Article
Biochemistry & Molecular Biology
Nada F. Abo El-Magd, Hasnaa Ali Ebrahim, Mohamed El-Sherbiny, Nada H. Eisa
Summary: The study demonstrates that quinacrine alleviates cisplatin-induced renal toxicity by upregulating SIRT-1, downregulating inflammatory markers (ICAM-1 and TNF-alpha), reducing oxidative stress, and inhibiting apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Qiang Wang, Yuemei Xi, Binyang Chen, Hairong Zhao, Wei Yu, De Xie, Weidong Liu, Furong He, Chenxi Xu, Jidong Cheng
Summary: The study revealed that deficiency of RAGE can alleviate cisplatin-induced acute nephrotoxicity by reducing apoptosis, inflammation, lipid accumulation, and restoring mitochondrial homeostasis and fatty acid oxidation in renal tubular epithelial cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chung-Hsi Hsing, Cheng-Chieh Tsai, Chia-Ling Chen, Yu-Hui Lin, Po-Chun Tseng, Rahmat Dani Satria, Chiou-Feng Lin
Summary: The study found that the activation of GSK-3 beta in the kidneys is associated with cisplatin-induced AKI, and inhibiting GSK-3 beta can alleviate renal injury and inflammation.
Article
Food Science & Technology
Iva Potocnjak, Lidija Simic, Lara Baticic, Hrvoje Krizan, Robert Domitrovic
Summary: Sinomenine has been found to alleviate kidney injury caused by cisplatin by targeting multiple signaling pathways to reduce oxidative stress, inflammation and apoptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Samir A. Salama, Gamil M. Abd-Allah, Ahmed M. Mohamadin, Mostafa M. Elshafey, Hesham S. Gad
Summary: The study demonstrates that ergothioneine can significantly ameliorate cisplatin-induced nephrotoxicity by modulating Nrf2, p53, and NF-xB signaling pathways and inhibiting gamma-glutamyl transpeptidase, suggesting its potential therapeutic application in controlling cisplatin-associated nephrotoxicity.
Article
Biotechnology & Applied Microbiology
Jian-Hong An, Chun-Yan Li, Chun-Ya Chen, Jian-Bin Wu, Hong Shen
Summary: Raloxifene demonstrated significant renoprotective effects in cisplatin-induced nephrotoxicity in mice, by reducing serum biochemical markers, improving kidney and liver tissue injuries, modulating oxidative stress reactions, and thus potentially serving as an adjuvant in cisplatin-based chemotherapeutic protocols.
ONCOTARGETS AND THERAPY
(2021)
Article
Plant Sciences
Jui-Yi Chen, Chia-Lin Tsai, Chiao-Yun Tseng, Pei-Rong Yu, Yu-Hsuan Chang, Yue-Ching Wong, Hui-Hsuan Lin, Jing-Hsien Chen
Summary: This study found that lotus seedpod extract (LSE) can alleviate cisplatin-induced nephrotoxicity by reducing oxidative stress and apoptosis in the kidneys.
Article
Biochemistry & Molecular Biology
Qingyu Zhou, James D. Quirk, Ying Hu, Huimin Yan, Joseph P. Gaut, Christine T. N. Pham, Samuel A. Wickline, Hua Pan
Summary: Researchers have discovered that using rapamycin-loaded perfluorocarbon nanoparticles (PFC NP) can effectively deliver the drug to the injured kidneys, mitigating cisplatin-induced acute kidney injury and preserving renal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Manal M. Hussein, Hussam A. Althagafi, Fahad Alharthi, Ashraf Albrakati, Khalaf F. Alsharif, Abdulrahman Theyab, Rami B. Kassab, Ahmad H. Mufti, Mohammad Algahtani, Atif Abdulwahab A. Oyouni, Roua S. Baty, Ahmed E. Abdel Moneim, Maha S. Lokman
Summary: This study aimed to investigate the therapeutic effects of apigenin on gentamicin-induced nephrotoxicity. The results showed that apigenin administration could alleviate kidney impairments, enhance antioxidant capacity, and suppress renal inflammation and apoptosis. The findings suggest that apigenin treatment may be beneficial in alleviating gentamicin-induced renal impairments.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Medicinal
Jing-Jing Xing, Xiao-Jie Mi, Jin-Gang Hou, En-Bo Cai, Si-Wen Zheng, Shi-Han Wang, Zi Wang, Chen Chen, Wei Li
Summary: Our current research aims to evaluate the efficiency of a flavor enhancer, maltol, in protecting against cisplatin-induced cardiotoxicity. In both animal and cell models, maltol was found to effectively suppress cardiac damage caused by cisplatin by inhibiting the activation of the PI3K/Akt signaling pathways, reducing oxidative stress, and alleviating apoptosis.
PHYTOTHERAPY RESEARCH
(2022)
Article
Cell Biology
Yuanyang Zhang, Yinping Dong, Ping Lu, Xinyue Wang, Wenxuan Li, Hui Dong, Saijun Fan, Deguan Li
Summary: UroA, a metabolite of ellagitannin from fruits like pomegranates, shows radioprotective effects by improving survival rates in irradiated mice, enhancing intestinal morphology and regeneration, and reducing apoptosis of enterocytes induced by radiation. Additionally, UroA helps in the recovery of intestinal microbiota changes caused by ionizing radiation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Chun-yan Fang, Da-yong Lou, Li-qin Zhou, Jin-cheng Wang, Bo Yang, Qiao-jun He, Jia-jia Wang, Qin-jie Weng
Summary: Cisplatin is a clinically advanced anticancer drug, but its severe nephrotoxic effects limit its clinical use. There are currently no effective drugs for cisplatin-induced kidney injury, but natural products may have potential therapeutic effects.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Environmental Sciences
Zhonggui Gong, Wenjing Liu, Ruilong Song, Wenxuan Dong, Kanglei Zhang, Jiahui Li, Hui Zou, Jiaqiao Zhu, Yonggang Ma, Gang Liu, Zongping Liu
Summary: Cadmium (Cd) is a heavy metal pollutant that targets the kidney. Previous studies have shown that Cd-induced nephrotoxicity is caused by apoptosis and autophagy disorders. The regulatory mechanisms of NF-kappa B in Cd-induced kidney injury are still unclear. This study found that Cd promotes the activation of NF-kappa B, which mediates the survival of NRK-52E cells through promoting autophagy and inhibiting apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Anatomy & Morphology
Morteza Saeedavi, Mehdi Goudarzi, Iman Fatemi, Zahra Basir, Seyyed Mohammad Ali Noori, Saeed Mehrzadi
Summary: This study evaluated the beneficial effects of gentisic acid (GA) on gentamicin (GEN)-induced nephrotoxicity in rat kidneys. GA treatment mitigated the deleterious effects of GEN on oxidative stress, inflammatory cytokines, and histopathological changes in the kidneys. GA improved biochemical, inflammatory, and oxidative stress indices against GEN-induced nephrotoxicity.
Article
Food Science & Technology
Zhenzhen Cheng, Jingjing Tu, Hongpan Zhang, Yi Zhang, Benhong Zhou
Summary: UA treatment significantly alleviates renal tissue damage induced by UUO, reducing macrophage infiltration and proinflammatory cytokine expression, inhibiting EMT progression, and regulating the TGF-beta 1/Smad and MAPK signaling pathways to suppress fibrosis.
JOURNAL OF FUNCTIONAL FOODS
(2021)