Article
Dentistry, Oral Surgery & Medicine
Alberto Monje, Maria Vera, Agustin Munoz-Sanz, Hom-Lay Wang, Jose Nart
Summary: This study investigated the characteristics related to SUP around dental implants and found that the presence and grade of SUP were associated with the prevalence of peri-implantitis and implant features, indicating a close relationship between SUP and the clinical manifestations and influencing factors of peri-implantitis.
JOURNAL OF PERIODONTOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Lena Freitag, Thomas Spinell, Annika Kroger, Gregor Wuerfl, Michael Lauseker, Reinhard Hickel, Moritz Kebschull
Summary: This study aims to systematically review the impact of titanium particles on oral-related cells by examining changes in molecular signatures. Through a systematic search, 12 eligible publications were identified, and a significant overlap of gene expression in oral-related cells exposed to titanium particles was found in four studies. Changes in immune/inflammatory and stress response processes, as well as toll-like receptor and mitogen-activated protein kinase signaling pathways, were associated with titanium exposure in transcriptome and proteome studies. However, the findings regarding epigenetic changes caused by titanium were inconsistent.
Review
Dentistry, Oral Surgery & Medicine
Jovania Alves Oliveira, Roberta de Oliveira Alves, Isabella Mazarelo Nascimento, Marco Antonio Rimachi Hidalgo, Raquel Mantuaneli Scarel-Caminaga, Suzane Cristina Pigossi
Summary: This study aimed to review the levels of pro- and anti-inflammatory cytokines and osteoclastogenesis-related factors in peri-implant diseases. The results showed that the levels of IL-1β, IL-6, IL-10, and RANKL/OPG were not balanced in peri-implant diseases, suggesting their involvement in the host response related to peri-implantitis.
Article
Dentistry, Oral Surgery & Medicine
Leif Jansson, Anna Lundmark, Carolina Modin, Denise Abadji, Tulay Yucel-Lindberg
Summary: This study aimed to investigate cytokine profiles and intra-individual correlations in gingival crevicular fluid samples. The results showed lower cytokine levels in healthy tooth and implant sites compared to diseased sites, with significant intra-individual correlations in peri-implant sites. Additionally, IFN-lambda 1 and TNFSF12 were significantly correlated with peri-implantitis.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Review
Infectious Diseases
Asma Gasmi Benahmed, Amin Gasmi, Torsak Tippairote, Pavan Kumar Mujawdiya, Oleksandr Avdeev, Yurii Shanaida, Geir Bjorklund
Summary: Dental implants are commonly used to replace lost teeth, and titanium implants have a high success rate. However, there is an increasing risk of peri-implantitis, an inflammatory disease that affects the tissues around the implant. This review highlights the impact of different metabolic conditions on peri-implantitis and emphasizes the importance of considering both local and systemic factors in dental implant procedures and treatment.
Article
Medicine, General & Internal
Lu Song, Jimin Jiang, Jia Li, Chuan Zhou, Yanqi Chen, Hongye Lu, Fuming He
Summary: Peri-implantitis sites have higher microbial diversity, with an abundance of gram-negative and anaerobic bacteria. Patients with peri-implantitis show elevated levels of bacteria such as Peptostreptococcaceae XIG-1, Treponema, Porphyromonas, Lachnospiraceae G-8, as well as cytokines IL-17A, IL-6, IL-15, G-CSF, RANTES, and IL-1 beta. These bacteria and cytokines are positively associated with clinical parameters such as probing depth, bleeding on probing, and marginal bone loss. Biomarkers can aid in the diagnosis of peri-implantitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mario Romandini, Jessica Berglundh, Jan Derks, Mariano Sanz, Tord Berglundh
Summary: The study aimed to evaluate the diagnostic accuracy of clinical and radiographic evaluations made at a single time point during follow-up. The bone levels observed at 9 years were highly accurate in identifying pronounced bone loss. In the absence of baseline documentation, a secondary case definition based on clinical findings provided the best overall diagnostic accuracy in identifying peri-implantitis cases.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Review
Dentistry, Oral Surgery & Medicine
Pedro Diaz, Esther Gonzalo, Luis J. Gil Villagra, Barbara Miegimolle, Maria J. Suarez
Summary: This systematic review estimates the overall prevalence of peri-implantitis and explores the impact of different study designs, function times, and use of probing depth on the prevalence rate. The results show that the prevalence of peri-implantitis is highly variable and the use of probing depth as a diagnostic criterion affects the prevalence data. It is important to identify diagnostic markers for more accurate disease classification.
Review
Medicine, Research & Experimental
Carlos Henrique Alves, Karolayne Larissa Russi, Natalia Conceicao Rocha, Fabio Bastos, Michelle Darrieux, Thais Manzano Parisotto, Raquel Girardello
Summary: In recent decades, there have been significant advances in ortho-aesthetic-functional rehabilitation with the introduction of implantology. However, there is still a percentage of failures in implantology surgeries, mainly due to infections caused by bacterial proliferation, fungi presence, and biofilm formation, leading to peri-implantitis. Various studies have been conducted to explore the interaction between the host-oral microbiome and the development of peri-implantitis. Peri-implantitis is associated with a diversity of bacterial species, with Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia being identified in higher proportions of peri-implantitis samples. In addition, the injury of peri-implant tissue triggers an inflammatory response mediated by the activation of innate immune cells, such as macrophages, dendritic cells, mast cells, and neutrophils. Activation of the host immune system may disrupt the balance of oral microbiota, leading to dysbiosis and the production of various substances that contribute to implant loss.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Andrea Butera, Maurizio Pascadopoli, Matteo Pellegrini, Simone Gallo, Paolo Zampetti, Andrea Scribante
Summary: Peri-implant infections are common complications of dental implants, and this review evaluates the changes in oral microbiota associated with peri-implant disease. The study finds similarities and differences between peri-implantitis and periodontitis in microbial composition. The use of probiotics, in combination with mechanical debridement, shows potential for reducing peri-implant pockets. Transcriptomics can provide valuable insights into bacterial virulence factors for the prevention, diagnosis, and treatment of peri-implant pathology.
APPLIED SCIENCES-BASEL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Iva Milinkovic, Ana Djinic Krasavcevic, Nadja Nikolic, Zoran Aleksic, Jelena Carkic, Marija Jezdic, Sasha Jankovic, Jelena Milasin
Summary: This study aimed to compare the levels of Notch signaling pathway, bone remodeling mediators, and pro-inflammatory cytokines in peri-implantitis patients and healthy implants. The results showed that down-regulation of Notch 1 and increased expression of inflammation modulators in peri-implantitis may lead to increased osteoclast activity and subsequent bone resorption.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Muhammad H. A. Saleh, Hadiya Khurshid, Suncica Travan, Khaled Sinjab, Ali Bushahri, Hom-Lay Wang
Summary: The study found that implants placed in sites with a history of apical surgery do not have an increased risk of implant failure or retrograde peri-implantitis. The incidence of RPI was 20%, with an increased trend in cases of persistent apical periodontitis.
JOURNAL OF PERIODONTOLOGY
(2021)
Review
Medicine, General & Internal
Andrea Roccuzzo, Alexandra Stahli, Alberto Monje, Anton Sculean, Giovanni E. Salvi
Summary: Dental implants are considered a reliable routine procedure for replacing missing teeth, but the presence of peri-implantitis has become a concern due to its negative impact on patients' quality of life. The surgical therapeutic modalities for managing this disorder include indications, contraindications, complexity, predictability, and effectiveness.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
J. Martinez-Amargant, B. de Tapia, A. Pascual, J. Takamoli, C. Esquinas, J. Nart, C. Valles
Summary: This study aimed to determine the association between tobacco and peri-implant diseases and investigate patient- and implant-related variables associated with peri-implant diseases. Data from 117 patients treated with implant-supported restorations were analyzed, and the study found that smoke intensity was associated with an increased risk of peri-implant diseases.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Medicine, General & Internal
Pablo Galindo-Moreno, Andres Catena, Lucia Lopez-Chaichio, Tiago Borges, Francisco O'Valle, Laura Torrecillas-Martinez, Miguel Padial-Molina
Summary: The aim of this study was to analyze the long-term marginal bone level (MBL) of implants supporting fixed full-arch restoration in patients who had previously lost their dentition due to severe periodontitis. The results showed that dental implants restored with fixed segmented full-arch rehabilitation in patients with a history of severe periodontal disease do not suffer important marginal bone loss if some specific factors are considered, mainly the use of long transmucosal abutments (>= 2 mm).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Microbiology
Christopher Nile, Monica Falleni, Daniela Cirasola, Abeer Aighamdi, Oliver F. Anderson, Christopher Delaney, Gordon Ramage, Emerenziana Ottaviano, Delfina Tosi, Gaetano Bulfamante, Giulia Morace, Elisa Borghi
Article
Dentistry, Oral Surgery & Medicine
Pinar Meric, Nurcan Buduneli, Burcu Kanmaz, Onder Gurlek, Erhan Comlekoglu, Gareth Calvert, David F. Lappin, Christopher Nile
JOURNAL OF CLINICAL PERIODONTOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Burcu Kanmaz, David F. Lappin, Christopher J. Nile, Nurcan Buduneli
JOURNAL OF PERIODONTOLOGY
(2020)
Review
Microbiology
Sumaya Abusrewil, Om Alkhir Alshanta, Khawlah Albashaireh, Saeed Alqahtani, Christopher J. Nile, James Alun Scott, William McLean
CRITICAL REVIEWS IN MICROBIOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
James R. Allison, Charlotte C. Currie, David C. Edwards, Charlotte Bowes, Jamie Coulter, Kimberley Pickering, Ekaterina Kozhevnikova, Justin Durham, Christopher J. Nile, Nicholas Jakubovics, Nadia Rostami, Richard Holliday
Summary: This study aimed to evaluate the distribution and persistence of dental aerosol and splatter by introducing fluorescein into irrigation reservoirs. The results showed that dental procedures generate aerosol and splatter, with contamination being effectively cleared by suction and within 30 minutes post-procedure. The two analytic methods used in the study showed good correlation.
JOURNAL OF ORAL REHABILITATION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Richard Holliday, James R. Allison, Charlotte C. Currie, David C. Edwards, Charlotte Bowes, Kimberley Pickering, Sarah Reay, Justin Durham, Joanna Lumb, Nadia Rostami, Jamie Coulter, Christopher Nile, Nicholas Jakubovics
Summary: This study investigated splatter/aerosol distribution from dental procedures and aerosol settling time in an open plan clinic. The results showed that cross-infection risk is small at distances of 5 meters or more in open plan clinics. Dental suction and ventilation have a substantial beneficial effect in reducing contamination. Most settled aerosol is detectable within 10 minutes, indicating the need for environmental cleaning after this period.
JOURNAL OF DENTISTRY
(2021)
Article
Microbiology
Sheeba Thomas, David F. Lappin, Christopher J. Nile, Julie Spears, David Bennett, Bernd W. Brandt, Marcello P. Riggio
Summary: In this study, it was found that the oral microbiomes associated with the FORL-1 subgroup are distinct from those found in the healthy group and FORL-2 subgroup, with lower bacterial diversity and levels. Lampropedia species may play a role in the tooth and bone resorption observed in FORL.
JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Microbiology
Emily McKloud, Christopher Delaney, Leighann Sherry, Ryan Kean, Shanice Williams, Rebecca Metcalfe, Rachael Thomas, Riina Richardson, Konstantinos Gerasimidis, Christopher J. Nile, Craig Williams, Gordon Ramage
Summary: This study identified changes in vaginal microbiome in RVVC, showing a reduction in Lactobacillus crispatus and an increase in Lactobacillus iners. The presence of Candida albicans biofilm formation and interactions with Lactobacillus species were also highlighted, suggesting potential mechanisms for RVVC and the importance of understanding these interactions for developing effective therapies.
Review
Dentistry, Oral Surgery & Medicine
Nontawat Chuinsiri, David Edwards, Vsevolod Telezhkin, Christopher J. Nile, Frederic Van der Cruyssen, Justin Durham
Summary: This systematic review focused on changes in neuropeptide expression following trigeminal neuropathic pain in animal models, with CGRP and substance P being the most frequently reported neuropeptides. However, included studies showed varying levels of bias risk, ranging from unclear to high.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jason L. Brown, Eleanor Townsend, Robert D. Short, Craig Williams, Chris Woodall, Christopher J. Nile, Gordon Ramage
Summary: Infected wounds can lead to chronicity, and the choice of treatment should take into account the tissue's response.
NPJ BIOFILMS AND MICROBIOMES
(2022)
Article
Cell & Tissue Engineering
Saeed Alqahtani, Mark C. C. Butcher, Gordon Ramage, Matthew J. J. Dalby, William McLean, Christopher J. J. Nile
Summary: Mesenchymal stem cells (MSCs) have the potential to regenerate tissues. However, the signaling mechanisms and pathways that control their proliferation and differentiation are not fully understood. Recent studies suggest that the non-neuronal cholinergic signaling system, specifically acetylcholine (ACh), plays a significant role in cell-to-cell communication and stem cell function. ACh receptors (AChRs) have been identified in MSCs and have been found to impact their regenerative potential. This review summarizes the expression and function of AChRs in different types of MSCs, highlighting their pivotal role in regulating MSC regenerative function.
STEM CELLS AND DEVELOPMENT
(2023)
Article
Infectious Diseases
Om Alkhir Alshanta, Suror Shaban, Christopher J. Nile, William McLean, Gordon Ramage
Article
Microbiology
Christopher Delaney, Lindsay E. O'Donnell, Ryan Kean, Leighann Sherry, Jason L. Brown, Gareth Calvert, Christopher J. Nile, Laura Cross, David J. Bradshaw, Bernd W. Brandt, Douglas Robertson, Gordon Ramage
Article
Microbiology
Christopher Delaney, Ryan Kean, Bryn Short, Maria Tumelty, William McLean, Christopher J. Nile, Gordon Ramage
CURRENT CLINICAL MICROBIOLOGY REPORTS
(2018)
Article
Dentistry, Oral Surgery & Medicine
Ceren Gurlek, Fahinur Ertugrul, Christopher Nile, David F. Lappin, Nurcan Buduneli
ORAL HEALTH & PREVENTIVE DENTISTRY
(2018)