Article
Gastroenterology & Hepatology
Theresa H. Nguyen, Aaron P. Thrift, Rollin George, Daniel G. Rosen, Hashem B. El-Serag, Gyanprakash A. Ketwaroo
Summary: This study aimed to evaluate the proportion of missed dysplasia within 18 months of the initial diagnosis of Barrett's esophagus (BE). The results showed a decrease in the occurrence of missed dysplasia over time. Patients with long segment BE were more likely to have missed dysplasia and could benefit from dysplasia surveillance within 18 months of diagnosis.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Elissa M. Ozanne, Elisabeth R. Silver, Sameer D. Saini, Joel H. Rubenstein, Iris Lansdorp-Vogelaar, Nicole Bowers, Sarah Xinhui Tan, John M. Inadomi, Chin Hur
Summary: Physicians' recommendations for BE surveillance cessation vary based on patient age, comorbidities, and BE length, with age showing the most significant variation in decisions. It appears that age and comorbidities influence BE surveillance cessation decisions, but with differences among clinicians. Clear guidelines balancing the risks and benefits of BE surveillance cessation are needed.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Edward H. Tsoi, Puneet Mahindra, Georgina Cameron, Richard Williams, Richard Norris, Paul Desmond, Spiro Raftopoulos, Darren Pavey, Arti Rattan, Luke F. Hourigan, Richard Lee, Michael J. Bourke, Naaz Sidhu, Rajvinder Singh, Andrew Chan, Sudarshan Krishnamurthi, Andrew C. F. Taylor
Summary: This study aimed to determine the proportion of prevalent HGD or EAC detected in Barrett's esophagus (BE) patients referred from the community with a recent diagnosis of low-grade dysplasia (LGD). The results showed that BERU assessment endoscopy identified more visible lesions than community referral endoscopy and identified HGD or EAC in 27% of patients referred from the community with a recent diagnosis of LGD. Reported progression rates from LGD to HGD or EAC may be overestimated.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Medicine, General & Internal
Francesco Maione, Alessia Chini, Rosa Maione, Michele Manigrasso, Alessandra Marello, Gianluca Cassese, Nicola Gennarelli, Marco Milone, Giovanni Domenico De Palma
Summary: Barrett's Esophagus is a common condition associated with chronic gastroesophageal reflux disease and has a higher risk of developing esophageal adenocarcinoma. Low and high-grade dysplasia precede neoplastic transformation in this condition. The evaluation of low-grade dysplastic esophageal mucosa is still controversial, but endoscopic surveillance and minimally invasive endoscopic treatments such as endoscopic mucosal resection and radiofrequency ablation are available options. Cryotherapy ablation and argon plasma coagulation are novel endoscopic treatments with high eradication rates and fewer complications and post-procedural pain.
Review
Medicine, General & Internal
Peter M. M. Stawinski, Karolina N. N. Dziadkowiec, Lily A. A. Kuo, Juan Echavarria, Shreyas Saligram
Summary: Barrett's esophagus (BE) is a premalignant mucosal transformation characterized by the replacement of esophageal squamous epithelium with metaplastic columnar epithelium. It is associated with an increased risk of esophageal adenocarcinoma and is often caused by gastroesophageal reflux disease. Screening for BE is selective based on risk factors and is not recommended for the general population. Diagnosis involves endoscopic recognition, targeted biopsies, and histologic confirmation of columnar metaplasia. This review provides a comprehensive overview of the epidemiology, pathogenesis, screening, and advanced techniques for detecting and eradicating Barrett's esophagus.
Article
Gastroenterology & Hepatology
Blake Jones, J. Lucas Williams, Srinadh Komanduri, V. Raman Muthusamy, Nicholas J. Shaheen, Sachin Wani
Summary: Black patients with Barrett's esophagus have lower diagnosis rates, are less likely to be recommended appropriate surveillance intervals, and are less likely to follow the Seattle biopsy protocol compared to white patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Oncology
Lu Zhang, Binyu Sun, Xi Zhou, QiongQiong Wei, Sicheng Liang, Gang Luo, Tao Li, Muhan Lu
Summary: This article briefly describes the etiology and clinical significance of intestinal metaplasia in Barrett's esophagus, as well as its impact on diagnosis, monitoring, and treatment according to different guidelines. The basis for endoscopic diagnosis and identification techniques of goblet cells in Barrett's esophagus are explored, along with current treatment methods related to the condition.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Mohamed Hussein, David Lines, Juana Gonzalez-Bueno Puyal, Rawen Kader, Nicola Bowman, Vinay Sehgal, Daniel Toth, Omer F. Ahmad, Martin Everson, Jose Miguel Esteban, Raf Bisschops, Matthew Banks, Michael Haefner, Peter Mountney, Danail Stoyanov, Laurence B. Lovat, Rehan Haidry
Summary: This study developed a computer-aided characterization system to support the diagnosis of dysplasia in Barrett's esophagus (BE) on magnification endoscopy. By training a neural network with high-definition images and videos, the system showed high accuracy and speed in characterizing dysplasia in BE, making a step towards real-time automated diagnosis.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Gastroenterology & Hepatology
Robert D. Odze, John Goldblum, Vivek Kaul
Summary: Barrett's esophagus (BE) is a premalignant condition that can be effectively monitored and managed using the Wide-area transepithelial sampling with computer-assisted three-dimensional analysis (WATS(3D)) technique, which has shown to significantly increase detection rates of dysplasia and intestinal metaplasia in BE patients.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Claire A. Beveridge, Chetan Mittal, V. Raman Muthusamy, Amit Rastogi, Vladimir Kushnir, Mariah Wood, Sachin Wani, Srinadh Komanduri
Summary: This study aimed to assess the rate of visible lesion (VL) detection by academic and community endoscopists using high-definition white-light endoscopy (HD-WLE) and narrow-band imaging (NBI). Participants identified VLs using HD-WLE and NBI, and the results showed that 28% and 31% of VLs were not identified using HD-WLE and NBI respectively. The study also found that the rate of VL detection was associated with the endoscopist's experience and the number of surveillance endoscopies performed each month.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Theresa H. Nguyen, Aaron P. Thrift, Gyanprakash A. Ketwaroo, Xianglin L. Du, Luis Leon Novelo, Rollin George, Daniel G. Rosen, Hashem B. El-Serag
Summary: This external validation study provides further evidence that the model including sex, LGD status, smoking status, and BE length may help to risk stratify BE patients. A simplified version excluding LGD status and/or reducing the number of risk groups has increased utility in clinical practice without loss of discriminatory ability.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Mathew Vithayathil, Ines Modolell, Jacobo Ortiz-Fernandez-Sordo, Apostolos Pappas, Wladyslaw Januszewicz, Maria O'Donovan, Michele Bianchi, Jonathan. R. R. White, Philip Kaye, Krish Ragunath, Massimiliano di Pietro
Summary: For patients with Barrett's esophagus without clearly visible dysplastic lesions, longer procedural time is associated with a higher dysplasia detection rate. Adequate time is needed to perform high-quality surveillance and maximize dysplasia detection.
Review
Gastroenterology & Hepatology
V. Raman Muthusamy, Sachin Wani, C. Prakash Gyawali, Srinadh Komanduri
Summary: This article summarizes the best practice advice for screening and surveillance of Barrett's esophagus, including screening criteria, endoscopic examination methods, and sampling techniques.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hsin-Yu Fang, Stefan Stangl, Sabrina Marcazzan, Marcos J. Braz Carvalho, Theresa Baumeister, Akanksha Anand, Julia Strangmann, Julia Slotta Huspenina, Timothy C. Wang, Roland M. Schmid, Marcus Feith, Helmut Friess, Vasilis Ntziachristos, Gabriele Multhoff, Dimitris Gorpas, Michael Quante
Summary: This study evaluated the use of a highly specific Hsp70-specific contrast agent in guided fluorescence molecular endoscopy biopsy, showing promising potential to improve tumor surveillance in BE patients, especially in cases with dysplasia and EAC.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Gastroenterology & Hepatology
Joel H. Rubenstein, Jennifer A. Burns, Maria E. Arasim, Elizabeth M. Firsht, Matthew Harbrecht, Marilla Widerquist, Richard R. Evans, John M. Inadomi, Joy W. Chang, William D. Hazelton, Chin Hur, Jacob E. Kurlander, Francesca Lim, Georg Luebeck, Peter W. Macdonald, Chanakyaram A. Reddy, Sameer D. Saini, Sarah Xinhui Tan, Akbar K. Waljee, Iris Lansdorp-Vogelaar
Summary: This study aimed to estimate the yield of repeat esophagogastroduodenoscopy (EGD) performed at prolonged intervals after a normal index EGD. The results showed that a longer duration between EGD was associated with a greater odds of a new diagnosis of Barrett's esophagus, esophageal adenocarcinoma, or esophagogastric junction adenocarcinoma, especially among younger individuals.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
