imanzadeh, Ruth Reid, David Lodwick, Robert I. Norman, Richard D. Rainbow
BIOCHEMICAL JOURNAL
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
Pengyun Li, Hussein N. Rubaiy, Guilan Chen, Thomas Hallett, Nawel Zaibi, Bo Zeng, Rahul Saurabh, Shangzhong Xu
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2020)
Review
Pharmacology & Pharmacy
Hussein N. Rubaiy
Summary: Pharmacology provides core knowledge for health care and research programs, emphasizing the importance of preventing medication errors for patient safety. Both educators and students need to work together to create an effective learning environment in pharmacology courses to improve student engagement and success.
Meeting Abstract
Pharmacology & Pharmacy
Hussein Nori Rubaiy, Dietmar Wolf, John A. Beutler, David J. Beech
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Review
Pharmacology & Pharmacy
Hussein N. Rubaiy
ACTA PHARMACEUTICA
(2016)
Review
Pharmacology & Pharmacy
Michael Bergin, Ian Norman, Michelle Foley, Richard Harris, Anna Rapca, Eileen Rich, Marie-Claire Van Hout
ACTA PHARMACEUTICA
(2015)