期刊
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
卷 39, 期 3, 页码 217-222出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MPH.0000000000000786
关键词
acute liver failure; deferasirox; drug induced liver injury; hepatotoxicity
This case report details a unique case of acute, reversible liver failure in a 12-year-old male with sickle cell anemia on chronic transfusion protocol and deferasirox chelation. There is substantial literature documenting deferasirox-induced renal injury, including Fanconi syndrome, but less documentation of hepatic toxicity and few reports of hepatic failure. The case highlights the importance of close monitoring of ferritin, bilirubin, and transaminases for patients on deferasirox.
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