期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 145, 期 -, 页码 209-218出版社
ELSEVIER
DOI: 10.1016/j.jpba.2017.06.015
关键词
Torasemide; Fragmentation behaviour; Degradation product; High resolution mass spectrometry; Multi-stage mass spectrometry; Density functional theory
Mass spectrometry tools (HRMS/LC-HRMS, MSn, and/or on-line HID exchange) were employed to establish mass fragmentation pattern of torasemide and to characterize its degradation products. During collision-induced dissociation, multiple rearrangement processes and unusual losses of sulfur (S), sulfanyl (HS center dot), sulfur dioxide (SO2), sulphinic acid radical (HSO2 center dot), sulfur monoxide (SO), carbon monoxide (CO), formyl radical (CHO center dot) and C5H3NOS were observed. The same were successfully explained by study of energy profiles, established by application of density functional theory (DFT). (C) 2017 Elsevier B.V. All rights reserved.
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