Article
Clinical Neurology
Ayaka Hayashi, Sadasivam Suresh, Ajay Kevat, Jacob Robinson, Nitin Kapur
Summary: The study aims to describe the outcomes of central sleep apnea requiring home supplemental oxygen therapy in otherwise healthy term infants. The findings suggest that central sleep apnea in otherwise healthy term infants generally has a good prognosis, and oxygen therapy can improve oxygen saturation and decrease apnea-hypopnea index when assessed with polysomnography.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Clinical Neurology
Darko Stefanovski, Ignacio E. Tapia, Janet Lioy, Shaon Sengupta, Sagori Mukhopadhyay, Aoife Corcoran, Mary Anne Cornaglia, Christopher M. Cielo
Summary: This study evaluated the changes in respiratory indices during sleep in healthy infants during the first six months of life. The results showed that central and obstructive apnea hypopnea index (AHI) were higher in healthy newborns compared to older children, and there was a significant spontaneous reduction in events and change in event type in the first six months of life.
Review
Medicine, General & Internal
Eleanor Jones, Fiona Stewart, Beck Taylor, Peter G. Davis, Stephanie J. Brown
Summary: The study assessed the effects of early postnatal discharge from hospital for healthy mothers and term infants, finding that early discharge may increase the risk of infant readmission within 28 days, but has little impact on maternal readmission within six weeks postpartum. However, the evidence is currently of moderate to low certainty, indicating a need for further research.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Immunology
Kim Anderson, Emma Kalk, Hlengiwe P. Madlala, Dorothy C. Nyemba, Nisha Jacob, Amy Slogrove, Mariette Smith, Max Kroon, Michael C. Harrison, Brian S. Eley, Andrew Boulle, Landon Myer, Mary-Ann Davies
Summary: Infants who are HIV exposed but uninfected did not show increased all-cause or infection-related hospitalization compared with HIV unexposed uninfected infants. However, they were more likely to experience very preterm birth, very low birthweight, and ICU admission, indicating increased severity of neonatal morbidity.
Article
Medicine, General & Internal
Monika Kamianowska, Marek Szczepanski, Elzbieta E. Kulikowska, Barbara Bebko, Alicja Koput, Anna Wasilewska
Summary: This study aimed to determine the normal concentrations of urinary netrin-1 in healthy full-term newborns, finding that it is independent of gender and time of urine collection, but negatively correlated with birth weight. Future research is needed to confirm its potential role as a marker of kidney function in this age group.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Genetics & Heredity
Siiri Sarv, Tiina Kahre, Eve Vaidla, Sander Pajusalu, Kai Muru, Haide Poder, Katrin Gross-Paju, Sandra Utt, Riina Zordania, Inga Talvik, Eve Oiglane-Shlik, Kristina Muhu, Katrin Ounap
Summary: The study in Estonia described the birth prevalence of SMA from 1996 to 2020 and found that the birth prevalence of SMA in the country is similar to the median in Europe. The research provided valuable information on the epidemiology of SMA, which can guide the implementation of spinal muscular atrophy into the newborn screening program in Estonia.
FRONTIERS IN GENETICS
(2021)
Article
Cardiac & Cardiovascular Systems
Casey Crump, Jan Sundquist, Kristina Sundquist
Summary: This study found that preterm delivery is associated with an increased risk of stroke, which remains elevated for at least 40 years after delivery and is independent of other factors and familial influences.
Article
Pediatrics
James T. Nugent, Chelsea Young, Melissa C. Funaro, Kuan Jiang, Ishan Saran, Lama Ghazi, F. Perry Wilson, Jason H. Greenberg
Summary: This study estimated the prevalence of secondary hypertension in otherwise healthy children diagnosed with hypertension in outpatient settings. The results showed that studies conducted in primary care or school settings reported a lower prevalence of secondary hypertension compared to studies conducted in referral clinics.
JOURNAL OF PEDIATRICS
(2022)
Review
Medicine, General & Internal
Anna Gavine, Shona C. Shinwell, Phyll Buchanan, Albert Farre, Angela Wade, Fiona Lynn, Joyce Marshall, Sara E. Cumming, Shadrach Dare, Alison McFadden
Summary: The study reviewed 116 trials on breastfeeding support from various countries, emphasizing the importance of breastfeeding support in prolonging breastfeeding duration.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Pediatrics
Alexandra Bower, Perrine Lorain, Gilles Kayem, Marc Dommergues, Laurence Foix-L'Helias, Isabelle Guellec
Summary: The study found that newborns with pathological foetal acidemia but without moderate or severe HIE may have metabolic disorders, require organ support, hospitalization, and blood sampling for detecting biological anomalies. Prospective studies are needed to establish consensus guidelines for managing this vulnerable population.
Article
Multidisciplinary Sciences
Giovanna de Paula Vidigal, David M. Garner, Amanda N. Akimoto, Vitor E. Valenti
Summary: The study found that healthy term-born women with low birth weight showed slower heart rate autonomic recovery after exercise.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Lauren Bishop, Kieron Barclay
Summary: This study examines whether higher birth order is associated with adverse health outcomes related to alcohol or narcotics in midlife. The findings suggest that birth order has limited effects on these outcomes after considering familial background characteristics.
SSM-POPULATION HEALTH
(2022)
Article
Pediatrics
Cecilia Caldeman, Anna Fogelstrom, Jenny Oddsberg, Carmen Mesas Burgos, Anna Lof Granstrom
Summary: The study in Sweden found a stable birth prevalence of gastroschisis at 1.52 per 10,000 live births over a 20-year period. The mortality rate was low at 4.4%, but termination of pregnancies was high at 21%, with gastrointestinal anomalies being the most common associated anomalies.
Article
Genetics & Heredity
Aleksandra Jezela-Stanek, Lidia Suchon, Agnieszka Sobczynska-Tomaszewska, Kamila Czerska, Katarzyna Kusmierska, Joanna Taybert, Mariusz Oltarzewski, Jolanta Sykut-Cegielska
Summary: Biotinidase deficiency (BD) is a rare metabolic disease. This study presents the molecular spectrum of BD in Polish patients diagnosed within the national newborn screening program. The prevalence of BD in this population was estimated to be 1:66,966 (1:178,577 for profound forms and 1:107,146 for partial forms). The study also provided novel data on the molecular etiology of BD.
Article
Psychiatry
Christina Mikkelsen, Margit A. H. Larsen, Erik Sorensen, Thomas Folkmann Hansen, Susan Mikkelsen, Christian Erikstrup, Kaspar R. Nielsen, Mie T. Bruun, Henrik Hjalgrim, Lars Kessing, Thomas Werge, Henrik Ullum, Sisse R. Ostrowski, Ole B. Pedersen, Lise W. Thorner, Maria Didriksen
Summary: This study investigated the point prevalence of Major Depressive Disorder (MDD) and sex differences in symptomatology among undiagnosed, healthy adults. It also explored whether specific symptoms increased the likelihood of later needing anti-depressive medication. The results showed that MDD was associated with an increased risk of receiving a prescription for anti-depressive medication in the future, with the risk increasing as the severity of MDD increased. Feeling that life is not worth living was the strongest predictive symptom for women, while trouble sleeping was the strongest for men.
PSYCHIATRY RESEARCH
(2022)
Article
Biochemical Research Methods
Brian Chang, J. Levin, William A. Thompson, William G. Fairbrother
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2010)
Article
Pediatrics
Jonathan C. Levin, Lisa Gagnon, Xiaoxuan He, Eric D. Baum, David E. Karas, Geoffrey L. Chupp
PEDIATRIC RESEARCH
(2014)
Review
Obstetrics & Gynecology
Alejandra Barrero-Castillero, Kristyn S. Beam, Laura B. Bernardini, Erika G. Cordova Ramos, Patricia E. Davenport, Anna R. Duncan, Yarden S. Fraiman, Lauren C. Frazer, Helen Healy, Emily M. Herzberg, Madeline L. Keyes, Kristen T. Leeman, Kristin Leone, Jonathan C. Levin, Matthew Lin, Ravikiran M. Raju, Anne Sullivan
Summary: This review provides a comprehensive overview of neonatal-perinatal perspectives of COVID-19, ranging from the basic science of infection and recommendations for care of pregnant women and neonates to important psychosocial, ethical, and racial/ethnic topics emerging as a result of both the pandemic and the response of the healthcare community to the care of infected individuals.
JOURNAL OF PERINATOLOGY
(2021)
Article
Obstetrics & Gynecology
Jonathan C. Levin, Andrew L. Beam, Kathe P. Fox, Kenneth D. Mandl
Summary: This study compared medication dispensing in children born preterm and full-term during the first two years of life. It found that preterm children had a higher number and cost of prescriptions, with differences peaking at 4-9 months and resolving by 19 months after discharge. The utilization of palivizumab, anti-reflux, and respiratory medications drove prescription medication usage among preterm children under 2 years.
JOURNAL OF PERINATOLOGY
(2021)
Article
Pediatrics
Joseph M. Collaco, Amit Agarwal, Eric D. Austin, Lystra P. Hayden, Khanh Lai, Jonathan Levin, Winston M. Manimtim, Paul E. Moore, Catherine A. Sheils, Michael C. Tracy, Stamatia Alexiou, Christopher D. Baker, A. Ioana Cristea, Julie L. Fierro, Lawrence M. Rhein, Natalie Villafranco, Leif D. Nelin, Sharon A. McGrath-Morrow
Summary: This study investigated a diverse outpatient cohort of former preterm infants with BPD in geographically distinct clinics, finding variations in management strategies and a majority of nonwhite children. Neither management variation nor BPD severity at 36 weeks influenced outpatient acute care utilization, suggesting that post-neonatal ICU factors may independently modify respiratory outcomes in BPD.
PEDIATRIC PULMONOLOGY
(2021)
Article
Obstetrics & Gynecology
Chandler A. Annesi, Jonathan C. Levin, Jonathan S. Litt, Catherine A. Sheils, Lystra P. Hayden
Summary: The study comparing tBPD and sBPD children showed that tBPD subjects experience more severe long-term impairment in respiratory function and neurodevelopment, including lower maximal childhood FEV1 % predicted, greater cognitive and motor delays.
JOURNAL OF PERINATOLOGY
(2021)
Article
Critical Care Medicine
A. Ioana Cristea, Clement L. Ren, Reshma Amin, Laurie C. Eldredge, Jonathan C. Levin, Parevi P. Majmudar, Anne E. May, Rebecca S. Rose, Michael C. Tracy, Karen F. Watters, Julian Allen, Eric D. Austin, Mary E. Cataletto, Joseph M. Collaco, Robert J. Fleck, Andrew Gelfand, Don Hayes, Marcus H. Jones, Sheila S. Kun, Erica W. Mandell, Sharon A. McGrath-Morrow, Howard B. Panitch, Rizwana Popatia, Lawrence M. Rhein, Alejandro Teper, Jason C. Woods, Narayan Iyer, Christopher D. Baker
Summary: This document provides an evidence-based clinical practice guideline on the outpatient management of premature infants, children, and adolescents with post-prematurity respiratory disease (PPRD), including recommendations for common medical therapies and diagnostic evaluations to improve patient care. The recommendations were developed based on limited evidence and expert opinion, with important areas for future research identified.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Obstetrics & Gynecology
Jonathan C. Levin, Andrew L. Beam, Kathe P. Fox, Lystra P. Hayden
Summary: The study aimed to compare rates of hospitalizations for respiratory illnesses in preterm and full-term children before and after the 2014 update to the American Academy of Pediatrics respiratory syncytial virus immunoprophylaxis guidance. The results showed that hospitalization rates for RSV or respiratory illnesses did not increase after the implementation of the policy change, and cost savings were obtained.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Pediatrics
Robin L. McKinney, Natalie Napolitano, Jonathan J. Levin, Matthew J. Kielt, Steven H. Abman, Milenka Cuevas Guaman, Rebecca S. Rose, Sherry E. Courtney, David Matlock, Amit Agarwal, Kristen T. Leeman, Lauren A. Sanlorenzo, Richard Sindelar, Joseph M. Collaco, Christopher D. Baker, Kathleen E. Hannan, Matthew Douglass, Laurie C. Eldredge, Khanh Lai, Sharon A. McGrath-Morrow, Michael C. Tracy, William Truog, Tamorah Lewis, Anarina L. Murillo, Martin Keszler
Summary: A point prevalence study was conducted on infants with severe bronchopulmonary dysplasia (BPD), revealing significant center-specific variation in ventilator modes among the 187 infants from 15 centers, with 51% on invasive positive-pressure ventilation (IPPV).
JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Joseph M. Collaco, Michael C. Tracy, Catherine A. Sheils, Jessica L. Rice, Lawrence M. Rhein, Leif D. Nelin, Paul E. Moore, Winston M. Manimtim, Jonathan C. Levin, Khanh Lai, Lystra P. Hayden, Julie L. Fierro, Eric D. Austin, Stamatia Alexiou, Amit Agarwal, Natalie Villafranco, Roopa Siddaiah, Antonia P. Popova, Ioana A. Cristea, Christopher D. Baker, Manvi Bansal, Sharon A. McGrath-Morrow
Summary: This study found that children with BPD who received Medicaid coverage were more likely to utilize acute care and have nighttime respiratory symptoms during the first 3 years of life.
PEDIATRIC PULMONOLOGY
(2022)
Article
Pediatrics
Sharon A. McGrath-Morrow, Amit Agarwal, Stamatia Alexiou, Eric D. Austin, Julie L. Fierro, Lystra P. Hayden, Khanh Lai, Jonathan C. Levin, Winston M. Manimtim, Paul E. Moore, Lawrence M. Rhein, Jessica L. Rice, Catherine A. Sheils, Michael C. Tracy, Manvi Bansal, Christopher D. Baker, A. Ioana Cristea, Antonia P. Popova, Roopa Siddaiah, Natalie Villafranco, Leif D. Nelin, Joseph M. Collaco
JOURNAL OF PEDIATRICS
(2022)
Article
Respiratory System
Laurie C. Eldredge, Jonathan C. Levin, Michael C. Tracy, A. Ioana Cristea, Christopher D. Baker, Joseph K. Ruminjo, Carey C. Thomson
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Respiratory System
Jonathan C. Levin, Catherine A. Sheils, Jonathan M. Gaffin, Craig P. Hersh, Lawrence M. Rhein, Lystra P. Hayden
Summary: Survivors of prematurity are at risk for abnormal childhood lung function. This study found that children born preterm demonstrate worsening obstruction in lung function throughout childhood, with factors such as longer duration of mechanical ventilation, postnatal steroid exposure, and maternal atopy and asthma contributing to diminished rate of rise in lung function.
RESPIRATORY RESEARCH
(2021)
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)